刘云宝

刘云宝，博士，副研究员，硕士生导师，兼任“天然药物活性物质与功能”国家重点实验室办公室主任和药物研究所二部管理办公室副主任。
联系电话：010 8316 2679
邮箱：liuyunbao@imm.ac.cn


教育背景
2008.4-2011.10 美国密歇根州立大学，博士后
2004.9-2007.7 中国医学科学院药物研究所，获博士学位
2001.9-2004.7 河南中医学院，获硕士学位
1997.9-2001.7 河南中医学院，获学士学位
工作经历
2011.12-至今 中国医学科学院药物研究所，助理研究员、副研究员
2007.8-2008.3 中国医学科学院药物研究所，助理研究员
专业研究方向领域
有毒药用植物及其内生真菌中的活性成分研究。

承担的课题
主持国家自然科学基金面上项目1项、北京市生物医药创新品种研发项目1项，“天然药物活性物质与功能”国家重点实验室优秀青年基金1项。

近年发表论文
1. Yunbao Liu, Yong Li, Jing Qu, Shuanggang Ma, Caixia Zang, Yutian Zhang, and Shishan Yu*. Eremophilane Sesquiterpenes and Polyketones Produced by an Endophytic Guignardia Fungus from the Toxic Plant Gelsemium elegans. J. Nat. Prod. 2015, 78, 2149−2154. (IF: 3.79)
2. Yu-Sheng Shi, Yan Zhang, Xiao-Zhong Chen, Ning Zhang and Yun-Bao Liu*. Metabolites Produced by the Endophytic Fungus Aspergillus fumigatus from the Stem of Erythrophloeum fordii Oliv. Molecules, 2015, 20, 10793-10799. (IF: 2.9)
3. Yan Zhang, Yun-Bao Liu*, Yong Li, Li Li, Shuang-Gang Ma, Jing Qu, Jian-Dong, Jiang, Xiao-Guang Chen, Dan Zhang and Shi-Shan Yu*. Terpenoids from the roots of Alangium chinense. J. Asian. Nat. Prod. 2015, 17, 1025–1038. (IF: 0.9, co-corresponding author)
4. Yusheng Shi, Yunbao Liu, Yong Li, Li Li, Jing Qu, Shuanggang Ma, and Shishan Yu. Chiral Resolution and Absolute Configuration of a Pair of Rare Racemic Spirodienone Sesquineolignans from Xanthium sibiricum. Org. Lett. 2014, 16, 5406−5409. (IF, 6.3, co-first author)
5. Yong Li, Yun-Bao Liu, Yang-Lan Liu, Chen Wang, Lian-Qiu Wu, Li Li, Shuang-Gang Ma, Jing Qu, and Shi-Shan Yu^*. Mollanol A, a Diterpenoid with a New C?Nor?D?homograyanane Skeleton from the Fruits of Rhododendron molle. Org. Lett., 2014, 16, 4320−4323. (IF: 6.3, co-first author)
6. Yunbao Liu, Guangzhi Ding, Yong Li, Jing Qu, Shuanggang Ma, Haining Lv,Yang Liu, Wenjie Wang, Jungui Dai, Yi Tang, Shishan Yu*. Structures and Absolute Configurations of Penicillactones A-C from an Endophytic Microorganism, Penicilliumdangeardii Pitt. Org. Lett., 2013, 15:5206-5209. (IF:6.1)
7. Yunbao Liu, Subhra Saikat Roy, Roger H. C. Nebie, Yanjun Zhang, Muraleedharan G. Nair.* Functional Food Quality of Curcuma caesia, Curcuma zedoariaand Curcuma aeruginosa Endemic to Northeastern India. Plant Foods Hum Nutr, 2013, 68,72–77.（IF:2.5)
8. Yunbao Liu, Muraleedharan G. Nair.* Curcuma longa and Curcuma mangga leaves exhibit functional food property. Food Chemistry, 2012, 135, 634–640. (IF: 3.4).
9. Yunbao Liu and Muraleedharan G. Nair.* Compounds in fenugreek spice exhibit antioxidant and antiinflammatory activities. Food Chemistry, 2012, 131, 1187-1192. (IF: 3.4)
