Name:
Zhigang Tian（田志刚）
Address:
School of Life Sciences ,

University of Science and Technology of China, 230026 Hefei, P. R. China
Tel:
86-
Fax:
86-
E-mail:
tzg@ustc.edu.cn

---

　EDUCATION AND RESEARCH EXPERIENCE
03/1978-12/1982
M.D., Shanxi Medical University, China
03/1983-08/1985
M.S., Immunol, Shandong Acad Med Sci, China
03/1986-03/1989
Ph.D., Immunology, Normal Bethune Med Univ, China
04/1989-12/2001
Assist/Asso/Full Professor, Shandong Acad Med Sci
08/1994-06/1996
Visiting Scientist, NCI, NIH, USA
02/1999-08/1999
Visiting Professor, Med College Virginia, Richmond
08/2000-12/2000
Visiting Scientist, NCI, NIH, USA
01/2001-present
Professor, Univ Sci Tech China, China
01/2002-04/2002
Visiting Scientist, NIAAA, NIH, USA
05/2002-04/2003
Visiting Professor, Kanazawa Univ Cancer Inst, Japan


　RESEARCH INTERESTS
1.
NK cell subsets and differentiation
2.
NK cell-based immunotherapy of cancer
3.
Liver immune tolerance and diseases


　REPRESENTATIVE PUBLICATIONS
1.
Zong L, Peng H , Sun C, Li F, Zheng M, Chen Y, Wei H, Sun R,Tian Z*. Breakdown of adaptiveimmunotolerance induces hepatocellularcarcinoma in HBsAg-tg mice.Nat Commun.2019 Jan; 10(1):221.
2.
Zhou J, Peng H*, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R,Tian Z*. Liver-resident NK cells control antiviral activity of hepatic T cells via PD-1/PD-L1 axis.Immunity.2019 Feb; 50(2):403-417.
3.
Wang X, Sun R, Hao X, Lian Z, Wei H, Tian Z*. IL-17 constrains natural killer cell activity by restraining IL-15-driven cell maturation via SOCS3.PNAS 2019; 116:17409-17418.
4.
Wang X,Peng H*,Cong J,Wang X,Lian Z,Wei H,Sun R*,Tian Z*. Memory formation and long-term maintenance of IL-7Rα⁺ILC1s via a lymph node-liver axis.Nat Commun.2018 Nov; 9(1):4854.
5.
Cong J, Wang X, Zheng X, Wang D, Fu B, Sun R,Tian Z*, Wei H*. Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression.Cell Metab.2018 Aug; 28(2):243-255.
6.
Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, Sun R*,Tian Z*. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity.Nat Immunol.2018 Jul; 19(7):723-732.
7.
Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G , Song J, Wang J, Wei H, Zhang J, Sun R, Zhang C*, Tian Z*. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.Nat Commun.2018 Mar; 9(1):1241.
8.
Fu B, Zhou Y，Ni X, Tong X, Xu X, Dong Z, Sun R,Tian Z*, Wei H*. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.Immunity.2017 Dec; 47:1100-1113.
9.
Li F, Hao X, Chen Y, Bai L, Gao X, Lian Z, Wei H, Sun R,Tian Z*. Microbiota maintains homeostasis of liver-resident γδT-17 cells in a lipid antigen-CD1d–dependent manner.Nat Commun.2017 Jan; 7:13839.
10.
Yu X, Lan P, Hou X, Han Q, Lu N, Li T, Jiao C, Zhang J, Zhang C*,Tian Z*. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production.J Hepatol.2017 Apr; 66(4):693-702.
11.
Chen S, Yang M, Du J, Li D, Li Z, Cai C, Ma Y, Zhang L,Tian Z*, Dong Z*. The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education.Immunity.2016 Aug; 45(2):292-304.
12.
Zeng Z, Li L, Chen YY, Wei HM, Sun R,Tian Z*. Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance.J Exp Med.2016 May; 213(6):1079-93.
13.
Wu X, Sun R, Chen Y, Zheng X, Bai L, Lian Z, Wei H,Tian Z*. Oral ampicillin inhibits liver regeneration by breaking hepatic innate immune tolerance normally maintained by gut commensal bacteria.Hepatology.2015 Jul; 62(1):253-64.
14.
Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*,Tian Z*. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice.J Hepatol.2015 Jun; 62(6):1311-8.
15.
Yan Y, Jiang W, Liu L, Wang X, Ding C,Tian Z*, Zhou R*. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.Cell.2015 Jan; 160(1-2):62-73.