姓 名：梁高林 教授 博导
电 话：
电子邮件： gliang@ustc.edu.cn
传 真：
主页：http://lianglab.ustc.edu.cn/



个人简历
教育背景
2002年9月－2005年7月 复旦大学药学院药物化学专业，博士。论文：植物雌激素Kobophenol A的体内代谢产物及其机理研究。导师：胡昌奇 教授。
2000年9月－2002年7月 郑州大学工学院化学工艺专业，硕士。论文：双膦酸盐类药物的合成研究。导师：蒋登高 教授。
1989年9月-1993年7月 南京大学强化部理科强化班物理化学专业，学士。论文：沸石催化性质研究。导师：须沁华 教授。
工作经历
2010,3-现在 中国科技大学化学系，分析化学教授，博导。
2008，1－2010，5 美国斯坦福大学放射系博士后，设计分子探针，细胞内或动物体内生物过程示踪；肿瘤早期诊断和治疗。
. 发明一种全新的聚合反应，用于体内外合成纳米粒子。合成的纳米粒子用于体内外消化酶活性成像和肿瘤治疗。
. 设计纳米探针，用于肿瘤的早期诊断显像和治疗。
. 各种成像手段用于体内外消化酶的活性显像。
2005,9-2008,1 香港科技大学化学系博士后，超分子胶和纳米材料在生物医学方面的应用研究。
. 固相合成成胶小分子，体内外自组装成胶研究。
. 小分子胶和纳米材料的光动力学疗法（PDT）和过热疗法（HT）研究。
. 细胞培养（HeLa，Osteoblast等），细菌培养，肿瘤模型鼠建立。
1993.8--2002，8 江苏省原子医学研究所 核医学国家重点实验室
研究实习员，助理研究员。从事核医学诊断药、骨质疏松症治疗药的研究。
. 合成数十个诊断用原料药。
. 发明骨质疏松治疗药二类新药一个。
. 合成MDP, MIBI, EC, ECD, EHIDA, NGA, TF, BZM, NTA, HL-91等化合物用于核医学研究。
. 合成帕米膦酸钠，阿伦膦酸钠和埃本膦酸钠用于治疗骨质疏松症。

主要研究方向
1， 纳米分析化学：新型“click”反应的研究，用于体内外控制性合成发光纳米材料。包括超分子水凝胶，大分子纳米粒子。用于细胞显像和疾病诊断分析。
2， 生物分析：细胞内各种蛋白水解酶的分析研究，细胞荧光、免疫荧光、电子电镜显像分析，动物肿瘤模型分析。
3， 医学分析：各种显像剂的研究，显像分析技术包括光学，CT, SPECT, PET,MRI。研究新型的显像剂用于肿瘤的早期诊断分析及术后评价分析。以及新 型抗肿瘤药物的研究。
获奖及荣誉

1：2011年 中国科学技术大学“研究生导师招生先锋奖”
2：2011年 中国科学技术大学“优秀青年教师奖”
3：2011年 安徽省“****科学基金”
4：2010年 教育部“新世纪优秀人才支持计划”

