于聪
单位：中国科学院长春应用化学研究所，电分析化学国家重点实验室
地址：吉林省，长春市，人民大街5625号
邮编：130022
电话：
个人主页： https://www.x-mol.com/groups/yu_cong
实验室介绍： https://bioanalysissensing.wixsite.com/congyu


个人简历 Personal resume


于聪（博士，研究员，博士生导师），1991年毕业于吉林大学化学系，1993年赴瑞典隆德大学生物化学系攻读博士学位，师从非共价分子印记技术创始人Prof. Klaus Mosbach，并于1998年获得博士学位。1999年至2002年在美国加州大学，伯克利分校化学系做博士后工作，师从Prof. J.M.J. Fréchet (美国国家科学院、工程学院双院士)。2002至2008年在香港大学，中国科学院院士任咏华教授研究组任高级研究助理，在此期间主要从事核酸相关的传感、检测的研究。2008年应聘到中国科学院长春应用化学研究所工作。多年来带领课题组成员致力于结合荧光小分子探针、纳米探针、功能核酸等方面相关知识，开发检测分析核酸、蛋白质，活细胞成像，肿瘤治疗等的研究新方法。在Angew. Chem. Int. Ed., Anal. Chem., Chem. Commun., Org. Lett., Chem. Eur. J.等国际核心期刊发表高质量论文多篇。主持了国家科技部“973计划”重大研究计划项目子课题以及多项国家自然科学基金项目、省市科研项目等。


