姓名：林文楚
地址：科学岛
类型：博导
所在科研单元：强磁场中心


导师介绍



林文楚，男，研究员，博士生导师。1996年本科毕业于四川大学生物工程系，2001年获得中国科学院上海生命科学研究院生化与分子生物学硕士， 2006年于美国德州大学MD安德森癌症中心与德州大学健康科学中心获得生物医学博士学位。继而先后在美国德州大学MD安德森癌症中心生化与分子生物学系与美国哈佛大学医学院Dana-Farber癌症研究所从事博士后研究。2012年受聘于Dana-Farber癌症研究所医学肿瘤学系高级研究员（Research Scientist）。 2013年加入中国科学院强磁场科学中心磁共振生命科学部任研究员/课题组长。2015年担任新成立的中科院合肥物质科学研究院实验动物中心主任和中科院合肥技术创新工程院“肿瘤高通量测序与分子诊断工程技术研发中心”主任。林文楚研究员长期以来主要从事肿瘤分子机制与诊断、高通量测序和肿瘤动物模型的研究工作，在国际著名学术期刊发表论文17篇，其中第一作者或通讯作者（含并列）论文10篇，包括 Cell, PNAS, Cancer Discovery, Genes & Development等。论文被引用700余次。研究兴趣肿瘤基因组学，肿瘤分子诊断与治疗，癌症表观遗传学，肿瘤小鼠动物模型，主要科研项目1，组蛋白H3甲基化修饰酶Mll1和Rbp2在小细胞肺癌形成和发展中的调控机制 （国自然面上项目）；2，联合用药治疗小细胞肺癌及其协同作用的分子机制;3，新型皮肤癌小鼠模型的构建、鉴定和肿瘤发生与消退（tumor regression）的分子机制;4，基于高通量测序的肺癌分子诊断试剂盒的研发。获奖与荣誉安徽省年度新闻人物“心动2013”拟招生要求欢迎具有肿瘤学、生物学、医学、生物信息学等相关专业背景的同学报考。

Introduction



Dr. Wenchu Lin, professor of the High Magnetic Field Laboratory, CAS. He received his PhD degree from University of Texas M D Anderson Cancer Center & University of Texas Health Science Center at Houston in 2006. Before joining High Magnetic Field Laboratory as a “Hundred Talents Program” researcher of Chinese Academy of Sciences, he conducted postdoctoral researches at M D Anderson Cancer Center and Harvard Medical School & Dana-Farber Cancer institute and worked at Harvard Medical School and Dana-Farber Cancer institute.Laboratory of Cancer genomics and epigeneticsCancer is one of the most important public health problems in China. Our lab is interested on understanding genetic alterations and epigenetic aberration of cancer initiation, metastasis through integrated studies of genomic studies of human cancer and new mouse models of cancers. Our research involves in multidiscipline including biochemistry, pathology, genomics, magnetic resonance imaging (MRI) and nanotechnology. The Lab is also expanding its efforts to targeted therapies against cancer through collaboration with several groups in High Magnetic Field Laboratory (HMFL), Chinese Academy of Sciences. The long-term goal of our studies is to develop new diagnostic methods and to discover novel therapeutic strategies for personalized cancer care. Our research is specifically focusing on following areas:1.Pathogenesis of cancer progression and metastasis with special focus on lung cancer, gastric cancera.The underlying mechanisms for cancer and potential therapeutic strategies for cancer treatment. b.The molecular mechanism of cancer metastasis using new mouse models of cancer2.Magnetic nanoparticles for targeting therapy and diagnosis for cancer a.Development of the drug delivery methods via magnetic field guided nanoparticles for cancer treatmentb.Magnet-based diagnosis for metastatic cancer3.Translation of cancer genomea.Molecular diagnosis of cancer using genomic approaches such as next generation sequencing (NGS)b. In vivo screening and validation of cancer biomarkers using mouse as a model for cancers.

