Name:
Wei Xiong (熊伟)
Address:
Division of Life Sciences and Medicine,

University of Science and Technology of China

443 Huangshan Street, Hefei City, Anhui 230027, P.R.China
Tel:
+86 551-6360-1736
E-mail:
wxiong@ustc.edu.cn

---

　EDUCATION AND RESEARCH EXPERIENCE
03/2013- present
Professor, University of Science and Technology of China
10/2011-03/2013
Research Fellow, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
10/2006-10/2011
Postdoctoral Fellow, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
09/2001-07/2006
Ph.D., School of Life Sciences, Peking University
09/1997-07/2001
B.S., School of Life Sciences, Peking University


　RESEARCH INTERESTS
1.
The neurochemical mechanisms of brain aging and neurodegenerative diseases
2.
Development of new mass spectrometry technology for neuroscience
3.
The neural circuits underlying sensory perception
4.
Modulation of ion channels


　DESCRIPTION

Our lab has been focusing in the field of neurochemical mechanism of brain functions and brain diseases for a long period. We are developing the multi-scale technology platforms for research of brain small molecules such as single-cell mass spectrometry, single-organelle mass spectrometry, mass spectrometry imaging. Our studies focus on the changes of small molecule metabolites in the brain during aging and neurodegeneration, and the roles of these changed small molecules in the brain aging and neurodegeneration. We are investigating the neuronal circuit mechanism of sensory (especially pain) processing and its related neurological disorders, such as chronic inflammatory pain and allodynia and hyperalgesia in neuropathic pain. We are also developing new therapeutic medicine and treatment to relieve chronic pain.



　CURRENT RESEARCH PROJECTS

National Key R&D Program of China, National Natural Science Foundation of China, the Key Research Program of Frontier Sciences, the Strategic Priority Research Program of the Chinese Academy of Sciences, the Users with Excellence Program/Project of Hefei Science Center CAS.



　REPRESENTATIVE PUBLICATIONS
1.
Hongying Zhu^#; Ning Wang^#; Lei Yao; Qi Chen; Ran Zhang; Junchao Qian; Yiwen Hou; Weiwei Guo; Sijia Fan; Siling Liu; Qiaoyun Zhao; Feng Du; Xin Zuo; Yujun Guo; Yan Xu; Jiali Li; Tian Xue; Kai Zhong; Xiaoyuan Song; Guangming Huang*; Wei Xiong*. Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell, 173, 1716-1727 (2018)

2.
Guichang Zou, Xin Zuo, Kai Chen, Yushu Ge, Xiaoqun Wang, Guangwei Xu, Huan Wang, Chenjian Miao, Zhenyu Xu, Shuangshuang Tian, Zhen Wang, Yifeng Zhou, Wei Wei, Guangming Huang, Dan Liu and Wei Xiong*. Cannabinoids Rescue Cocaine-induced Seizure by Restoring Brain Glycine Receptor Dysfunction. Cell Reports, accepted (2020)

3.
Hongying Zhu^#, Guichang Zou^#, Ning Wang^#, Meihui Zhuang, Wei Xiong* & Guangming Huang*. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry. PNAS, 114: 2586-2591 (2017)

4.
Zou Guichang, Xia Jing, Han Qianqian, Liu Dan, and Xiong Wei*. The synthetic cannabinoid dehydroxylcannabidiol restores the function of a major GABAA receptor isoform in a cell model of hyperekplexia. The Journal of Biological Chemistry. 295: 138-145 (2020)

5.
Wang Xiaoqun^#; Hou Yiwen^#; Hou Zhuanghao; Xiong Wei*; Huang Guangming*. Mass Spectrometry Imaging of Brain Cholesterol and Metabolites with Trifluoroacetic Acid-Enhanced Desorption Electrospray Ionization, Analytical Chemistry, 91(4): 2719~2726 (2019)

6.
Chengyuan Liu, Keke Qi, Lei Yao, Ying Xiong, Xuan Zhang , Jianye Zang, Changlin Tian, Minggao Xu, Jiuzhong Yang , Zhenkun Lin , Yongmei Lv, Wei Xiong*, and Yang Pan*. Imaging of Polar and Nonpolar Species Using Compact Desorption Electrospray Ionization/Postphotoionization Mass Spectrometry. Analytical Chemistry, 91(10): 6616-6623 (2019)

7.
Guichang Zou, Qi Chen, Kai Chen, Xin Zuo, Yushu Ge, Yiwen Hou, Tao Pan, Huilin Pan, Dan Liu, Li Zhang and Wei Xiong*. Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABAA Receptors. iScience, 19: 634-646 (2019)

8.
Jieping Lu^#*; Sijia Fan^#; Guichang Zou; Yiwen Hou; Tao Pan; Weiwei Guo; Lei Yao; Feng Du; GE Homanics; Dan Liu; Li Zhang; Wei Xiong*. Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia. Neuropharmacology, 133: 224-232 (2018)

9.
Wei Xiong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-Lin Zhao, Hong Chen, De-Pei Li, Gregg E. Homanics, John Peever, Kenner C. Rice, Ling-gang Wu, Hui-Lin Pan & Li Zhang. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease.Nature Neuroscience, 17: 232-239 (2014)

10.
Wei Xiong, KeJun Chen, Tanxing Cui, Grzegorz Godlewski, Kenner Rice, Yan Xu and Li Zhang. Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia.Nature Chemical Biology, 7: 296-303(2011)

