李涛
单位：化学与材料科学学院
地址：安徽省合肥市包河区金寨路96号
邮编：230026
电话：
个人主页：
实验室介绍： http://staff.ustc.edu.cn/~tlitao/


个人简历 Personal resume


李涛，中国科学技术大学化学系教授，博士生导师。主要从事四链核酸调控的DNA纳米分析与应用研究，涉及到以下三个方面：（1）双分子G-四链体、i-motif结构设计与靠近诱导生物分析；（2）四链核酸引导的细胞DNA计算与基因调控；（3）球形核酸酶(SNAzyme)催化发光分析平台与疾病标志物检测。已在Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Nano, Nucleic Acids Res., Anal. Chem.等上发表SCI收录论文60余篇，在Web of Science上累计被引4000余次，H指数为33，在DNA相关领域具有一定的国际影响。


研究方向 Research direction


1、双分子四链核酸结构设计与靠近诱导生物分析
2、四链核酸引导的细胞DNA计算与基因调控
3、球形核酸酶催化发光体系与疾病标志物检测



招生信息 Enrollment information


化学、生物或材料科学背景。


论文专著 The monograph Researcher ID


1)Reconfigurable Bioinspired Framework Nucleic Acid Nanoplatform Dynamically Manipulated in Living Cells for Subcellular Imaging - Angew. Chem. Int. Ed. 2019, 58, 1648–1653 - -
2)Ultrastable Bimolecular G-Quadruplexes Programmed DNA Nanoassemblies for Reconfigurable Biomimetic DNAzymes - ACS Nano 2019, 13, 11947-11954 - -
3)DNA Logic Operations in Living Cells Utilizing Lysosome-Recognizing Framework Nucleic Acid Nanodevices for Subcellular Imaging - ACS Nano 2019, 13, 5778-5784 - -
4)Target-Induced Payload Amplification for Spherical Nucleic Acid Enzyme (SNAzyme) Catalyzed Electrochemiluminescence Detection of Circulating miRNAs - Anal. Chem. 2019, 91, 12948-12953 - -
5)Spherical Nucleic Acid Enzyme (SNAzyme) Boosted Chemiluminescence miRNA Imaging Using a Smartphone - Anal. Chem. 2019, 91, 3652–3658 - -
6)Composition-Tunable Hollow Au/Ag SERS Nanoprobes Coupled with Target-Catalyzed Hairpin Assembly for Triple-Amplification Detection of miRNA - Anal. Chem. 2018, 90, 11614–11621 - -
7)Programmable I-Motif DNA Folding Topology for a pH-Switched Reversible Molecular Sensing Device - Nucleic Acids Res. 2017, 45, 4306–4314 - -
8)Thioflavin T Binds Dimeric Parallel-Stranded GA-Containing Non-G-quadruplex DNAs. A General Approach to Lighting up Double-stranded Scaffolds - Nucleic Acids Res. 2017, 45, 12080–12089 - -
9)A DNA nanoswitch-controlled reversible nanosensor - Nucleic Acids Res. 2017, 45, 541-546 - -