- 邵峰导师简介 -
基本信息
姓名*邵峰
姓名拼音Shao Feng
教师号不公开
出生日期不公开
性别男
所属院系生物学院
国籍中国
民族籍贯不公开参加何党派不公开加入党派时间不公开最高学历博士研究生最高学位博士毕业学校美国密西根大学毕业时间2003-04-30最高学位授予国别美国最高学位授予单位美国密西根大学最高学位授予专业最高学位授予时间2003-08-30外语语种英语外语熟练程度精通来校时间不公开参加工作时间不公开在职状态不公开教师来源不公开职称研究员职称评聘时间不公开职务其他任职时间不公开证件类型不公开证件号码不公开办公电话**家庭电话不公开手机不公开传 真不公开通信地址北京市中关村生命科学园科学园路七号邮政编码102206电子邮箱shaofeng@nibs.ac.cn教师主页导师类型博导是否外聘是兼职聘期起始日期2012-03-01兼职聘期终止日期2017-02-28兼职所在原单位北京生命科学研究所是否在外单位担任兼职导师不公开主要兼职单位名称不公开专家类别国家杰出青年基金获得者从事学科专业1生物学071009-细胞生物学从事学科专业2首任导师时间2005-02研究方向1病原细菌感染宿主和宿主先天性免疫防御的分子机制研究方向2研究方向3研究方向4备注

目前指导研究生
在籍

博士研究生2人 （其中 2011级:1 2012级:1） 硕士研究生 0人
不在籍
博士研究生7人 （其中 2007级:2 2008级:2 2009级:1 2010级:1 2011级:1） 硕士研究生 0人
个人简历
http://www.nibs.ac.cn/en/pi/shaofeng.html

Education

09/1991-07/1996 B.S., Applied Chemistry, Peking University, Beijing, China.

09/1996-06/1999M.S., Molecular Biology, Institute of Biophysics, CAS, Beijing, China.

07/1999-03/2003 Ph.D., Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.

Positions

· 06/2014-present, Associate Director for Research, National Institute of Biological Sciences, Beijing

· 10/2012-present, Investigator, National Institute of Biological Sciences, Beijing (accelerated promotion, equivalent to tenured professor in the western system)

· 10/2009-09/2012, Associate investigator, National Institute of Biological Sciences, Beijing (accelerated promotion, equivalent to tenured associate professor in the western system)

· 07/2005-09/2009, Assistant investigator, National Institute of Biological Sciences, Beijing

· 01/2004-06/2005, Damon Runyon Postdoctoral Fellow, Harvard Medical School, Boston, MA

· 04/2003-12/2003, Postdoctoral fellow, University of California, San Diego, CA, USA.

· 07/1999-03/2003, Graduate student research assistant, University of Michigan, Ann Arbor, MI

· 09/1997-06/1999, Graduate student research assistant, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China.

遴选学科专业
不公开
论文与专著
代表文章:

1. Lu Q, Yao Q, Xu Y, Li L, Li S, Liu Y, Gao W, Niu M, Sharon M, Ben-Nissan G, Zamyatina A, Liu X, Chen S & Shao F. (2014) An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis, Cell Host & Microbe, 16, 351–363.

2. Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, Hu L & Shao F. (2014) Inflammatory caspases are innate immune receptors for intracellular LPS, Nature (Article), 514, 187-192 (Published online 06 August 2014).

3. Xu H, Yang J, Gao W, Li L, Li P, Zhang L, Gong YN, Peng X, Xi JJ, Chen S, Wang F, Shao F. (2014) Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature, 513, 237–241 (Published online 11 June 2014).

4. Li S, Zhang L, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S & Shao F. (2013) Pathogen blocks host death receptor signaling by arginine GlcNAcylation of death domains. Nature, 501, 242-246.

5. Yang J, Zhao Y, Shi J & Shao F. (2013) Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation. Proc. Natl. Acad. Sci., 110, 14408-13.

6. Dong N, Zhu Y, Lu Q, Hu L, Zheng Y, Shao F. (2012) Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses. Cell,150, 1029-41.

7. Zhang L, Ding X, Cui J, Xu H, Chen J, Gong YN, Hu L, Zhou Y, Ge J, Lu Q, Liu L, Chen S, Shao F. (2012) Cysteine methylation disrupts ubiquitin-chain sensing in NF-kB activation. Nature, 481, 204-8.

