瞿昆，男，博士，中国科学技术大学生命科学与医学部教授、博士生导师。长期从事生物信息学、基因组学和免疫学等领域的研究。在Nature、Nature Methods、Nature Communications、Cell、Cancer Cell、Cell Systems、Science Advances等国际学术期刊上共发表论文50余篇，Google学术引用超过7000次，总影响因子超过800，H-index 35。
实验室主页：http://qulab.ustc.edu.cn/
教育和研究经历：
1999-2004年中国科学技术大学化学物理系，获学士学位
2004-2010年美国印第安纳大学化学系，获物理化学博士学位
2009-2010年美国希望之城，贝克曼癌症研究中心，生物信息学专家
2010-2016年美国斯坦福大学医学院，生物信息高级研究员，中心主任
2016年至今中国科学技术大学生命科学学院，教授，博士生导师
获奖情况：
ORISE Fellowship 2007
生命学院学术成果奖2017
生命学院杰出论文研究奖2017
主要研究领域：
（1）精准医疗，肿瘤和免疫疾病的个性化表观遗传调控机制
（2）单细胞转录组和表观遗传基因组学技术开发及其在疾病诊疗中的应用
（3）生物大数据分析，云计算基础上的生物信息系统分析软件的开发和应用
代表性学术论文：（#共同一作,*共同通讯）
Q. Liu^#, L. Zaba^#, A. Satpathy, M. Longmire, W. Zhang, K. Li, J. Granja, C. Guo, J. Lin, R. Li, K. Tolentino, G. Kania, O. Distler, D. Fiorentino, L. Chung, K. Qu*, H. Chang* “Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis”, Nature Communications, 2020.
C. Guo^#, B. Li^#, H. Ma, X. Wang, P. Cai, Q. Yu, Lin. Zhu, L. Jin, C. Jiang, J. Fang, Q. Liu, D. Zong, W. Zhang, Y. Lu, K. Li, X. Gao, B. Fu, L. Liu, X. Ma, J. Weng, H. Wei, T. Jin*, J. Lin*, K. Qu* “Tocilizumab treatment in severe COVID-19 patients attenuates the inflammatory storm incited by monocyte centric immune interactions revealed by single-cell analysis”, Nature Communications, 2020.
B. Li^#, Y. Li^#, K. Li, L. Zhu, Q. Yu, P. Cai, J. Fang, W. Zhang, P. Du, C. Jiang, J. Lin, K. Qu*. “APEC: an accesson-based method for single-cell chromatin accessibility analysis”, Genome Biology, 2020.
Haohuan Xie^#, Wen Zhang^#, Mei Zhang^#*, Tasneem Akhtar, Young Li, Wenyang Yi, Xiao Sun, Zuqi Zuo, Min Wei, Xin Fang, Ziqin Yao, Kai Dong, Suijuan Zhong, Qiang Liu, Yong Shen, Qian Wu, Xiaoqun Wang, Huan Zhao, Jin Bao, Kun Qu*, Tian Xue*. “Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC-derived retinal organoids”,Science Advances, 2020
Fang J^#, Ma Q^#, Chu C, Huang B, Li L, Cai P, Batista PJ, Tolentino KEM, Xu J, Li R, Du P, Qu K*, Chang HY* “Functional classification of chromatin associated lncRNAs via histone modification specific PIRCh-seq analysis”, Genome Biology, 2020
Kun Li^#, Yang Wu^#, Young Li, Qiaoni Yu, Zhigang Tian, Haiming Wei*, Kun Qu*, “Landscape and dynamics of the transcriptional regulatory network during natural killer cell differentiation”, Genomics, Proteomics & Bioinformatics, 2020 (In press)
Pengfei Cai^#, Auke BC Otten^#, Binbin Cheng, Mitsuhiro A. Ishii, Wen Zhang, Beibei Huang, Kun Qu*, Bryan K. Sun*, “A genome-wide long noncoding RNA CRISPRi screen identifies PRANCR as a novel regulator of epidermal homeostasis”, Genome Research, 2019
Z. Zuo, Y. Jin, W. Zhang, Y. Lu, B. Li* & K. Qu*, “ATAC-pipe: general analysis of genome-wide chromatin accessibility”, Briefings in Bioinformatics, 2018.
K. Qu^#, L. Zaba^#, et al, H. Chang “Chromatin accessibility landscape of cutaneous T cell lymphoma and dynamic response to HDAC inhibitors”, Cancer Cell, 32:27-41, 2017
K. Qu^#, S. Garamszegi^#, F. Wu^#, et al, J. Mesirov* “Integrative genomic analysis by interoperation of bioinformatics tools in GenomeSpace”, Nature Methods, 13, 245–247, 2016.
K. Qu^#, L. Zaba^#, P. Giresi, et al, H. Chang* “Individuality and dynamics of personal regulomes in human T cells”, Cell Systems, 1:51-61, 2015 (Previewed in Cell System)
Y. Wan^#, K. Qu^#, Q. Zhang, R. Flynn, O. Manor, Z. Ouyang, J. Zhang, R. Spitale, M. Snyder, E. Segal* and H. Chang* “Landscape and variation of RNA secondary structure across the human transcriptome” Nature, 505:706-9, 2014 (Highlighted in Nature News & Views)
V. Lopez-Pajares, K. Qu, et al, P. Khavari “A LncRNA-MAF/MAFB Transcription Factor Network Regulates Epidermal Differentiation”, Developmental Cell, 32(6), 693-706, 2015 (Cover Article, Previewed in Developmental Cell)
J. Quinn, I. Ilik*, K. Qu^#, P. Georgiev^#, et al., H. Chang “Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification”, Nature Biotechnology, 32:933-940, 2014
P. Batista, B. Molinie, J. Wang, K. Qu, et al., H. Chang “m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells”, Cell Stem Cell, 15(6), 707-719, 2014 (Impact Factor 22.3)
O. Wapinski*, T. Vierbuchen*, K. Qu, et al., H. Chang, and M. Wernig “Hierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons” Cell, 155(3), 2013







Google学术页面:http://scholar.google.com/citations?hl=en&user=2CdOi4EAAAAJ
ResearcherID: http://www.researcherid.com/rid/G-3359-2012

招生招聘：
实验室招聘生物信息学、计算生物学，免疫和分子生物学等相关背景的博士后和特任（副）研究员，待遇从优。同时热忱欢迎感兴趣的本科生前来攻读博（硕）士学位。

联系方式：qukun@ustc.edu.cn