研究领域



1，肿瘤发生发展的生物学特性和肿瘤转移的分子病理机制； 2， 磁场和磁性材料介导的肿瘤治疗和诊断；3，高通量测序、大数据分析与肿瘤基因组的转化 。

招生专业



博士招生计划：          1、专业：生物物理学招生方向：肿瘤生物学学术硕士招生计划：          1、专业：生物物理学（硕士）招生方向：肿瘤生物学专业学位硕士招生计划：          1、专业：生物与医药（专硕）招生方向：肿瘤生物学博士招生计划：          1、专业：生物物理学招生方向：肿瘤生物学          2、专业：生物物理学招生方向：肿瘤药物学学术硕士招生计划：          1、专业：生物物理学（硕士）招生方向：肿瘤生物学          2、专业：生物物理学（硕士）招生方向：肿瘤药物学专业学位硕士招生计划：          1、专业：生物与医药（专硕）招生方向：肿瘤生物学博士招生计划：          1、专业：生物物理学招生方向：肿瘤生物学学术硕士招生计划：          1、专业：生物物理学（硕士）招生方向：肿瘤生物学          2、专业：生物物理学（硕士）招生方向：肿瘤药物学

研究成果



1.Xing Bian, Wenchu Lin. Targeting DNA Replication Stress and DNA Double-Strand Break Repair for Optimizing SCLC Treatment. (2019) Cancers. 2019 Sep 2; 11(9). pii: E1289. doi: 10.3390/cancers**. (IF～6.16)
2.Ao Xu, Wei Wang, Bo Hong, Wenchu Lin. Germline mutation and aberrent transcripts of WWOX gene in syndrome with multiple primary tumors. (2019) Journal of Pathology. 249(1):19-25. (co-corresponding authorship) (IF～6.84)
3.Xiaoli Liu, Wei Wang,Yanping Yin, Ming Li, Hong Li, Hang Xiang, Ao Xu, Xiaodong Mei, Bo Hong, Wenchu Lin. A high-throughput drug screen identifies auranofin as a potential sensitizer of cisplatin in small cell lung cancer. (2019) Investigational New Drugs. 2019 Mar 2. doi: 10.1007/s10637-019-00750-2. (co-corresponding authorship) (IF～3.80)
4.Hong Li, Huogang Wang, Bo Hong, Wenchu Lin. The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer. (2019) Cancer Biomarkers. 24(1):51-59. (co-corresponding authorship) (IF～2.39)
5.Haibo Wu*, Wei Wang*, Jun Du*, Hong Li, Huogang Wang, Liangliang Huang, Hang Xiang, Jing Xie, Xiaoli Liu, Heng Li, Wenchu Lin. The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China. (2019) Cancer Management and Research. 11: 1473–1492 (corresponding authorship) (IF～3.80)
6.Ke Deng, Jiawei Shen, Wei Wang, Ming Li, Hong Li, Cheng Chen, Huan Zhao, Mei Zhang, Tian Xue, Qingsong Liu, Vivian Wai Yan Lui, Bo Hong, Wenchu Lin. Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer. (2019) Cancer Biology & Therapy. 20(1): 52-64. (co-corresponding authorship) (IF～3.37)
7.Yi Sheng*, Wei Wang*, Bo Hong, Xingwang Jiang, Ruochuan Sun, Qiang Yan, Shangxin Zhang, Deguan Li, Mingdian Lu, Zhen Zhang, Wenchu Lin and Yongxiang Li. Up-regulation of KIF20A correlates with poor prognosis in gastric cancer. (2018) Cancer Management and Research. 10: 6205–6216 (co-corresponding authorship) (IF～3.80)
8.Bo Hong, Huogang Wang, Ke Deng, Wei Wang, Haiming Dai, Vivian Wai Yan Lui, Wenchu Lin. Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer. (2017) Oncotarget. 8(63): 106486-106498. (corresponding authorship) (IF～5.17)
