Name:
Zhenye Yang (杨振业)
Address:
School of Life Sciences

University of Science & Technology of China,

443 Huangshan Street, Hefei City, Anhui 230027
Tel:

E-mail:
zhenye@ustc.edu.cn

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　EDUCATION AND RESEARCH EXPERIENCE
2013-
Professor, School of Life Sciences, University of Science & Technology of China
2010-2013
Research Fellow, National Cancer Institute, NIH
2005-2010
Research Scientist, Wadsworth Center, New York State Department of Health
1999-2005
Ph.D, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
1995-1999
B.S., School of Life Science, Shanghai Jiao Tong University


　RESEARCH INTERESTS
1.
Function of cell division regulators in tumor progression
2.
Mechanism of anti-mitotic therapeutics and combination therapy
3.
Roles of inflammation in anti-mitotic and target chemotherapy


　REPRESENTATIVE PUBLICATIONS
1.
Cheng A#, Zhang P#, Wang B#，Yang D#, Duan X, Jiang Y, Xu T, Jiang Y, Shi J, Ding C, Wu G, Sang Z, Wu Q, Wang H, Wu M , Zhang Z, Pan X, Pan Y, Gao P, Zhang H, Zhou C, Guo J* and Yang Z*. 2019. Aurora-A Mediated Phosphorylation of Lactate Dehydrogenase B promotes glycolysis and tumor growth by relieving the substrate inhibition effect. Nat. Commun. 2019, 10(1):5566.
2.
Yin T#, Zhao ZB#, Guo J#, Wang T, Yang JB, Wang C, Long J, Ma S, Huang Q, Zhang K, Ma X, Liu C, Liu S, Lian ZX*, Yang Z*. 2019. Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer. Cancer Res. 79(13):3431-3444.
3.
Huang Y, Lin L, Liu X, Ye S, Yao PY, Wang W, Yang F, Gao X, Li J, Zhang Y, Zhang J, Yang Z, Liu X, Yang Z, Zang J, Teng M, Wang Z, Ruan K, Ding X, Li L, Cleveland DW, Zhang R, Yao X. 2019. BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res. 29, 562–578.
4.
Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, GuoJ* and Yang Z* 2017. Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B Feedback Loop in late G2 phase. Cell Discovery, 3:16049.
5.
Ma X, Wang L, Huang, Li Y, Yang D, Li T, Li F, Sun L, Wei H, He K, Yu F, Zhao D, Hu L, Xing S, Liu Z, Li K, Guo J, Yang Z, Pan X, Li A, Shi Y, Wang J, Gao P, Zhang H. 2017. Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway. Nat Commun. 8(1):1506.
6.
Zhang L, Hou Y, Li Z, Ji X, Wang Z, Wang H, Tian X, Yu F, Yang Z, Pi L, Mitchison TJ, Lu Q, Zhang X. 2017. 27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells. 2017. Elife. 6. pii: e22911.
7.
Ma W, Jia J, Liu Z, Yang Y, Yang J, Zhao Z, Yang Z, Shi Q, Ma H, Gershwin E and Lian ZX. 2017. Modulation of liver regeneration via myeloid PTEN deficiency. Cell death & Disease. 8(5):e2827.
8.
Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y and Zhu X. 2012. Misfolded Gbeta2 is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell Res. 22:1140–1154.
9.
Yang Z., Kenny A., Brito D. and Rieder C. 2009. Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. J Cell Biol.186: 675-684.
10.
Yang Z., Loncarek J., Khodjakov A. and Rieder C. 2008. Extra centrosomes and/or chromosomes prolong mitosis in human cells. Nat. Cell Biol. 10: 748-751.
11.
Brito D.*, Yang Z.* and Rieder C. 2008. Microtubules do not promote mitotic slippage when the Spindle Assembly Checkpoint cannot be satisfied. J Cell Biol. 182(4):623-9. (* Co-first author)
12.
Yang Z., Tulu S., Wadsworth P. and Rieder C. 2007. Kinetochore Dynein is Required for Normal Chromosome Motion and Congression Independent of the Spindle Checkpoint. Curr. Biol. 17(11): 973-80.
13.
Guo J, Yang Z, Song W, Chen Q, Wang F., Zhang Q. and Zhu X. 2006. Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. Mol. Biol. Cell. 17(2):680-9.
14.
Yang Z., Guo J., Chen Q., Du J., Ding C., and Zhu X. 2005. Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol. Cell. Biol. 25: 4062-4074.
15.
Yang, Z., Guo J., Li N., Qian M., Wang S, and. Zhu X. 2003. Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Cell Res. 13:275-83.