- 江海洋导师简介 -
基本信息
目前指导研究生
在籍
- 博士研究生4人 （其中 2013级:1 2014级:1 2015级:2） 硕士研究生4人 （其中 2014级:2 2015级:2）
不在籍
- 博士研究生 0人 硕士研究生6人 （其中 2009级:1 2010级:1 2011级:1 2012级:2 2013级:1）
个人简历
江海洋，四川省德阳市人，博士，教授，博士生导师，入选2008年度教育部新世纪优秀人才支持计划。中国畜牧兽医学会兽医药理学与毒理学分会理事，北京市第一届食品安全地方标准审评委员会委员，科技部、农业部、食药总局、国家基金委项目评审专家。主要从事基础兽医学方面的教学和科研工作，研究方向为动物源食品安全检测技术、兽医药理学与毒理学。
食品安全已成为国内外关注的焦点，与其相关的检测和控制关键技术已成为当前研究的热点。针对动物源食品中存在的兽用抗菌药物（磺胺类、喹诺酮类、四环素类、青霉素类、头孢菌素类、大环内酯类、氨基糖苷类等）、违禁药物（瘦肉精、氯霉素、硝基呋喃类、硝基咪唑类等）、非法添加物（三聚氰胺、苏丹红等）、霉菌毒素（黄曲霉毒素、玉米赤霉醇、呕吐毒素等）等近百种重要有害化合物，开展了小分子化合物抗原抗体制备技术、有害化合物残留检测技术（快速筛查、定量和确证分析）、药效/药代动力学等方面的研究。建立了小分子化合物抗原抗体制备技术平台，构建了库容量超过200种的抗原抗体资源库；建立了残留检测的胶体金免疫分析方法、酶联免疫分析方法、化学发光免疫分析方法、量子点免疫分析方法等20余种，并研制出了相应的快速检测产品（胶体金检测卡、ELISA试剂盒和免疫亲和色谱柱）近40个，产品在2011年十一五国家重大科技成就展、2012年全国科普会上展出；研究建立了残留检测的HPLC、GC、GC-MS、UPLC-MS/MS等仪器分析方法30余种，形成国家（或行业）检测方法标准35项，其中21项已发布。快速检测产品和检测方法标准已在国家兽药残留监控计划、农业部无公害食品行动计划、农业部三聚氰胺和瘦肉精专项整治行动、农业部生鲜乳质量安全监测计划、北京奥运会、六十周年国庆阅兵村、上海世博会、广州亚运会、深圳大运会、辽宁全运会、南京青奥会等例行监测和重大赛事的食品安全保障工作中应用，有效保障了食品安全；开展了替米考星、马杜霉素、爱普菌素、头孢噻呋等药物效应动力学、药物代谢动力学、毒理学以及生态环境中富集、降解和消除研究，为兽药安全性评价提供了科学依据。
主持和参加科研项目40余项，包括十二五科技支撑项目、十一五科技支撑项目、973项目、863项目、十五国家科技攻关计划、公益性行业专项课题、国家食品安全重大科技专项课题、国家自然科学基金面上项目和重点项目、农业部残留专项及国家农业行业标准制定项目等。在国内外学术刊物上发表论文135篇，其中SCI收录论文82篇；申请国家发明专利35项，其中27项获得授权；参编著（译）作3部；2013年获得中华农业科技奖科学研究成果一等奖和优秀创新团队奖；2010年获得北京市科学技术进步三等奖；2006年获得国家科学技术二等奖；2005年获得北京市科学技术一等奖；2001年获得北京市科学技术进步二等奖。2015年指导硕士研究生陈敏获得院级优秀论文、校级优秀研究生称号、北京市优秀研究生毕业生称号；2014年指导硕士研究生朱爱玲获得院级优秀论文、校级优秀研究生称号和北京市优秀研究生毕业生称号，陈敏获得国家奖学金；2013年指导硕士研究生朱景慧获得院级优秀论文和校级优秀研究生称号、硕士研究生朱爱玲获得国家奖学金，合作指导博士研究生陶晓奇获得国家奖学金、校级三好学生称号和校级优秀研究生称号；2012年指导硕士研究生胡婷获得校级优秀论文、校级优秀研究生毕业生称号和北京市优秀研究生毕业生称号，朱景慧获得国家奖学金。
联系方式：
地址：北京市海淀区圆明园西路2号国家兽药安全评价中心，100193
电话：**；传真：**
邮箱：haiyang@cau.edu.cn
遴选学科专业
不公开
论文与专著
1. Jie Xie, Tao Peng, Jianli He, Yu Shao, Chunlin Fan, Ying Chen, Wenxiao Jiang, Min Chen, Qi Wang, Xingyao Pei, Shuangyang Ding, Haiyang Jiang*. Preparation and characterization of an immunoaffinity column for theselective extraction of aflatoxin B1in 13 kinds of foodstuffs. Journal of Chromatography B. 2015, 998, 50-56
2. Min Chen, Shuangyang Ding, Kai Wen, Sanlei Xie, Qi Wang, Xingyao Pei, Jie Xie, Zhanhui Wang, Haiyang Jiang*. Development of a fluorescence-linked immunosorbent assay for detection of avermectins using a fluorescent single-domain antibody. Analytical Methods，2015, 7（9）, 3728-3734
3. Wenxiao Jiang, Natalia V. Beloglazova, Zhanhui Wang, Haiyang Jiang, Kai Wen, Sarah de Saeger, Pengjie Luo, Yongning Wu, Jianzhong Shen*. Development of a multiplex flow-through immunoaffinity chromatography test for the on-site screening of 14 sulfonamide and 13 quinolone residues in milk. Biosensors and Bioelectronics. 2015, 66, 124-128
4. Hui Li, Xi Xia, Xiaowei Li, Gaowa Naren, Qin Fu, Yang Wang, Congming Wu, Shuangyang Ding, Suxia Zhang, Haiyang Jiang, Jiancheng Li, Jianzhong Shen*. Untargeted Metabolomic Profiling of Amphenicol-Resistant Campylobacter jejuni by Ultra-High-Performance Liquid Chromatography Mass Spectrometry. Journal of Proteome Research. 2015, 14, 1060-1068
