沈玉先职称：教授
联系电话：
email：shenyx@ahmu.edu.cn
研究方向：1.内质网应激与疾病2.功能蛋白与药物作用靶点3.蛋白转录后修饰与蛋白降解

个人简历科研项目论文专著专利与技术许可荣誉与奖励
沈玉先博士、二级教授、博士生导师，教育部“新世纪优秀人才支持计划”入选者，省领军人才团队带头人、省“115”产业创新团队带头人、省学术技术带头人、省高校拔尖人才、省先进工作者、全国妇女十二大代表等。现任安徽医科大学基础医学院院长、生物药物研究所所长。


一、学历
1984.09 -1989.06 安徽医科大学医学系本科/学士
1989.09 -1992.06 安徽医科大学药理学专业研究生/硕士
1997.09 -2000.06 安徽医科大学药理学专业研究生/博士


二、工作经历
1992.07 -1995.06 安徽医科大学临床药理研究所助教
1995.07 -1999.10 安徽医科大学临床药理研究所讲师
1999.11-2003.10 安徽医科大学临床药理研究所副教授
2003.02 -2004.08 美国马利兰大学生物技术研究所博士后研究
2005.05 -2008.12 中国科学技术大学生命科学院博士后研究
2003.11-2007.05 安徽医科大学临床药理研究所教授
2007.06 -2010.06 省部共建教育部重点实验室教授
2009.01 -2010.12 安徽医科大学护理学院副院长
2010.07 -2012.05 安徽医科大学基础医学院教授，常务副院长
2012.06 -至今 安徽医科大学基础医学院教授，院长


三、主要学术任职
中国药理学会抗炎免疫专业委员会委员、世界中医药学会联合会中医药免疫专业委员会常务理事；安徽省药理学会常务理事；安徽省色谱学会常务理事；Journal of Pharmacological Science编委、中国药理学通报编委、安徽医科大学学报编委、NatComm、FreeRadicalBioMed、BrainBehaviorandImmunity、SciRep等10 余种SCI源期刊的审稿人。

1. 国家自然科学基金委员会，面上项目，**，神经因子MANF介导的单核/巨噬细胞表型及功能的可塑性对肝纤维化的抑制作用及机制研究，2020-01至2023-12，55万元，在研，主持；


2. 国家自然科学基金委员会，面上项目，**，肝细胞源性神经营养因子MANF经外泌体靶向HSCs的抗肝纤维化作用及机制研究，2017-01至2020-12，60万元，在研，主持；


3. 安徽省转化医学研究院，科研基金项目，2017zhyx34，基于新型神经营养因子MANF的双级靶向纳米递送系统的设计及其在缺血性脑卒中治疗中的应用，2018-01至2020-12，30万元，在研，主持；


4. 安徽省教育厅，安徽省领军人才团队项目，慢性应激与重大疾病研究，2017-01至2018-12，400万元，已结题，团队带头人；


5. 国家科技部，国家重点研发计划重大慢性非传染性疾病防控研究项目，2016YFC**，基于单细胞基因表达谱的神经环路解析，2016-09至2020-12，36万元，在研，子课题负责人；


6. 国家自然科学基金委员会，面上项目，**，新型神经营养因子MANF对肝细胞癌的抑制作用及其机制研究，2014-01至2017-12，85万元，已结题，主持；


7. 国家自然科学基金委员会，重大研究计划（培育项目），**，内质网应激在乙型肝炎-肝硬化-肝癌转化过程中的调节机制及相关药物作用靶分子筛选，2012-01至2014-12，80万元，已结题，主持；


8. 国家自然科学基金委员会，面上项目，**，炎症诱导的ARMET转录激活及其对NF-κB信号通路的调节机制，2012-01至2015-12，63万元，已结题，主持；


9. 国家教育部，博士点基金（博导类），201**，炎症诱导的ARMET转录激活及其对NF-κB信号通路的调节机制，2012-01至2014-12，12万元，已结题，主持；


