童光志

研究领域：兽医微生物及其分子生物学
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电子邮件：gztong@shvri.ac.cn
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简历（200-500字）：
童光志，男，博士，研究员，博士生导师，中国农业科学院上海兽医研究所所长。1982年毕业于华中农学院牧医系兽医专业, 获农学学士学位，1985年毕业于中国农业科学院研究生院,获农学硕士学位，1990年毕业于中国人民解放军兽医大学，获农学博士学位。曾任中国农业科学院哈尔滨兽医研究所副所长，兽医生物技术国家重点实验室主任, 中国畜牧兽医学会畜牧兽医生物技术分会理事长。现任中国畜牧兽医学会动物传染病学分会、禽病学分会、畜牧兽医生物技术分会副理事长，中国微生物学会兽医微生物分会副主任委员，兽医生物技术国家重点实验室、家畜疫病病原生物学国家重点实验室和农业微生物国家重点实验室学术委员会委员，国家农业转基因生物安全委员会委员。多年来一直从事动物传染病病原流行病学及新型基因工程疫苗的研究，目前主要研究方向为猪繁殖障碍相关疫病（猪蓝耳病、猪流感、猪伪狂犬病、猪乙型脑炎等）的预防（动物用基因工程疫苗）与控制技术的应用与基础研究。
获奖及荣誉：
研究成果获国家科技进步二等奖2项，省部级自然科学奖、技术发明奖、科技进步奖14项；两项疫苗产品获得新兽药证书，8种基因工程疫苗获得转基因安全证书，获得国家发明专利23项；在国内外专业期刊上发表学术论文600余篇，其中在国际杂志发表190余篇，主编/参编著作11部；培养博士后16名、博士研究生63名、硕士研究生86名；曾获中华农业英才奖、农业部突出贡献中青年专家、全国优秀科技工作者、六部委共同颁发的留学人员成就奖、黑龙江省劳动模范、全国优秀博士论文指导教师、上海领军人才（2008）、上海市十大科技精英（2011）等。
承担科研项目情况：
1、国家重点研发计划
2、中国农业科学院创新工程
3、国家生猪现代产业技术体系科研专项
代表论著：
（1）Xuchen Zheng#, Hao Zheng#, Wu Tong, Guoxin Li, Tao Wang, Liwei Li, Fei Gao, Tongling Shan, Hai Yu, Yanjun Zhou, Yafeng Qiu, Zhiyong Ma, Guangzhi Tong*.Acid/base character of the Japanese Encephalitis Virus E protein residue 138 alters neurovirulence in mice. Journal of Virology, 2018, 92（22）:e00108-18.
（2）Liwei Li,Yanjun Zhou, Yifeng Jiang, Fei Gao, Kuan Zhao, Yujiao Zhang, Lin Li, Tongling Shan, Guangzhi Tong*. Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro. Virus Research, 2018, 253:87-91.
（3）Fei Gao, Yifeng Jiang, Guoxin Li, Yanjun Zhou, Lingxue Yu, Liwei Li, Wu Tong, Hao Zheng, Yujiao Zhang, Hai Yu, Tongling Shan, Shen Yang, Huan Liu，Kuan Zhao, Guangzhi Tong*.Porcine reproductive and respiratory syndrome virus expressing E2 of classical swine fever virus protects pigs from a lethal challenge of highly- pathogenic PRRSV and CSFV. Vaccine, 2018, 36:3269-3277.
（4）Kuan Zhao^§, Li-Wei Li^§, Yu-Jiao Zhang,Yi-Feng Jiang, Fei Gao, Guo-Xin Li, Ling-Xue Yu, Wen-Ying Zhao, Yan-Jun Zhou, Guang-Zhi Tong^*. MOV10 inhibits replication ofporcine reproductive and respiratorysyndromevirus by retainingviralnucleocapsid proteinin the cytoplasmof Marc-145 cells. Biochemical and Biophysical Research Communications, 2018, 504:157-163.
（5）Zhi-qing Yu, Wu Tong, Hao Zheng, Li-wei Li, Guo-xin Li, Fei Gao, Tao Wang, Chao Liang, Chao Ye, Ji-qiang Wu, Qinfeng Huang*, Guang-zhi Tong*. Variations in glycoprotein Bcontribute to immunogenic differencebetween PRV Variant JS-2012 and Bartha-K61. Veterinary Microbiology, 2017, 208:97-105.
（6）Hao Zheng, Xuchen Zheng, Wu Tong, Fei Liu, Chao Liang, Tao Wang, Fei Gao, Tongling Shan, Guoxin Li, Guangzhi Tong*. A Simple method for developing an infectious cDNA clone of Japanese encephalitis virus.Virus Genes, 2017, 53:4-14.
（7）Shen Yang, Yuan Zhan, Yanjun Zhou, Yifeng Jiang, Xuchen Zheng, Lingxue Yu, Wu Tong, Fei Gao,Zhiyong Ma, Guangzhi Tong*.Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity. Scientific Reports, 2016, 6:29665.
