姓　名：查正宝

职　称：教授

职　务：

所属系：食品质量与安全系

邮　箱：zbzha@hfut.edu.cn

电　话：

个人学习工作简介


查正宝，合肥工业大学黄山青年****，教授。中国医药生物技术协会造影技术分会委员，中国生物医学工程学会光子学分会青年委员，Chinese Chemical Letters青年编委，中国化学会会员，抗癌协会纳米肿瘤专业委员会会员。
近年来，开展以解决临床医学瓶颈为目标的产学研研究，与医院、企业共建控释药物研究室、微波转化医学中心及聚焦超声治疗研究中心。针对微生物感染、炎症、肿瘤等机体稳态失调类疾病的发生、发展机制，构建基于病灶生理微环境及外源刺激（如光、声、微波等）响应的药物制剂，提高患者临床受益度。
迄今，相关研究成果以第一或通讯作者身份在Advanced Materials，ACS Nano，Nano Letters，Advanced Functional Materials，Materials Horizons，Chemical Science，Biomaterials，Acta Pharmaceutica Sinica B，Chinese Chemical Letters等国内外期刊发表论文38篇（含6篇封面论文），授权专利4项，相关成果曾被新华社（全国通稿）、中国科学报头版及国家自然科学基金委第47期科学基金通讯等媒体报道。
学习工作简历：
2018.08~至今合肥工业大学食品与生物工程学院黄山青年****，教授
2015.01~2018.08合肥工业大学生物与医学工程学院黄山青年****，教授
2013.10~2014.12美国德州医学中心休斯敦卫理公会医院研究所纳米医药系博士后
2009.11~2011.1美国亚利桑那大学航天机械工程系访问****
2009.9~2013.7哈尔滨工业大学生物医学工程博士
2007.9~2009.7哈尔滨工业大学生物医学工程硕士
2003.9~2007.7哈尔滨工业大学生物工程学士
主要研究领域与方向


招生专业：药学、制药工程、生物学、生物医学工程等相关专业
1、基于细胞代谢及微环境特征响应的药物制剂研究
2、临床热疗（聚焦超声FUS，微波等）及放疗增敏研究
3、仿生型可注射肿瘤治疗凝胶的开发
4、多功能诊断治疗制剂的开发（重点结合临床超声，核磁影像）
目前承担科研项目

1、基于靶标的炎症免疫性疾病药物设计，合成，筛选与成药性研究，安徽高校协同创新项目，分课题主持，在研。
2、超声诊治肿瘤的增效研究，合肥工业大学优秀青年人才培育计划A项目，主持，在研。
3、多功能CuS纳米摇铃的构建及其在癌症诊治中的应用研究，国家自然科学青年基金项目，主持，已结题。
4、多功能癌症诊疗一体化制剂的开发及医学应用研究，合肥工业大学春华计划，主持，已结题。
5、合肥工业大学黄山青年启动经费，主持，在研
著作论文（代表作）



