杜卫东职称：教授
联系电话：**
email：weidong.du@ahmu.edu.cn
研究方向：1.新型生物芯片研发与应用2.疾病基因型和临床表型相关性分析

个人简历科研项目论文专著专利与技术许可荣誉与奖励
1978年9月-1983年7月 徐州医学院，医学学士；
1983年9月-1986年8月 徐州医学院病理学教研室，助教；
1986年9月-1989年8月 安徽医科大学病理学教研室，硕士研究生；
1989年9月-1993年8月 徐州医学院病理学教研室，讲师；
1993年9月-1995年8月 上海医科大学病理学教研室，博士研究生；
1995年12月-1997年12月 中国科学院上海生理研究所，博士后、副研究员；
1998年1月-2000年5月 德国马普生化所分子生物学实验室，博士后，研发基因芯片；
2000年6月-2002年3月 德国Thermo Electron (ThermoHybaid–Interactiva) 生物技术有限公司，生物芯片研发部，该公司着重于新型芯片研发及修饰平台销售，生物芯片项目经理；
2002年4月-2008年12月 德国Ulm大学医学院麻醉系，欧盟第5 框架协议项目，生物芯片研发员；
2009年1月-2011年6月 德国海德堡大学曼海姆医学院外科系，欧盟第6框架协议项目Conticanet课题协调人；
2011年7月起 德国乌尔姆大学医学院麻醉学系，科研与教学项目助理；
2003年起 安徽医科大学海外****、2012年全职教授。生物芯片研发员；前国际教育学院副院长。



1. 安徽省转化医学研究院科研基金项目（中央财政支持地方高校改革发展专项基金）：基于一种新型自主研发凝集素组合芯片建立，检测肝细胞性肝癌患者手术前后血清糖链变化及判断其预后转归。（项目批号：2017zhyx37），2018/1-2020/12，20万，在研，主持；


2. 国家自然科学基金面上项目（**），2012/01 – 2015/12，58万元、已结题，主持；


3. 安徽省科技厅对外科技合作项目（）, 10万，已结题，主持；


4. 国家自然科学基金青年基金项目: 全基因组外显子测序寻找点状掌跖角化症治病基因研究（项目批准号：**，2012.01-2014.12），25万，已结题，课题第一参与人；


5. 安徽省自然科学基金面上项目（）、2009/01–2011/12，5万元，已结题，主持；


6. 国家自然科学基金面上项目（**）、2005/01–2007/12、19万元、已结题、主持；


7. 安徽省自然科学基金面上项目（）、2005/01–2007/12，5万元，已结题、主持。



1. Liu SS, Gao Y, Yin SP, Ye L, Song ZJ, Liu Q, Li SG, Du WD?. Expression of Narcissus pseudonarcissus lectin [and] mannose recept[or] positive macrophages predict progression [and] prognosis of patients with gastric cancer. Transl Cancer Res 2020;9(10)| http://dx.doi.org/10.21037/tcr-20-1459 (in press)


2. Du YX, Ye L, Song ZJ, Lv H, Liu Q, Li SG, Liu, Hong SS, J. Gao Y., Schneider ME., Du WD?. Development of a dendrimer PAMAM-based gold biochip f[or] rapid [and] sensitive detection of endogenous IFN-γ [and] anti-IFN-γ IgG in patients with hemophagocytic lymphohistiocytosis. Mol Med Rep. 2020 (in press)


3. Yin SP, Gao Y, Xie XS, Xu DD, Riabov V, Du WD?. Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival. Oncol Lett. 2020 Mar;19(3):2404-2412. doi: 10.3892/ol.2020.11310. Epub 2020 Jan 16.


4. Gao Y, Li SG, Liu Q, Liu SS, Ye L, Song ZJ, Du WD?. Establishment of a 1, 4, 7, 10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono-N- hydroxysuccinimide ester (DOTA-NHS-ester) based lectin microarray f[or] efficiently detecting serum glycans in gastric cancers. Anal Biochem. 2020 May 15;597:113686. doi: 10.1016/j.ab.2020.113686. Epub 2020 Mar 7.