（8）Wu Tong, Guoxin Li, Chao Liang,Fei Liu, Qin Tian, Yanyun Cao, Lin Li, Xuchen Zheng, Hao Zheng*, Guangzhi Tong*. A live, attenuated Pseudorabies virus strain JS-2012 deleted for gE/gI protects against both classical and emerging strains. Antiviral Research, 2016, 130:110-117.
（9）Wu Tong, Fei Liu, Hao Zheng, Chao Liang, Yan-jun Zhou, Yi-feng Jiang,Tong-ling Shan, Fei Gao, Guo-xin Li*, Guang-zhi Tong*.Emergence of a Pseudorabies virus variant with increased virulence to piglets. Veterinary Microbiology, 2015, 181:236-240.
（10）Liwei Li, Fei Gao, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Hao Zheng, Wu Tong, Shen Yang, Tianqi Xia, Zehui Qu, Guangzhi Tong*. Cellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo. Scientific Reports, 2015, 5:17010.
（11）Yi-feng Jiang^#，Tian-qi Xia^#，Yan-jun Zhou，Ling-xue Yu，Shen Yang， Qin-feng Huang, Li-wei Li，Fei Gao，Ze-hui Qu，Wu Tong，Guang-zhi Tong*. Characterization of three porcine reproductive and respiratory syndrome virus isolates from a single swine farm bearing strong homology to a vaccine strain. Veterinary Microbiology, 2015, 179:242-249.
（12）Chao Ye^?, Qing-Zhan Zhang^?, Zhi-Jun Tian^?, Hao Zheng, Kuan Zhao, Fei Liu, Jin-Chao Guo, Wu Tong, Cheng-Gang Jiang, Shu-Jie Wang,Mang Shi, Xiao-Bo Chang,Yi-Feng Jiang,Jin-Mei Peng, Yan-Jun Zhou,Yan-Dong Tang,Ming-Xia Sun,Xue-Hui Cai, Tong-Qing An*, Guang-Zhi Tong*. Genomic characterization of emerged pseudorabies virus in China reveals marked sequence divergence: evidencefor existence of two major genotypes. Virology, 2015, 483:32-43.
（13）Liwei Li, Zuzhang Wei,Yanjun Zhou, Fei Gao, Yifeng Jiang, Lingxue Yu,Hao Zheng, Wu Tong, Shen Yang, Haihong Zheng, Tongling Shan, Fei Liu, Tianqi Xia, Guangzhi Tong*.Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons. Virus Research, 2015, 195:86-94.
（14）Tong-Qing An¹, Jin-Mei Peng¹, Zhi-Jun Tian¹,Hong-Yuan Zhao, Na Li, Yi-Min Liu, Jia-Zeng Chen,Chao-Liang Leng, Yan Sun, Dan Chang, Guang-Zhi Tong*. Pseudorabies Virus VariantinBartha-K61–Vaccinated Pigs,China, 2012. Emerging Infectious Diseases, 2013, 19(11):1749-1755.
（15）Zuzhang Wei, Tao Lin, Lichang Sun, Yanhua Li, Xiaoming Wang, Fei Gao, Runxia Liu, Chunyan Chen,Guangzhi Tong*,Shishan Yuan*. N-linked Glycosylation of GP5 of Porcine Reproductive and Respiratory Syndrome Virus Is Critically Important for Virus Replication invivo.Journal of Virology, 2012, 86（18）：9941-9951.
（1）Xuchen Zheng#, Hao Zheng#, Wu Tong, Guoxin Li, Tao Wang, Liwei Li, Fei Gao, Tongling Shan, Hai Yu, Yanjun Zhou, Yafeng Qiu, Zhiyong Ma, Guangzhi Tong*. Acid/base character of the Japanese Encephalitis Virus E protein residue 138 alters neurovirulence in mice. Journal of Virology, 2018, 92（22）:e00108-18.
（2）Liwei Li, Yanjun Zhou, Yifeng Jiang, Fei Gao, Kuan Zhao, Yujiao Zhang, Lin Li, Tongling Shan, Guangzhi Tong*. Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro. Virus Research, 2018, 253:87-91.
（3）Fei Gao, Yifeng Jiang, Guoxin Li, Yanjun Zhou, Lingxue Yu, Liwei Li, Wu Tong, Hao Zheng, Yujiao Zhang, Hai Yu, Tongling Shan, Shen Yang, Huan Liu，Kuan Zhao, Guangzhi Tong*. Porcine reproductive and respiratory syndrome virus expressing E2 of classical swine fever virus protects pigs from a lethal challenge of highly- pathogenic PRRSV and CSFV. Vaccine, 2018, 36:3269-3277.