文章及专著
1: Xiaoli Zhang, Xinlei Chu, Ling Wang, Huaimin Wang, Gaolin Liang, Jinxiu Zhang, Jiafu Long*, and Zhimou Yang*. Rational Design of A Tetrameric Protein to Enhance Interactions Between Self-assembled Fibers Confers Molecular Hydrogels. Angewandte Chemie-International Edition. 2012, (in press)。
2: Yue Chen, and Gaolin Liang*. Enzymatic self-assembly of nanostructures for theranostics. Theranostics. 2012, 2(2), 139-147.
3: Yun Deng, Shuang Liu, Kun Mei, Anming Tang, Chunyan Cao, and Gaolin Liang*. Multifunctional small molecule for controlled assembly of oligomeric nanoparticles and crosslinked polymers. Organic & Biomolecular Chemistry. 2011, 9 (20), 6917-6919.
4: Chunyan Cao, Yue Chen, Fangzhou Wu, Yun Deng, and Gaolin Liang*. Caspase-3 controlled assembly of nanoparticles for fluorescence turn on. Chemical Communications. 2011, 47 (37), 10320-10322.
5: Gaolin Liang, John Ronald, Yuanxin Chen, Deju Ye, Prachi Pandit, Manlung Ma, Brian Rutt, and Jianghong Rao. Controlled Self-Assembling of Gadolinium Nanoparticles as “Smart” Molecular Magnetic Resonance Imaging Contrast Agents. Angewandte Chemie-International Edition. 2011, 50 (28): 6283-6286.
6: Deju Ye, Gaolin Liang, Manlung Ma, and Jianghong Rao. Controlling intracellular macrocyclization for the imaging of protease activity. Angewandte Chemie-International Edition. 2011, 50 (10): 2275-2279.
7: Gaolin Liang, Hongjun Ren, and Jianghong Rao. A biocompatible condensation reaction for controlled assembly of nanostructures in living cells. Nature chemistry. 2010, 2: 54-60.
8: Anca Dragulescu-Andrasi, Gaolin Liang, and Jianghong Rao. “In vivo Bioluminescence Imaging of furin activity in breast cancer cells using bioluminogenic substrates” Bioconjugate Chemistry. 2009, 20: 1660-1666.
9: Gaolin Liang, Zhimou Yang, Rongjun Zhang, Lihua Li, Yijun Fan, Yi Kuang, Yuang Gao, Ting Wang, W William Lu, and Bing Xu. “Supramolecular hydrogel of a D-aminoacid dipeptide for controlled drug release in vivo” Langmuir. 2009, 25(15): 8419-8422.
10: Jinhao Gao, Gaolin Liang, Jerry S Cheung, Yue Pan, Yi Kuang, Fan Zhao, Bei Zhang, Xixiang Zhang, Ed X Wu, and Bing Xu. “Multifunctional yolk-shell nanoparticles: A potential MRI contrast and anticancer agent” Journal of the American Chemical Society. 2008, 130(35): 11828-11833.
11: Zhimou Yang, Gaolin Liang, and Bing Xu* "Enzymatic hydrogelation of small molecules" Accounts of Chemical Research. 2008, 41(2): 315-326.
12: Gaolin Liang, Keming Xu, Lihua Li, Liang Wang, Yi KuangY, Zhimou Yang, and Bing Xu* "Using Congo red to report intracellular hydrogelation resulted from self-assembly of small molecules" Chemical Communications. 2007, 40: 4096-4098.
13: Zhimou Yang, Gaolin Liang, Zufeng Guo, Zhihong Guo, and Bing Xu* "Intracellular Hydrogelation of Small Molecules Inhibits Bacterial Growth" Angewandte Chemie-International Edition. 2007, 46(43) 8216-8219.
14: Zhimou Yang, Gaolin Liang, Manlung Ma, Yuan Gao, and Bing Xu* "In Vitro and In Vivo Enzymatic Formations of Supramolecular Hydrogels Based on Self-Assembled Nanofibers of a beta-Amino Acid Derivative" Small, 2007, 3(4): 558-562.
15: Zhimou Yang, Gaolin Liang, and Bing Xu* "Enzymatic Control of the Self-Assembly of Small Molecules: A New Way to Generate Supramolecular Hydrogels" Soft Matter, 2007, 3: 515-520. (Highlight)
16: Zhimou Yang, P. L. Ho, Gaolin Liang, K. H. Chow, Qigang Wang, Yang Cao, Zhihong Guo, and Bing Xu* "Using beta-Lactamase to Trigger Supramolecular Hydrogelation" Journal of the American Chemical Society, 2007, 129 (2): 266-267.
17: Jinhao Gao, Gaolin Liang, Bei Zhang, Yi Kuang, Xixiang Zhang, and Bing Xu* "FePt@CoS2 Yolk-shell Nanocrystals as A Potent Agent to Kill HeLa Cells" Journal of the American Chemical Society, 2007, 129(5): 1428-1433.
18: Zhimou Yang, Gaolin Liang, Manlung Ma, A. Sunny Abbah, William Lu, and Bing Xu* "D-glucosamine-based supramolecular hydrogels to improve wound healing" Chemical Communications, 2007, 8: 843-845.
19: Zhimou Yang, Gaolin Liang, Manlung Ma, Yuan Gao, and Bing Xu* "Conjugates of naphthalene and dipeptides confer molecular hydrogelators with high efficiency of hydrogelation and superhelical nanofibers" Journal of Materials Chemistry, 2007, 17(9): 850-854.
20: Gaolin Liang, Ling Wang, Zhimou Yang, Hokee Koon, Naiki Mak, Chi K Chang*, and Bing Xu* "Using enzymatic reaction to enhance photodynamic therapy effect of porphyrin dityrosine phosphates" Chemical Communications, 2006, 5021-5023.
21: Zhimou Yang, Gaolin Liang, Ling Wang, and Bing Xu. Using a Kinase / hosphatase Switch to Regulate a Supramolecular Hydrogel and Forming the Supramolecular Hydrogel in Vivo. Journal of the American Chemical Society, 2006, 128 (9): 3038-3043.
22: Zhimou Yang, Gaolin Liang, and Bing Xu. Supramolecular hydrogels based on β-amino acid derivatives. Chemical Communications, 2006, 7: 738-740.
23: Gaolin Liang, Jingbo Bi, Qinghong Huang, Su Zhang, Changqi Hu. Metabolites and the pharmacokinetics of kobophenol A from Caragana sinica in rats. Journal of Ethnopharmacology. 2005, 101 (3): 324-329.
24: Gaolin Liang, Tong Zhang, Jingmei Wang, Buyun Chen, Kejun Cheng, and Changqi Hu. X-ray single crystal analysis of (-)-(S)-equol from rats’ feces fed the phytoestrogen daidzin. Chemistry & Biodiversity. 2005, 2 (7): 959-963.
25: Gaolin Liang, Lisheng Qian, Yiling Cui, and Changqi Hu. Formation of oxidative metabolite from kobophenol A by human intestinal bacterium Klebsilla pneumoniae. Chemistry & Biodiversity. 2005, 2 (4): 506-509.
26: Gaolin Liang, Kejun Cheng, Hong Zhou and Changqi Hu. Koboquinone A and B, New Metabolites of Kobophenol A in Rats. Chemical and Pharmaceutical Bulletin. 2004, 52(12): 1489-1491.