马双刚

马双刚，安徽桐城人，博士，副研究员，硕士研究生导师。
联系方式：
Tel: ;E-mail:mashuanggang@imm.ac.cn
1999年本科毕业于沈阳药科大学中药制药专业，2004年7月获沈阳药科大学药物化学硕士学位，2008年7月获中国医学科学院&北京协和医学院药物化学博士学位，2008年8月至今在药物研究所天然药物化学研究室工作。研究方向为天然药物活性物质研究。
先后承担教育部新教师基金课题、医科院药物所基本科研基金—科研重点与团队建设专项，国家自然基金面上项目；参与国家自然科学基金面上项目及重点项目、“十一五”、“十二五”、 “十三五”国家“重大新药创制”科技重大专项，中国医学科学院协同创新团队等科研项目。
近年来对少药八角等7种八角属植物开展了系统的化学成分和生物活性研究，发现新骨架化合物8个，发现抗病毒、抗炎、抗氧化、肿瘤细胞毒、神经细胞保护等活性化合物40余个。其中具有抗病毒活性的含有多个手性中心的螺环新骨架化合物spirooliganones A-B(Hot off the press)及其生源途径假说引起合成化学家的兴趣，先后被仿生全合成。研究结果在国际本领域重要期刊上发表SCI论文40余篇；获得授权专利5项，其中1项专利获得美国、日本授权；获得国家、省部级奖励5项，其中国家科技进步二等奖1项（2014-J-234-2-01-R09）、北京市科技进步奖一等奖1项（2013中-1-001-09）、教育部自然科学一等奖1项（2010-38）。参编专著3部。
代表性论文：
1. Shuang-Gang Ma, Shao-Peng Yuan, Yun-Bao Liu, Jing Qu, Yong Li, Xiao-Jing Wang, Ru-Bing Wang, Song Xu, Qi Hou, Shi-Shan Yu*, 3-Hydroxy-3-Methylglutaryl Flavone Glycosides from the Leaves of Turpinia arguta, Fitoterapia, 2018, 80-85.
2. Shuang-Gang Ma^#, Mi Li^#, Min-Bao Lin, Li Li, Yun-Bao Liu, Jing Qu*, Yong Li, Xiao-Jing Wang, Ru-Bing Wang, Song Xu, Qi Hou, and Shi-Shan Yu*, Illisimonin A, a Caged Sesquiterpenoid with a New Tricyclo[5.2.1.0^1,6]decane Skeleton from the Fruits of Illicium simonsii, Org. Lett.,2017,19, 6160−6163.
3. Feng-Min Xi, Yun-Bao Liu, Jing Qu, Yong Li, Zhong-Hai Tang, Li Li, Yu-Huan Li, Xiao-Guang Chen,Shuang-Gang Ma*, andShi-Shan Yu*, Bioactive Sesquiterpenoids from the Roots of Artabotrys hexapetalus, Tetrahedron,2017, 73, 571-582.
4. Zhong-Hai Tang^#, Yun-Bao Liu^#, Shuang-Gang Ma^#, Li Li, Yong Li, Jian-Dong Jiang, Jing Qu*, and Shi-Shan Yu*, Antiviral Spirotriscoumarins A and B: Two Pairs of Oligomeric Coumarin Enantiomers with a Spirodienone−Sesquiterpene Skeleton from Toddalia asiatica, Org. Lett.,2016, 18, 5146-5149.
5. Shuang-Gang Ma, Ya Gao, Hui-Qiang Wang, Yun-Bao Liu, Jing Qu, Yong Li, Li Li, Song Xu, Hai-Ning Lv, Yu-Huan Li, and Shi-Shan Yu*, Antiviral Mono- and Bis-prenylated C₆-C₃ Derivatives from the Roots of Illicium oligandrum, Tetrahedron, 2016, 3003-3013.
