李维祖职称：教授
联系电话：
email：liweizu@126.com
研究方向：1.神经药理学2.内分泌药理学

个人简历科研项目论文专著专利与技术许可荣誉与奖励
李维祖，男，1971年6月生，教授，博士，博士生导师，安徽医科大学基础医学院药理学教研室副主任，安徽省药理学会理事。主要从事药理学教学和科研工作，研究方向为神经药理学和内分泌药理学，主要从事自然衰老过程中皮层和海马神经元结构和功能变化及机制；慢性应激和糖皮质激素促进皮层和海马神经元损伤、衰老及人参皂苷Rg1抗衰老作用等的研究；黄芪甲苷对糖尿病及其并发症的作用及机制研究等。


教育经历


2007.9–2010.7, 安徽医科大学, 药理学, 博士, 导师: 李卫平
2002.9–2005.7, 安徽医科大学, 药理学, 硕士, 导师: 李卫平
1991.9–1996.7, 兰州医学院, 预防医学, 学士, 导师:


工作经历


2015.9-2016.9, 北方德克萨斯大学, 健康科学中心, 访问****

2014.10-至今, 安徽医科大学, 基础医学院, 教授

2010.10-2014.9, 安徽医科大学, 基础医学院, 副教授

2005.7-2010.9, 安徽医科大学, 基础医学院, 讲师。




1. 安徽省科技重大专项，201903a**，化药1类缺血性脑卒中治疗新药——HY-021068 I期临床研究，2019.07- 2022.06，150万元，在研，参加。


2. 国家自然科学基金，面上项目，**，基于DAG/TRPC6/NFAT信号通路探讨游离脂肪酸联合高糖对糖尿病肾病肾小球纤维化的影响及其机制，2020.01- 2023.12，55万元，在研，参加。


3. 国家自然科学基金，面上项目，**，NADPH氧化酶介导的NLRP-1炎症小体激活在脑老化认知功能障碍中的作用及人参皂苷Rg1的调节作用，2017.01-2018.12，25万元，已结题，主持。


4. 国家自然科学基金，面上项目，**，糖皮质激素对海马神经元NLRP1炎症小体的调节作用及在海马神经元损伤中的作用， 2014.01-2017.12，70万元，已结题，主持。


5. 国家自然科学基金，面上项目，**，TRPC6蛋白在糖尿病肾病发病机制中的调控作用及其黄芪总苷的防治作用研究，2012.1-2015.12，56万元，已结题，参加。



1. Shixin Ding(#), Han Zhang(#), Zhenghao Sun(#), Yuli Han, Yan Li, Xianan Dong, Yanyan Yin, Weiping Li(*), Weizu Li(*). Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice[J]. Journal of Functional Foods, 2020, 72:104049.


2. Yong Su, Qingqing Chen, Yinghui Ju, Weizu Li(*), Weiping Li(*). Palmitate induces human glomerular mesangial cells fibrosis through CD36-mediated transient recept[or] potential canonical channel 6/nuclear fact[or] of activated T cell 2 activation[J]. Biochimica et Biophysica Acta (BBA) - Molecular [and] Cell Biology of Lipids, 2020, 12:1865.


3. Zhongyuan Wang(#); Yunfeng Zhu(#); Yanhua Zhang(#); Jie Zhang(#); Tianjiao Ji; Weizu Li(*); Weiping Li(*). Protective effects of AS-IV on diabetic cardiomyopathy by improving myocardial lipid metabolism in rat models of T2DM. Biomed Pharmacother. 2020, 127:110081.


4. Xiaoyan Shen(#); Xianan Dong(#); Yuli Han(#); Yan Li(#); Shixin Ding; Han Zhang; Zhenghao Sun; Yanyan Yin; Weiping Li(*); Weizu Li(*). Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 [and] NLRP3 inflammasome activation in SAMP8 mice. Int Immunopharmacol. 2020, 82:106339.


5. Sun, Lingling(#); Chen, Yali(#); Shen, Xiaoyan(#); Xu, Tanzhen; Yin, Yanyan; Zhang, Han; Ding, Shixin; Zhao, Yan; Zhang, Yuling; Guan, Yajun; Li, Weizu(*). Inhibition of NOX2-NLRP1 signaling pathway protects against chronic glucocorticoids exposure-induced hippocampal neuronal damage. International Immunopharmacology, 2019, 74: 105721.


6. Ma Yuhong(#); Li Weizu(#); Shotorbani Parisa Yazdizadeh; Dubansky Brooke Hopkins; Huang Linjing; Chaudhari Sarika; Wu Peiwen; Wang Lei A; Ryou Myoung Gwi; Zhou Zhengyang; Ma Rong(*). Comparison of diabetic nephropathy between male [and] female eNOS(-/-) db/db mice. American Journal of Physiology - Renal Fluid [and] Electrolyte Physiology, 2019, 316(5): F889-F897.