5. Min Chen, Kai Wen, Xiaoqi Tao, Shuangyang Ding, Jie Xie, Xuezhi Yu, Jiancheng Li, Xi Xia, Yang Wang, Sanlei Xie, Haiyang Jiang*. A novel multiplexed fluorescence polarization immunoassay based on a recombinant bi-specific single-chain diabody for simultaneous detection of fluoroquinolones and sulfonamides in milk. Food Additives & Contaminants: Part A. 2014, 31(12), 1959-1967
6. Min Chen, Kai Wen, Xiaoqi Tao, Jie Xie, Limiao Wang, Yang Li, Shuangyang Ding, Haiyang Jiang*. Cloning, expression, purification and characterization of a bispecific single-chain diabody against fluoroquinolones and sulfonamides in Escherichia coli. Protein Expression and Purification. 2014, 100C: 19-25
7. Ailing Zhu, Tao Peng, Dongdong Chen, Ping Wang, Guomin Wang, Jinhua Wang, Chunlin Fan, Ying Chen, Haiyang Jiang*. Determination of l-hydroxyproline using hydrophilic interaction chromatography coupled to tandem mass spectrometry with lyophilized concentrated extraction in milk and dairy products. Journal of Separation Science. 2014, 37(14), 1773-1780
8. Fei Xu, Wenjun Wang, Haiyang Jiang, Zhaopeng Wang, Zhanhui Wang, Ping Guo, Shuangyan Sun, Shuangyang Ding. Indirect competitive enzyme-linked immunosorbent assay for the detection of dibutyl phthalate in white wine, compared with GC-MS. Food Analytical Methods. 2014, 7(8), 1619-1626
9. Xu Fei, Jiang Wenxiao, Zhou Jie, Wen Kai, Wang Zhanhui, Jiang Haiyang, Ding Shuangyang*. Production of monoclonal antibody and development of a new immunoassay for apramycin in food. Journal of Agricultural and Food Chemistry. 2014, 62 (14), 3108-3113
10. Dongdong Zhang, Xiaoqi Tao, Haiyang Jiang, Kai Wen, Jianzhong Shen, Xingyuan Cao. Simultaneous Detection of Forbidden Chemical Residues in Milk Using Dual-Label Time-Resolved Reverse Competitive Chemiluminescent Immunoassay Based on Amine Group Functionalized Surface. PLOS ONE. 2014, 9, e**
11. Tao Xiaoqi, Wang Wenjun, Wang Zhanhui, Cao Xingyuan, Zhu Jinghui, Niu Lanlan, Wu Xiaoping, Jiang Haiyang*, Shen Jianzhong*. Development of a highly sensitive chemiluminescence enzyme Immunoassay using enhanced luminol as substrate. Luminescence. 2014, 29(4), 301-306
12. Jiang Haiyang, Wang Wenjun, Zhu Jinghui, Tao Xiaoqi, Li Jiancheng, Xia Xi, Wen Kai, Xu Fei, Wang Zhaopeng, Chen Min, Li Xiangmei, Wu Xiaoping, Wang Shien, Ding Shuangyang*. Determination of zeranol and its metabolites in bovine muscle and liver by a chemiluminescence enzyme immunoassay: compared to an UPLC-MS/MS Method. Luminescence. 2014, 29(4), 393-400
13. Tao Xiaoqi, Yu Xuezhi, Zhang Dongdong, Shi Weimin, Jiang Haiyang, Wang Xia, Wang Zhanhui, Niu Lanlan, Wu Xiaoping, Xia Xi, Shen Jianzhong*. Development of a rapid chemiluminescent ciELISA for simultaneous determination of florfenicol and its metabolite florfenicol amine in animal meat products. Journal of the Science of Food and Agriculture. 2014, 94(2), 301-307