6. Feng-Min Xi, Shuang-Gang Ma, Yun-Bao Liu, Li Li, and Shi-Shan Yu*, Artaboterpenoids A and B, Bisabolene-Derived Sesquiterpenoids from Artabotrys hexapetalus, Org. Lett.,2016,18(14), 3374–3377.
7. Hua Jiang, Shuang-Gang Ma, Yong Li, Yun-Bao Liu, Li Li, Jing Qu and Shi-Shan Yu*, Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity, Bioorg. Med. Chem. Lett., 2016, 26, 4832–4836.
8. Nan Zhao, Xiao-Dong Ren, Jin-Hong Ren, Hai-Ning Lu?, Shuang-Gang Ma, Rong-Mei Gao, Yu-Huan Li, Song Xu, Li Li, and Shi-Shan Yu*, Total Syntheses of (−)-Spirooliganones A and B and Their Diastereoisomers: Absolute Stereochemistry and Inhibitory Activity against Coxsackie Virus B3, Org. Lett., 2015, 17 (12), 3118–3121.
9. Xiao-Dong Ren, Nan Zhao, Song Xu, Hai-Ning Lü, Shuang-Gang Ma, Yun-Bao Liu, Yong Li, Jing Qu, Shi-Shan Yu, Total synthesis of illicidione A and illihendione A, Tetrahedron, 2015, 71 (29), 4821-4829.
10. Hai-Ning Lv, Song Xu, Shuang-Gang Ma, Yun-Bao Liu, Yong Li, Jing Qu, Shi-Shan Yu*, A Novel asymmetric synthesis of (+)-Deoxytylophorinine, Synthesis. 2015, 47, 1399-1404.
11. Hong-Shun Gu, Shuang-Gang Ma*, Jing Qu, Yun-Bao Liu, and Shi-Shan Yu*, Diketopiperazines and Sesquilignans from the Branches and Leaves of Claoxylon polot, Planta Med., 2015, 81, 748-753.
12. Hai-Ning Lv, Shuang-Gang Ma*, Yun-Bao Liu, Jing Qu, Yong Li, Song Xu, Hua Zhu*, Shi-Shan Yu*, Sesquiterpenes from the roots of Illicium oligandrum, J. Asian Nat. Prod. Res., 2015, 17(5): 430-438.
13. Hong-Shun Gu, Shuang-Gang Ma, Yu-Huan Li, Ya-Dan Wang, Yun-Bao Liu, Li Li, Yong Li, Jing Qu*, Hai-Ning Lv, Xiao-Guang Chen, Jian-Dong Jiang, and Shi-Shan Yu*, Claoxylones A–I, Prenylbisabolane Diterpenoids with Anti-Coxsackie B Virus Activity from the Branches and Leaves of Claoxylon polot, Tetrahedron, 2014, 70, 7476-7483.
14. Shuang-Gang Ma, Rong-Mei Gao, Yu-Huan Li, Jian-Dong Jiang, Ning-Bo Gong, Li Li, Yang Lü, Wen-Zhao Tang, Yun-Bao Liu, Jing Qu, Hai-Ning Lü, Yong Li, and Shi-Shan Yu*, Antiviral Spirooliganones A and B with Unprecedented Skeletons from the Roots of Illicium oligandrum, Org. Lett., 2013, 15(17), 4450-4453.
15. Peng-Yu Zhuang^#, Shuang-Gang Ma^#, Gui-Jie Zhang, Xiao-Jing Wang, Yan Zhang, Shi-Shan Yu*, Yun-Bao Liu, Jing Qu, Yong Li, and Qi Hou, Novel Prenylated C6−C3 compounds from the Roots of Illicium henryi, Phytochemistry Lett. 2013, 6(3), 444-448.
16. Hui Chen^#, Shuang-Gang Ma^#, Zhen-Feng Fang, Jian Bai, Shi-Shan Yu*, Xiao-Guang Chen,Qi Hou, Shao-Peng Yuan, and Xia Chen. Tirucallane Triterpenoids from the Stems of Brucea mollis, Chem. & Biodiv., 2013, 10, 695-701.
