Name: Jianye Zang (臧建业)
　Born: March 27, 1976, Jiangsu, P. R. China
　Address: School of life science, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China
　Tel: 86-
　Fax: 86-
　E-mail: zangjy@ustc.edu.cn

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　EDUCATION AND RESEARCH EXPERIENCE
　　1994-1998 Bachelor, University of Science and Technology of China, China
　　1998-2003 Ph. D, University of Science and Technology of China, China

　　2003-2007 Post-doctoral fellow, National Jewish Medical and Research Center, UCHSC, USA
　　2007- Present Professor, University of Science and Technology of China, China


　RESEARCH INTERESTS
　　1. Regulation and function of histone modifications
　　2. Molecular mechanism of kinetochore assembly
　　3. Structural and functional studies of Staphylococcus aureus virulence factors


　CURRENT RESEARCH PROJECTS
　　1. Structural basis of writing, reading and erasing histone modifications, Ministry of Science & Technology of China
　　2. Molecular basis and function of kinetochore assembly, National Natural Science Foundation of China
　　3. Structural biological research of Staphylococcus aureus virulence factors, National Natural Science Foundation of China


　REPRESENTATIVE PUBLICATIONS
　　1. Hang, T., Chen, W., Wu, M., Zhan, L., Wang, C., Jia, N., Zhang, X and Zang, J. (2019) Structural insights into the molecular mechanism underlying Sirt5-catalyzed desuccinylation of histone peptides, Biochem J 476, 211-223.
　　2. Fang, T., Chen, W., Sheng, Y., Yuan, S., Tang, Q., Li, G., Huang, G., Su, J., Zhang, X., Zang, J. and Liu, Y. (2019) Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein, Nature commun 10, 186.
　　3. Wang, C., Zhan, L., Wu, M., Ma, R., Yao, J., Xiong, Y., Pan, Y., Guan, S., Zhang, X. and Zang, J. (2018) Spindlin-1 recognizes methylations of K20 and R23 of histone H4 tail, FEBS lett 592, 4098-4110.
　　4. Chen, X., Wang, C., Zhang, X., Tian, T. and Zang, J. (2018) Crystal structures of the N-terminal domain of the Staphylococcus aureus DEAD-box RNA helicase CshA and its complex with AMP,Acta Crystallogr F Struct Biol Commun74, 704-709.
　　5. Tian, T., Wang, C., Wu, M., Zhang, X. and Zang, J. (2018) Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion,Biochemistry57, 4252-4262.
　　6. Tian, T., Li, X., Liu, Y., Wang, C., Liu, X., Bi, G., Zhang, X., Yao, X., Zhou, Z. H., and Zang, J. (2018) Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore,Cell Res28, 374-378.
　　7. Hang, T., Zhang, X., Wu, M., Wang, C., Ling, S., Xu, L., Gong, Q., Tian, C., Zhang, X. and Zang, J. (2018) Structural insights into a novel functional dimer of Staphylococcus aureus RNase HII,Biochem Biophys Res Commun503, 1207-1213.
　　8. Zhou, X., Zheng, F., Wang, C., Wu, M., Zhang, X., Wang, Q., Yao, X., Fu, C., Zhang, X. and Zang, J. (2017) Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis, Proc Natl Acad Sci USA114, E10667-E10676.
　　9. Zhang, Y., Wu, M., Hang, T., Wang, C., Yang, Y., Pan, W., Zang, J., Zhang, M., and Zhang, X. (2017) Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion, Biochem J 474, 1619-1631.
　　10. Wang, X., Wang, C., Wu, M., Tian, T., Cheng, T., Zhang, X. and Zang, J. (2017) Enolase binds to RnpA in competition with PNPase in Staphylococcus aureus, FEBS lett. 591, 3523-3535.
　　11. Li, Y., Chen, X. B., Jia, N., Zhang, X. and Zang, J.(2017) Identification of Set11 from Staphylococcus aureus Mu50 strain as a ortholog of SSL7 via bioinformatic analysis and determination of its possible targets from human serum using CNBr-pull down assays, Biotechnol Lett 39, 1413-1423.
　　12. Chen, W., Wu, M., Hang, T., Wang, C., Zhang, X. and Zang, J. (2017) Structure insights into the molecular mechanism of the interaction between UHRF2 and PCNA, Biochem Biophys Res Commun 494, 575-580.
　　13. Wang C, Zhang Q, Hang T, Tao Y, Ma X, Wu M, Zhang X and Zang J. (2015). Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8. Acta Crystallogr D Biol Crystallogr 71:1955-64.
　　14. Song Y, Zhang F, Li X, Zang J. and Zhang X. (2015). Crystallographic studies of SarV, a global regulator from Staphylococcus aureus. Acta Crystallogr F Struct Biol Commun 71:1038-41.
　　15. Zhang W, Wang C, Song Y, Shao C, Zhang X. and Zang J. (2015). Structural insights into the mechanism of Escherichia coli YmdB: A 2'-O-acetyl-ADP-ribosedeacetylase. J Struct Biol 192:478-86.