5. Xu F, Ye L, Hu Y, Cai C, Wang Z, Fan L, Song L, Xu Z, Du WD?. A novel protein biochip screening serum anti-sperm antibody expression [and] natural pregnancy rate in a follow-up study in Chinese infertility. Biosci Rep. 2020 Feb 28;40(2):BSR**. doi: 10.1042/BSR**.


6. Lv H, Ye L, Liu Q, Li SG, Li T, Huang NL, Gao Y, Fan LB, Du WD?. S-S-PEG-COOH Self-Assembled Monolayer on Gold Surface Enabled a Combined Assay f[or] Serological EBV Antibody Isotypes. Proteomics Clin Appl. 2019 May;13(3):e**. doi: 10.1002/prca.. Epub 2018 Nov 2.


7. Gao Y, Yin SP, Xie XS, Xu DD, Du WD ?. The relationship between stromal cell derived SPARC in human gastric cancer tissue [and] its clinicopathologic significance. Oncotarget, 2017;8(49):86240-52 (IF: 5.18/2016)


8. Ye L, Huang NL, Du YX, Schneider ME, Du WD ?. Succinyl-β-cyclodextrin modified gold biochip improved seroimmunological detection sensitivity f[or] Lyme disease. Analytica Chimica Acta. 2017; 953:48-56.


9. Ye L, Hu Y, Xu FH, Cai CY, Song DW, Xu ZS*, Du WD ?. Protein biochip-based semi-quantitative detection f[or] plasma leptin. Proteom Clin Appl. 2017;11(5-6)


10. Huang NL, Ye L, Du YX, Schneider EM, Fan LB*, Du WD ?. A biochip-based combined immunoassay f[or] detection of infectious status of Borrelia burgdorferi in Lyme borreliosis. Clin Chim Acta. 2017; 472:13-19 (IF: 2.873/2016)


11. Ye L, Huang NL, Ma XL, Schneider M, Huang XJ, Du WD?. Establishment of N-succinimidyl 4-(maleimidomethyl) cyclohexanecarboxylate (SMCC) modified biochip enabling concurrent detection of serum infectious antibodies in neuroborreliosis. Biosens Bioelectron. 2016 Apr 15;78:404-10. doi: 10.1016/j.bios.2015.11.050. Epub 2015 Nov 22.


12. Huang NL, Ye L, Schneider ME, Du YX, Xu YH, Fan LB, Du WD?. Development of a novel protein biochip enabling validation of immunological assays [and] detection of serum IgG [and] IgM antibodies against Treponema pallidum pathogens in the patients with syphilis. Biosens Bioelectron. 2016 Jan 15;75:465-71. doi: 10.1016/j.bios.2015.08.036. Epub 2015 Sep 3.


13. Qiu Y, Hu Y, Zhang ZY, Ye L, Xu FH, Schneider ME, Ma XL, Du YX, Zuo XB, Zhou FS, Chen G, Xie XS, Zhang Y, Xia HZ, Wu JF, Du WD?. Genetic association of osteopontin (OPN) [and] its recept[or] CD44 genes with susceptibility to Chinese gastric cancer patients. J Cancer Res Clin Oncol. 2014 Jul 10. [Epub ahead of print]


14. Yuan Zhou, Wei-Dong Du?, Qiang Wu, Yi Liu, Gang Chen, Jian Ruan, Song Xu, Feng Yang, Fu-Sheng Zhou, Xian-Fa Tang, Hua-Yang Tang, Xian-Bo Zuo, Feng-Yu Zhang, Liang-Dan Sun [and] Xue-Jun Zhang. EZH2 genetic variants affect risk of gastric cancer in the Chinese Han population. Molecular Carcinogenesis 2014 Aug. ;53(8):589- 597.