14. Tao Xiaoqi, Shen Jianzhong, Cao Xingyuan, Wang Zhanhui, Wu Xiaoping, Jiang Haiyang*. Simultaneous determination of chloramphenicol and clenbuterol in milk with hybrid chemiluminescent immunoassays. Analytical Methods. 2014, 6, 1021-1027
15. Tao Xiaoqi, Jiang Haiyang, Zhu Jinghui, Shi Weimin, Wang Zhanhui, Niu Lanlan, Wu Xiaoping, Shen Jianzhong*. An ultrasensitive chemiluminescent ELISA for determination of chloramphenicol in milk, milk powder, honey, eggs and chicken muscle. Food and Agricultural Immunology. 2014, 25(1), 137-148
16. Yuping Wu, Fei Xu, Haiyang Jiang, Xiaoqi Tao, Kui Zhu, Wenli Liu, Yifang Cui, Xiaoyong Huang, Shuangyang Ding. Determination of salbutamol, clenbuterol, and brombuterol in urine by a highly sensitive chemiluminescence enzyme immunoassay. Analytical Letters. 2014, 47(16), 2761-2773
17. Jie Zhou, Kui Zhu, Fei Xu, Wenjun Wang, Haiyang Jiang, Zhanhui Wang, Shuangyang Ding. Development of a microsphere-based fluorescence immunochromatographic assay for monitoring lincomycin in milk, honey, beef, and swine urine. Journal of Agricultural and Food Chemistry. 2014, 62(49), 12061-12066
18. Wang Yahui, Wang Zhanhui, Jiang Haiyang, Xia Xi, Shen Jianzhong, Ding Shuangyang*. Development of a monoclonal antibody-based enzyme-linked immunosorbent assay for the analysis of diclazuril in chicken tissues. Food Analytical Methods. 2013, 6(6), 1685-1692
19. Tao Xiaoqi, Chen Min, Jiang Haiyang, Shen Jianzhong, Wang Zhanhui, Wang Xia, Wu Xiaoping, Wen Kai*. Chemiluminescence competitive indirect enzyme immunoassay for 20 fluoroquinolone residues in fish and shrimp based on a single-chain variable fragment. Analytical and Bioanalytical Chemistry. 2013, 405(23), 7477-7484
20. Zhu Ailing, Peng Tao, Liu Liang, Xia Xi, Hu Ting, Tao Xiaoqi, Wen Kai, Cheng Linli, Li Jiancheng, Ding Shuangyang, Cao Xingyuan, Jiang Haiyang*. Ultra-performance liquid chromatography-tandem mass spectrometry determination and depletion profile of flunixin residues in tissues after single oral administration in rabbits. Journal of Chromatography B. 2013, 934, 8-15
21. Peng Tao, Zhu Ailing, Zhou Yuening, Hu Ting, Yue Zhenfeng, Chen Dongdong, Wang Guomin, Kang Jian, Fan Chunlin, Chen Ying, Jiang Haiyang*. Development of a simple method for simultaneous determination of nine subclasses of non-steroidal anti-inflammatory drugs in milk and dairy products by ultra-performance liquid chromatography with tandem mass spectrometry. Journal of Chromatography B. 2013, 933, 15-23
22. Tao Xiaoqi, Jiang Haiyang, Yu Xuezhi, Zhu Jinghui, Wang Xia, Wang Zhanhui, Niu Lanlan, Wu Xiaoping, Shen Jianzhong*. Simultaneous determination of chloramphenicol, florfenicol and florfenicol amine in ham sausage with a hybrid chemiluminescent immunoassay. Food Additives & Contaminants: Part A. 2013, 30(5), 804-812