　　16. Wu Y, Wang C, Lin S, Wu M, Han L, Tian C, Zhang X and Zang J. (2015). Octameric structure of Staphylococcus aureus enolase in complex with phosphoenolpyruvate. Acta Crystallogr D Biol Crystallogr 71(Pt 12):2457-2470.
　　17. Shao, C., Wang, C. and Zang, J. (2014). Structural basis for the substrate selectivity of PvuRts1I, a 5-hydroxymethylcytosine DNA restriction endonuclease. Acta Crystallogr D Biol Crystallogr 70, 2477-86.
　　18. Wang, J., Liu, X., Dou, Z., Chen, L., Jiang, H., Fu, C., Fu, G., Liu, D., Zhang, J., Zhu, T., Fang, J., Zang, J., Cheng, J., Teng, M., Ding, X. and Yao, X. (2014). Mitotic regulator Mis18beta interacts with and specifies the centromeric assembly of molecular chaperone holliday junction recognition protein (HJURP). J Biol Chem 289, 8326-36
　　19. Tao, Y., Wu, M., Zhou, X., Yin, W., Hu, B., de Crombrugghe, B., Sinha, K.M. andZang, J. (2013) Structural Insights into Histone Demethylase NO66 in Interaction with Osteoblast-specific Transcription Factor Osterix and Gene Repression.J Biol Chem, 288, 16430-16437.
　　20. Sun, D., Liu, Q., He, Y., Wang, C., Wu, F., Tian, C. and Zang, J. (2013). The putative propeptide of MycP1 in mycobacterial type VII secretion system does not inhibit protease activity but improves protein stability. Protein Cell 4, 921-31.
　　21. Wu, M., Tao, Y., Liu, X. andZang, J.(2013) Structural Basis for Phosphorylated Autoinducer-2 Modulation of the Oligomerization State of the Global Transcription Regulator LsrR from Escherichia coli.J Biol Chem, 288, 15878-15887.
　　22. Zhang, X., Chen, J., Wu, M., Wu, H., Arokiaraj, A.W., Wang, C., Zhang, W., Tao, Y., Huen, M.S. andZang, J.(2013) Structural basis for role of ring finger protein RNF168 RING domain.Cell Cycle, 12, 312-321.
　　23. Ruan, J., Xu, C., Bian, C., Lam, R., Wang, J.P., Kania, J., Min, J. andZang, J. (2012) Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1.FEBS Lett, 586, 314-318.
　　24. Li, J., Wang, C., Wu, Y., Wu, M., Wang, L., Wang, Y. andZang, J. (2012) Crystal structure of Sa239 reveals the structural basis for the activation of ribokinase by monovalent cations.J Struct Biol, 177, 578-582.
　　25. Bian, C., Xu, C., Ruan, J., Lee, K. K., Burke, T. L., Tempel, W., Barsyte, D., Li, J., Wu, M., Zhou, B. O., Fleharty, B. E., Paulson, A., Allali-Hassani, A., Zhou, J. Q., Mer, G., Grant, P. A., Workman, J. L.*,Zang, J.*& Min, J.* (2011). Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.EMBO J30, 2829-42. (*Co-corresponding author)
　　26. Wang, L., Wu, M. &Zang, J. (2011). Crystal structure of Sa240: A ribose pyranase homolog with partial active site from Staphylococcus aureus.J Struct Biol174, 413-9.
　　27. Hong, X.*,Zang, J.*,White, J.*, Wang, C., Pan, C. H., Zhao, R., Murphy, R. C., Dai, S., Henson, P., Kappler, J. W., Hagman, J. & Zhang, G. (2010). Interaction of JMJD6 with single-stranded RNA.Proc Natl Acad Sci USA107, 14568-72. (*Co-first author)
　　28. Liu, Y., Huang, H., Zhou, B. O., Wang, S. S., Hu, Y., Li, X., Liu, J.,Zang, J., Niu, L., Wu, J., Zhou, J. Q., Teng, M. & Shi, Y. (2010). Structural analysis of Rtt106p reveals a DNA binding role required for heterochromatin silencing.J Biol Chem285, 4251-62.
　　29. Lai, C., Wu, M., Li, P., Shi, C., Tian, C. &Zang, J. (2010). Solution NMR characterization of Sgf73(1-104) indicates that Zn ion is required to stabilize zinc finger motif.Biochem Biophys Res Commun397, 436-40.
　　30. Wang, J., Zhang, W., Song, W., Wang, Y., Yu, Z., Li, J., Wu, M., Wang, L.,Zang, J. & Lin, Q. (2010). A biosynthetic route to photoclick chemistry on proteins.J Am Chem Soc132, 14812-8.
　　31. Wang, J., Zhang, W., Song, W., Wang, Y., Yu, Z., Li, J., Wu, M., Wang, L.,Zang, J. & Lin, Q. (2010). A biosynthetic route to photoclick chemistry on proteins.J Am Chem Soc132, 14812-8.
　　32. Chen, Z.,Zang, J., Kappler, J., Hong, X., Crawford, F., Wang, Q., Lan, F., Jiang, C., Whetstine, J., Dai, S., Hansen, K., Shi, Y. & Zhang, G. (2007). Structural basis of the recognition of a methylated histone tail by JMJD2A.Proc Natl Acad Sci USA104, 10818-23.
　　33. Chen, Z.*,Zang, J.*, Whetstine, J., Hong, X., Davrazou, F., Kutateladze, T. G., Simpson, M., Mao, Q., Pan, C. H., Dai, S., Hagman, J., Hansen, K., Shi, Y. & Zhang, G. (2006). Structural insights into histone demethylation by JMJD2 family members.Cell125, 691-702. (*Co-first author)
　　34. Wang, D., Guo, M., Liang, Z., Fan, J., Zhu, Z.,Zang, J., Li, X., Teng, M., Niu, L., Dong, Y. & Liu, P. (2005). Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites.J Biol Chem280, 22962-7.