姓名：吴杭
邮箱：wuhang@ahu.edu.cn; wuh5008@qq.com
职称：副教授
电话：
通讯地址：合肥市经开区九龙路111号
邮编：230601
科研简历
安徽大学学士（2004）与硕士（2007），上海交通大学微生物学博士（2012），曾先后在军事医学科学院、国家人类基因组南方中心、波士顿大学和麻省理工学院生物工程系进行研究工作。安徽大学青年骨干教师培养对象（2015）和首批优秀人才计划入选者（2018），兼任安徽省生物工程学会和医药生物技术协会理事（2019）、安徽省微生物药物工程研究中心副主任（2020）。长期从事微生物天然活性产物与基因工程的研发工作，研究兴趣涉及基因调控与合成生物学、功能组学与代谢工程、工业微生物遗传改造及其产业化探索等。主持和参与承担了国家自然科学基金项目、国家重点基础研究发展计划项目子课题、安徽省重点研发计划项目、留学人员创新扶持计划项目等科研任务。在分子微生物学/系统生物工程研究领域的主流期刊Metabolic Engineering,Applied and EnvironmentalMicrobiology等已发表SCI研究论文23篇，申报/授权发明专利15项。应邀为Appl Microbiol Biotechnol、科学通报等期刊论文审稿。
ResearchgateURL: https://www.researchgate.net/profile/Hang_Wu7
学术论文
Xu Y, Tang Y, Wang N,LiuJ, CaiX, CaiH, LiJ, TanG, LiuR, BaiL, ZhangL, WuH*,ZhangB*. Transcriptional regulation of a Leucine-responsive regulatory protein for directly controlling lincomycin biosynthesis in Streptomyces lincolnensis.Appl Microbiol Biotechnol. 2020;104(6):2575-2587. (IF: 3.530)
Cao B, Wu X, Zhou J, Wu H, Liu L, Zhang Q, DeMott MS, Gu C, Wang L, You D, Dedon PC.Nick-seq for single-nucleotide resolution genomic maps of DNA modifications and damage. Nucleic Acids Res. 2020;48(12):6715-6725.(IF: 11.501)
Xu Y, Ke M, Li J, Tang Y, Wang N, Tan G, Wang Y, Liu R, Bai L, Zhang L, Wu H*, Zhang B*.TetR-Type Regulator SLCG_2919 Is a Negative Regulator of Lincomycin Biosynthesis in Streptomyces lincolnensis.Appl Environ Microbiol. 2019;85(1). pii: e02091-18.(IF: 4.007)
Wu H, Chu Z, Zhang W, Zhang C, Ni J, Fang H, Chen Y, Wang Y, Zhang L, Zhang B. Transcriptome-guided target identification of the TetR-like regulator SACE_5754 and engineered overproduction of erythromycin in Saccharopolyspora erythraea. Journal of Biological Engineering. 2019. 24;13:11. (IF: 5.256)
Li J, Wang N, Tang Y, Cai X, Xu Y, Liu R, Wu H*, Zhang B*. Developmental regulator BldD directly regulates lincomycin biosynthesis in Streptomyces lincolnensis. Biochem Biophys Res Commun. 2019,518(3): 548-553.(IF: 2.705)
Liu J, Chen Y, Li L, Yang E, Wang Y, Wu H, Fang H, Zhang L, Wang W, Zhang B. Characterization and engineering of a Lrp/AsnC family regulator SACE_5717 forerythromycin overproduction in Saccharopolyspora erythraea. J Ind Microbiol Biotechnol. 2019. (IF: 3.103)
Xu Y, Tan G, Ke M, Li J, Tang Y, Meng S, Niu J, Wang Y, Liu R, Wu H*, Bai L, Zhang L, Zhang B.Enhanced lincomycin production by co-overexpression of metK1and metK2in Streptomyces lincolnensis.J Ind Microbiol Biotechnol. 2018, 45(5): 345-355. (IF: 3.103)
Liu J, Chen Y, Wang W, Ren M, Wu P, Wang Y, Li C, Zhang L, Wu H*, Weaver DT*, Zhang B*. Engineering of an Lrp family regulator SACE_Lrp improves erythromycin production in Saccharopolyspora erythraea. Metab Eng. 2017; 39: 29-37. (IF: 8.142)
Liu J, Li J, Dong H, Chen Y, Wang Y, Wu H, Li C, Weaver DT, Zhang L, Zhang B. Characterization of an Lrp/AsnC family regulator SCO3361, controlling actinorhodin production and morphological development in Streptomyces coelicolor.Appl Microbiol Biotechnol. 2017,101(14): 5773-5783. (IF: 3.42)
Meng S, Wu, H, Wang L, Zhang B, Bai L. Enhancement of antibiotic productions by engineered nitrate utilization in actinomycetes. Appl Microbiol Biotechnol. 2017,101(13):5341-5352.(IF: 3.42)