23. Tao Xiaoqi, Jiang Haiyang, Yu Xuezhi, Zhu Jinghui, Wang Xia, Wang Zhanhui, Niu Lanlan, Wu Xiaoping, Shen Jianzhong*. An ultrasensitive chemiluminescence immunoassay of chloramphenicol based on gold nanoparticles and magnetic beads. Drug Testing and Analysis. 2013, 5(5), 346-352
24. Jiang Wenxiao, Wang Zhanhui, Ross C. Beier, Jiang Haiyang, Wu Yongning, Shen Jianzhong*. Simultaneous determination of 13 fluoroquinolone and 22 sulfonamide residues in milk by a dual-colorimetric enzyme-linked immunosorbent assay. Analytical Chemistry. 2013, 85(4), 1995-1999
25. Shen Jianzhong, Wang Wenjun, Xia Xi, Zhu Jinghui, Wu Xiaoping, Wang Shien, Niu Lanlan, Ding Shuangyang, Wang Zhanhui, Wang Zhaopeng, Li Xiaowei, Jiang Haiyang*. Determination of four nitrofuran metabolites and chloramphenicol in biological samples using enzyme-linked immunosorbent assay. Analytical Letters. 2013, 46(9), 1404-1418
26. Wu Jiao, Xu Fei, Zhu Kui, Wang Zhanhui, Wang Yahui, Zhao Kunxia, Li Xiaowei, Jiang Haiyang*, Ding Shuangyang*. A rapid and sensitive fluoroimmunoassay based on quantum dots for detection of melamine in milk. Analytical Letters. 2013, 46(2), 275-285
27. Wen Kai, N?lke G, Schillberg S, Wang Zhanhui, Zhang Suxia, Wu Congming, Jiang Haiyang, Meng Hui, Shen Jianzhong*. Improved fluoroquinolone detection in ELISA through engineering of a broad-specific single-chain variable fragment binding simultaneously to 20 fluoroquinolones. Analytical and Bioanalytical Chemistry. 2012, 403(9), 2771-2783
28. Luo Pengjie, Jiang Wenxiao, Beier Ross C, Shen Jianzhong, Jiang Haiyang, Miao Hong, Zhao Yunfeng, Chen Xia, Wu Yongning*. Development of an enzyme-linked immunosorbent assay for determination of the furaltadone etabolite, 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ) in animal tissues. Biomedical and Environmental Science. 2012, 25(4), 449-457 449
29. Tao Xiaoqi, Jiang Haiyang, Yu Xuezhi, Zhu Jinghui, Wang Xia, Wang Zhanhui, Niu Lanlan, Wu Xiaoping, Xia Xi, Shi Weimin, Shen Jianzhong*. Development and validation of a chemiluminescent ELISA for simultaneous determination of florfenicol and its metabolite florfenicol amine in chicken muscle. Analytical. Methods. 2012, 4, 4083-4090(并列第一)
30. Zhu Jinghui, Tao Xiaoqi, Ding Shuangyang, Shen Jianzhong, Wang Zhanhui, Wang Yang, Xu Fei, Wu Xiaoping, Hu Ting, Zhu Ailing, Jiang Haiyang*. Micro-plate chemiluminescence enzyme immunoassay for determination of zeranol in bovine milk and urine. Analytical Letters. 2012, 45(17), 2538-2548
31. Tao Xiaoqi, Jiang Haiyang*, Zhu Jinghui, Niu Lanlan, Wu Xiaoping, Shi Weimin, Wang Zhanhui, Shen Jianzhong*. Detection of ultratrace chloramphenicol residues in milk and chicken muscle samples using a chemiluminescent ELISA. Analytical Letters. 2012, 45(10), 1254-1263
32. Hu Ting, Peng Tao, Chen Dongdong, Li Xiaojuan, Dai Hanhui, Deng Xiaojun, Yue Zhenfeng, Wang Guomin, Shen Jianzhong, Xia Xi, Ding Shuangyang, Zhou Yuening, Zhu Ailing, Jiang Haiyang*. Simultaneous determination of thirty non-steroidal anti-inflammatory drugs residues in swine muscle by ultra-high-performance liquid chromatography with tandem mass spectrometry. Journal of Chromatography A. 2012, 1219, 104-113
