姓　　名:
张志勇
地　　址:
安徽省合肥市黄山路443号中国科技大学生命学院
邮　　编:
230026
电　　话:

电　　邮:
zzyzhang@ustc.edu.cn
主　　页:
https://biox.ustc.edu.cn/2015/0713/c692a3269/page.htm

---

　教育与科研经历
1994年9月至1998年7月
就读于中国科学技术大学生物系，分子与细胞生物学学士学位
1998年9月至2003年7月
在中国科学技术大学生命科学学院免试硕博连读，生化与分子生物学博士学位，获“求是”及“中国科学院院长”奖
2003年12月至2006年12月
在美国得克萨斯休斯顿健康科学中心从事博士后研究，期间获得Keck Center Pharmacoinformatics Fellowship资助
2006年12月至2010年3月
在犹他大学化学系从事博士后研究
2010年4月至2010年12月
在芝加哥大学化学系从事博士后研究
2010年6月至今
通过中国科技大学优秀人才引进，受聘为生命科学学院教授


　目前研究方向
1.
发展生物大分子多尺度模拟的新方法，如构象空间增强采样技术和粗粒化模拟，等等；
2.
多尺度模拟整合核磁共振、冷冻电镜以及X射线小角散射等结构数据，研究生物大分子（蛋白、核酸及复合物）的结构及动态变化。


　代表性论文
1.
Junhui Peng#, Chuang Yuan#, Rongsheng Ma, Zhiyong Zhang*. Backmapping from multiresolution coarse-grained models to atomic structures of large biomolecules by restrained molecular dynamics simulations using Bayesian inference. Journal of Chemical Theory and Computation 2019 (15): 3344-3353
2.
Zilong Wang, Shuang Wang, Zheng Xu, Mingwei Li, Kuan Chen, Yaqun Zhang, Zhimin Hu, Meng Zhang, Zhiyong Zhang*, Xue Qiao*, Min Ye*. Highly promiscuous flavonoid 3-O-glycosyltransferase from Scutellaria baicalensis. Organic Letters 2019 (21): 2241-2245
3.
Chun Ye, Chengtao Ding, Rongsheng Ma, Junfeng Wang, Zhiyong Zhang*. Electrostatic interactions determine entrance/release order of substrates in the catalytic cycle of adenylate kinase. Proteins 2019 (87): 337-347
4.
Difei Xu, Rongsheng Ma, Jiahai Zhang, Zhijun Liu, Bo Wu, Junhui Peng, Yanan Zhai, Qingguo Gong, Yunyu Shi, Jihui Wu, Qiang Wu,Zhiyong Zhang*, Ke Ruan*. Dynamic nature of CTCF tandem 11 zinc fingers in multivalent recognition of DNA as revealed by NMR Spectroscopy.The Journal of Physical Chemistry Letters2018(9): 4020-4028
5.
Bin Wen, Weiwei Wang, Jiahai Zhang, Qingguo Gong, Yunyu Shi, Jihui Wu*,Zhiyong Zhang*. Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies.Physical Chemistry Chemical Physics2017(19): 21152-21164
6.
Peng Cheng#, Junhui Peng#,Zhiyong Zhang*. SAXS-oriented ensemblerefinement of flexible biomolecules.Biophysical Journal2017(112): 1295-1301
7.
Junhui Peng,Zhiyong Zhang*. Unraveling low-resolution structural data of large biomolecules by constructing atomic models with experiment-targeted parallel cascade selection simulations.Scientific Reports2016(6): 29360
8.
Yonghui Zhang, Junhui Peng,Zhiyong Zhang*. Structural modeling of proteins by integrating small-angle X-ray scattering data.Chinese Physics B2015(24): 126101
9.
Junhui Peng, Debiao Zhao, Bin Wen,Zhiyong Zhang*. Determining structural models of biomolecular complexes integrating nuclear magnetic resonance, small-angle X-ray scattering and computational simulations.Chinese Journal of Magnetic Resonance2015(32): 181-194
10.
Yonghui Zhang, Bin Wen, Junhui Peng, Xiaobing Zuo, Qingguo Gong,Zhiyong Zhang*. Determining structural ensembles of flexible multi-domain proteinsusing small-angle X-ray scattering and molecular dynamics simulations.Protein & Cell2015(6): 619-623
11.
Zhiyong Zhang*. Systematic methods for defining coarse-grained maps in large biomolecules.Advances in Structural Bioinformatics2015(827): 33-48