11.
Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu and Li Zhang. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.Journal of Experimental Medicine, 209 (6): 1121-1134 (2012)

12.
Wei Xiong, Xiongwu Wu, David M. Lovinger and Li Zhang. A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors.Journal of Neuroscience, 32 (15): 5200-5208 (2012)

13.
Wei Xiong, Masako Hosoi, Bon-Nyeo Koo, and Li Zhang. Anandamide Inhibition of 5-HT3A Receptors Varies with Receptor Density and Desensitization. Molecular Pharmacology, 73:314-322 (2008)

14.
Wei Xiong*, Bon-Nyeo Koo, Russell Morton and Li Zhang. Psychotropic and nonpsychotropic cannabis derivatives inhibit human 5-HT3A receptors through a receptor desensitization-dependent mechanism. Neuroscience, 184: 28-37 (2011) *Corresponding Author

15.
Wei Xiong, Long-Chuan Yu. Involvement of endogenous cholecystokinin in morphine tolerance in the nucleus accumbens of rats. Behavioural Brain Research, 173:116-121 (2006)

16.
Wei Xiong, Long-Chuan Yu. Involvements of mu- and kappa- opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats. Neuroscience Letters, 399: 167-170 (2006)

17.
Wei Xiong, Lian Gao, Aygul Sapra, Long-Chuan Yu. Antinociceptive role of galanin in the spinal cord of rats with inflammation, an involvement of opioid systems. Regulatory Peptides, 132: 85-90 (2005)

18.
Shijin Xu^#, Yan Xu^#, Xueying Cheng^#, Cheng Huang, Yonglu Pan, Shiyun Jin, Wei Xiong, Li Zhang, Shufang He, Ye Zhang. Inhibition of DRG-TRPV1 upregulation in myocardial ischemia contributes to exogenous cardioprotection. Journal of Molecular and Cellular Cardiology, 138: 175-184 (2020)

19.
Mengyun Dou^#, Zhenxiao Ma^#, Xueying Cheng, Guichang Zou, Yan Xu, Cheng Huang, Wei Xiong, Shufang He*, YeZhang*. "Intrathecal lentivirus-mediated RNA interference targeting nerve growth factor attenuates myocardial ischaemia-reperfusion injury in rat." British Journal of Anaesthesia, 123(4): 439-449 (2019)

20.
Cheng Huang^#, Jie Wang^#, Ning Wang, Feng Du, Wei Xiong, Junchao Qian, Kai Zhong, Aoling Cai, Shijin Xu, Jun Huang, Xueying Cheng, Shufang He*, Ye Zhang*. Effect of myocardial ischemic preconditioning on ischemia-reperfusion stimulation-induced activation in rat thoracic spinal cord with functional MRI. International Journal of Cardiology, 285: 59-64 (2019)

21.
Luis G Aguayo*, Patricio Castro, Trinidad Mariqueo, Braulio Mu?oz, Wei Xiong, Li Zhang, David M Lovinger & Gregg E Homanics*. Altered Sedative Effects of Ethanol in Mice with α1 Glycine Receptor Subunits that are Insensitive to Gβγ Modulation. Neuropsychopharmacology, 39: 2538–2548 (2014)

22.
Zhifeng Zhou, Camilla Karlsson, Tiebing Liang, Wei Xiong, Mitsuru Kimura, Jenica D. Tapocik, Qiaoping Yuan, Estelle Barbier, Austin Feng, Meghan Flanigan, Eric Augier, Mary-Anne Enoch, Colin A. Hodgkinson, Pei-Hong Shen, David M. Lovinger, Howard J. Edenberg, Markus Heilig, and David Goldman. Loss of metabotropic glutamate receptor 2 escalates alcohol consumption. PNAS, 110(42):16963-8 (2013)

23.
Yan Zhang, Wei Xiong, Xiaojin Lin, Xiang Ma and Long-Chuan Yu. Receptor trafficking induced by mu-opioid-receptor phosphorylation. Neuroscience & Biobehavioral Reviews, 33: 1192-1197 (2009)

24.
Cecilia M. Borghese, Wei Xiong, S. Irene Oh, Angel Ho, John Mihic, Li Zhang, David M. Lovinger and Gregg E. Homanics. Mutations M287L and Q266I in the glycine receptor alpha1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but Not the minimal alveolar concentration in Knockin Mice. Anesthesiology, 117(4):765-71 (2012)

25.
Cecilia M. Borghese, Yuri A. Blednov, Yu Quan, Sangeetha V. Iyer, Wei Xiong, S. John Mihic, Li Zhang, David M. Lovinger, James R. Trudell, Gregg E. Homanics, R. Adron Harris. Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols. Journal of Pharmacology and Experimental Therapeutics, 340: 304-316 (2012)

26.
Long-Chuan Yu, Shi-Lian Xu, Wei Xiong, Thomas Lundeberg. The effect of galanin on wide-dynamic range neuron activity in the spinal dorsal horn of rats. Regulatory Peptides, 101: 179-182 (2001)

27.
Li Zhang and Wei Xiong. Nonpsychoactive cannabinoid action on 5-HT3 and glycine receptors. endoCANNABINOIDS: Actions at Atypical, Non-Cannabinoid Receptors. Springer (2012)

28.
Li Zhang and Wei Xiong. Modulation of the cys-loop ligand-gated ion channels by fatty acid and cannabinoids. Vitamins and Hormones, Vol. 81, Burlington: Academic Press, 2009, pp. 315-335 (2009)