姓　　名:
金腾川
地　　址:
中区医学楼303
邮　　编:
230027
电　　话:

电　　邮:
Jint@ustc.edu.cn
主　　页:
Tjlab.ustc.edu.cn

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　教育与科研经历
1998 - 2003
中国科学技术大学，生物学理学学士
1998 - 2003
中国科学技术大学，工商管理学士
2003 - 2008
美国伊利诺伊理工大学，分子生物化学和生物物理学博士
2008 - 2012
博士后, 美国国立卫生研究院
2012 - 2014
研究员（Research Fellow）, 美国国立卫生研究院
2015 - 目前
特任研究员、博导，中国科学技术大学


　目前研究方向
1.
天然免疫受体的结构生物学
2.
炎症小体的结构与功能
3.
病原体与宿主相互作用的分子机制
4.
蛋白质工程与蛋白药物


　代表性论文
1.
Liu M, Zhou K, Xu Z, Ma H, Cao X, Yin X, Zeng W, Zahid A, Fu S, Ni K, Ye X, Zhou Y, Bai L, Zhou R, Jin T*. Crystal Structure of Caspase-11 CARD Provides Insights into Caspase-11 Activation (2020). Cell Discovery.
2.
Mekonnen D, Mengist HM, Derbie A, Nibret E, Munshea A, He H, Li B*, Jin T*. Diagnostic accuracy of serological tests and kinetics of SARS-COV-2 antibody: A systematic review and meta-Analysis. Reviews In Med Virology, Accepted.
3.
Tao W, Wang X, Zhang G, Guo M, Ma H, Zhao D, Sun Y, He J, Liu L, Zhang K, Wang Y, Weng J, Ma X, Jin T*, Zhu S*(2020). Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection. Protein & Cell. doi: 10.1007/s13238-020-00778-8.
4.
Ma H#, Zhao D#, Zeng W#, Yang Y, Hu X, Zhou P, Weng J, Cheng L, Zheng X*, Jin T*(2020). Decline of SARS-CoV-2-specific IgG, IgM and IgA in convalescent COVID-19 patients within 100 days after hospital discharge. Sci. China. Life Sci. doi: 10.1007/s11427-020-1805-0.
5.
Guo C#, Li B#, Ma H, Wang X, Cai P, Yu Q, Zhu L, Jin L, Jiang C, Fang J, Liu Q, Zong D, Zhang W, Lu Y, Li K, Gao X, Fu B, Liu L, Ma X, Weng J, Wei H, Jin T*, Lin J*, Qu K* (2020). Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm. Nat Commun. 11(1):3924.
6.
Li WY, Li Y, Chen YL, Hu JJ, Mengist HM, Liu GM, Jin T*, Cao MJ* (2020). Characterization and crystal structure of prolyl endopeptidase from abalone (Haliotis discus hannai). Food Chem. 333:127452.
7.
Li Y, Hu X, Tu Y, Wu T, Wang B, Ma H, Zeng W, Zhao D, Mengist HM, Kombe AJK, Zheng M, Xu Y*, Jin T* (2020). A low viral dose in COVID-19 patient: A case report. Frontiers in Public Health. 8:339. doi: 10.3389/fpubh.2020.00339.
8.
Fan X, Wang Y, Guo F, Zhang Y, Jin T* (2020). Atomic-resolution structures of type I ribosome inactivating protein alpha-momorcharin with different substrate analogs. Int J Biol Macromol. S0141-8130(20)33812-5.
9.
Ma H#, Zeng W#, He H#, Zhao D, Jiang D, Zhou P, Cheng L, Li Y*, Ma X*, Jin T* (2020). Serum IgA, IgM, and IgG responses in COVID-19. Cell Mol Immunol. doi: 10.1038/s41423-020-0474-z.
10.
Zeng W, Liu G, Ma H, Zhao D, Yang Y, Liu M, Mohammed A, Zhao C, Yang Y, Xie J, Ding C, Ma X, Weng J, Gao Y, He H*, Jin T* (2020). Biochemical characterization of SARS-CoV-2 nucleocapsid protein. Biochem Biophys Res Commun. 527(3):618-623. doi: 10.1016/j.bbrc.2020.04.136.
11.
Mengist HM, Fan X, Jin T* (2020). Designing of improved drugs for COVID-19: Crystal structure of SARS-CoV-2 main protease M^pro. Signal Transduct Target Ther. 5(1):67. doi: 10.1038/s41392-020-0178-y.