- 陈忠周导师简介 -
基本信息
目前指导研究生
在籍
- 博士研究生11人 （其中 2010级:1 2011级:2 2013级:2 2014级:3 2015级:3） 硕士研究生3人 （其中 2014级:1 2015级:2）
不在籍
- 博士研究生10人 （其中 2007级:1 2008级:4 2009级:3 2010级:1 2011级:1） 硕士研究生2人 （其中 2008级:1 2013级:1）
个人简历
Name:陈忠周
E-mail: chenzhongzhou@cau.edu.cn
邮编：100193
地址：北京市海淀区圆明园西路2号 中国农业大学西校区生物学院生命科学研究中心2071房间
电话:** (O)
工作经历:
2002-2007美国国立犹太人医学研究中心免疫系
2007-目前 中国农业大学生物学院
教育:
1992-1997清华大学化学系物理化学及仪器分析专业理学学士
1994-1997清华大学经济管理学院企业管理专业理学学士
1997-2002清华大学生命科学院生命有机磷专业理学博士
研究方向：
蛋白质表达，纯化和蛋白质晶体学以及信号传导和转录，药物设计等
获奖情况：
2006:NJMRCVestalViolaCoulterScholarship
2004:NominationawardsofthenationaloutstandingDoctoraldissertationsbytheMinistryofEducation(全国百篇优秀博士论文提名奖)andFirstgradeoutstandingPh.D.dissertationofTsinghuaUniversity
1992-2002:VariousscholarshipsofTsinghuaUniversityineveryyear.
Otherthanthese,
1997:ExcellentundergraduateThesisandHonoredGraduateofTsinghuaUniversity.
1994:ScholarshipfromHongkongalumniofTsinghuaUniversity.
1993:SecondPrize-5thMathematicscontestofundergraduatecourse(北京市高等数学本科甲组二等奖),Beijing,1993
1992:QuintessenceStudentofFujianProvince.
所加入的协会
American crystallographic association
2008年起成为中国晶体学学会 终身会员
2009年中国生物物理学会会员
教育部留学回国人员科研启动基金评审专家
第十届分子生物物理专业委员会委员
2012 年 全国优秀青年基金获得者
2011届, 2012届中国农业大学本科生”百篇优秀毕业设计”优秀指导教师奖
2007:入选2007年教育部"新世纪优秀人才支持计划"
2009年中国生物物理学大会的优秀青年科学家奖
遴选学科专业
不公开
论文与专著
1. Lun Jiang, Xingliang Zhang, Zhongzhou Chen*. Structural basis of ABA perception by PYR/PYL/RCAR receptors. In book “Abscisic Acid: Metabolism, Transport and Signaling”, chapter 7, Zhang, Da-Peng (Ed.),XII, 2014th. December 14, 2014.
2. Peng Zhou, Yang Liu, Qiaojuan Yan, Zhongzhou Chen, Zhen Qin, Zhengqiang Jiang. Structural insights into the substrate specificity and transglycosylation activity of a fungal glycoside hydrolase family 5 β-mannosidase. Acta Crystallographica Section D, in press.
3. Yusheng Zhao, Shaojun Xie, Xiaojie Li, Chunlei Wang, Zhongzhou Chen, Jinsheng Lai, Zhizhong Gong. REPRESSOR OF SILENCING 5 encodes a member of the small heat shock protein family and is required for DNA demethylation in Arabidopsis. Plant Cell. 2014 Jun 10;26(6):2660-2675.
4. Guoqiang Wang, Qingzhong He, Chong Feng, Yang Liu, Zengqin Deng, Xiaoxuan Qi, Wei Wu, Pinchao Mei, Zhongzhou Chen*. The atomic-resolution structure of human alkb homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism. J Biol Chem. 2014 Oct 3;289(40):27924-36.
5. Chao Wang1, Zhongzhou Chen1(co-first author), xia Hong, fangkun Ning, Haolin Liu, jianye Zang, Xiaoxue Yan, Jennifer Kemp, Catherine Musselman, Tatinna Kutateladze, Rui Zhao, chengyu Jiang*, Gongyi zhang*. The structural basis of urea-induced protein unfolding in beta-catenin. Acta Crystallographica Section D, in press.
