王振新
单位：中国科学院长春应用化学研究所电分析化学国家重点实验室
地址：吉林省长春市人民大街5625号
邮编：130022
电话：86-
个人主页： http://yjsb.ciac.jl.cn/daoshi_read.php?brow=66&lb=%B5%BC%CA%A6%BC%F2%BD%E9
实验室介绍：


个人简历 Personal resume


王振新研究员自2006年回中国科学院长春应用化学研究所工作至今，承担了包括国家自然科学基金，国家973计划，中科院方向性项目，中科院材料先导专项子任务，中科院科研项目十余项，取得了较为突出的成果。在生物芯片技术的研制与应用，生物纳米技术，自组装技术，纳米材料的合成与应用等研究中取得了突出成绩。（1）针对肿瘤微环境与正常组织的差异构建系列纳米探针应用于结直肠癌多模态成像，实现了对微小（约5mm3体积）肿瘤的检测；（2）以生物分子识别为基础研制微阵列生物传感器和发展比色分析方法应用于重大疾病相关生物分子（金属离子、多肽、酶、核酸、糖基化合物等）的高灵敏度、高通量检测。作为通讯作者发表包括Nat. Commun.、Small、Biomaterials、Anal. Chem.、ACS Appl. Mater. Interfaces、Chem. Commun.等SCI论文150余篇，被正面他引3700余次；撰写专论4章节；获授权专利12项；构建3台微阵列生物芯片检测/制作样机，其中2台已在中科院化学所和国家纳米中心推广试用。于2019年获得山东省泰山产业领军人才，2016年吉林省青年科学奖，2015年和2012年分别获得国家自然科学奖二等奖（排名第5）和吉林省科技进步二等奖（排名第一）。


