张　毅 （1982年1月）
博士 博士生导师
E-mail：yi.zhang@bnu.edu.cn


个人简历
2004年毕业于北京师范大学生命科学学院生物科学专业，获学士学位；2010年获北京师范大学生命科学学院细胞生物学专业博士学位，期间主要从事植物细胞骨架结构与功能方向的研究；2011年-2017年分别在德国马克斯-普朗克分子植物生理学研究所、英国剑桥大学从事博士后工作，主要研究植物细胞壁合成的分子调控机理和机械应力调控植物顶端分生组织形态的机制。在Nature Communications、Trends in Plant Science和The Plant Cell等学术期刊上发表论文多篇。2017年底被聘为北京师范大学研究员，就职于北京师范大学生命科学学院细胞增殖及调控生物学教育部重点实验室。


主要研究内容
1、植物细胞壁合成的分子调控机理：细胞壁是植物细胞区别于动物细胞的特征性结构之一，在维持植物细胞形态和调控细胞生长等过程中起重要作用，与植物尤其是农作物的株型、抗倒伏性和抗病虫害能力等重要农艺性状密切相关。此外，植物细胞壁具有广泛的工业应用价值，例如其主要成分纤维素不仅是造纸和纺织工业的主要原料，也是可被转化为安全、清洁的可再生能源的生物质资源。本实验室的一个主要方向是研究植物细胞壁中纤维素合成的分子基础，如纤维素合酶复合体新成员的筛选和功能分析、纤维素合酶复合体组装和分泌过程的分子调控机理、细胞壁和细胞骨架之间的相互作用关系等。
2、植物细胞感受和应答机械应力作用的分子机理：植物区别于动物的另一特性是其不具有移动性。为了应对风吹雨打等外界机械刺激，植物具有特异的响应机制来协调其生长发育。本实验室重点筛选和鉴定植物机械应力信号受体，研究细胞壁-细胞膜-细胞骨架连续体在植物细胞应答机械应力中的作用。
3、植物细胞骨架的上游信号通路：细胞骨架是广泛存在于真核细胞中的三维网络结构，在细胞分裂和生长等过程中发挥至关重要的作用。本实验室综合利用细胞生物学、生物化学和遗传学等技术手段研究植物细胞骨架的功能，筛选和鉴定细胞骨架动态变化的上游调控因子，研究这些蛋白质在细胞分裂和生长中的作用。