15. Qiu Y, Zhang ZY, Du WD ? . Ye L, Xu S, Zuo XB, Zhou FS, Chen G, Ma XL, Schneider ME, Xia HZ, Zhou Y, Wu JF, Yuan-Hong X, Zhang XJ. Association analysis of ERBB2 amplicon genetic polymorphisms [and] STARD3 expression with risk of gastric cancer in the Chinese population. Gene. 2014 Feb 10;535(2):225-32. doi: 10.1016/j.gene.2013.11.030. Epub 2013 Nov 28.


16. Song Xu, Yuan Zhou, Wei-Dong Du?, Gang Chen, Fu-Sheng Zhou, Marion Schneider, Xue-Ling Ma, Hong-Yuan Xu, Xue-Jun Zhang. Association of the Variant Rs** of Human DOC-2/DAB2 Interactive Protein Gene (hDAB2IP) With Gastric Cancer in the Chinese Han Population. Gene. 2013 Feb 15;515(1):200-4. doi: 10.1016/j.gene.2012.11.043. Epub 2012 Dec 14.


17. Ye L, Zhang ZY, Du WD?, Schneider ME, Qiu Y, Zhou Y, Zhou FS, Zuo XB, Chen G, Ma XL, Xia HZ, Xu S, Wu JF, Xu HY, Zhang XJ. Genetic analysis of ADIPOQ variants [and] gastric cancer risk: a hospital-based case-control study in China. Med Oncol. 2013 Sep;30(3):658. doi: 10.1007/s12032-013-0658-9. Epub 2013 Jul 25.


18. Song B, Zhang Y, He XJ, Du WD?, Ruan J, Zhou FS, Wu H, Zha X, Xie XS, Ye L, Wei ZL, Zhou P, Cao YX. Association of genetic variants in SOHLH1 [and] SOHLH2 with non-obstructive azoospermia risk in the Chinese population. Eur J Obstet Gynecol Reprod Biol. 2015 Jan;184:48-52. doi: 10.1016/j.ejogrb.2014.11.003. Epub 2014


19. Zhang Y, He XJ, Song B, Ye L, Xie XS, Ruan J, Zhou FS, Zuo XB, Cao YX, Du WD?. Association of single nucleotide polymorphisms in the USF1, GTF2A1L [and] OR2W3 genes with non-obstructive azoospermia in the Chinese population. J Assist Reprod Genet. 2015 Jan;32(1):95-101. doi: 10.1007/s10815-014-0369-y. Epub 2014 Nov 6.


20. Zhang Y, Song B, Du WD?, He XJ, Ruan J, Zhou FS, Zuo XB, Ye L, Xie XS, Cao YX.Genetic association study of RNF8 [and] BRDT variants with non-obstructive azoospermia in the Chinese Han population. Syst Biol Reprod Med. 2015 Jan;61(1):26-31. doi: 10.3109/**.2014.979513. Epub 2014 Nov 6.


21. He XJ, Song B, Du WD?, Cao YX, Zhang Y, Ruan J, Tian H, Zhou FS, Zuo XB, Wu H, Zha X, Xie XS, Wei ZL, Zhou P. CREM Variants rs** [and] rs** Conferred Susceptibility to Non-Obstructive Azoospermia Risk in the Chinese Population. Biol Reprod. 2014 Jun 18. pii: biolreprod.114.120527. [Epub ahead of print]


22. Song B, He X, Du WD?, Zhang Y, Ruan J, Zhou F, Zuo XB, Wu H, Zha X, Liu S, Xie XS, Ye L, Wei Z, Zhou P, Cao YX. Genetic study of Hormad1 [and] Hormad2 with non-obstructive azoospermia patients in the male Chinese population. J Assist Reprod Genet. 2014 May;31(7):873-879. [Epub ahead of print]


23. Xiao-Jin He, Jian Ruan, Wei-Dong Du?, Yun-Xia Cao, Gang Chen, Xian-Bo Zuo, Yu-Wan Peng, Huan Wu, Bing Song, [and] Xue-Jun Zhang. PRDM9 gene polymorphism may not be associated with defective spermatogenesis in the Chinese Han population. Syst Biol Reprod Med. 2013 Feb;59(1):38-41. doi: 10.3109/**.2012.723793. Epub 2012 Nov 29.