33. Hu Ting, Peng Tao, Li Xiaojuan, Chen Dongdong, Zhou Yuening, Dai Hanhui, Xia Xi, Ding Shuangyang, Zhu Ailing, Jiang Haiyang*. Ion exchange solid phase extraction coupled with liquid chromatography tandem mass spectrometry for determination of 8 classes of non-steroidal anti-inflammatory drugs residues in animal tissues. Chinese Journal of Analytical Chemistry. 2012, 40(2), 236-242
34. Zhu Kui, Li Jiancheng, Wang Zhanhui, Jiang Haiyang, Beier Ross C, Xu Fei, Shen Jianzhong, Ding Shuangyang*. Simultaneous detection of multiple chemical residues in milk using broad-specificity antibodies in a hybrid immunosorbent assay. Biosensors and Bioelectronics. 2011, 26(5), 2716-2719
35. Dong Yichun, Xia Xi, Wang Xia, Ding Shuangyang, Li Xiaowei, Zhang Suxia, Jiang Haiyang, Liu Jinfeng, Li Jiancheng, Feng Zhongze, Ye Ni, Zhou Mingxia, Shen Jianzhong*. Validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for determination of ractopamine: Application to residue depletion study in swine. Food Chemistry. 2011, 127(1), 327-332
36. Jiang Haiyang, Zhai Weihong, Xia Xi, Ding Shuangyang, Xu Fei, Shen Jianzhong*, Li Xiaowei, Liu Jinfeng. LC determination of nosiheptide in swine kidney and liver. Chromatographia. 2010, 71, 131-134
37. Shen Jianzhong, Zhang Suxia, Wu Congming, Jiang Haiyang, Wang Zhanhui, Cheng Linli*. Determination of six resorcylic acid lactones in feed by GC–MS. Chromatographia. 2010, 71, 163-165
近五年承担的主要项目
1.公益性行业专项任务课题“动物源食品中苯乙醇胺A等非法添加物的快速检测技术研究及应用”（**-5），经费102万元，2012.9-2014.9，主持人
2.国家自然科学基金项目“同时识别多种兽药的ScFv抗体的分子作用机制研究”（**），经费61万元，2012.1-2015.12，主持人
3.十二五国家科技支撑计划“阿维菌素类等抗体的制备及其产品研发”（2011BAK10B01-02），经费170万元，2011.1-2013.12，主持人
4.青年教师科研项目“β-内酰胺类抗生素受体蛋白的定向突变研究”（2011JS012），经费4万元，2011.4-2012.12，主持人
5.十一五国家科技支撑计划“食品安全快速检测技术研究与新产品开发”（2009BADB9B03-Z02），经费58万元，2009.1-2011.12，主持人
6.教育部新世纪优秀人才支持计划“磺胺类和喹诺酮类多残留同步检测免疫亲和色谱确证技术研究”（NCET-08-0538），经费50万元，2009.1-2011.12，主持人
7.上海市技术标准专项课题“食品中违法添加物快速检测确证技术标准的研究”（09DZ**），经费8万元，2008.9-2010.5，主持人
8.十一五国家科技支撑计划“兽用复方新制剂的研制与应用”（2006BAD31B08-04），经费50万元，2007.1-2010.12，主持人
9.十二五国家科技支撑计划“乳业安全生产过程检测技术集成及应用”（2011BAZ**），经费35万元，2012.1-2014.12，主要参加人
10.农业科研杰出人才及其创新团队专项（财预[2012]168号），2013.1-2015.12，经费80万元，主要参加人
11.农业行业标准制定与修订项目“饲料中卡巴氧、乙酰甲喹、喹烯酮和喹乙醇的检测”（农财发[2012]56号），2013.1-2013.12，经费10万元，主要参加人
12.有害化合物风险评估北京市国际合作基地建设项目，经费20万元，2012.1-2013.12，主要参加人
承担的教学工作
上课时间
主讲课程名称
授课时职称
授课学时/计划学时
年级、专业班级及人数
2014-2015-1
药物动力学
教授
16/16
硕士，20人
2014-2015-1
饲料添加剂
教授
16/32
动医2011级，75人
2013-2014-1
药物动力学
副教授
32/32
硕士，22人
2013-2014-1
饲料添加剂
副教授
16/32
动医2009级，62人
2012-2013-1
药物动力学
副教授
32/32
硕士，24人
2012-2013-1
饲料添加剂
副教授
16/32
动医2009级，52人
2011-2012-1
药物动力学
副教授
32/32
硕士，18人
2011-2012-1
饲料添加剂
副教授
16/32
动医2008级，38人
2010-2011-1
药物动力学
副教授
32/32
硕士，22人
2010-2011-1
饲料添加剂
副教授
16/32
动医2007级，41人
2009-2010-1
饲料添加剂
副教授
16/32
动医2006级，30人
2008-2009-1
饲料添加剂
副教授
16/32
动医2005级，32人