9.Huogang Wang*, Bo Hong*, Xuemin Li, Hong Li, Vivian Wai Yan Lui, Wenchu Lin. JQ1 sensitizes small cell lung cancer to ABT-263 through up-regulating BIM and disrupting BIM interation with BCL-2. (2017) Oncotarget. 8(49):86312-86324. * Equal contribution. (corresponding authorship) (IF～5.17)
10.Wenchu Lin, Joshua M. Francis, Hong Li, Xiaoping Gao, Chandra Sekhar Pedamallu, Patricia Ernst, Matthew Meyerson. Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets. (2016) Cancer Biology & Therapy. 17(12): 1274-1281. (First authorship & corresponding authorship) (IF～3.37)
11.Wenchu Lin, Hideo Watanabe, Shouyong Peng, Joshua Y. Francis, Nathan Kaplan, Chandra Sekhar Pedamallu, Aruna Ramachandran, Agoston Agoston, Adam J. Bass, Matthew Meyerson. Dynamic epigenetic regulation by menin during pancreatic islet tumor formation. (2015) Molecular Cancer Research. 13(4):689-98. (IF～4.97)
12.Hideo Watanabe, Joshua Y. Francis, Michele S. Woo, Banafsheh Etemad, Wenchu Lin, Daniel Fries, Shouyang Peng, Eric L.Snyder, Purushothama Rao Tata, Anna Schinzel, Jeoghee Cho, Peter S. Hammerman, Roel G. Verhaak, William C. Hahn, Jayaraj Rajagopal Tyler Jacks, Matthew Meyerson. Integrated cistromic and expression analysis of amplified NKX2-1 in Lung adenocarcinoma identifies LMO3 as a functional transcriptional target. (2013) Genes & Development. 27(2): 197-210.(IF～14.20)
13.Veronica Martínez-Cerdeño V, Jessica M. Lemen, Vanessa Chan, Alice Wey, Wenchu Lin, Sharon R. Dent, Paul S. Knoepfler. N-Myc and GCN5 Regulate Significantly Overlapping Transcriptional Programs in Neural Stem Cells. (2012) PLoS One. 7(6): e39456. (IF～4.11)
14.Wenchu Lin*, Jian Cao*, Jiayun Liu, Michael L. Beshiri, Yuko Fujiwara, Joshua Francis, Andrew D. Cherniack, Christoph Geisen, Lauren P. Blair, Mike R. Zou, Xiaohua Shen, Dan Kawamori, Zongzhi Liu, Chiara Grisanzio, Hideo Watanabe, Yoji Andrew Minamishima, Qing Zhang, Rohit N. Kulkarni, Sabina Signoretti, Scott J. Rodig, Roderick T. Bronson, Stuart H. Orkin, David P. Tuck, Elizaveta V. Benevolenskaya, Matthew Meyerson, William G. Kaelin, Jr., and Qin Yan. Loss of the RBP2 histone demethylase suppresses tumorigenesis in mouse models of Rb1 and Men1 tumor suppressor gene inactivation. (2011) PNAS. 108(33): 13379-86. * Equal contribution. (IF～10.50)
