姓 名：汪志勇 教授 博导
电 话：
电子邮件： zwang3@ustc.edu.cn
传 真：
主页：http://staff.ustc.edu.cn/~zwang3



个人简历
1978.09--1982.07 AnHui Normal University B.S.
1982.07--1986.09 AnHui Labour University Faculty
1986.09--1992.09 University of Science & Techonlogy of China M.S. and Ph.D.
1992.09--1997.05 University of Science & Techonlogy of China Faculty
1997.05--1997.09 University of Tulane Senior Visiting Professor
1997.10--1999.10 University of Brandeis Research Fellow

主要研究方向
Research in our group will focus on the general areas of reaction development and chemical synthesis. Our studies will be driven by the discovery of new and useful catalysts. By virtue of the developed organic reactions various organic ligands are synthesized and used as probes in biological progress. Brief summaries of three research directions illustrating these objectives are shown below.
The preparation of heterogeneous catalysts:
The preparation of the nano-particles of various metals and metal oxides will be investigated and the prepared different nano-particles are used in various organic reactions to search novel catalysts. Also, the supramolecular crystal engineering adjusted by different organic ligands is carried out to construct functional frameworks. On the basis of these assembled frameworks various heterogeneous catalysts were prepared via encapsulation of metal nano-particles. Harnessing these novel catalysts the powerful reactions and the synthetic methodologies will be a major focus. This direction is the mainstream in our research group.
The theoretical calculation for the mechanism of organic reactions:
The molecular orbit calculation on the basis of the first principle is performed to understand the influences of electronic effect, steric hindrance and solvent effect on the catalytic activity, reactivity and stereoselectivity of organic reactions. The calculation result will help us with the prediction to the reaction process and the recognition to the reaction mechanism. In combination with the modeling calculation of molecular kinetics, the molecular obit calculation is also employed to explore the molecular mechanism of HIV transcription and to provide 3 D structural models of organic ligands which will be potential inhibitors for HIV transcription.
The application of organic ligands as probes or inhibitors to explore the molecular mechanism of HIV transcription:
Collaboration with biologists the molecular mechanism of HIV transcription are investigated. Recent biological research showed that the formation of the complex between lysine-acetylated viral trans-activator(Tat-AcK50) and the human transcriptional co-activator (PCAF BRD) plays a crucial role in the HIV transcription. Taking this complex as a target position, we are going to design and sythesize a series of organic small molecules and assay the binding affinity and the binding selectivity between the complex and the corresponding small molecule via biological assay techniques to explore the effect of the binding between Tat-AcK50 and PCAF BRD on the HIV transcription and recognize the molecular mechanism of HIV transcription, finally attempting to screen out the small molecular inhibitors which can bind to the host cells.

获奖及荣誉
1996 Yilida Award For The Outstanding Young Teacher Of USTC
2000 Prize For The Excellent Oversea Expert

文章及专著
1. An Electrochemical tandem reaction: one-pot synthesis of homoallylic alcohols from alcohols in aqueous media, Chem. Commun., 2010, 46，7196
2. A novel and efficient methodology for
the construction of quinazolines based on
supported copper oxide nanoparticles
Chem. Commun., 2010, 46, 5244
3. A Simple and Efficient Approach to the Synthesis of 2-Phenylquinazolines via sp(3)
C-H Functionalization
Org. Lett., 2010，12， 2841
4. Facile Synthesis of Polysubstituted Oxazoles via a Copper-Catalyzed Tandem Oxidative Cyclization
Org. Lett., 2010，12， 2338
5. Simple and Efficient Preparation of 2,5-Disubstituted Oxazoles via a Metal- Free-
Catalyzed Cascade Cyclization,
Org. Lett., 2010, 12, 3902
6. Monodentate N-Ligand-Directed Bifunctional Transition-Metal ACHTUNGTRENUNG
Catalysis:Highly Enantioselective Friedel?Crafts Alkylation of Indoles with Nitroalkenes
Chem. Eur. J., 2010, 16, 6438
7. Facile synthesis of sulfonyl amidines via carbon?nitrogen bond formation
mediated by FeCl3
Chem. Common., 2009, 33, 7372
8. Facile construction of highly functionalized 2-pyrrolines via FeCl3-catalyzed reaction of aziridines with arylalkynes
Chem. Commun., 2009, 33, 5021
9. A metal-free catalytic system for the oxidation of benzylic methylenes and primary amines under solvent-free conditions
Green. Chem., 2009, 11, 1973
10. Facile construction of functionalized 4H-chromene via tandem benzylation and cyclization
Chem. Commun., 2008, 42, 5381
11. A Facile Synthesis of 2-Methylquinolines via Pd-Catalyzed AzaWacker Oxidative Cyclization
Org. Lett., 2008, 10, 173
12. Cascade Synthesis of 3-quinolinecarboxylic ester via Benzylation/ Propargylation-Cyclization
J. Org. Chem., 2008, 73, 8608
13. A Facile Access to Pyrroles from Amino Acides via an Aza-Wacker Cyclization
J. Org. Chem., 2008, 73, 5180
14. Facile construction of functionalized 4H-chromene via tandem benzylation
and cyclization
Chem.Commun, 2008, 42, 5381
15. Investigation of DNA as a Catalyst for Henry Reaction in Water
Chem. Commun., 2008, 42 3792
16. A Novel Palladium-Catalyzed Hydroalkoxylation of Alkenes with a
Migration of Double BondOrg. Biomol. Chem., 2008, 6, 1344
17. A Facile Synthesis of 2-Methylquinolines via Pd-Catalyzed Aza-Wacker
Oxidative Cyclization
Org. Lett., 2008, 10, 173
18. Synthesis of Chromanones: A Novel Palladium-catalyzed Wacker-type
Oxidative Cyclization Involving 1,5-Hydride Alkyl to Palladium Migration
Chem. Commun., 2007, 44, 4686
19. Diatomite-Supported Pd Nanoparticles: An Efficient Catalyst for Heck and
Suzuki Reactions
J. Org. Chem., 2006, 71, 7485
20. Catalysis and Regioselectivity of the Aqueous Heck Reaction by Pd(0)
Nanoparticles under Ultrasonic Irradiation
J. Org. Chem., 2006, 71, 4339
21. Facile construction of highly functionalized 2-pyrrolines via FeCl3-catalyzed
reaction of aziridines with arylalkynes
Chem. Comm., 2009, 33, 5021
22. Metal nanoparticles or metal oxide nanoparticles, an efficient and promising family
of novel heterogeneous catalysts in organic synthesis
Dolton. Trans, 2009, 43, 9363
23. Influence of co-ligands and solvents on the packing and photoluminescence of
three related Mn-II metal-organic frameworks
Crystengcomm, 2009, 11, 896
24. Palladium catalyzed isomerization of alkenes: a pronounced influence of an o-
phenol hydroxyl group
Org. Bio.Chem., 2009, 7, 3168
25. Rational Design of MOFs Constructed from Modified Aromatic Amino Acids
Chem. Eur. J. 2007, 13, 9399
26. Catalytic asymmetric formation of carbon-carbon bond in the presence of water
Coord. Chem. Rev., 2008, 252, 736
27. A One-Dimensional Coordination Polymer Based on Novel Radical Anion Ligand
Generated in situ: Notable Magnetic and Luminescence Properties
Orys.Growth. Desg., 2008, 8, 1465