研究方向 Research direction


1、新型微阵列生物芯片的构建与应用
2、功能化纳米粒子在多模态活体成像中的应用
3、体外诊断试剂盒研发



招生信息 Enrollment information


具有分析化学/生物化学等知识背景


论文专著 The monograph


1)Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications - Nature Communications - 2015 - 6, 8003
2)Rational Synthesis of Spatial Core-double Shell Upconversion Nanodendrites with Ultrabright Luminescence for Bioimaging Application - Chemical Science - 2019 - 10, 7591–7599
3)Uncovering the Binding Specificities of Lectins with Cells for Precision Colorectal Cancer Diagnosis Based on Multimodal Imaging - Adv. Sci - 2018 - 5,**
4)Peptide Microarray-Based Metal Enhanced Fluorescence Assay forMultiple Profiling of Matrix Metalloproteinases Activities - Analytical Chemistry - 2017 - 89, 6749-6757
5)Sensitive Detection of Polynucleotide Kinase Activity by Paper-Based Fluorescence Assay with λ Exonuclease Assistance - Analytical Chemistry - 2016 - 88, 11358-11363
6)Sensitive detection of protein kinase a activity in cell lysates by peptide microarray-based assay - Analytical Chemistry - 2013 - 85(15), 7033-7037
7)Construction of Lanthanide-Doped Upconversion Nanoparticle-Uelx Europaeus Agglutinin-I Bioconjugates with Brightness Red Emission for Ultrasensitive In Vivo Imaging of Colorectal Tumor - Biomaterials - 2019 - 212, 64–72
8)Conjugation of NaGdF4 upconverting nanoparticles on silica nanospheres as contrast agents for multi-modality imaging - Biomaterials - 2013 - 34, 5218-5225
9)Carbon nanofibers by pyrolysis of self-assembled perylene diimide derivative gels as supercapacitor electrode materials - Journal of Materials Chemistry A - 2015 - 3, 15513-1
10)Employing Tryptone as a General Phase Transfer Agent to Produce Renal Clearable Nanodots for Bioimaging - Small - 2015 - 11(30), 3676-3685
11)Poly(glycidyl methacrylate-co-2-hydroxyethyl methacrylate) Brushes as Peptide/Protein Microarray Substrate for Improving Protein Binding and Functionality - ACS Appl. Mater. Interfaces - 2016 - 8, 10174-10182
12)Evaluation of Matrix Metalloproteinase Inhibition by Peptide Microarray-Based Fluorescence Assay on Polymer Brush Substrate and in Vivo Assessment - ACS Appl. Mater. Interfaces - 2017 - 9, 44241-44250
13)Development of Sphere-Polymer Brush Hierarchical NanostructureSubstrates for Fabricating Microarrays with High Performance - ACS Applied Materials&Interfaces - 2017 - 9, 38101-38108
14)Poly(glycidyl methacrylate-co-2-hydroxyethyl methacrylate) brushes as peptide/protein microarray substrate for improving protein binding and functionality - ACS Applied Materials & Interfaces - 2016 - 8 (16), 10174-10182
15)Facile Fabrication of single-phase multifunctional BaGdF5 nanospheres as drug carriers - ACS Applied Materials & Interfaces - 2014 - 6, 12761-12770
16)Nanofibrous microspheres via emulsion gelation and carbonization - Chemical Communications - 2015 - 51(94), 16864-16867
17)Gold nanoparticle based dot-blot immunoassay for sensitively detecting Alzheimer’s disease related β-amyloid peptide - Chemical Communications - 2012 - 48, 8392-8394
18)Resonance light scattering as a powerful tool for sensitive detection of b-amyloid peptide by gold nanoparticle probes - Chemical Communications - 2011 - 47, 9339-9341
19) Polydopamine-coated downconversion nanoparticle as an efficient dual-modal near-infrared-II fluorescence and photoacoustic contrast agent for non-invasive visualization of gastrointestinal tract in vivo - Biosensors and Bioelectronics - 2020 - 151, 112000
20)Assaying multiple restriction endonucleases functionalities and inhibitions on DNA microarray with multifunctional gold nanoparticle probes - Biosensors and Bioelectronics - 2014 - 52, 118-123
21)Polyacrylamide-phytic acid-polydopamine conducting porous hydrogel forrapid detection and removal of copper (II) ions - Biosensors and Bioelectronics - 2017 - 91,306-312
22)Fabricating three-dimensional carbohydrate hydrogel microarray for lectin-mediated bacterium capturing - Biosensors and Bioelectronics - 2014 - 58, 92-100
23)A novel upconversion@polydopamine core@shell nanoparticle based aptameric biosensor for biosensing and imaging of cytochrome c inside living cells - Biosensors and Bioelectronics - 2017 - 87,638–645
24)Designing bifunctionalized gold nanoparticle for colorimetric detection of Pb2+ under physiological condition - Biosensors and Bioelectronics - 2012 - 31, 505-509
25)DNA Electrochemical Biosensor Based on Thionine-Graphene Nanocomposite - Biosensors and Bioelectronics - 2012 - 35, 507-511
26)Highly selective recognition of naphthol isomers based on the fluorescence dye-incorporated SH-α-cyclodextrin functionalized gold nanoparticles - Biosensors and Bioelectronics - 2011 - 26, 2329-2333
27)Cancer Theranostics: Facile preparation of doxorubicin-loaded upconversion@polydopamine nanoplatforms for simultaneous in vivo multimodality imaging and chemophotothermal synergistic therapy - Advanced Healthcare Materials - 2015 - 4, 559-568
28)Synthesis of stable carboxy- terminated NaYF4: Yb3+, Er3+@SiO2 nanoparticles with ultrathin hell for biolabeling applications - Nanoscale - 2013 - 5, 1047-1053
29)Phenylboronic acid functionalized gold nanoparticles for highly sensitive detection of staphylococcus aureus - Nanoscale - 2012 - 4, 451-454
30)Controllable synthesis of polydopamine nanoparticles in microemulsions with pH-activatable properties for cancer detection and treatment - Journal of Materials Chemistry B - 2015 - 3(33), 6731-6739
31)Preparation and application of thionin-bridged graphene-gold nanoparticle nanohybrids - Journal of Materials Chemistry B - 2013 - 1, 1432-1438