15.Peter S. Hammerman，Martin L. Sos，Alex H. Ramos，Chunxiao Xu，Amit Dutt，Wenjun Zhou，Lear E. Brace，Brittany A. Woods，Wenchu Lin，Jianming Zhang，Xianming Deng，Sang Min Lim，Stefanie Heynck，Martin Peifer，Jeffrey R. Simard，Michael S. Lawrence，Robert C. Onofrio，Helga B. Salvesen，Danila Seidel，Thomas Zander，Johannes M. Heuckmann，Alex Soltermann，Holger Moch，Mirjam Koker， Frauke Leenders， Franziska Gabler，Silvia Querings，Sascha Ansén，Elisabeth Brambilla，Christian Brambilla， Philippe Lorimier，Odd Terje Brustugun，Åslaug Helland，Iver Petersen，Joachim H. Clement，Harry Groen，Wim Timens，Hannie Sietsma，Erich Stoelben，Jürgen Wolf，David G. Beer，Ming Sound Tsao，Megan Hanna，Charles Hatton，Michael J. Eck，Pasi A. Janne，Bruce E. Johnson，Wendy Winckler，Heidi Greulich，Adam J. Bass，Jeonghee Cho，Daniel Rauh，Nathanael S. Gray，Kwok-Kin Wong，Eric B. Haura，Roman K. Thomas，Matthew Meyerson. Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer. (2011) Cancer Discovery. 1(1): 78-89. (IF～15.93)
16.Joshua Francis, Wenchu Lin, Orit Rozenblatt-Rosen, Matthew Meyerson. The menin tumor suppressor protein is phosphorylated in response to DNA damage. (2011) PloS One. 6(1): e16119. (IF～4.11)
17.Wenchu Lin, Zhijing Zhang, Geraldine Srajer, Yi Chun Chen, Maosheng Huang, Huy M. Phan, and Sharon Y.R. Dent. Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. (2008) Dev. Dyn. 237(4): 928-940. (IF～3.02)
18.Wenchu Lin, Chih-Hsin Chen, Richard R. Behringer, and Sharon Y.R. Dent. Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton. (2008) Dev Growth Differ. 50(5): 321-30. (IF～2.32)
19.Wenchu Lin, Geraldine Srajer, Yvonne A. Evrard, Huy M. Phan, Yas Furuta, and Sharon Y.R. Dent. Developmental potential of Gcn5-/- ES cells in vivo and in vitro. (2007) Dev. Dyn. 236(6): 1547-1557. * Equal contribution. (IF～3.02)
20.Ke Zhang, Wenchu Lin, John A. Latham, Gary M. Riefler, Jill M. Schumacher,Clarence Chan, Kelly Tatchell, David H. Hawke,Ryuji Kobayashi, and Sharon Y.R. Dent. The Set1 methyltransferase opposes Ipl1 Aurora kinase functions in chromosome segregation. (2005) Cell. 122: 1-12. (IF～34.77)
21.林文楚，叶晴，乔春红，尹光琳。微生物混合培养从D-山梨醇产生维生素前体-2-酮基-L-古龙酸发酵条件的研究。(2002) 微生物学通报 29(4): 27-41.
22.尹光琳，林文楚，乔春红，叶晴。微生物混合培养从D-山梨醇产生维生素前体-2-酮基-L-古龙酸 (2001) 微生物学报 41(6):709-715
23.林文楚，尹光琳。氧化葡萄酸杆菌SCB329基因组大小与结构的研究。(2001) 微生物学报41(5): 530-535.
24.林文楚，尹光琳。氧化葡萄酸杆菌SCB329染色体的测定。(2001) 微生物学报 41(1): 49-52.
25.薛震役，林文楚，尹光琳。微生物发酵中L-山梨糖脱氢酶的研究。 (2001) 中国医药工业杂志32(3): 102-104.
已发表的综述: 1.项航，王伟，林文楚。Claudin蛋白在胃癌中的作用和临床研究进展。（2019）中国肿瘤生物治疗杂志， Accepted2.王伙刚，洪波，林文楚。小细胞肺癌靶向治疗研究进展。（2017）中国药理学通报 33(10): 1333-1337.3.Wenchu Lin, and Sharon YR Dent. Functions of histone modifying enzymes in development. (2006) Current Opinion in Genetics and Development. 16(2):137-42. (IF～8.98) 4.林文楚。 氧化葡萄酸杆菌SCB329基因组与纯培养的研究进展。 (2000) 工业微生物 30(2): 18.
专利1.林文楚，王伟，洪波，李河南，尹燕萍，王晓雪，李浩浩，李圆. 基于高通量测序技术确定肺癌基因突变为点的引物、试剂盒及方法. 2018.03.02, 中国，3.3（授权号或申请号）2.李河南，王晓雪，李浩浩，李圆，徐志兰，花园，林文楚，洪波，王伟. 一种检测多种变异类型基因的高通量测序方法及应用. 2018.05.09，中国， 6.X（授权号或申请号）3.林文楚、王伟、洪波、李红、高小平、王伙刚. 非小细胞肺癌靶向治疗基因检测方法. 2016.05.16，中国， 8.6（授权号或申请号）。