6. Chong Feng, Yang Liu, Guoqiang Wang, Zengqin Deng, Qi Zhang, Wei Wu, Yufeng Tong, Changmei Cheng*, Zhongzhou Chen*. Crystal structures of the human rna demethylase Alkbh5 reveal basis for substrate recognition. J Biol Chem, 2014 Apr 25;289(17):11571-83
7. Zengqin Deng, Kathleen C. Lehmann, Xiaorong Li, Chong Feng, Guoqiang Wang,Qi Zhang, Xiaoxuan Qi, Lin Yu, Xingliang Zhang, Wenhai Feng, Wei Wu, Peng Gong, Ye Tao, Clara C. Posthuma, Eric J. Snijder, Alexander E. Gorbalenya*, Zhongzhou Chen*. Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Research, 2014;42(5):3464-77.
8. Peng Zhou, Zhongzhou Chen, Qiaojuan Yan, Shaoqing Yang, Rolf Hilgenfeld, Zhengqiang Jiang. The structure of a glycoside hydrolase family 81 endo-β-1,3-glucanase. Acta Cryst. (2013). D69, 2027–2038.
9. Xingliang Zhang, Lun Jiang, Guoqiang Wang, Lin Yu, Qi Zhang, Qi Xin, Wei Wu , Zhizhong Gong, Zhongzhou Chen*. Structural insights into the abscisic acid stereospecificity by the ABA receptors PYR/PYL/RCAR. Plos one, 2013, vol 8, iss7, e67477
10. Wenli Tian, Lingyu Gao, Yazhou Zhao, Wenjun Peng* and Zhongzhou Chen*. Simultaneous determination of metronidazole, chloramphenicol and 10 sulfonamide residues in honey by LC–MS/MS. Anal. Methods, 2013, 5 (5), 1283-1288
11. Yunyun Geng, Shamci Monajembashi, Anwen Shao, Di Cui, Weiyong He, Zhongzhou Chen, Peter Hemmerich, Jun Tang. Contribution of the C-terminal regions of promyelocytic leukemia protein (PML) isoforms II and V to PML nuclear body formation. J Biol Chem. 2012, 287(36), 30729-42.
12. Qi Zhang, Shankang Qi, Mingchu Xu, Lin Yu, Ye Tao, Zengqin Deng, Wei Wu, Zhongzhou Chen*, Jiemin Wong*. Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b. Cell Research, 2013(23),225-241
13. Zhao Liu, Zhongzhou Chen, Wei Wu. Crystallization and preliminary X-ray studies of ferric uptake regulator in Magnetospirillum gryphiswaldense. Acta Cryst. (2012). F68, 902-905.
14. Xingliang Zhang, Wei Wu, Zhongzhou Chen*. Crystallization and preliminary X-ray diffraction studies of the abscisic acid receptor PYL3 and its complex with pyrabactin. Acta Cryst. (2012). F68, 479-482. Online 28 March 2012, [doi:10.1107/S**07506 ]
15. Xingliang Zhang, Qi Zhang, Qi Xin, Lin Yu, Zheng Wang, Wei Wu, Lun Jiang, Guoqiang Wang, Wenli Tian, Zengqin Deng, Yang Wang, Zhao Liu, Jiafu Long, Zhizhong Gong，Zhongzhou Chen*. Complex structures of the abscisic acid receptor PYL3/RCAR13 reveal a unique regulatory mechanism. Structure, Volume 20, Issue 5, 780-790, 9 May 2012 (*Corresponding author)
16. Lin Yu, Yang Wang, Shuo Huang, Jianjun Wang, Zengqin Deng, Qi Zhang, Wei Wu, Xingliang Zhang, Zhao Liu, Weimin Gong, Zhongzhou Chen*. Structural insights into a novel histone demethylase PHF8. Cell Research, 2010 Feb;20(2):166-73. (*Corresponding author)
17. 黄硕 余琳 汪洋 刘音 陈忠周. 人PHF8蛋白的原核表达、纯化与结晶. 基础医学与临床 2010, 30(7) : 721-725. (通讯作者)
18. Zhongzhou Chen, Jianye Zang, Fei Lan, Xia Hong, Qin Wang, Shaodong Dai, Kirk Hansen, Yang Shi, and Gongyi Zhang. Structural basis of the recognition of a methylated histone tail by JMJD2A. PNAS, 2007, June 26, vol. 104, no. 26, 10818–10823. (Similar results are reported later by other groups on Nature 2007 Jul 5;448(7149):87-91 and Nat Struct Mol Biol. 2007 Aug;14(8):689-95)
19. Hong Wei Chu, Jyoti Thaikoottathil, John G. Rino, Gongyi Zhang, Qun Wu, Taylor Moss, Yosef Refaeli, Russell Bowler, Sally E. Wenzel, Zhongzhou Chen, Jeffrey Zdunek, Rachel Breed, Ryan Young, Erin Allaire, Richard J. Martin. Function and regulation of SPLUNC1 protein in mycoplasma infection and allergic inflammation. J Immunol. 2007, Sep 15;179(6):3995-4002.