10. 国家自然科学基金委员会，面上项目，**，内质网应激蛋白ARMET对关节炎滑膜细胞过度增殖的负性调控，2011-01至2011-12，10万元，已结题，主持；


11. 国家自然科学基金委员会，面上项目，**，泛素连接酶Hrd1介导的tau蛋白降解，2008-01至2010-12，34万元，已结题，主持；


12. 安徽省科技厅，科技攻关计划项目，，内质网应激蛋白stresslin检测方法的建立及临床应用， 2007-01至2009-12，15万元，已结题，主持；


13. 国家自然科学基金委员会，面上项目，**，泛素连接酶hHrd1对1-抗胰蛋白酶Z变异型的降解的调控机制，2006-01至2008-12，27万元，已结题，主持；


14. 国家教育部，重点项目，206067，泛素连接酶 hHrd1和异常磷酸化tau功能性相互作用研究， 2006-1至2008-12 ，8万元，已结题，主持；


15. 国家教育部，新世纪优秀人才支持计划，NCET-04-0589，泛素-蛋白酶体通路调控1-抗胰蛋白酶Z变异型的降解，2005-01至2007-12，50万元，已结题，主持；


16. 中国博士后科学基金会，一等资助，，泛素连接酶 hHrd1和异常磷酸化tau功能性相互作用研究，2005-01至2007-12，3万元，已结题，主持。



1. Goma Chhetri, Yanyan Liang, Juntang Shao, Dan Han, Yi Yang, Chao Hou, Peng Wang, XiaoFang Tao, Yujun Shen, Tongcui Jiang, Lijie Feng, Yuxian Shen*. Role of Mesencephalic Astrocyte-Derived Neurotrophic Fact[or] in Alcohol-Induced Liver Injury. Oxidative Medicine [and] Cellular Longevity, 2020, Jul 7;2020:**. doi: 10.1155/2020/**. eCollection 2020.


2. Ma YY, Di ZM, Cao Q, Xu WS, Bi SX, Yu JS, Shen YJ, Yu YQ, Shen YX*, Feng LJ*. Xanthatin induces glioma cell apoptosis [and] inhibits tum[or] growth via activating endoplasmic reticulum stress-dependent CHOP pathway. Acta Pharmacol Sin, 2020, 41: 404–414.


3. Fei Mengyu#, Song Meng-Meng #, Wang Pei, Pang Gaozong, Chen Jing, Lu Dapeng, Liu Rui, Zhang Guiyang, Zhao Tingting, Shen Yuxian*, Yu Yongqiang*. Folic acid modified Fe3O4 nanoclusters by a one-step ultrasonic technique f[or] drug delivery [and] MR imaging. RSC Advances, 2020, 10, 5294.


4. Liu Jun#, Wu Zhengsheng#, Han Dan, Wei Chuansheng, Liang Yanyan, Jiang Tongcui, Chen Lu, Sha Manqi, Cao Yajie, Huang Fan, Geng Xiaoping, Yu Jishuang, Shen Yujun, Wang Hua, Feng Lijie, Wang Dong, Fang Shengyun, Wang Siying*, Shen Yuxian*，MANF inhibits liver cancer via SUMOylation-related suppression of NF-κB/Snail signaling pathway [and] epithelial-mesenchymal transition，Hepatology, 2019.8.30, 71(4):1262-1278.


5. Hou Chao#,Wang Dong#, Li Xiang, He Yufeng, Wei Chuansheng, Jiang Rong, Liu Jun , Feng Lijie , Shen Yuxian*. MANF regulates splenic macrophage differentiation in mice. Immunology Letters, 2019, 212: 37-45.


6. Xiang Huihui#, Song Mengmeng#, Fei Mengyu, Wang Runjie, Tao Xiaofang, Shen Yuxian*, Yu Yongqiang*. Facile synthesis of multifunctional nanocomposites with good compatibility f[or] efcient dual mode T1 [and] T2 magnetic resonance imaging [and] gene delivery. Applied Nanoscience, 2019, 9(8): 2019-2030.