17. Hai-Ning Lv, Jin-Hong Ren, Shuang-Gang Ma, Song Xu, Jing Qu, Zhen-Jia Liu, Qin Zhou, Xiao-Guang Chen, Shi-Shan Yu*, Synthesis, biological evaluation and mechanism studies of deoxytylophorinine and its derivatives as potential anticancer agents, PLoS ONE, 2012, 7, e30342.
18. Shuang-Gang Ma, Wen-Zhao Tang, Yu-Xi Liu, You-Cai Hu, Shi-Shan Yu*, Yi Zhang, Xiao-Guang Chen, Jing Qu, Jin-Hong Ren, Yun-Bao Liu, Song Xu, Jing Liu, Yuan-Yan Liu, Yong Li, Hai-Ning Lü, and Xian-Fu Wu, Prenylated C₆-C₃ compounds with molecular diversity from the roots of Illicium oligandrum, Phytochemistry, 2011, 72(1), 115-125.
19. Shuang-Gang Ma^#, Wen-Zhao Tang^#, Shi-Shan Yu*, Xiao-Guang Chen, Yang Liu, Wen-Jie Wang, Jing Qu, Song Xu, Jin-Hong Ren, Yong Li, and Hai-Ning Lü, Four new phenolic diglycosides from the roots of Illicium oligandrum, Carbohydr. Res., 2011, 346(9), 1165-1168.
20. Wen-Zhao Tang^#, Shuang-Gang Ma^#, Jing Qu, Shi-Shan Yu*, Yun-Bao Liu, Dong-Min Su, and Jing Liu, Dimeric Prenylated C₆-C₃Compounds from the Stem Bark of Illicium oligandrum, J. Nat. Prod.,2011, 74(5), 1268-1271.
21. Rui Liu,Shuang-Gang Ma, Yu-Xi Liu, Shi-Shan Yu*, Xiao-Guang Chen, and Jian-Jun Zhang, Albizosides D and E, two new cytotoxic triterpene saponins fromAlbizia chinensis,Carbohydr. Res.,2010, 345(13), 1877-1881.
22. Wen-Zhao Tang,Shuang-Gang Ma, Shi-Shan Yu*, Jing Qu, Yun-Bao Liu, and Jing Liu, Rearranged Prenylated C₆-C₃Compounds and a Highly Oxygenated seco-Prezizaane-Type Sesquiterpene from the Stem Bark ofIllicium oligandrum,J. Nat. Prod.,2009, 72(6), 1017-1021.
23. Rui Liu,Shuang-Gang Ma, Shi-Shan Yu*, Yue-Hu Pei, Sen Zhang, Xiao-Guang Chen, and Jian-Jun Zhang, Cytotoxic Oleanane Triterpene Saponins from Albizia chinensis,J. Nat. Prod.,2009, 72(4), 632-639.
24. Shuang-Gang Ma, You-Cai Hu, Shi-Shan Yu*, Yi Zhang, Xiao-Guang Chen, Jing Liu, and Yu-Xi Liu, Cytotoxic Triterpenoid Saponins Acylated with Monoterpenic Acid fromPithecellobium lucidum,J. Nat. Prod., 2008, 71(1), 41-46.
25. 马双刚,吕海宁,丁广治,庾石山*,陈晓光,亮叶围涎树根的化学成分及其肿瘤细胞毒活性研究,中国中药杂志,2011, 36(13),1769-1771.
26. 马双刚,袁绍鹏,侯琦,李勇,陈霞，庾石山*,山香圆叶中黄酮苷类成分及其抗炎活性研究,中国中药杂志,2013,38(11),1747-1750.
*corresponding author;#equal contribution
参编专著：
1.《三萜化学》，庾石山主编，化学工业出版社，2008年10月。
2.《中草药现代研究（第五卷）》，协和医科大学出版社，2010年11月。
3.《高速发展的中国化学:1982—2012》，科学出版社，2012年4月。