姓 名：康彦彪 教授 博导
电 话：
电子邮件： ybkang@ustc.edu.cn
传 真：
主页：




个人简历
2012-至今中国科学技术大学化学系：博导、特任研究员、教授
2008-2012德国海德堡大学：洪堡****、博士后
2007-2008 美国Brandeis大学：博士后
2002-2007 中国科学院上海有机化学研究所：博士
1998-2002 南京大学化学化工学院：学士
主要研究方向
1. 面向工业化的选择性清洁氧化反应。
1. 前沿手性催化与合成。
2. 基于化学反应动力学的有机反应机理研究。
4. 新型聚合材料新型聚合方法。

经费支持和荣誉
(1) 国家优秀青年科学基金(2019)
(2) 国家自然科学基金NSFC (主持**, **, **; 参与U**, **)
(3) 中科院先导B专项经费(XDB**, 参与)
(4) Thieme Chemistry Journals Award (2018)
(5) 张宗植青年教师奖(2016)
(6) ACS Membership Award (3-year) (2015)
(7) 国家自然科学奖（二等奖），2012（排名第五）
(8) 洪堡奖学金，亚历山大.冯.洪堡基金会，2007
论文发表：
ORCID: http://orcid.org/0000-0002-7537-4627
本课题组一直致力于独具特色的前沿和应用兼顾的基础研究，在基础性科学问题方面取得有意义的发现或发展，尤其是基于有机反应动力学的反应机理探索方面取得诸多发现，并且在实用性合成新方法方面取得系列成果。新反应可以应用在二十多种药物或活性分子的大量制备中。近年发表通讯作者研究论文五十来篇，包括J. Am. Chem. Soc.3篇，Angew. Chem.1篇，Nat. Commun. 1篇，ACS Catal.1篇，Org. Lett.18篇，Chem. Commun.3篇，J. Org. Chem.8篇，Org. Chem. Front. 3篇，Adv. Synth. Catal.3篇等。部分工作多次被Synfacts以及有机化学网站Organic Chemistry Portal给予积极评述。
(1) Zi-Hong Luan, Jian-Ping Qu, Yan-Biao Kang*, Discovery of Oxygen α-Nucleophilic Addition to α,β-Unsaturated Amides Catalyzed by Redox-Neutral Organic Photoreductant,J. Am. Chem. Soc.2020, 142, 20942-20947:https://pubs.acs.org/doi/10.1021/jacs.0c10707.
(2) Peng-Fei Dai, Xiao-Shan Ning, Hua Wang, Xian-Chao Cui, Jie Liu, Jian-Ping Qu*, Yan-Biao Kang*, Cleavage Of C(Aryl)-Ch₃Bonds in The Absence of Directing Groups under Transition Metal Free Conditions,Angew. Chem. Int. Ed. 2019, 58, 5392.(VIP paper, Highlighted by Paul Knochel in Synfacts 2019,12, 0556): https://doi.org/10.1002/anie..
(3) Xiang-Huan Shan, Hong-Xing Zheng, Bo Yang, Lin Tie, Jia-Le Fu, Jian-Ping Qu*, Yan-Biao Kang*, Copper-Catalyzed Oxidative Benzylic C-H Cyclization via Iminyl Radical from Intermolecular Anion-Radical Redox Relay,Nat. Commun.2019, 10, 908: https://doi.org/10.1038/s41467-019-08849-z.
(4) Jie Liu, Hong-Xing Zheng, Chuan-Zhi Yao, Bing-Feng Sun, Yan-Biao Kang*,Pharmaceutical-Oriented Selective Synthesis of Mononitriles and Dinitriles Directly From Methyl(Hetero)Arenes: Access to Chiral Nitriles and Citalopram,J. Am. Chem. Soc.2016, 138, 3294. (Highlighted by Kocienski in Synfacts 2016, 12, 0556): https://doi.org/10.1021/jacs.6b00180.