代表性论著
■Yi Zhang*, Youjun Zhang, Heather E. McFarlane, Toshihiro Obata, Andreas S. Richter, Mark Lohse, Bernhard Grimm, Staffan Persson, Alisdair R. Fernie*, Patrick Giavalisco*. Inhibition of TOR represses nutrient consumption, which improves greening after extended periods of etiolation. Plant Physiology, 2018, 178(1):101-117. (共同通讯作者)
■Chang Liu#, Yi Zhang#, Haiyun Ren. Actin polymerization mediated by AtFH5 directs the polarity establishment and vesicle trafficking for pollen germination in Arabidopsis. Molecular Plant, 2018, 5;11(11):1389-1399.
■Yi Zhang#, Nino Nikolovski#, Mathias Sorieul, Tamara Vellosillo, Heather E.McFarlane, Ray Dupree, Christopher Kesten, René Schneider, Carlos Driemeier, Rahul Lathe, Edwin Lampugnani, Xiaolan Yu, Alexander Ivakov, Monika S. Doblin, Jenny C Mortimer, Steven P Brown, Staffan Persson*, Paul Dupree*. Golgi-localized STELLO proteins regulate the assembly and trafficking of cellulose synthase complexes in Arabidopsis. Nature Communications, 2016, 7, Article number: 11656. doi:10.1038/ncomms11656.
■Yi Zhang, Staffan Persson, Jennifer Hirst, Margaret S. Robinso, Daniel van Damme, Clara Saenchez-Rodriguez. Change your Tplate, change your fate: plant CME and beyond. Trends in Plant Science, 2014, 20: 41-48.
■Zengyu Liu, Staffan Persson, Yi Zhang*, The connection of cytoskeletal network with plasma membrane and the cell wall. Journal of Integrative Plant Biology, 2014, 57 (4): 330-340. (通讯作者)
■Yi Zhang, Staffan Persson, Patrick Giavalisco. Differential regulation of carbon partitioning by the central growth regulator Target of Rapamycin (TOR). Molecular Plant, 2013, 6 (6): 1731-1733.
■Jiaojiao Wang#, Yi Zhang#, Jing Wu, Lei Meng, Haiyun Ren. AtFH16, an Arabidopsis type II formin, binds and bundles both microfilaments and microtubules and preferentially binds to microtubules. Journal of Integrative Plant Biology, 2013, 55(11): 1002-1015.
■Zheng Zhang#, Yi Zhang#, Hexin Tan, Ying Wang, Gang Li, Wanqi Liang, ZhengYuan, Jianping Hu, Haiyun Ren, Dabing Zhang. RICE MORPHOLOGY DETERMINANT encodes the type II formin FH5 and regulates rice morphogenesis. The Plant Cell, 2011, 23:681-700.
■Yi Zhang#, Yingyu Xiao#, Fei Du, Lijuan Cao, Huaijian Dong, Haiyun Ren. Arabidopsis VILLIN4 is involved in root hair growth through regulating actin organization in a Ca2+-dependent manner. New Phytologist, 2011, 190: 667-682.
■Rene Schneider, Lu Tang, Edwin R. Lampugnani, Sarah Barkwill, Rahul Lathe, Yi Zhang, Heather E. McFarlane, Edouard Pesquet, Totte Niittyla, Shawn D. Mansfield, Yihua Zhou, and Staffan Persson. Two complementary mechanisms underpin cell wall patterning during xylem vessel development. The Plant Cell, 2017, 29: 2433–244.
■Zengyu Liu, Rene Schneider, Christopher Kesten, Yi Zhang, Marc Somssich,Youjun Zhang, Alisdair R. Fernie, Staffan Persson. Cellulose-Microtubule Uncoupling 1 and 2 are necessary to prevent lateral displacement of microtubules during cellulose synthesis in Arabidopsis. Developmental cell, 2016, 38: 305-315.
■Anne Endler#, Christopher Kesten#, René Schneider, Yi Zhang, Alexander Ivakov, Anja Froehlich, Norma Funke, Staffan Persson. A mechanism for sustained cellulose synthesis during salt stress. Cell, 2015, 162: 1353-1364.
■Yu Luo#, Stefan Scholl#, Anett Doering#, Yi Zhang, Niloufer G. Irani, SimoneDi Rubbo, Lutz Neumetzler, Praveen Krishnamoorthy, Isabelle Van Houtte, EvelienMylle, Volker Bischoff, Samantha Vernhettes, Johan Winne, Jiří Friml, York-DieterStierhof, Karin Schumacher*, Staffan Persson*, Eugenia Russinova*. V-ATPase activity in the TGN/EE is required for exocytosis and recycling in Arabidopsis. Nature Plants, 2015, doi:10.1038/nplants.2015.94.
■Camila Caldana#*, Yan Li#, Andrea Leisse, Yi Zhang, Lisa Bartholomaeus, Alisdair R. Fernie, Lothar Willmitzer, Patrick Giavalisco*. Systemic analysis of inducible target of rapamycin mutants reveal a general metabolic switch controlling growth in Arabidopsis thaliana. The Plant Journal, 2013, 73: 897-909.
■Weike Pei, Fei Du, Yi Zhang, Tian He, Haiyun Ren. Control of theactin cytoskeleton in root hair development. Plant Science, 2012, 187: 10-18.
■Fei Du, Yi Zhang, Haiyun Ren. The universal bundling activity of AtVLN4 in diffusely growing cells. Plant Signaling & Behavior, 2011, 6 (9): 1290-1293.
(#同等贡献，*通讯作者)