Name: Shiyong Liu（S. Y. Liu 刘世勇）
　Address: Department of Polymer Science and Engineering,

University of Science and Technology of China, 230026 Hefei, P. R. China
　Tel: 86-
　Fax: 86-
　E-mail: sliu@ustc.edu.cn

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　EDUCATION AND RESEARCH EXPERIENCE
1989-1993
B.S., Wuhan University
1993-1996
M.S. Wuhan University
1996-2000
Ph.D. Fudan University
2000-2002
Research Fellow, University of Sussex, England
2002-2003
Research Associate, University of Delaware
2004-present
Professor, University of Science and Technology of China


　RESEARCH INTERESTS
1.
Controlled Synthesis of Polymers with Complex Architectures
2.
Chemosensors and Biosensors for Clinical Diagnostics
3.
Supramolecular Self-Assembly and Functional Materials
4.
Kinetics of Chain Folding, Aggregation, and Assembly
5.
Biomaterials, Nanomedicine, Bioimaging


　REPRESENTATIVE PUBLICATIONS
1.
X. R. Wang, J. M. Hu, G. H. Liu, J. Tian, H. J. Wang, M. Gong, S. Y. Liu* "Reversibly Switching Bilayer Permeability and Release Modules of Photochromic Polymersomes Stabilized by Cooperative Noncovalent Interactions", J. Am. Chem. Soc. 2015, 137, 15262-15275.
2.
G. H. Liu, G. F. Zhang, J. M. Hu, X. R. Wang, M. Q. Zhu, S. Y. Liu* "Hyperbranched Self-Immolative Polymers (hSIPs) for Programmed Payload Delivery and Ultrasensitive Detection", J. Am. Chem. Soc. 2015, 137, 11645-11655.
3.
X. L. Hu, G. H. Liu, Y. Li, X. R. Wang, S. Y. Liu* “Cell-Penetrating Hyperbranched Polyprodrug Amphiphiles for Synergistic Reductive Milieu-Triggered Drug Release and Enhanced Magnetic Resonance Signals”J. Am. Chem. Soc.2015, 137,362-368 (JACS Spotlights).
4.
Y. M. Li, G. H. Liu, X. R. Wang, J. M. Hu, S. Y. Liu* "Enzyme-Responsive Polymeric Vesicles for Bacterial Strain-Selective Delivery of Antimicrobial Agents", Angew. Chem. Int. Ed. DOI: 10.1002/anie. (2015)
5.
Y. M. Li, H. S. Yu, Y. F. Qian, J. M. Hu, S. Y. Liu*“Amphiphilic Star Copolymer-Based Bimodal Fluorogenic/Magnetic Resonance Probes for Concomitant Bacteria Detection and Inhibition” Adv. Mater.2014, 26, 6734-6741.
6.
X. R. Wang, J. M. Hu, G. Y. Zhang, S. Y. Liu*“Highly Selective Fluorogenic Multianalyte Biosensors Constructed via Enzyme-Catalyzed Coupling and Aggregation-Induced Emission” J. Am. Chem. Soc.2014, 136, 9890-9893.
7.
G. H. Liu, X. R. Wang, J. M. Hu, G. Y. Zhang, S. Y. Liu* “Self-Immolative Polymersomes for High-Efficiency Triggered Release and Programmed Enzymatic Reactions” J. Am. Chem. Soc.2014, 136, 7492-7497.
8.
X. R. Wang, G. H. Liu, J. M. Hu, G. Y. Zhang, S. Y. Liu* “Concurrent Block Copolymer Polymersome Stabilization and Bilayer Permeabilization via Stimuli-Regulated ‘Traceless’ Crosslinking” Angew. Chem. Int. Ed. 2014, 53, 3138-3142.
9.
X. L. Hu, J. M. Hu*, J. Tian, Z. S. Ge, G. Y. Zhang, K. F. Luo, S. Y. Liu*"Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking and Drug Delivery", J. Am. Chem. Soc.2013, 135, 17617-17629 (SciBX).
10.
J. M. Hu, T. Wu, G. Y. Zhang, S. Y. Liu*"Efficient Synthesis of Single Gold Nanoparticle Hybrid Amphiphilic Triblock Copolymers and Their Controlled Self-Assembly",J. Am. Chem. Soc. 2012,134, 7624-7627.
11.
G. C. Yu, C. Y. Han, Z. B. Zhang, J. Z. Chen, X. Z. Yan, B. Zhang, S. Y. Liu*, F. H. Huang* "Pillar[6]arene-Based Photo-Responsive Host-Guest Complexation", J. Am. Chem. Soc.2012,134, 8711-8717.
12.
C. H. Li, T. Wu, C. Y. Hong, G. Q. Zhang, S. Y. Liu*"A General Strategy to Construct Fluorogenic Probes from Charge-Generation Polymers (CGPs) and AIE-Active Fluorogens via Triggered Complexation",Angew. Chem. Int. Ed., 2012,51, 455-459.
13.
C. H. Li, Y. X. Zhang, J. M. Hu, J. J. Cheng*, S. Y. Liu*, "Reversible Three-State Switching of Multicolor Fluorescence Emission via Multiple Stimuli-Modulated FRET Processes within Thermoresponsive Polymeric Micelles",Angew. Chem. Int. Ed., 2010,49, 5120-5124.
14.
Z. S. Ge, Y. M. Zhou, J. Xu, H. W. Liu, D. Y. Chen*, S. Y. Liu*“High-Efficiency Preparation of Macrocyclic Diblock Copolymers via Selective Click Reaction in Micellar Media” J. Am. Chem. Soc.2009, 131, 1628-1629.
15.
Z. S. Ge, J. M. Hu, F. H. Huang*, S. Y. Liu*“Responsive Supramolecular Gels Constructed via Crown Ether-Based Molecular Recognition” Angew. Chem. Int. Ed.2009, 48, 1798-1802.
16.
J. Xu, Z. Y. Zhu, S. Z. Luo, C. Wu, S. Y. Liu* “First observation of two-stage collapsing kinetics of a single synthetic polymer chain” Phys. Rev. Lett. 2006, 96, 027802.
17.
J. M. Hu, S. Y. Liu* “Engineering Responsive Polymer Building Blocks with Host-Guest Molecular Recognition for Functional Applications” Acc. Chem. Res.2014, 47, 2084-2095
18.
J. M. Hu, G. Y. Zhang, Z. S. Ge, S. Y. Liu* “Stimuli-Responsive Tertiary Amine Methacrylate-Based Block Copolymers: Synthesis, Supramolecular Self-Assembly and Functional Applications” Prog. Polym. Sci. 2014, 39, 1096-1143.
19.
Z. S. Ge*, S. Y. Liu* “Functional Block Copolymer Assemblies Responsive to Tumor and Intracellular Microenvironments for Site-Specific Drug Delivery and Enhanced Imaging Performance” Chem. Soc. Rev. 2013, 42, 7289-7325.
20.
J. M. Hu, G. Q. Zhang, S. Y. Liu* “Enzyme-Responsive Polymeric Assemblies, Nanoparticles and Hydrogels” Chem. Soc. Rev. 2012, 41, 5933-5949.