(5) Mei-Mei Wang, Xiao-Shan Ning, Jian-Ping Qu*, Yan-Biao Kang*, Dehydrogenative Synthesis of Linear α,β-Unsaturated Aldehydes with Oxygen at Room Temperature Enabled by tBuONO,ACS Catal.2017, 7, 4000-4003: https://doi.org/10.1021/acscatal.7b01008.
(6) Ya-Wei Li, Hong-Xing Zheng, Bo Yang, Xiang-Huan Shan, Jian-Ping Qu*, Yan-Biao Kang*, ^tBuOK-Promoted Cyclization of Imines with Aryl Halides, Org. Lett.2020, 22, 4553–4556: https://doi.org/10.1021/acs.orglett.0c01615.
(7) Qing Huang, Ya-Wei Li, Xiao-Shan Ning, Guo-Qing Jiang, Xiao-Wei Zhang, Jian-Ping Qu,* Yan-Biao Kang*, Regioselective Wacker-Type Oxidation of Internal Olefins in tBuOH Using Oxygen as the Sole Oxidant and tBuONO as the Organic Redox Cocatalyst, Org. Lett.2020, 22, 965-969: https://doi.org/10.1021/acs.orglett.9b04503.
(8) Xiang-Huan Shan,^#Mei-Mei Wang,^#Lin Tie, Jian-Ping Qu, Yan-Biao Kang*, CuSO₄?Catalyzed Tandem C(sp3)?H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles, Org. Lett.2020, 22, 357-360: https://doi.org/10.1021/acs.orglett.9b03751.
(9) Ting-Hui Ding, Jian-Ping Qu,* Yan-Biao Kang*Visible-Light-Induced, Base-Promoted Transition-Metal-Free Dehalogenation of Aryl Fluorides, Chlorides, Bromides, and Iodides, Org. Lett.2020, 22, 3084–3088: https://doi.org/10.1021/acs.orglett.0c00827.
(10)Peng-Fei Dai, Jian-Ping Qu,* Yan-Biao Kang*, Organocatalyzed Aerobic Oxidation of Aldehydes to Acids, Org. Lett. 2019, 21, 1393-1396: https://doi.org/10.1021/acs.orglett.9b00101.
(11)Xiang-Huan Shan, Bo Yang, Hong-Xing Zheng, Jian-Ping Qu*, Yan-Biao Kang*, Phenanthroline?tBuOK Promoted Intramolecular C?H Arylation of Indoles with ArI under Transition-Metal-Free Conditions, Org. Lett. 2018, 20, 7898-7901: https://doi.org/10.1021/acs.orglett.8b03449.
(12)Hong-Xing Zheng, Xiang-Huan Shan, Jian-Ping Qu*, Yan-Biao Kang*,Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C?H and C?O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans, Org. Lett. 2018, 20, 3310-3313: https://doi.org/10.1021/acs.orglett.8b01207.
(13)Zu-Feng Xiao, Ting-Hui Ding, Sheng-Wei Mao, Zaher Shah, Xiao-Shan Ning, Yan-Biao Kang*, Iridium-Catalyzed Cyclization of Isoxazolines and Alkenes: Divergent Access to Pyrrolidines, Pyrroles, and Carbazoles, Org. Lett. 2016, 18, 5672-5675. (Highlighted by Snieckus & Trujillo in Synfacts 2017, 13, 0023): https://doi.org/10.1021/acs.orglett.6b02905.
(14)Hong-Xing Zheng,^#Xiang-Huan Shan,^#Jian-Ping Qu*, Yan-Biao Kang*, Transition-Metal-Free Hydrogenation of Aryl Halides: From Alcohol to Aldehyde,Org. Lett. 2017, 19, 5114-5117: https://doi.org/10.1021/acs.orglett.7b02399.
