张业教授博士生导师

研究方向
染色质修饰与表观遗传调控；
真核基因转录调控与信号转导；
疾病发生的表观遗传学机制

主要学习及工作简历

2003.9-
北京协和医学院，生物化学与分子生物学系，医学分子生物学国家重点实验室
研究员

2006.9-2007.3
美国哥伦比亚大学医学中心
VisitingResearchAssociate,

2005.10-2005.12
哈佛医学院
VisitingResearchFellow

2002.7-2003.8
哈佛医学院附属BrighamandWomen’sHospital
博士后

2000.9-2002.6
哈佛医学院
博士后

1997.8-2000.7
中国协和医科大学，生物化学与分子生物学专业
博士学位

1981.9-1989.10
河北医科大学
学士，硕士学位
代表性学术论文
1.ChengMB,ZhangY,ZhongX,SutterB,CaoCY,ChenXS,ChengXK,ZhangY*,XiaoLandShenYF.(2010)Stat1mediatesanauto-regulationofhsp90beta?geneinheatshockresponse.CellSignal..
2.GaoX,PanWS,DaiH,ZhangY*,WuNHandShenYF.(2010)CARM1ActivatesMyogeninGeneviaPCAFintheEarlyDifferentiationofTPA-inducedRhabdomyosarcoma-derivedCells.JCellBiochem.
3.FangHB,MiY,ZhangY*,WuNH,ShenYF.(2010)HDAC3augmentstheautoregulationofneuroDgeneinP19cells.Neuroreport21:19-23.
4.Zhang,Y.,Wen,G.,Shao,G.,Wang,C.,Lin,C.,Fang,H.,Balajee,A.S.,Bhagat,G.,Hei,T.K.andZhao,Y.(2009)TGFBIdeficiencypredisposesmicetospontaneoustumordevelopment.CancerRes,69,37-44.
5.Wu,M,ZhangY*,WuNH,ShenYF.(2009)Histonemarksandchromatinremodelersontheregulationofneurogenin1geneinRAinducedneuronaldifferentiationP19cells.JCellBiochem,107,264-271.
6.Fang,HB,MiY,WuNH,ZhangY*,ShenYF.(2009)Genome-widedistributionofhistoneH3acetylationinall-transretinoicacidinducedneuronaldifferentiationofSH-SY5Ycells.ChinSciBull,54(6),1043-1049.
7.Di,Y.,Li,S.,Wang,L.,Zhang,Y.,andDorf,M.E.(2008).HomeostaticinteractionsbetweenMEKK3andTAK1involvedinNF-kappaBsignaling.CellSignal20,705-713.
8.LiZY,YangJ,GaoX,LuJY,ZhangY,WangK,ChengMB,WuNH.,ZhangY,WuZ,andShenYF.(2007).SequentialrecruitmentofPCAFandBRG1contributestomyogeninactivationin12-O-tetradecanoylphorbol-13-acetate-inducedearlydifferentiationofrhabdomyosarcoma-derivedcells.JBiolChem282,18872-18878.
9.ChenXS,ZhangY,WangJS,LiXY,ChengXK,ZhangY,WuNH,andShenYF.(2007).DiverseeffectsofStat1ontheregulationofhsp90alphageneunderheatshock.JCellBiochem102,1059-1066.
10.ShenJH,ZhangY*,WuNH,andShenYF.(2007).Resistancetogeldanamycin-inducedapoptosisindifferentiatedneuroblastomaSH-SY5Ycells.Neuroscilett414,110-114.
11.LiS,WangL,BermanMA,ZhangY,DorfME.（2006）RNAiscreeninmouseastrocytesidentifiesphosphatasesthatregulateNF-kappaBsignaling.MolCell,24(4):497-509.
12.ZhangY,WangJS,ChenLL,ZhangY,ChengXK,HengFY,WuNH,ShenYF.（2004）Repressionofhsp90{beta}Genebyp53inUVIrradiation-inducedApoptosisofJurkatCells.JBiolChem,279(41):42545-42551.
13.ZhangY,DannielK,MondalN,andParvinJD.（2004）PhosphorylationofhistoneH2Ainhibitstranscriptiononchromatintemplates.JBiolChem,279(21):21866-72.
14.Zhang,Y.,Luo,Y.,Zhai,Q.,Ma,L.,andDorf,M.E.(2003).NegativeroleofcAMP-dependentproteinkinaseAinRANTES-mediatedtranscriptionofproinflammatorymediatorsthroughRaf.FasebJ17,734-736.
15.Zhang,Y.,Zhai,Q.,Luo,Y.,andDorf,M.E.(2002).RANTES-mediatedChemokineTranscriptioninAstrocytesInvolvesActivationandTranslocationofp90RibosomalS6ProteinKinase(RSK).J.Biol.Chem.277,19042-19048.

主编或副主编的著作/译著

染色质与表观遗传调控
高等教育出版社
副主编
2006.1
联系方式
邮箱：yezhang@pumc.edu.cn；yz2210@gmail.com