20. Zhongzhou Chen, Jianye Zang, Johnathan Whetstine,Xia Hong,Foteini Davrazou,Tatiana G. Kutateladze, Michael Simpson, Qilong Mao, Cheol-Ho Pan, Shaodong Dai, James Hagman,Kirk Hansen, Yang Shi, Gongyi Zhang. Structural insights into histone demethylation by JMJD2 family members. Cell, 2006, 125, 691–702.
21. Johnathan R. Whetstine, Amanda Nottke, Fei Lan, Maite Huarte, Sarit Smolikov, Zhongzhou Chen, Eric Spooner, En Li, Gongyi Zhang, Monica Colaiacovo, Yang Shi. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell, 2006, 125, 467–481.
22. Yufen Zhao, Xiaohong Liu, Ming Sun, Changmei Cheng, Yanmei Li, Bo Tan, Zhong-Zhou Chen. Theoretical studies on N-phosphoryl amino acids for the origin of biomolecules. ORIGINS OF LIFE AND EVOLUTION OF THE BIOSPHERE, 2006,36 (3): 261-263 JUN
23. Zhong-Zhou Chen, Yan-Mei Li, Hai-Yan Wang, Jin-Tang Du, Yu-Fen Zhao. Theoretical study on the rearrangement of beta-OH and gamma-OH in ESI mass spectrometry by N-phosphorylation. Journal of Physical Chemistry A, 2004, 108, 7686-7690.
24. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yu-Fen Zhao, Yu-Feng Tong, Jin-Feng Wang. Activity difference between alpha-COOH and beta-COOH in N-phosphorylaspartic acids. Journal of Organic Chemistry, 2003, 68, 4052-4058.
25. Zhong-Zhou Chen, Yan-Mei LI, Yu-Fen Zhao. Hydrolysis of dipeptide n-heptyl esters with Newlase F. Journal of Chemical Research(Synopses), 2003, 1, 1.
26. Zhong-Zhou Chen, Yan-Mei Li, Jing Ma, Bo Tan, Satoshi Inagaki, Yu-Fen Zhao, Comparing the activities of alpha-COOH and gamma-COOH in N-phosphoryl glutamic acid by theoretical study. Journal of Physical Chemistry A, 2002, 106, 11565-11569
27. Zhong-Zhou Chen, Yan-Mei Li, Xi Peng, Fu-Rong Huang, Yu-Fen Zhao. The Use of crude lipase in deprotection of C-terminal protecting groups. Journal of Molecular Catalysis B: Enzymatic, 2002,18, 243–249
28. Zhong-Zhou Chen, Shui-Bing Chen, Yi Chen, Yan-Mei Li, Jing Chen, Yu-Fen Zhao. Negative-ion ESI mass spectrometry of N-phosphoryl amino acids and dipeptides. Rapid Commun. Mass Spectrom. 2002, 16: 790-796
29. Zhong-Zhou Chen, Yu-Feng Tong, Shui-Bing Chen, Yi Chen, Yan-Mei Li, Yu-Fen Zhao. Direction of peptide formation from N-phosphoryl amino acids. Chinese Science Bull. 2002,47, 1866-1870
30. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yu-Fen Zhao. Comparing the penta-coordinate phosphoric intermediates from N-dimethylphosphoryl L-aspartic acid. Phosphorus Sulfur Silicon Relat. Elem., 2002, 177,2073-2074
31. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yu-Fen Zhao. Differentiation of alpha-COOH from beta-COOH in aspartic acids by N-phosphorylation. International Journal of Quantum Chemistry, 2001, 83, 41-51.
32. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yi Chen, Chang-Mei Cheng, Yu-Fen Zhao Differentiation of alpha-COOH from gamma-COOH in glutamic acids by N-phosphorylation. Journal of Molecular Structure: THEOCHEM, 2001, 574, 163-175.