10. Yunbao Liu and Muraleedharan G. Nair.* Pods of Khejri (Prosopis cineraria) consumed as a vegetable showed functional food properties. Journal of Functional Food, 2012, 4, 116-121. ( IF: 1.3)
11. Yunbao Liu and Muraleedharan G. Nair.* Labdane diterpenes in Curcuma mangga rhizomes inhibit lipid peroxidation, cyclooxygenase enzymes and human tumour cell proliferation. Food Chemistry, 2011, 124, 527-532. (IF: 3.4)
12. Yunbao Liu, Vivek R. Yadev, Bharat B. Aggarwas and Muraleedharan G. Nair.*Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B. Natural Product Communications, 2010, 5, 1253-1257. (IF: 0.7)
13. Yunbao Liu and Muraleedharan G. Nair.* Capsaicinoids in the hottest pepper Bhut Jolokia and its antioxidant and antiinflammatory activities. Natural Product Communications, 2010, 5, 91-94. (IF: 0.7)
14. Yunbao Liu and Muraleedharan G. Nair.* An efficient and economical MTT Assay for determining the antioxidant activity of plant aatural product extracts and pure compounds. Journal of Natural Products,2010, 73, 193–1195.(IF: 2.9)
15. Yunbao Liu and Muraleedharan G. Nair.* Non-pungent functional food components in the water extracts of hot peppers. Food Chemistry, 2010, 122, 731-736. (IF: 3.4)
16. Yunbao Liu, Vanisree Mulabagal, Camille S Bowen-Forbes, Muraleedharan G. Nair*. Inhibition of lipid peroxidation, cyclooxygenase enzyme and human tumor cell proliferation by compounds in herbal water. Molecular Nutrition & Food Research, 2009, 53, 1177-1186. (IF: 4.7)
17. Yunbao Liu, ENuo Su, Jianbei Li, Shishan Yu,* et al.; Steroidal glycosides from Dregea sinensis var. corrugata screened by liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of Natural Products, 2009, 72, 229-237. (IF: 2.9)
18. Yunbao Liu, Jing Qu, Shishan Yu,* et al.; Nine novel C-21 steroidal glycosides substituted with orthoacetate from Dregea sinensis var. corrugata. Steroids, 2008, 73, 184-192. (IF: 3.1)
19. Yunbao Liu, Wenzhao Tang, Shishan Yu,* et al.; Eight new C-21 steroidal glycosides from Dregea sinensis var. corrugata. Steroids, 2007, 72, 514-523. (IF: 3.1)
20. 吕海宁，陈辉，屈晶，李勇，马双刚，刘云宝*。内生真菌Trichoderma harzianum.次生代谢产物研究.中国现代中药. 2015,17,427-430。
近年专著
《天然产物化学丛书—三萜化学》，化学工业出版社，2008年，庾石山主编。
近年专利
1、 庾石山、李勇、刘云宝、张建军、刘洋、马双刚、屈晶、吕海宁、徐嵩；闹羊花毒素III、闹羊花毒素VI和木藜芦毒素III在制备镇痛药物中的用途，8.6。
2、 庾石山，陈晓光，吕海宁，李超，徐嵩，刘云宝，马双刚，李勇；3-酰氧基取代右旋去氧娃儿藤宁衍生物、其制法和药物组合物与用途.申请号：2.6。
3、 庾石山，陈晓光，吕海宁，李超，徐嵩，刘云宝，马双刚，李勇；3-酰氧基取代右旋去氧娃儿藤宁衍生物、其制法和药物组合物与用途.申请号：PCT/CN2015/000249。