Lu C, Wu H, Su X, Bai L. Elimination of indigenous linear plasmids in Streptomyces hygroscopicus var.jinggangensisand Streptomycessp. FR008 to increase validamycin A and candicidin productivities. Appl Microbiol Biotechnol. 2017; 101(10):4247-4257.(IF:3.42)
Wu H, Wang Y, Yuan L, Mao Y, Wang W, Zhu L, Wu P, Fu C, Müller R, Weaver DT, Zhang L, Zhang B. Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea. Synthetic Systems Biotechol. 2016; 1(1): 39-46. Inaugural issue.2019CiteScore: 6.5
Wu H, Li W, Xin C, Zhang C, Yuan L, Zhao W, Wang Y, Ren S, Ren M, Huang X, Xu Z, Yuan H, Geng M, Zhang L, Weaver D, Zhang B. In vivo Investigation to the Macrolide-Glycosylating Enzyme Pair DesVII/DesVIII in Saccharopolyspora erythraea. Appl Microbiol Biotechnol. 2016; 100(5): 2257-2266.(IF: 3.376)
Wu H, Mao Y, Chen M, Pan H, Huang X,Ren M, Wu H, Li J, Xu Z, Yuan H, GengM, Weaver D, Zhang L, Zhang B. Capturing the target sequences of BldD in Saccharopolyspora erythraeausing a revised SELEX method.Appl Microbiol Biotechnol. 2015; 99(6): 2683-2692.(IF: 3.337)
Qu S, Kang Q, Wu H, Wang L, Bai L. Positive and negative regulation of GlnR in validamycin A biosynthesis by binding to different loci in promoter region. Appl Microbiol Biotechnol. 2015; 99(11): 4771-4783.(IF: 3.337)
Zhang P, Wu H, Chen X, Deng Z, Bai L, Pang X. Regulation of the biosynthesis of thiopeptide antibiotic cyclothiazomycin by the transcriptional regulator SHJG8833 in Streptomyces hygroscopicus5008. Microbiology. 2014; 160 (Pt 7): 1379-1392.(IF: 2.835)
Wu H, Chen M, Mao Y, Li W, Liu J, Huang X, Zhou Y, Ye B, Zhang L, Weaver D, Zhang B. Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea.Microb Cell Fact. 2014, 13: 158. (IF: 4.25)
Wu P, Pan H, Zhang C, Wu H*, Yuan L, Huang X, Zhou Y, Ye B, Weaver D, Zhang L, Zhang B*. SACE_3986, a TetR family transcriptional regulator, negatively controls erythromycin biosynthesis in Saccharopolyspora erythraea. J Ind Microbiol Biotechnol. 2014; 41(7):1159-1167.(IF: 2.505)
Yin X, Xu X, Wu H*, Yuan L, Huang X, Zhang B*. SACE_0012, a TetR family transcriptional regulator, affects the morphogenesis of Saccharopolyspora erythraea. Curr Microbiol. 2013; 67(6):647-651.(IF:1.52)
Wu H, Qu S, Lu C, Zheng H, Zhou X, Bai L, Deng Z. Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus5008. BMC Genomics. 2012; 13: 37.(IF:4.25)
FanY, DaiY, ChengQ, ZhangG, ZhangD, FangP, WuH, BaiL, DengZ, QinZ. A self-ligation method for PCR-sequencing the telomeres of Streptomycesand Mycobacteriumlinear replicons. Journal of Microbial Methods. 90, 105-107, 2012. (IF: 2.544)
Wei ZH, Wu H, Bai L, Deng Z, Zhong JJ.Temperature shift-induced reactive oxygen species enhanced validamycin A production in fermentation of Streptomyces hygroscopicus 5008. Bioprocess Biosyst Eng. 2012 Oct;35(8):1309-1316. (IF: 1.808)
Zhou X, Wu H,Li Z, Zhou X, Bai L, Deng Z. Over-expression of UDP-glucose pyrophosphorylase increases validamycin A but decreases validoxylamine A production in Streptomyces hygroscopicus5008. Metab Eng. 2011; 13, 768-776.(IF: 5.512)