(15)Xiao-Shan Ning, Mei-Mei Wang, Chuan-Zhi Yao, Xian-Min Chen, Yan-Biao Kang*,tert-Butyl Nitrite: Organic Redox Cocatalyst for Aerobic Aldehyde-Selective Wacker-Tsuji Oxidation,Org. Lett.2016, 18, 2700-2703: https://doi.org/10.1021/acs.orglett.6b01165.
(16)Jie Liu, Kang-Fei Hu, Jian-Ping Qu*, Yan-Biao Kang*, Organopromoted Selectivity-Switchable Synthesis of Polyketones, Org. Lett. 2017, 19, 5593-5596: https://doi.org/10.1021/acs.orglett.7b02731.
(17)Jing-Jie Ge,^#Chuan-Zhi Yao,^#Mei-Mei Wang, Hong-Xing Zheng, Yan-Biao Kang*, Yadong Li, Transition-Metal-Free Deacylative Cleavage of Unstrained C(sp3)-C(sp2) Bonds: Cyanide-Free Access to Aryl and Aliphatic Nitriles from Ketones and Aldehydes,Org. Lett.2016, 18, 228-231: https://doi.org/10.1021/acs.orglett.5b03367.
(18)Xian-Min Chen, Xiao-Shan Ning, Yan-Biao Kang*, Aerobic Acetoxyhydroxylation of Alkenes Co-catalyzed by Organic Nitrite and Palladium,Org. Lett. 2016, 18, 5368-5371: https://doi.org/10.1021/acs.orglett.6b02743.
(19)Qiang-Qiang Li, Zu-Feng Xiao, Chuan-Zhi Yao, Hong-Xing Zheng, Yan-Biao Kang*, Direct Alkylation of Amines with Alcohols Catalyzed by Base, Org. Lett.2015, 17, 5328-5331: https://doi.org/10.1021/acs.orglett.5b02685.
(20)Hong-Xing Zheng, Zu-Feng Xiao, Chuan-Zhi Yao, Qiang-Qiang Li, Xiao-Shan, Ning, Yan-Biao Kang*, Yong Tang, Transition-Metal-Free Self-Hydrogen-Transferring Allylic Isomerization,Org. Lett.2015, 17, 6102-6105: https://doi.org/10.1021/acs.orglett.5b03124.
(21)Zu-Feng Xiao, Chuan-Zhi Yao, Yan-Biao Kang*, Ruthenium-Catalyzed Asymmetric N?Demethylative Rearrangement of Isoxazolidines and Its Application in the Asymmetric Total Syntheses of (-)-(1R,3S)?HPA-12 and (+)-(1S,3R)?HPA-12, Org. Lett.2014, 16, 6512-6514: https://doi.org/10.1021/ol503261h.
(22)Chuan-Zhi Yao, Zu-Feng Xiao, Xiao-Shan Ning, Jie Liu, Xiao-Wei Zhang, Yan-Biao Kang*,Synthesis of syn-1,3-Aminoalcohols via a Ru-Catalyzed N?Demethylative Rearrangement of Isoxazolidines and Its Application in a Three-Step Total Synthesis of HPA-12, Org. Lett.2014, 16, 5824-5826: https://doi.org/10.1021/ol502956j.
(23)Chuan-Zhi Yao, Zu-Feng Xiao, Jie Liu, Xiao-Shan Ning, Yan-Biao Kang*, Ru-Catalyzed Rearrangement of N?Methyl Isoxazolidines to N-H 1,3?Oxazinanes: A Strategy of Self-Hydride Transferring Cleavage of N-O Bonds,Org. Lett.2014, 16, 2498-2501: https://doi.org/10.1021/ol500869p.
(24)Xiang-Huan Shan,^#Bo Yang,^# Jian-Ping Qu, Yan-Biao Kang*, CuSO₄-Catalyzed Dual Annulation to Synthesize O, S or N-Containing Tetracyclic Heteroacenes, Chem. Commun.2020,56, 4063-4066: https://doi.org/10.1039/d0cc01172j.