24. Jian Ruan, Xiao-Jin He, Wei-Dong Du?, Gang Chen, Yuan Zhou, Song Xu, Xian-Bo Zuo, Li-Bin Fang, Yun-Xia Cao, Xue-Jun Zhang. Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population. Reproductive Sciences, 2012;19(11):1190-1196, doi:10.1177/ **46076


25. Zhenshan Xu, Weidong Du?, Ping Zhang, Xuan Wang, Xueling Ma, Liqin Shi [and] Lihua Song. Development of a protein biochip to identify six monoclonal antibodies against subtypes of recombinant human interferons. ASSAY Drug Dev Tech 2010,8(2): 212-218 (IF 2.700)


26. Weidong Du?, Wei Li, Gang Chen, Huimin Cao, Huayang Tang, Xianfa Tang, Qinghui Jin, Zhongwu Sun, Hui Zhao, Wenming Zhou, Sumin He, Yongmei Lv, Jianlong Zhao [and] Xuejun Zhang. Detection of known base substitution mutations in human mitochondrial DNA of MERRF [and] MELAS by biochip technology. Biosens Bioelectron 2009;24(8):2371-76


27. Geistlinger J, Du WD, Groll J, Liu FG, Hoegel J, Foehr KJ, Pasquarelli A, Schneider M. P2RX7 genotype association in severe sepsis [and] hemophagocytic syndromes identified by a novel Multi-Individual Array (MIA) f[or] rapid screening [and] replication of risk SNPs. Clin Chim Acta. 2012 Jan 18;413(1-2):39-47


28. Du WD?, Chen G, Cao HM, Jin QH, Liao RF, He XC, Chen DB, Huang SR, Zhao H, Lv YM, Tang HY, Tang XF, Wang YQ, Sun S, Zhao JL, Zhang XJ A simple oligonucleotide biochip capable of rapidly detecting known mitochondrial DNA mutations in Chinese patients with Leber's hereditary optic neuropathy (LHON). Disease Markers 2011;30(4):181-90


29. Ghulam M. Anjum§, Weidong Du§, Rachel Klein, Umme Amara, Markus Huber-Lang, E. Marion Schneider, Peter Wiegand. Establishing a novel multiplexed SNP analysis system f[or] two hypervariable regions HV-I/HV-II of the human mitochondrial D-loop by pyrosequencing. Electrophoresis 2010, 31(2):309-314 (§: equal contribution)


30. Xia HZ, Du WD?, Wu Q, Chen G, Zhou Y, Tang XF, Tang HY, Liu Y, Yang F, Zuo XB, Ruan J, Xu S, Zhang XJ. E-selectin rs5361 [and] FCGR2A rs** variants were associated with increased risk of gastric cancer in the Chinese Han population. Molecular Carcinogenesis 2012 Aug;51(8):597-607. (IF 4.772)


31. Xiao-Jin He, Jian Ruan, Wei-Dong Du?, Gang Chen, Yuan Zhou, Song Xu, Xian-Bo Zuo, Yun-Xia Cao, Xue-Jun Zhang. PRM1 variant rs** (Ser>Arg) was associated with severe oligozoospermia in the Chinese population. Reproductive BioMedicine Online 2012;25(6):627-634, DOI 10.1016/j.rbmo.2012.09.005,


32. Tian-Qing Chu, Hao Ding, David H. Garfield, Ai-Qin Gu, Jun Pei, Wei-Dong Du?, Bao-Hui Han?. Can Determination of Circulating Endothelial Cells [and] Serum Caspase-cleaved CK18 Predict f[or] Response [and] Survival in Advanced Non-small Cell Lung Cancer Patients Receiving Endostatin [and] Paclitaxel-carboplatin Chemotherapy?: a retrospective study. J Thorac Oncol. 2012 Dec;7(12):1781-9. doi: 10.1097/JTO.0b013e**fe0.