7. Su Yong; Chen Qingqing; Ma Keke; Ju Yinghui; Ji Tianjiao; Wang Zhongyuan; Li Weizu(*); Li Weiping(*). Astragaloside IV inhibits palmitate-mediated oxidative stress [and] fibrosis in human glomerular mesangial cells via downregulation of CD36 expression. Pharmacological Reports, 2019, 71(2): 319-329.


8. Ju Yinghui; Su Yong; Chen Qingqing; Ma Keke; Ji Tianjiao; Wang Zhongyuan; Li Weizu(*); Li Weiping(*). Protective effects of Astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats. Biomedicine & Pharmacotherapy, 2019, 109: 84-92.


9. Xu Tan-Zhen(#); Shen Xiao-Yan(#); Sun Ling-Ling(#); Chen Ya-Li(#); Zhang Bi-Qiong; Huang Da-Ke; Li Wei-Zu(*). Ginsenoside Rg1 protects against H2O2induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro. International Journal of Molecular Medicine, 2019, 43(2): 717-726.


10. Tanzhen Xu(#); Lingling Sun(#); Xiaoyan Shen(#); Yali Chen(#); Yanyan Yin; Junyan Zhang; Dake Huang; Weiping Li; Weizu Li(*). NADPH oxidase 2-mediated NLRP1 inflammasome activation involves in neuronal senescence in hippocampal neurons in vitro. International Immunopharmacology, 2019, 69: 60-70.


11. Chen, Qingqing; Su, Yong; Ju, Yinghui; Ma, Keke; Li, Weizu(*); Li, Weiping(*). Astragalosides IV protected the renal tubular epithelial cells from free fatty acids-induced injury by reducing oxidative stress [and] apoptosis. Biomedicine & Pharmacotherapy, 2018, 108: 679-686.


12. Li, Weizu (#); Ding, Yanfeng; Smedley, Crystal; Wang, Yanxia; Chaudhari, Sarika; Birnbaumer, Lutz; Ma, Rong (*), Increased glomerular filtration rate [and] impaired contractile function of mesangial cells in TRPC6 knockout mice, Scientific Reports, 2017.6.23, 7: 1~12.


13. Zhang, Biqiong (#); Zhang, Yaodong; Wu, Wenning; Xu, Tanzhen; Yin, Yanyan; Zhang, Junyan; Huang, Dake; Li, Weizu (*), Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage, Journal of Neuroinflammation, 2017.7.21, 14: 139~152.


14. Zhang, Yaodong (#); Hu, Wen; Zhang, Biqiong; Yin, Yanyan; Zhang, Junyan; Huang, Dake; Huang, Rongrong; Li, Weiping; Li, Weizu (*), Ginsenoside Rg1 protects against neuronal degeneration induced by chronic dexamethasone treatment by inhibiting NLRP-1 inflammasomes in mice, International Journal of Molecular Medicine, 2017.10, 40(4): 1134~1142.


15. Biqiong Zhang (#); Yaodong Zhang; Tanzhen Xu; Yanyan Yin; Rongrong Huang; Yuchan Wang; Junyan Zhang; Dake Huang; Weizu Li (*), Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro, International Immunopharmacology, 2017.8, 49: 222~230.


16. Wen Hu (#); Yaodong Zhang; Wenning Wu; Yanyan Yin; Dake Huang; Yuchan Wang; Weiping Li; Weizu Li (*), Chronic glucocorticoids exposure enhances neurodegeneration in the frontal cortex [and] hippocampus via NLRP-1 inflammasome activation in male mice, Brain, Behavior, [and] Immunity, 2016.2, 52: 58~70.


17. Wang, Yu-Chan (#); Li, Wei-Zu (#); Wu, Yu; Yin, Yan-Yan; Dong, Liu-Yi; Chen, Zhi-Wu; Wu, Wen-Ning, Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons, J Neuroinflammation, 2015, 12(1): 246~246.


18. Kan, Hongwei (#); Hu, Wen; Wang, Yuchan; Wu, Wangyang; Yin, Yanyan; Liang, Yan; Wang, Chunyan; Huang, Dake; Li, Weizu (*), NADPH oxidase-derived production of reactive oxygen species is involved in learning [and] memory impairments in 16-month-old female rats, Molecular Medicine Reports, 2015.9, 12(3): 4546~4553.



专利与技术许可建设中...
1. 安徽医科大学2016年度最具影响力十佳论文


2. 2013年、2018年获安徽医科大学优秀教师