- 王晓晨导师简介 -
基本信息
目前指导研究生
在籍
- 博士研究生3人 （其中 2012级:1 2013级:2） 硕士研究生 0人
不在籍
- 博士研究生 0人 硕士研究生 0人
个人简历
http://www.nibs.ac.cn/index.php?act=view&id=627
遴选学科专业
不公开
论文与专著
1. Wu, Y.W., Cheng, S.Y., Zhao, H.Y., Zou, W., Yoshina, S., Mitani, S., Zhang, H., *Wang, X.C. (2014) Autolysosome formation requires clearance of phosphatidylinositol-3-phosphate by the myotubularin phosphatase MTM-3 in C. elegans.EMBO Rep15(9):973-81.2014/09
2.Wang H, Lu Q, Cheng S,*Wang X, *Zhang H(2013). Autophagy activity contributes to programmed cell death in Caenorhabditis elegans.Autophagy.9(12):1975-82
3.Cheng S , Wu Y , Lu Q , Yan J, Zhang H， *Wang X(2013).Autophagy genes coordinate with the class II PI3 kinase PIKI-1 to regulate apoptotic cell clearance in C. elegans. Autophagy .9(12):2022-32, 2013/12
4.Li X, Chen B, Yoshina S, Cai T, Yang F, Mitani S, *Wang X(2013).Inactivation of C. elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants，Mol Biol Cell. 24(8):1163-75.
5.Huang J; Wang H; Chen Y; *Wang X; *Zhang H.Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance Development, 139(24), pp 4613-4622, 2012/12.
6.Zhang Y, Wang H, Kage-N, Mitani S, *Wang X (2012)，C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment. Current Biol. 22(14), pp 1276-1284
7.Liu B, Du H, Rutkowski R, Gartner A, *Wang X(2012).LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis.Science.337(6092), pp 351-354
8.Kang Y, Zhao D, Liang H, Liu B, Zhang Y, Liu Q, *Wang X, *Liu Y(2012).Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment.Genes & Dev, 26(12), pp1339-1350
9.Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, Tian D, *Wang X, *Vale RD, *Ou G(2012).Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. J Cell Biol. 197(1), pp27-35, 2012/3/26
10.*Zou W, Wang X, Vale RD, Ou G(2012).Autophagy genes promote apoptotic cell corpse clearance，Autophagy, 8(8),pp 1267-1268.
11.Wu YC, Wang X, Xue D，Methods for Studying Programmed Cell Death in C. elegans，Methods in Cell Biology,Xue D, ELSEVIER ACADEMIC PRESS INC, 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA, pp 297-320,美国, 2012
12.Guo P, Hu T, Zhang J, Jiang S, *Wang X (2010).Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation . Proceedings of the National Academy of Sciences of the United States of America.107(42), pp 18016-18021, 10/19
13.*Wang X, Li W, Zhao D, Liu B, Shi Y, Chen, B, Yang H, Guo P, Geng X, Shang Z, Peden E, Kage-Nakadai E,Mitani S, *Xue D (2010).Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor.Nature Cell Biology. 12(7), pp 655-664
14.Guo P, *Wang X(2010).Rab GTPases act in sequential steps to regulate phagolysosome formation，Small GTPases,1(3), pp 170-173,
15.Chen B, Jiang Y, Zeng S, Yan J, Li X, Zhang Y, Zou W, *Wang X(2010). Endocytic Sorting and Recycling Require Membrane Phosphatidylserine Asymmetry Maintained by TAT-1/CHAT-1. PLoS Genetics.6(12), p e**
16.Tian Y, Li Z, Hu W, Ren H, Tian E, Zhao Y, Lu Q, Huang X, Yang P, Li X, WangX, Kovacs AL, *Yu L, *Zhang H，(2010) . C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms. Cell. 141(6), pp 1042-1055
17.Zou W, Lu Q, Zhao D, Li W, Mapes J, Xie Y, *Wang X(2009). Caenorhabditis elegans Myotubularin MTM-1 Negatively Regulates the Engulfment of Apoptotic Cells. PLoS Genetics. 5(10), p e**
18. Li W, Zou W, Zhao D, Yan J, Zhu Z, Lu J, and Wang X* (2009). C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5. Development.136, 2445-2455.
19. Lu Q, Zhang Y, Hu T, Guo P, Li W, and Wang X* (2008). C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells. Development.135, 1069-1080.
20.Darland-Ransom M, Wang X, Sun CL, Mapes J, Gengyo-Ando K, Mitani S, and Xue D (2008) Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Science.320(5875), 528-31.
21. Wang X, Wang J, Gengyo-Ando K, Gu L, Sun CL, Yang C, Shi Y, Kobayashi T, Shi Y,Mitani S, Xie XS, and Xue D (2007). C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid cramblase SCRM-1. Nat Cell Biol.9, 541-549.
22.Yang C, Yan N, Parish J, Wang X, Shi Y, and Xue D (2006). RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in Caenorhabditis elegans. J BiolChem. 281(14), 9137-9144.
23.Wang X, Wu Y, Fadok V, Lee MC, Gengyo-Ando K, Cheng L, Ledwich D, Hsu P,Chen J, Chou B, Henson P, Mitani S, and Xue D (2003). Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.Science 302, 1563-1566.
24.Wang X, Yang C, Cai J, Shi Y, and Xue D (2002). Mechanisms of AIF-apoptotic DNA degradation in Caenorhabditis elegans. Science 298, 1587-1592. (Research article)
25.Wang X, Bauw G, Van Damme E, Peumans W, Chen Z, Van Montagu M, Angenon G,and Dillen W (2001). Gastrodianin-like mannose-binding proteins: a novel class of plant proteins with antifungal properties，Plant Journal, 25(6), pp 651-661
近五年承担的主要项目
1.线虫凋亡细胞清除机制的研究 2007AA02Z1A0696 万2007.06.01-2010.11.30科技部863项目主持负责人
2.秀丽线虫凋亡细胞清除机制的研究 2010CB**万2010.05.01-2012.12.31科技部“国家重大科学研究计划”（973 项目）主持，负责人
3.胁迫环境中自噬-溶酶体通路与细胞代谢调控机制 2013CB**万2013.1.1-2017.12.31科技部“国家重大科学研究计划”（973 项目）骨干
4.精子发育过程中残余体的清除和吞噬信号磷脂酰丝氨酸PS的调控 **万2014.01.01-2017.12.31国家自然科学基金委国家杰出青年科学基金负责人
承担的教学工作
PTN项目的模块课教学