8. Zhao Y, Yang J, Shi J, Gong YN, Lu Q, Xu H, Liu L, Shao F. (2011) The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature, 477, 596–600.

9. Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F. (2010) Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science, 329, 1215-8.

10.Li H, Xu H, Zhou Y, Zhang J, Long C, Li S, Chen S, Zhou JM, Shao F. (2007) The phosphothreonine lyase activity of a bacterial type III effector family. Science, 315, 1000-3.

其它文章 (不包括综述):

1. Yao Q, Zhang L, Wan X, Chen J, Hu L, Ding X, Li L, Karar J, Peng H, Chen S, Huang N, Rauscher FJ, Shao F. (2014) Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway. PLoS Pathogens, 10: e**.

2. Yao Q, Lu Q, Wan X, Song F, Xu Y, Zamyatina A, Huang N, Zhu P & Shao F. (2014) A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family, eLife, 2014; 3:e03714.

3. Pan M, Li S, Li X, Shao F, Liu L and Hu HG (2014) Synthesis and Specific Antibody Generation of Glycopeptides with Arginine N-GlcNAcylation. Angew Chem Int Ed Engl. Article first published online: 29 Oct 2014, DOI:10.1002/anie.** (co-corresponding author).

4. Lu Q, Xu Y, Yao Q, Niu M and Shao F. (2014) A polar-localized iron-binding protein determines the polar targeting of Burkholderia BimA autotransporter and actin tail formation, Cellular Microbiology, 2014 Oct 8. doi: 10.1111/cmi.12376. [Epub ahead of print].

5. Ding J, Luo AF, Hu L, Wang DC, Shao F. (2014) Structural basis of the ultrasensitive calcium indicator GCaMP6. SCIENCE CHINA Life Sciences,57, 269–274.

6. Li T, Lu Q, Wang G, Xu H, Huang H, Cai T, Kan B, Ge J & Shao F. (2013) SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription. EMBO Reports, 14, 733-40.

7. Yu Q, Hu L, Yao Q, Zhu Y, Dong N, Wang DC, Shao F. (2013) Structural analyses of a Legionella RabGAP effector reveal a new GAP fold that catalytically mimics eukaryotic RasGAP. Cell Research, 23, 775-87.

8. Zhou Y, Dong N, Hu L, Shao F. (2013) The Shigella Type Three Secretion System Effector OspG Directly and Specifically Binds to Host Ubiquitin for Activation. PLoS One, 8: e57558.

9. Yao Q, Cui J, Wang J, Li T, Wan X, Luo T, Gong YN, Xu Y, Huang N, Shao F. (2012) Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosis. Proc. Natl. Acad. Sci., 109, 20395-400.

10. Ku B, Lee KH, Park WS, Yang CS, Ge J, Lee SG, Cha SS, Shao F, Heo WD, Jung JU, Oh BH. (2012) VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages. PLoS Pathogen, 8: e**.

11. Ge J, Gong YN, Xu Y, Shao F. (2012) Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking. Proc. Natl. Acad. Sci., 109, 6193-8.

12. He S, Liang Y, Shao F, Wang X. (2011) Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3–mediated pathway. Proc. Natl. Acad. Sci., 108, 20054-9.

13. Li C, Tu S, Wen S, Li S, Chang J, Shao F, and Lei X. (2011) Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C. The Journal of Organic Chemistry, 76, 3566-70.

14. Gong YN, Wang X, Wang J, Yang Z, Li S, Yang J, Liu L, Lei X, Shao F. (2010) Chemical probing reveals insights into the signaling mechanism of inflammasome activation. Cell Research, 20, 1289-305.

15. Dong N, Liu L, Shao F. (2010) A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis. The EMBO J., 29, 1363-76.

16. Zhu Y, Hu L, Zhou Y, Yao Q, Liu L, Shao F. (2010) Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. Proc. Natl. Acad. Sci., 107, 4699-704.

17. Ge J, Xu H, Li T, Zhou Y, Zhang Z, Li S, Liu L, Shao F.(2009)A Legionella type IV effector activates the NF-κB pathway by phosphorylating the IκB family of inhibitors. Proc. Natl. Acad. Sci., 106, 13725-30.

