Name:
CAI Gang （蔡刚）
Address:
No. 443 Huangshan Rd, Hefei, Anhui, China, 230027


School of Life Science, University of Science & Technology of China
Tel:
86-
E-mail:
gcai@ustc.edu.cn

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　EDUCATION AND RESEARCH EXPERIENCE
2010.11-present
Professor, University of Science and Technology
2006.03-2010.11
Research Associate, the Scripps Research Institute, USA
2001.09-2006.03
Ph.D. Shanghai Institutes for Biological Sciences
1997.09-2001.07
B.S. Anhui University B.S. in Microbiology, 2001


　RESEARCH INTERESTS

I am interested in examining the structures and functional interactions of key macromolecular complexes responsible for regulation of chromatin structure and genomic stability, aiming at a structural understanding of the molecular mechanism and designing novel pharmaceuticals for cancer therapy.


　REPRESENTATIVE PUBLICATIONS
1.
Wang, X., Ran, T., Zhang, X., Xin, J., Zhang, Z., Wu, T., Wang, W. and Cai, G*. (2017) 3.9 ? structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. Science, 358, 1206-1209.
2.
Xin, J#., Xu, Z#.,Wang, X#., Tian Y., Zhang, Z. and Cai, G*.（2019） Structural basis of allosteric regulation of Tel1/ATM kinase. Cell Research 29: 655–665. (Cover story)
3.
Qiu, S#., Liu, S#., Zaoti, Z., Wang, X*, Cai, G*. (2019）Modulation of Fatty Acid Synthase by ATR checkpoint kinase Rad3. Journal of Molecular Cell Biology 11: 1098-1100.
4.
Zhang, X., Wang, X*., Zhang, Z., and Cai, G*. (2019) Structure and Functional Interactions of INO80 Actin/Arp Module. J Mol Cell Biol. 11: 345-355. (cover story)
5.
Wang, X*., Ahmad, S., Zhang, Z., C?té, J., Cai, G*. (2018) Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. Nature communications, 9, 1147.
6.
Zhang, Z., Wang, X*., Xin, J., Ding, Z., Liu, S., Fang, Q., Yang, N., Xu, R., Cai, G*. (2018) Architecture of SWI/SNF chromatin remodeling complex. Protein Cell, 9, 1045-1049.
7.
Wang, X., Chu, H., Lv, M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W*., Cai, G*. (2016) Structure of the intact ATM/Tel1 kinase. Nature communications 7, 11655.
8.
Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G.* (2014) Redefining the Modular Organization of the Core Mediator Complex. Cell Research 24, 796-808. (cover story)
9.
Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G.* (2013) Structural flexibility and functional interaction of mediator Cdk8 module, Protein & Cell, 12.4, 4(12): 911~920 (cover story)