(25)Yan-Biao Kang,*Xian-Min Chen, Chuan-Zhi Yao, Xiao-Shan Ning, Direct Oxidative Lactonization of Alkenoic Acids Mediated Solely by NaIO₄: Beyond A Simple Oxidant, Chem. Commun. 2016, 52, 6193-6196: https://doi.org/10.1039/c6cc02246d.
(26)Chuan-Zhi Yao, Qiang-Qiang Li, Mei-Mei Wang, Xiao-Shan Ning, Yan-Biao Kang*, (E)-Specific Direct Julia-Olefination of Aryl Alcohols without Extra Reducing Agents Promoted by Bases, Chem. Commun. 2015, 51, 7729-7732: https://doi.org/10.1039/c5cc01965f.
(27)Peng-Fei Dai, Hua Wang, Xian-Chao Cui, Jian-Ping Qu*, Yan-Biao Kang*, Recent Progress in C(aryl)–C(alkyl) Bond Cleavage of Alkylarenes, Org. Chem. Front., 2020, 7, 820–828: https://doi.org/10.1039/C9QO01438A.
(28)Hong-Xing Zheng,^#Chuan-Zhi Yao,^#Jian-Ping Qu*, Yan-Biao Kang*, nBu₄NOTf-promoted Radical Self-Hydrogen Transferring Isomerization under Transition Metal-Free Conditions, Org. Chem. Front. 2018, 5, 1213-1216: https://doi.org/10.1039/c7qo01138e.
(29)Hong-Xing Zheng, Jian-Ping Qu*, Yan-Biao Kang*, One-pot One-base Conditions for Two Shots: Organocatalyzed Tandem Isomerization–Olefination of Allylic Alcohols, Org. Chem. Front. 2018, 5, 2349-2352: https://doi.org/10.1039/c8qo00505b.
(30)Yan-Jun Zhuang, Jian-Ping Qu, Yan-Biao Kang*,Deprotonated Salicylaldehyde as Visible Light Photocatalyst, J. Org. Chem.2020, 85, 4386-4397: https://doi.org/10.1021/acs.joc.0c00102.
(31)Hua Wang, Jie Liu, Jian-Ping Qu,* Yan-Biao Kang*, Overcoming Electron-Withdrawing and Product-Inhibition Effects by Organocatalytic Aerobic Oxidation of Alkylpyridines and Related Alkylheteroarenes to Ketones, J. Org. Chem. 2020, 85, 3942-3948: https://doi.org/10.1021/acs.joc.9b03205.
(32)Yi-Jie Niu,^#Guo-Hui Sui,^#Hong-Xing Zheng, Xiang-Huan Shan, Lin Tie, Jia-Le Fu, Jian-Ping Qu*, Yan-Biao Kang*, Competing Dehalogenation versus Borylation of Aryl Iodides and Bromides under Transition-Metal-Free Basic Conditions, J. Org. Chem.2019, 84, 10805-10813: https://doi.org/10.1021/acs.joc.9b01350.
(33)Mei-Mei Wang, Guo-Hui Sui, Xian-Chao Cui, Hui Wang, Jian-Ping Qu*, Yan-Biao Kang*, Radical α,β-Dehydrogenation of Saturated Amides via α?Oxidation with TEMPO under Transition Metal-Free Conditions, J. Org. Chem.2019, 84, 8267-8274: https://doi.org/10.1021/acs.joc.9b00872.
(34)Kang-Fei Hu,^#Xiao-Shan Ning,^#Jian-Ping Qu*, Yan-Biao Kang*, Tuning Regioselectivity of Wacker Oxidation in One Catalytic System: Small Change Makes Big Step, J. Org. Chem.2018, 83, 11327-11332: https://doi.org/10.1021/acs.joc.8b01547.