18. Chen Y, Yang Z, Meng M, Zhao Y, Dong N, Yan H, Liu L, Ding M, Peng, HB, Shao F. (2009) Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol. Cell, 35, 841-55.

19. Dowen RH, Engel JL, Shao F, Ecker JR, Dixon JE. (2009) A family of bacterial cysteine protease type III effectors utilizes acylation-dependent and -independent strategies to localize to plasma membranes.J. Biol. Chem., 284, 15867-79.

20. Yao Q, Cui J, Zhu Y, Wang G, Hu L, Long C, Cao, R, Liu X, Huang N, Chen S, Liu L, Shao F. (2009) A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle. Proc. Natl. Acad. Sci., 106, 3716-21.

21. Zhu Y., Li H., Hu L., Wang, J., Zhou Y., Pang Z., Liu L., Shao F. (2008) Structure of a Shigella effector reveals a new class of ubiquitin ligases. Nature Structural & Molecular Biology, 15, 1302-8.

22. Zhu Y, Li H, Long C, Hu L, Xu H, Liu L, Chen S, Wang DC, Shao F. (2007) Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase. Mol. Cell, 28, 899-913.

23. Zhang J, Shao F, Li Y, Cui H, Chen L, Li H, Zou Y, Long C , Lan L, Chai J, Chen S, Tang X, Zhou JM. (2007) A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity. Cell Host & Microbe, 1, 175-85.

24. Alto NM, Shao F, Lazar CS, Brost RL, Chua G, Mattoo, SM, McMahon SA, Ghosh P, Hughes TR, Boone C, Dixon JE. (2006) Identification of a bacterial type III effector family with G-protein mimicry functions. Cell, 124, 133-45.

25. Armstrong MB, Bian X, Liu Y, Subramanian C, Ratanaproeska AB, Shao F, Yu V, Kwok R, Opipari AW, Jr., Castle VP. (2006) Signaling from p53 to NF-kappaB determines chemotherapy responsiveness of neuroblastoma. Neoplasia, 8, 964-74.

26. Zhu M, Shao F, Innes RW, Dixon JE, Xu Z. (2004) The crystal structure of Pseudomonas avirulence protein AvrPphB: a papain-like fold with a distinct substrate-binding site. Proc. Natl. Acad. Sci., 101, 302-7.

27. Shao F, Golstein, C, Ade J, Stoutemyer M., Dixon JE, Innes RW. (2003) Cleavage of Arabidopsis PBS1 by a bacterial type III effector. Science, 301, 1230-3.

28. Shao F, Vacratsis PO, Bao Z, Bowers KE, Fierke CA, Dixon JE. (2003) Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases. Proc. Natl. Acad. Sci., 100, 904-9.

29. Shao F, Merritt PM, Bao Z, Innes RW, Dixon JE. (2002) A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. Cell, 109, 575-88.

30. Bian X, McAllister-Lucas LM, Shao F, Schumacher KR, Feng Z, Porter AG, Castle VP, Opipari AW, Jr. (2001) NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells. J. Biol. Chem., 276, 48921-9.

31. Shao F, Bader MW, Jakob U, Bardwell JC. (2000) DsbG, a protein disulfide isomerase with chaperone activity. J. Biol. Chem., 275, 13349-52.

32. Wang CG, He XL, Shao F, Liu W, Ling MH, Wang DC, Chi CW. (2001) Molecular characterization of an anti-epilepsy peptide from the scorpion Buthus martensi Karsch. Eur. J. Biochem., 268, 2480-5.

33. Shao F, Hu Z, Xiong YM, Huang QZ, Wang CG, Zhu RH, Wang DC. (1999) A new antifungal peptide from the seeds of Phytolacca americana: characterization, amino acid sequence and cDNA cloning. Biochim. Biophys. Acta, 1430, 262-8.

34. Shao F, Xiong YM, Zhu RH, Ling M, Chi CW, Wang DC. (1999) Expression and purification of the BmK M1 neurotoxin from the scorpion Buthus martensii Karsch. Protein Expr. Purif., 17, 358-65.
近五年承担的主要项目
2010CB835400重要疾病或基础细胞生命活动相关的新生物化学机制探索和深入研究
2010CB835401 致病菌效应分子和宿主分子作用的生化机理

承担的教学工作
北大、清华和北京生命科学研究所联合培养博士生项目的模块课教学