研究方向 Research direction


1、生物分析，化学生物学
2、荧光探针，纳米探针
3、活细胞成像，肿瘤治疗



招生信息 Enrollment information


生源背景：分析化学，化学生物学，有机合成，分子生物学，材料化学，物理化学，细胞生物学，医学等相关专业


论文专著 The monograph


1)Wang, Bin(#)，Yu, Cong(*)，Fluorescence Turn-On Detection of a Protein through the Reduced Aggregation of a Perylene Probe - Angewandte Chemie International Edition - 2010 - 49（8）：1485-1488
2)Wang, Yan(#)，Chen, Jian，Chen, Yang，Li, Wenying，Yu, Cong(*)，Polymer-Induced Perylene Probe Excimer Formation and Selective Sensing of DNA Methyltransferase Activity through the Monomer-Excimer Transition - Analytical Chemistry - 2014 - 86（9）：4371-4378
3)Jian Chen(#), Hong Jiang, Huipeng Zhou, Zhenzhen Hu, Niu Niu, Sohail Anjum Shahzad and Cong Yu(*), Specific detection of cancer cells through aggregation-induced emission of a light-up bioprobe - Chemical Communications - 2017 - 53，2398-2401
4)Cuiyun Zhang(#), You Fan, Yunyi Zhang, Cong Yu(*), Hongfei Li, Yu Chen, Ian W. Hamley, and Shichun Jiang (*), Self-Assembly Kinetics of Amphiphilic Dendritic Copolymers - Macromolecules - 2017 - 50，1657-1665
5)Yunyi Zhang(#), Cuiyun Zhang, Jian Chen, Yongxin Li, Huipeng Zhou, Cong Yu (*) and Shichun Jiang(*) A real-time fluorescence turn-on assay for acetylcholinesterase activity based on the controlled release of a perylene probe from MnO2 nanosheets - Journal of Materials Chemistry C - 2017 - 5，4691-4694
6)Xinan Huang (#), Hong Jiang, Yongxin Li, Cong Yu (*), Synthesis of silica nanoparticles doped with [Ru(bpy)3]2+ and decorated with silver nanoclusters for the ratiometric photoluminescent determination and intracellular imaging of Cu(II) ions - Microchim Acta - 2017 - 184：2325-2331
7)Yongxin Li(#), Huipeng Zhou, Jian Chen, Sohail Anjum Shahzad, Cong Yu(*), Controlled self-assembly of small molecule probes and the related applications in bioanalysis - Biosensors and Bioelectronics - 2016 - 76，38-53
8)Meiding Yang(#), Jian Chen, Huipeng Zhou, Wenying Li, Yan Wang, Juanmin Li, Cuiyun Zhang, Chuibei Zhou, Cong Yu(*), Polycation-induced benzoperylene probe excimer formation and the ratiometric detection of heparin and heparinase - Biosensors and Bioelectronics - 2016 - 75，404-410
9)Bin Wang(*), YanfenChen, YuanyaWu, BoWeng, YingshuaiLiu, Zhisong Lu, ChangMingLi, CongYu(*), Aptamer induced assembly of fluorescent nitrogen-doped carbon dots on gold nanoparticles for sensitive detection of AFB1 - Biosensors and Bioelectronics - 2016 - 78，23-30
10)Cuiyun Zhang,(#) Cong Yu (*), Yuyuan Lu, Hongfei Li, Yu Chen, Hong Huo, Ian William Hamley and Shichun Jiang (*), Hydrodynamic behaviors of amphiphilic dendritic polymers with different degrees of amidation - Polymer Chemistry - 2016 - 7，3126-3133
11)Juanmin Li(#),Yongxin Li, Sohail Anjum Shahzad, Jian Chen, Yang Chen, Yan Wang, Meiding Yang, Cong Yu(*), Fluorescence turn-on detection of glucose via the Ag nanoparticle mediated release of a perylene probe - Chemical Communications - 2015 - 51, 6354-6356
12)Wenying Li(#),Qingfeng Zhang, Huipeng Zhou, Jian Chen, Yongxin Li, Cuiyun Zhang, Cong Yu(*), Chemiluminescence Detection of a Protein through the Aptamer-Controlled Catalysis of a Porphyrin Probe - Analytical Chemistry - 2015 - 87, 8336-8341
13)Chen, Jian(#)，Wang, Yan，Li, Wenying，Zhou, Huipeng，Li, Yongxin，Yu, Cong(*)，Nucleic Acid-Induced Tetraphenylethene Probe Noncovalent Self-Assembly and the Superquenching of Aggregation-Induced Emission - Analytical Chemistry - 2014 - 86（19）：9866-9872
14)Li, Wenying(#)，Yang, Yue，Chen, Jian，Zhang, Qingfeng，Wang, Yan，Wang, Fangyuan，Yu, Cong(*)，Detection of lead(II) ions with a DNAzyme and isothermal strand displacement signal amplification - Biosensors and Bioelectronics - 2014 - 53：245-249
15)Huping Jiao (#), Jian Chen, Wenying Li, Fangyuan Wang, and Cong Yu(*), Nucleic Acid-Regulated Perylene Probe-Induced Gold Nanoparticle Aggregation: A New Strategy for Colorimetric Sensing of Alkaline Phosphatase Activity and Inhibitor Screening - ACS Applied Materials & Interfaces - 2014 - 6（3），1979-1985
16)Chen, Yang，Li, Wenying，Wang, Yan，Yang, Xudong，Chen, Jian，Jiang, Yingnan，Yu, Cong(*)，Cysteine-directed fluorescent gold nanoclusters for the sensing of pyrophosphate and alkaline phosphatase - Journal of Materials Chemistry C - 2014 - 2（20）：4080-4085
17)Wang, Yan(#)，Chen, Jian，Jiao, Huping，Chen, Yang，Li, Wenying，Zhang, Qingfeng，Yu, Cong(*)，Polymer-Templated Perylene-Probe Noncovalent Self-Assembly: A New Strategy for Label-Free Ultrasensitive Fluorescence Turn-On Biosensing - Chemistry - A European Journal - 2013 - 19（38）：12846-12852
18)Chen, Jian(#)，Liao, Dongli，Wang, Yan，Zhou, Huipeng，Li, Wenying，Yu, Cong(*)，Real-Time Fluorometric Assay for Acetylcholinesterase Activity and Inhibitor Screening through the Pyrene Probe Monomer-Excimer Transition - Organic Letters - 2013 - 15（9）：2132-2135
19)Chen, Jian，Jiao, Huping，Li, Wenying，Liao, Dongli，Zhou, Huipeng，Yu, Cong(*)，Real-time fluorescence turn-on detection of alkaline phosphatase activity with a novel perylene probe - Chemistry-An Asian Journal - 2013 - 8（1）：276-281
20)Liao, Dongli，Chen, Jian，Zhou, Huipeng，Wang, Yan，Li, Yongxin，Yu, Cong(*)，In Situ Formation of Metal Coordination Polymer: A Strategy for Fluorescence Turn-On Assay of Acetylcholinesterase Activity and Inhibitor Screening - Analytical Chemistry - 2013 - 85：2667-2672
21)Zhang, Qingfeng(#)，Li, Wenying，Chen, Jian，Wang, Fangyuan，Wang, Yan，Chen, Yang，Yu, Cong(*)，An Ultrasensitive Chemiluminescence Turn-on Assay for Protease and Inhibitor Screening with a Natural Substrate - Chemical Communications - 2013 - 49：3137-3139
22)Liao, Dongli(#)，Chen, Jian，Li, Wenying，Zhang, Qingfeng，Wang, Fangyuan，Li, Yongxin，Yu, Cong(*)，Fluorescence turn-on detection of a protein using cytochrome c as a quencher - Chemical Communications - 2013 - 49（82）：9458-9460
23)Chen, Yang(#)，Zhou, Huipeng，Wang, Yan，Li, Wenying，Chen, Jian，Lin, Quan(*)，Yu, Cong(*)，Substrate hydrolysis triggered formation of fluorescent gold nanoclusters - a new platform for the sensing of enzyme activity - Chemical Communications - 2013 - 49（84）：9821-9823
24)Li, Wenying(#)，Chen, Jian，Jiao, Huping，Zhang, Qingfeng，Zhou, Huipeng，Yu, Cong(*)，A label-free real time fluorometric assay for protease and inhibitor screening with a released heme - Chemical Communications - 2012 - 48（81）：10123-10125
25)Jiao, Huping(#)，Wang, Bin，Chen, Jian，Liao, Dongli，Yu, Cong(*)，Label free fluorescence turn-on detection of polynucleotide kinase activity with a perylene probe - Chemical Communications - 2012 - 48（63）：7862-7864
26)Tang, Dan(#)，Liao, Dongli，Zhu, Qiankun，Wang, Fangyuan，Jiao, Huping，Zhang, Yujing，Yu, Cong(*)，Fluorescence turn-on detection of a protein through the displaced single-stranded DNA binding protein binding to a molecular beacon - Chemical Communications - 2011 - 47（19）：5485-5487
27)Wang, Bin(#)，Zhu, Qiankun，Liao, Dongli，Yu, Cong(*)，Perylene probe induced gold nanoparticle aggregation - Journal of Materials Chemistry - 2011 - 21（13）：4821-4826
28)Wang, Bin(#)，Jiao, Huping，Li, Wenying，Liao, Dongli，Wang, Fangyuan，Yu, Cong(*)，Superquencher formation via nucleic acid induced noncovalent perylene probe self-assembly - Chemical Communications - 2011 - 47（37）：10269-10271