(35)Qiang-Qiang Li, Zaher Shah, Jian-Ping Qu*, Yan-Biao Kang*, Direct Wittig Olefination of Alcohols, J. Org. Chem.2018, 83, 296-302: https://doi.org/10.1021/acs.joc.7b02720.
(36)Ting-Hui Ding, Zu-Feng Xiao, Jian-Ping Qu*, Yan-Biao Kang*,Synthesis of Highly Functionalized Indoles and Indolones via Selectivity-Switchable Olefinations, J. Org. Chem.2018, 83, 2467-2472: https://doi.org/10.1021/acs.joc.7b03158.
(37)Xiao-Shan Ning, Mei-Mei Wang, Jian-Ping Qu*, Yan-Biao Kang*, Synthesis of Functionalized Indoles via Palladium-Catalyzed Aerobic Cycloisomerization of o?Allylanilines Using Organic Redox Cocatalyst,J. Org. Chem.2018, 83, 13523-13529: https://doi.org/10.1021/acs.joc.8b01999.
(38)Xiao-Shan Ning, Xin Liang, Kang-Fei Hu, Chuan-Zhi Yao, Jian-Ping Qu*, Yan-Biao Kang*, Pd-tBuONO Cocatalyzed Aerobic Indole SynthesisAdv. Synth. Catal.2018, 360, 1590-1594: https://doi.org/10.1002/adsc..
(39)Zu-Feng Xiao, Ting-Hui Ding, Sheng-Wei Mao, Xiao-Shan Ning, Yan-Biao Kang*,Zinc Iodide-Mediated Direct Synthesis of 2,3-Dihydroisoxazoles from Alkynes and Nitrones, Adv. Synth. Catal.2016, 358, 1859-1863: https://doi.org/10.1002/adsc..
(40)Xiao-Wei Zhang, Zu-Feng Xiao, Yan-Jun Zhuang, Mei-Mei Wang,Yan-Biao Kang*, Metal-Free Autoxidative Nitrooxylation of Alkenyl Oximes with Molecular Oxygen,Adv. Synth. Catal.2016, 358, 1942-1945: https://doi.org/10.1002/adsc..
(41)Xiao-Wei Zhang, Zu-Feng Xiao, Mei-Mei Wang, Yan-Jun Zhuang, Yan-Biao Kang*, Transition-Metal-Free Oxychlorination of Alkenyl Oximes: in Situ Generated Radicals with tert-Butyl Nitrite, Org. Biomol. Chem.2016, 14, 7275-7281: https://doi.org/10.1039/c6ob01374k.
(42)Yan-Jun Zhuang, Jie Liu, Yan-Biao Kang*, Tin or Gallium-Catalyzed Cyanide-Transition Metal-Free Synthesis of Nitriles from Aldehydes or Oximes, Tetrahedron Lett. 2016, 57, 5700-5702: https://doi.org/10.1016/j.tetlet.2016.11.034.
(43)Xiao-Shan Ning, Xue-Jiao Dong, Zu-Feng Xiao, Chuan-Zhi Yao, Yan-Biao Kang*, Ion-Pair-Catalyzed Sodium Borohydride Reduction in Aprotic Organic Solvents,Asian J. Org. Chem.2015, 4, 333-336: https://doi.org/10.1002/ajoc..
(44)Palladium-Catalyzed Intramolecular Asymmetric C–H Functionalization/Cyclization Reaction of Metallocenes: An Efficient Approach toward the Synthesis of Planar Chiral Metallocene Compounds, Ruixian Deng, Yunze Huang, Xinna Ma, Gencheng Li, Rui Zhu, Bin Wang, Yan-Biao Kang,*Zhenhua Gu*, J. Am. Chem. Soc.2014, 136, 4472.
(45)Jiying Pei, Yanbiao Kang*Guangming Huang*, Reactive Intermediate Detection in Real Time via Paper Assisted Thermal Ionization Mass Spectrometry, Analyst2014, 139, 5354-5357.