33. Xia HZ, Wu Q, Du WD?, Liu Y, Chen G, Yang F, Zhou FS, Tang XF, Tang HY, Ruan J, Chen YL, Sun LD, Zhang XJ. Association of genetic variants of VEGF gene with gastric carcinoma risk. J Biochips [and] Tissue Chips 2011; S1, doi: 10.4172/2153-0777.S1-005


34. P. Hohenberger, W. Du [and] S. Post. Extended resections f[or] colorectal cancer - indications f[or] supraradical lymphadenectomy. Colorectal Disease 2011;13(suppl 7):74-77


35. Schneider M, Du W, Fiedler J, H?gel J, Günther KP, Brenner H, Brenner RE.. The (-765 G→C) promoter polymorphism of the COX-2/PTGS2 gene is a protective fact[or] f[or] end-stage hip [and] knee osteoarthritis. Ann Rheum Dis. 2011;70(8):1458-60


36. Ma T, Li YY, Zhu J, Fan LL, Du WD, Wu CH, Sun GP, Li JB. Enhanced autophagic flux by endoplasmic reticulum stress in human hepatocellular carcinoma cells contributes to the maintenance of cell viability. Oncol Rep. 2013 Jul;30(1):433-40. doi: 10.3892/or.2013.2474. Epub 2013 May 15.


37. Barzan D, Veldwijk MR, Herskind C, Li Y, Zhang B, Sperk E, Du WD, Zhang XJ, Wenz F. Comparison of genetic variation of breast cancer susceptibility genes in Chinese [and] German populations. Eur J Hum Genet. 2013 Nov;21(11):1286-92. doi: 10.1038/ejhg.2013.38. Epub 2013 Mar 13.


38. Guo BR, Zhang X, Chen G, Zhang JG, Sun LD, Du WD, Zhang Q, Cui Y, Zhu J, Tang XF, Xiao R, Liu Y, Li M, Tang HY, Yang X, Cheng H, Li M, Gao M, Li P, Wang JB, Xu FP, Zuo XB, Zheng XD, Zhang XG, Yang L, Liu JJ, Wang J, Yang S, Zhang XJ. Exome sequencing identifies a COL14A1 mutation in a large Chinese pedigree with punctate palmoplantar keratoderma.J Med Genet. 2012 Sep;49(9):563-8


39. Tang R, Kong F, Hu L, You H, Zhang P, Du W, Zheng K.Role of hepatitis B virus X protein in regulating LIM [and] SH3 protein 1 (LASP-1) expression to mediate proliferation [and] migration of hepatoma cells. Virol J. 2012 Aug 16;9(1):163


40. Tang XF, Zhang Z, Hu DY, Xu AE, Zhou HS, Sun LD, Gao M, Gao TW, Gao XH, Chen HD, Xie HF, Tu CX, Hao F, Wu RN, Zhang FR, Liang L, Pu XM, Zhang JZ, Han JW, Pan GP, Wu JQ, Li K, Su MW, Du WD, Zhang WJ, Liu JJ, Xiang LH, Yang S, Zhou YW, Zhang XJ. Association Analyses Identify Three Susceptibility Loci f[or] Vitiligo in the Chinese Han Population. J Invest Dermatol. 2013 Feb;133(2):403-10. doi: 10.1038/jid.2012.320. Epub 2012 Sep 6.


