陈苏仁 （1987年4月出生）
博士
E-mail：chensr@bnu.edu.cn
个人主页：https://www.researchgate.net/profile/Su_Ren_Chen


个人简历
2009年内蒙古大学生命科学学院本科毕业后，保送进入中国科学院动物研究所干细胞与生殖生物学国家重点实验室硕博连读，博士研究生导师为刘以训院士。2014年7月博士毕业后留所担任助理研究员，2016年底破格晋升为副研究员，2018年晋升硕士研究生导师。期间主要利用基因敲除小鼠、体外培养模型和分子生物学等多种手段研究基因/非编码RNA在小鼠精子发生和生殖细胞肿瘤中的作用与机制。迄今为止已在PNAS, National Science Review, Cellular and Molecular Life Sciences, BMC Biology, Cell Death & Disease, Oncotarget, Biology of Reproduction, Reproduction等杂志上发表SCI论文20余篇。获得国家自然科学青年基金项目、中国科协“青年人才托举工程”等基金资助。2019年4月调入北京师范大学生命科学学院，任副教授。


主要研究内容
1. 蛋白质降解与翻译后修饰：蛋白质降解调控细胞命运的机制及其在生殖健康和生殖细胞肿瘤等诸多过程中的作用与机制；
2. 精子发生与生殖系统肿瘤：利用基因敲除小鼠、裸鼠成瘤模型和细胞分子生物学等手段研究基因/非编码RNA在精子发生和生殖细胞肿瘤中的作用与机制。


代表性论著
1.Batool A, Karimi N, Wu XN, Chen SR*, Liu YX. (2019) Testicular germ cell tumor: a comprehensive review. Cell Mol Life Sci, 76(9):1713-1727.
2.Batool A, Wang YQ, Hao XX, Chen SR*, Liu YX*. (2018) A miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth. Cell Death Dis, 9(10):962.
3.Wang YQ, Batool A, Chen SR*, Liu YX*. (2018) GATA4 is a negative regulator of contractility in mouse testicular peritubular myoid cells. Reproduction,156(4):341-351.
4.Chen SR*, Liu YX*. (2017) Focuses on the impact of Zika virus infection on the male reproductive tract. Natl Sci Rev, 4(2):157.
5.Chen SR*, Batool A, Wang YQ, Hao XX, Chang CS, Cheng CY, Liu YX*. (2016) The control of male fertility by spermatid-specific factors: searching for contraceptive targets from spermatozoon's head to tail. Cell Death Dis, 7(11):e2472.
6.Chen SR*, Tang JX, Cheng JM, Hao XX, Wang YQ, Wang XX, Liu YX*. (2016) Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models. Cell Death Dis, 7(6):e2281.
7.Chen SR*, Liu YX*. (2016) Myh11-Cre is not limited to peritubular myoid cells and interaction between Sertoli and peritubular myoid cells needs investigation. Proc Natl Acad Sci U S A, 113(17):E2352.
8.Chen SR*, Chen M, Deng SL, Hao XX, Wang XX, Liu YX*. (2016) Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility. Cell Death Dis, 7:e2152..
9.Chen SR, Tang JX, Cheng JM, Li J, Jin C, Li XY, Deng SL, Zhang Y, Wang XX, Liu YX*. (2015) Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling. Oncotarget, 6(35):37012-27.
10.Chen SR*, Liu YX*. (2015) Regulation of spermatogonial stem cell self-renewal and spermatocyte meiosis by Sertoli cell signaling. Reproduction, 149(4):R159-67.
11.Chen SR, Zheng QS, Zhang Y, Gao F*, Liu YX*. (2013) Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration. BMC Biol, 11:22.
12.Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F*, Liu YX*. (2013) The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2. Biol Reprod, 88(3):56.
(*通讯作者)