张海元
单位：中国科学院长春应用化学研究所化学生物学实验室
地址：吉林省长春市人民大街5625号
邮编：130022
电话：+36
个人主页： http://hzhang.ciac.jl.cn/
实验室介绍： http://hzhang.ciac.jl.cn/


个人简历 Personal resume


2013年12月至今：中科院长春应用化学研究所化学生物学实验室；职位：研究员；2009年3月至2013年11月：美国加州大学洛杉矶分校加州纳米所；职位：研究助理； 2007年11月至2009年2月：美国伦斯勒理工学院生物技术多学科研究中心；职位：博士后； 2005年11月至2007年10月：美国韦恩州立大学医学院；职位：博士后； 1999年9月至2005年8月：中科院长春应用化学研究所；攻读博士学位。


研究方向 Research direction


1、纳米-生物界面水平理解纳米材料生物效应及其安全性设计；
2、异质纳米材料的肿瘤光动力学治疗；
3、纳米材料非侵入性调控下的干细胞定向分化及组织工程构建



招生信息 Enrollment information


欢迎具有化学、材料、生物和医学背景的同学加入我们的科研团队。


论文专著 The monograph


1)Spatiotemporally Synchronous Oxygen Self‐Supply and Reactive Oxygen Species Production on Z‐Scheme Heterostructures for Hypoxic Tumor Therapy - Advanced Materials - 2020 -
2)Nitric Oxide Stimulated Programmable Drug Release of Nanosystem for Multidrug Resistance Cancer Therapy. - Nano Letters - 2019 -
3)Anisotropic Plasmonic Metal Heterostructures as Theranostic Nanosystems for Near Infrared Light-Activated Fluorescence Amplification and Phototherapy - Advanced Science - 2019 -
4)Electron Compensation Effect Suppressed Silver Ion Release and Contributed Safety of Au@Ag Core–Shell Nanoparticles. - Nano Letters - 2019 -
5)Time-staggered delivery of erlotinib and doxorubicin by gold nanocages with two smart polymers for reprogrammable release and synergistic with photothermal therapy. - Biomaterials - 2019 -
6)Bismuth Sulfide Nanorods with Retractable Zinc Protoporphyrin Molecules for Suppressing Innate Antioxidant Defense System and Strengthening Phototherapeutic Effects - Advanced Materials - 2019 -
7)Deep-Level Defect Enhanced Photothermal Performance of Bismuth Sulfide-Gold Heterojunction Nanorods for Photothermal Therapy of Cancer Guided by Computed Tomography Imaging - Angewandte Chemie International Edition - 2018 -
8)MAPK-Targeted Drug Delivered by a pH-Sensitive MSNP Nanocarrier Synergizes with PD-1 Blockade in Melanoma without T-Cell Suppression. - Advanced Functional Materials - 2019 -
9)Resonance Energy Transfer-Promoted Photothermal and Photodynamic Performance of Gold- Copper Sulfide Yolk-Shell Nanoparticles for Chemophototherapy of Cancer - Nano Letters - 2018 -
10)Crystallographic Facet-Induced Toxicological Responses by Faceted Titanium Dioxide Nanocrystals. - ACS Nano - 2016 -
11)PdO Doping Tunes Band-Gap Energy Levels as Well as Oxidative Stress Responses to a Co3O4 p-Type Semiconductor in Cells and the Lung - Journal of the American Chemical Society - 2014 -
12)Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation - ACS Nano - 2012 -
13)Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic - Journal of the American Chemical Society - 2012 -
14)Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells - ACS Nano - 2011 -
15)Gene Delivery in Three-Dimensional Cell Cultures by Superparamagnetic Nanoparticles - ACS Nano - 2010 -