（4）Kuan Zhao§, Li-Wei Li§, Yu-Jiao Zhang, Yi-Feng Jiang, Fei Gao, Guo-Xin Li, Ling-Xue Yu, Wen-Ying Zhao, Yan-Jun Zhou, Guang-Zhi Tong*. MOV10 inhibits replication of porcine reproductive and respiratory syndrome virus by retaining viral nucleocapsid protein in the cytoplasm of Marc-145 cells. Biochemical and Biophysical Research Communications, 2018, 504:157-163.
（5）Zhi-qing Yu, Wu Tong, Hao Zheng, Li-wei Li, Guo-xin Li, Fei Gao, Tao Wang, Chao Liang, Chao Ye, Ji-qiang Wu, Qinfeng Huang*, Guang-zhi Tong*. Variations in glycoprotein B contribute to immunogenic difference between PRV Variant JS-2012 and Bartha-K61. Veterinary Microbiology, 2017, 208:97-105.
（6）Hao Zheng, Xuchen Zheng, Wu Tong, Fei Liu, Chao Liang, Tao Wang, Fei Gao, Tongling Shan, Guoxin Li, Guangzhi Tong*. A Simple method for developing an infectious cDNA clone of Japanese encephalitis virus. Virus Genes, 2017, 53:4-14.
（7）Shen Yang, Yuan Zhan, Yanjun Zhou, Yifeng Jiang, Xuchen Zheng, Lingxue Yu, Wu Tong , Fei Gao, Zhiyong Ma, Guangzhi Tong*. Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity. Scientific Reports, 2016, 6:29665.
（8）Wu Tong, Guoxin Li, Chao Liang, Fei Liu, Qin Tian, Yanyun Cao, Lin Li, Xuchen Zheng, Hao Zheng*, Guangzhi Tong*. A live, attenuated Pseudorabies virus strain JS-2012 deleted for gE/gI protects against both classical and emerging strains. Antiviral Research, 2016, 130:110-117.
（9）Wu Tong, Fei Liu, Hao Zheng, Chao Liang, Yan-jun Zhou, Yi-feng Jiang, Tong-ling Shan, Fei Gao, Guo-xin Li*, Guang-zhi Tong*. Emergence of a Pseudorabies virus variant with increased virulence to piglets. Veterinary Microbiology, 2015, 181:236-240.
（10）Liwei Li, Fei Gao, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Hao Zheng, Wu Tong, Shen Yang, Tianqi Xia, Zehui Qu, Guangzhi Tong*. Cellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo. Scientific Reports, 2015, 5:17010.
（11）Yi-feng Jiang#，Tian-qi Xia#，Yan-jun Zhou，Ling-xue Yu， Shen Yang， Qin-feng Huang, Li-wei Li，Fei Gao，Ze-hui Qu，Wu Tong，Guang-zhi Tong*. Characterization of three porcine reproductive and respiratory syndrome virus isolates from a single swine farm bearing strong homology to a vaccine strain. Veterinary Microbiology, 2015, 179:242-249.
（12）Chao Ye?, Qing-Zhan Zhang?, Zhi-Jun Tian?, Hao Zheng, Kuan Zhao, Fei Liu, Jin-Chao Guo, Wu Tong, Cheng-Gang Jiang, Shu-Jie Wang, Mang Shi, Xiao-Bo Chang, Yi-Feng Jiang, Jin-Mei Peng, Yan-Jun Zhou, Yan-Dong Tang, Ming-Xia Sun, Xue-Hui Cai, Tong-Qing An*, Guang-Zhi Tong*. Genomic characterization of emerged pseudorabies virus in China reveals marked sequence divergence: evidence for existence of two major genotypes. Virology, 2015, 483:32-43.
（13）Liwei Li, Zuzhang Wei, Yanjun Zhou, Fei Gao, Yifeng Jiang, Lingxue Yu, Hao Zheng, Wu Tong, Shen Yang, Haihong Zheng, Tongling Shan, Fei Liu, Tianqi Xia, Guangzhi Tong*. Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons. Virus Research, 2015, 195:86-94.
（14）Tong-Qing An1, Jin-Mei Peng1, Zhi-Jun Tian1, Hong-Yuan Zhao, Na Li, Yi-Min Liu, Jia-Zeng Chen, Chao-Liang Leng, Yan Sun, Dan Chang, Guang-Zhi Tong*. Pseudorabies Virus Variant in Bartha-K61–Vaccinated Pigs, China, 2012. Emerging Infectious Diseases, 2013, 19(11):1749- 1755.
（15）Zuzhang Wei, Tao Lin, Lichang Sun, Yanhua Li, Xiaoming Wang, Fei Gao, Runxia Liu, Chunyan Chen, Guangzhi Tong*, Shishan Yuan*. N-linked Glycosylation of GP5 of Porcine Reproductive and Respiratory Syndrome Virus Is Critically Important for Virus Replication in vivo. Journal of Virology, 2012, 86（18）：9941-9951.