10篇代表性研究论文
1.Zhaohua Miao^#, Doudou Huang^#, Yichuan Wang, Weijian Li*, Linxin Fan, Jingguo Wang, Yan Ma, Qingliang Zhao* and Zhengbao Zha*. Safe-by-Design Exfoliation of Niobium Diselenide Atomic Crystals as a Theory-Oriented 2D Nanoagent from Anti-Inflammation to Antitumor. Advanced Functional Materials, 2020, DOI: 10.1002/adfm..
2.Xianwen Wang, Linxin Fan, Liang Cheng*, Yanbin Sun, Xiyu Wang, Xiaoyan Zhong, Qianqian Shi, Fei Gong, Yu Yang, Yan Ma, Zhaohua Miao and Zhengbao Zha*. Biodegradable Nickel Disulfide Nanozymes with GSH-Depleted Function for High-Efficiency Photothermal-Catalytic Antibacterial Therapy. iScience, 2020, 23, 101281.
3.Zhaohua Miao^#, Shanshan Jiang^#, Mengli Ding^#, Siyuan Sun, Yan Ma, Muhammad Rizwan Younis, Gang He, Jingguo Wang, Jing Lin, Zhong Cao*, Peng Huang* and Zhengbao Zha*. Ultrasmall Rhodium Nanozyme with RONS Scavenging and Photothermal Activities for Anti-Inflammation and Antitumor Theranostics of Colon Diseases. Nano Letters, 2020, 20, 3079-3089.
4.Junhong Zhou^#, Wancheng Zhao^#, Zhaohua Miao^#, Jingguo Wang, Yan Ma, Haitao Wu, Tiedong Sun*, Haisheng Qian and Zhengbao Zha*. Folin-Ciocalteu Assay Inspired Polyoxometalate Nanoclusters as a Renal Clearable Agent for Non-Inflammatory Photothermal Cancer Therapy. ACS Nano, 2020, 14, 2126-2136.
5.Xianli Xie^#, Tianci Sun^#, Jingzhe Xue, Zhaohua Miao, Xu Yan, Weiwei Fang, Qing Li, Rupei Tang, Yang Lu, Longxiang Tang, Zhengbao Zha*and Tao He*. Ag Nanoparticles Cluster with pH-Triggered Reassembly in Targeting Antimicrobial Applications. Advanced Functional Materials, 2020, 30, **. (封面论文)
6.Gang He^#, Sheng Chen^#, Yunjun Xu, Zhaohua Miao, Yan Ma, Haisheng Qian, Yang Lu*andZhengbao Zha*. Charge Reversal Induced Colloidal Hydrogel Acts as a Multi-Stimuli Responsive Drug Delivery Platform for Synergistic Cancer Therapy. Materials Horizons, 2019, 6, 711-716. (内封面论文)
7.Zhaohua Miao^#, Sheng Chen^#, Cheng-Yan Xu, Yan Ma*, Haisheng Qian, Yunjun Xu, Huajian Chen, Xianwen Wang, Gang He, Yang Lu*, Qingliang Zhao and Zhengbao Zha*. PEGylated Rhenium Nanoclusters: A Degradable Metal Photothermal Nanoagent for Cancer Therapy. Chemical Science, 2019, 10, 5435-5443. (封面论文)
8.Zhengbao Zha, Xiuli Yue*, Qiushi Ren and Zhifei Dai*. Uniform Polypyrrole Nanoparticles with High Photothermal Conversion Efficiency for Photothermal Ablation of Cancer cells. Advanced Materials, 2013, 25: 777-782.
9.Zhengbao Zha, Celine Cohn, Zhifei Dai*, Weiguo Qiu, Jinhong Zhang and Xiaoyi Wu*.Nanofibrous Lipid Membranes Capable of Functionally Immobilizing Antibodies and Capturing Specific Cells. Advanced Materials, 2011, 23: 3435-3440.
10.Zhengbao Zha, Jinrui Wang, Shuhai Zhang, Shumin Wang, Enze Qu, Youyi Zhang and Zhifei Dai*. Engineering of Perfluorooctylbromide Polypyrrole Nano-/Microcapsules for Simultaneous Contrast Enhanced Ultrasound Imaging and Photothermal Treatment of Cancer.Biomaterials, 2014, 35: 287-293.
学术会议
1.Zhengbao Zha. Hydrogel-based Trauma Fillers for Preventing Postsurgical Tumor Recurrence. 2019 International Conference on Molecular Imaging and Minimally Invasive Therapy, October 18-20, 2019, Beijing, China. (分会场邀请报告)
2.查正宝，肿瘤热疗增敏的若干策略，首届粤港澳大湾区妇科微无创技术与快速康复高峰论坛，June 28-30，2019，深圳。(邀请报告)
3.Zhengbao Zha. Development of Multifunctional Theranostic Agents for Cancer Treatment. The 2^ndLing-Nan International Conference on Pharmaceutical Sciences, December 1-3, 2017, Guangzhou, China. (分会场邀请报告)
4.Zhengbao Zha. Ambient Aqueous Synthesis of Ultrasmall Ni_0.85Se Nanoparticles for Non-Invasive Photoacoustic Imaging and Combined Photothermal-Chemo Therapy of Cancer. 2017 International Conference on Molecular Imaging and Minimally Invasive Therapy, November 10-15, 2017, Beijing, China. (分会场邀请报告)
5.Zhengbao Zha. Echogenic Polypyrrole Microspheres for Ultrasound Imaging Guided Photothermal Treatment of Cancer Cells. 2016 Westlake International Forum on Ultrasound in Medicine and Biology, November 9-13, 2016, Hangzhou, China. (分会场邀请报告)
6. Zhengbao Zha. Electorspun Cholesterol Nanofibrous Membranes Capable of Functionally Immobilizing Antibodies for Cell Capture. The 9^thWorld Biomaterials Congress, June 1-5, 2012, Chengdu, China. (口头报告)
7. Zhengbao Zha.Preparation of Hemocompatible Coating and Fuzzy Mathematics Evaluation.CIMNE-2009 China International Micronano New Technology Forum, April 1-3, 2009, Shanghai, China. (口头报告)
其它情况


毕业生就业情况
2018届硕士毕业生：
王咸文（苏州大学读博，导师：李述汤院士、刘庄教授）
陈华健（筑波大学-日本国立材料研究所读博，导师：陈国平教授）
2019届硕士毕业生：
贺港（深圳大学读博，导师：黄鹏教授）
周俊红（湖南华联康生物科技有限公司）
2020届硕士毕业生：
范林昕（浙江华海药业股份有限公司）
孙雁斌（OPPO广东移动通信有限公司）

欢迎勤奋踏实、有良好团队协作精神的有志青年加入我们大家庭！