姓　　名:
郭　昌
出生年月:
1987年6月
地　　址:
合肥微尺度物质科学国家研究中心


中国科学技术大学
邮　　编:
230026
电　　话:
**
邮　　箱:
guochang@ustc.edu.cn

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　教育与科研经历
2018.03 - 至今
特任教授，博士生导师，合肥微尺度物质科学国家研究中心
2017.02-2018.02
特任研究员，中国科学技术大学，合肥微尺度物质科学国家研究中心
2013.08-2017.01
博士后，德国明斯特大学
2007.09-2013.06
博士，中国科学技术大学
2003.08-2007.06
学士，中国科学技术大学


　目前研究方向

　　研究工作主要集中在不对称合成方向，以新型不对称催化研究为基础，发展惰性化学键的直接手性官能团化反应，建立手性催化模型，提高反应活性与选择性，并将这些方法学用于天然产物的合成，发展高效、原子经济性和环境友好的现代有机合成化学。


　代表性论文
1.
Chang, X.; Zhang, Q.; Guo, C.* Asymmetric Electrochemical Transformation. Angew. Chem. Int. Ed. 2020, doi: 10.1002/anie..
2.
Wang, H.; Hu, Q.; Wang, M.; Guo, C.* Enantioselective [4+2] Annulation to the Concise Synthesis of Chiral Dihydrocarbazoles. iScience 2020, 23, 100840.
3.
Zhang, Q.; Chang, X.; Peng, L.; Guo, C.* Asymmetric Lewis Acid Catalyzed Electrochemical Alkylation. Angew. Chem. Int. Ed. 2019, 131, 7073-7077.
4.
Chang, X.; Zhang, Q.; Guo, C.* Switchable Smiles Rearrangement for Enantioselective O-Aryl Amination. Org. Lett. 2019, 21, 4915-4918.
5.
Wang, H.;Guo, C.* Enantioselective γ‐Addition of Pyrazole and Imidazole Heterocycles to Allenoates Catalyzed by Chiral Phosphine.Angew. Chem. Int. Ed.2019, 58, 2854-2858.
6.
Chang, X.; Zhang, Q.;Guo. C.* Electrochemical Reductive Smiles Rearrangement for C?N Bond Formation.Org. Lett.2019, 21, 10-13.
7.
Guo, C.*; Janssen-Müller, D.; Fleige, M.;Lerchen, A.; Daniliuc, C. G.; Glorius, F.* Mechanistic studies on a cooperative NHC organocatalysis/palladium catalysis system: uncovering significant lessons for mixed chiral Pd(NHC)(PR3) catalyst design.J. Am. Chem. Soc.2017, 139, 4443-4451.
8.
Guo, C.; Fleige, M.; Janssen-Müller, D.; Daniliuc, C. G.; Glorius, F.* Cooperative N-heterocyclic carbene/palladium-catalyzed enantioselective umpolungannulations,J. Am. Chem. Soc.2016, 138, 7840-7843.
9.
Guo, C.; Fleige, M.; Janssen-Müller, D.; Daniliuc, C. G.; Glorius, F. *Switchable selectivity in an NHC-catalyseddearomatizing annulation reaction,Nat. Chem.2015, 7, 842-847.
10.
Guo,C.; Sahoo, B.; Daniliuc, C. G.; Glorius, F.*N-Heterocyclic carbenecatalyzed switchable reactions of enals with azoalkenes: formal [4+3] and [4+1] annulations for the synthesis of 1,2-diazepines and pyrazoles,J. Am. Chem. Soc.2014, 136,17402-17405.
11.
Guo, C.; Schedler, M.; Daniliuc, C. G.; Glorius, F.*N-Heterocyclic carbenecatalyzed formal [3+2] annulation reaction of enals: an efficient enantioselective access to spiro-heterocycles,Angew. Chem. Int. Ed.2014, 53, 10232-10236.
12.
Guo, C.; Song, J.; Huang, J.-Z.; Chen, P.-H.; Luo, S.-W.; Gong, L.-Z. *Core-structure-oriented asymmetric organocatalyticsubstitution of3-hydroxyoxindoles: application in the enantioselective total synthesis of (+)-folicanthine.Angew. Chem. Int. Ed.2012, 51, 1046-1050.
13.
Guo, C.; Song, J.; Luo, S.-W.; Gong, L.-Z. *Enantioselective oxidative cross-coupling reaction of 3-indolylmethyl C-H bonds with 1,3-dicarbonyls using a chiral Lewis acid-bonded nucleophile to control stereochemistry.Angew. Chem. Int. Ed.2010, 49, 5558-5562.
14.
Guo, C.; Xue, M.-X.; Zhu, M.-K.; Gong, L.-Z.* Organocatalytic asymmetric formal [3+2] cycloaddition reaction of iocyanoesters to nitroolefinsleading to highly optically active dihydropyrroles.Angew. Chem. Int. Ed.2008, 47, 3414-3417.