33. Zhong-Zhou Chen, Yan-Mei Li, Yu-Fen Zhao. Hydrolysis of dipeptide n-heptyl esters with Newlase F. Journal of Chemical Research(M), 2003, 0101–0110
34. Jin-Tang Du, Yan-Mei Li, Zhong-Zhou Chen, Shi-Zhong Luo, Yu-Fen Zhao. The self-catalytic esterification reaction of O-phosphoryl serine derivative. Chinese Chemical Letters, 2005,16, 856-858
35. Jin-Tang Du, Yan-Mei Li, Zhong-Zhou Chen, Yang Jiang, Ru-Gang Zhong, Yu-Fen Zhao. Theoretical studies on N-phosphorylized amino acids properties by quantum chemical calculation. Chemical Journal Of Chinese Universities-Chinese,2005, 26, 540-545
36. Bo Tan, Matthew C. Lee, Meng Cui, Tong Liu, Zhong-Zhou Chen, Yan-Mei Li, Yong Ju, Yu-Fen Zhao, Kaixian Chen, Hualiang Jiang. A common intermediate for prebiotic synthesis of proteins and nucleosides: a density functional theory (DFT) study on the formation of penta-coordinate phosphorus carboxylic–phosphoric mixed anhydride from N-phosphoryl amino acids. Journal of Molecular Structure (Theochem), 2004,672, 51–60.
37. Yang Jiang, Bo Tan, Zhong-Zhou Chen, Tong Liu, Ru-Gang Zhong, Yan-Mei Li, David Jeremy Stewart, Yu-Fen Zhao, Hua-Liang Jiang. Phosphoryl group differentiating alpha-amino acids from beta- and gama-amino acids in prebiotic peptide formation. International Journal of Quantum Chemistry, 2003, 94, 232–241.
38. Shi-Zhong Luo, Yan-Mei Li, Zhong-Zhou Chen, H Abe, Li-Pin Cui, H Nakanishi, Xu-Rong Qin, Yu-Fen Zhao. Synthesis and matrix assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry study of phosphopeptide. Letters In Peptide Science,2003, 10, 57-62.
39. Hua Fu, JH Xu, RJ Wang, Zhong-Zhou Chen, GZ Tu, QZ Wang, Yu-Fen Zhao. Synthesis, crystal structure, and diastereomeric transfer of pentacoordinated phosphoranes containing valine or iso-leucine residue. Phosphorus Sulfur Silicon Relat. Elem.,2003, 178, 1963-1971.
40. Zhong-Zhou Chen, Yan-Mei Li, Gang Zhao, Yu-Fen Zhao. “The application of enzymatic protecting group in the organic synthesis”. Organic Chemistry (Chinese), 2001, 21, 273-277
41. Zhong-Zhou Chen, Yan-Mei Li, Xiu-Fen Kou, Xue Li, Fu-Rong Huang, Hai-Yan Wang, Ming-Ming Ma, Yu-Fen Zhao. Hydrolysis of dipeptide heptyl esters with Newlase F. Chinese chemical letter, 2001, 12, 693-696.
42. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yu-Fen Zhao. Theoretical study on the activity of a-COOH and b-COOH of N-phosphoryl aspartic acids. Chinese Chemical Letter, 2001, 12, 1093-1096.
43. Gang Zhao, Yan-Mei Li, Zhong-Zhou Chen, Yu-Fen Zhao. Chemical synthesis of O-phosphopeptide and their analogous”. Organic Chemistry (Chinese), 2001, 21, 8-15
44. Zhong-Zhou Chen, Yan-Mei Li, G.Zhao, Yu-Fen Zhao. The properties and synthesis of conjugated linoleic acids. China Oils and Fats (Chinese), 2000, 25(5), 41-45
45. Zhong-Zhou Chen, Yan-Mei Li, Gang Zhao, Yu-Fen Zhao. Study in the synthesis of b-peptides and its secondary structures, Chemistry (Chinese), 1999, 11, 21-29.
46. Zenghua Wu, Ling Xu, Zhong-zhou Chen, xinyao Hu. Computer aided study on the influence of catalysts on the coal ignition property(I). The influence of alkali and alkaline earth metal salts on the coal ignition property. Computers and Applied Chemistry(Chinese), 1996, 13, 270-273.
近五年承担的主要项目
承担主要科研项目：
动脉炎病毒属的RNA解旋酶的结构和功能研究
表观遗传学中重要蛋白质的结构和功能研究
干细胞分化与重新编程中蛋白质的结构与功能研究
利用结构生物学方法研究组蛋白甲基化调控的分子机制和功能研究
表观遗传学的结构机理研究
承担的教学工作
与其他老师共同 上 本科生的 结构生物学和 分子生物学
研究生的高级生物化学与分子生物学课程