41. Yuan Zhou, Wei-Dong Du?, Gang Chen, Jian Ruan, Song Xu, Fu-Sheng Zhou, Xian-Bo Zuo, Xian-Fa Tang, Hua-Yang Tang, Zhao-Jie Lv, Xue-Jun Zhang. Association analysis of genetic variants in microRNA networks [and] gastric cancer risk in the Chinese Han population. J Cancer Res Clin Oncol. 2012 Jun;138(6):939-45


42. Xia HZ, Wu Q, Du WD?, Liu Y, Chen G, Yang F, Zhou FS, Tang XF, Tang HY, Ruan J, Chen YL, Sun LD, Zhang XJ. Association of genetic variants of VEGF gene with gastric carcinoma risk. J Biochips [and] Tissue Chips 2011; S1, doi: 10.4172/2153-0777.S1-005


43. Wang WJ, Yin XY, Zuo XB, Cheng H, Du WD, Zhang FY, Yang S, Zhang XJ. Gene–gene interactions in IL23/Th17 pathway contribute to Psoriasis Susceptibility in Chinese Han population. J Eur Acad Dermatol Venereol. 2013 Sep;27(9):1156-62. doi: 10.1111/j.1468-3083.2012.04683.x. Epub 2012 Aug 22.


44. Tang XF, Tang HY, Sun LD, Xiao FL, Zhang Z, Li Y, Zuo XB, Zhou FS, Yang KL, Fang P, Liu YH, Du WD, Yang S, Duan ML, Zhang XJ. Genetic variant rs** at 14q11.2 is associated with allergic rhinitis in a Chinese Han population running title: 14q11.2 is a susceptibility locus f[or] allergic rhinitis. J Investig Allergol Clin Immunol. 2012;22(1):55-62.



1. 杜卫东、刘胜胜。一种用于检测肝癌血清糖链的SPDP修饰凝集素芯片及其制备与应用。中国发明专利。申请号：2.X：（实审中）。授权公布日期2020年06月12日；


2. 杜卫东、高毅。一种适用于人类血清十种糖链检测的凝集素芯片及其制备和使用方法。中国方面专利。申请号： 2018 1 **.0（实审中）。授权公布日期2018年07月27日；


3. 杜卫东、刘倩。一种用于检测液相蛋白质交互作用的蛋白质芯片及其制备方法和应用。中国方面专利。申请号： 2018 1 **.8（实审中）。授权公布日期2018年12月18日；


4. 杜卫东、吕慧。一种用于EV病毒衣壳抗原和核抗原1蛋白抗体联合检测的蛋白质芯片及其制备和应用。中国方面专利。专利号：ZL2016 1 **.5。授权公告日2018年11月23日


5. 杜卫东、黄娜丽、叶雷。一种琥珀酰-β-环糊精修饰的莱姆病诊断用蛋白质芯片及其制备与应用。中国发明专利。专利号：ZL2016 1 **.X。授权公告日：2017年09月19日；


6. 杜卫东、叶雷。一种用于莱姆病鞭毛抗原免疫血清学诊断的蛋白质芯片及其制备方法和应用。国家发明专利。专利号：ZL2014 1 **.6。授权公告日：2016年09月07日


7. 杜卫东、黄娜丽、叶雷。一种基于梅毒血清学检测蛋白质芯片制备与应用。中国发明专利。专利号：ZL2015 1 **.7，授权公告日：2016年09月28日


8. 杜卫东，张学军，曹慧敏，赵建龙，陈刚，李伟。线粒体病MELAS和MERRF综合征相关mtDNA突变位点检测基因芯片及检测方法。 中国发明专利，专利号： ZL 2007 1 **.0，授权公告日：2011年11月05日


9. 杜卫东，赵建龙，张学军，曹慧敏，金庆辉，陈刚。Leber氏遗传性视神经病变相关mtDNA突变位点集成检测基因芯片及其制备与应用。 中国发明专利，专利号：ZL 2008 1 **.7，授权公告日：2012年05月02日



荣誉与奖励建设中...