7. He Kewu, Li Jiajia, Shen Yuxian*, Yu Yongqiang*, pH-Responsive polyelectrolyte coated gadolinium oxide-doped mesoporous silica nanoparticles (GdO@MSNs) f[or] synergistic drug delivery [and] magnetic resonance imaging enhancement, Journal of Materials Chemistry B, 2019, 7(43): 6840-6854


8. Feng Lijie#, Murugan Madhuvika#, Bosco Dale B., Liu Yong, Peng Jiyun, Worrell Gregory A., Wang Hailong, Ta Lauren E., Richardson Jason R., Shen Yuxian*, WuLongjun*, Microglial Proliferation [and] Monocyte Infiltration Contribute to Microgliosis following Status Epilepticus, Glia, 2019, 67(8): 1434-1448.


9. Xu Shengchun, Di Zemin, He Yufeng, Wang Runjie, Ma Yuyang, Sun Rui, Li Jing, Wang Tao, Shen Yujun, Fang Shengyun, Feng Lijie*, Shen Yuxian*, Mesencephalic astrocyte-derived neurotrophic fact[or] (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress, Journal of Neuroinflammation, 2019.2.13, 16(1)


10. Song Mengmeng, Xiang Huihui, Fei, Mengyu, Lu, Dapeng, Jiang Tongcui, Yu Yongqiang, Liu Rui*, Shen Yuxian*. Facile fabrication of water-dispersible nanocomposites based on hexa-peri-hexabenzocoronene [and] Fe3O4 f[or] dual mode imaging (fluorescent/MR) [and] drug delivery. RSC Advances, 2018, 8(71): 40554-40563.


11. Wang Changhui, Jiang Tongcui, Qiang Weimin, Zang Li, Feng Lijie, Shen Yujun [and] Shen Yuxian*. Activat[or] protein 1 is a novel regulat[or] of mesencephalic astrocyte derived neurotrophic fact[or] tranion. Molecular Medicine Reports, 2018, 18(5): 5765-5774.


12. Bi Sixing, Li Xiaohu, Wei Chuansheng, Xiang Huihui, Shen Yuxian*, Yu Yongqiang. The antitumour growth [and] antiangiogenesis effects of xanthatin in murine glioma dynamically evaluated by dynamic contrast‐enhanced magnetic resonance imaging. Phytotherapy Research, 2018, 33(1): 149-158.


13. Wang Dong, Hou Chao, Cao Yajie, Cheng Qiyao, Zhang Li, Li Hong, Feng Lijie, Shen Yuxian*. XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF promoter region in hepatitis B. Int J Biochem Cell B, 2018, 99: 140-146.


14. Shi Tianlu, Zhang Lei, Cheng Qiyao, Yu Jishuang, Liu Jun, Shen Yujun, Feng Xiaojun, Shen Yuxian*. Xanthatin induces apoptosis by activating endoplasmic reticulum stress in hepatoma cells. European Journal of Pharmacology, 2019, 843: 1–11.


15. Song MM*, Xu HL, Liang JX, Xiang HH, Liu R,Shen YX*. Lactoferrin modified graphene oxide iron oxide nanocomposite f[or] glioma-targeted drug delivery. Materials Science & Engineering C-Materials f[or] Biological Applications. 2017 Aug 1;77:904-911.


16. Zhang WP, Chen LH, Feng H, Wang W, Cai Y , Qi F, Tao XF, Liu J, Shen YJ, Ren XF, Chen X , Xu JM*, Shen YX*. Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression [and] enhancing the Nrf2-mediated adaptive response. Free Radical Biology [and] Medicine. 2017,112: 24-35.


17. Zhang D, Li MM, Dong Y, Zhang XH, Liu XY, Chen ZM, Zhu YJ, Wang HM, Liu XW, Zhu JL, Shen YJ, Korner H, Ying SC*, Fang SY* [and] Shen YX*. 1α, 25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells. Innate Immunity. 2017 Jan 1:**25391. doi: 10.1177/**25391. Epub ahead of print.


18. Feng LJ, Zhang J, Zhu N, Ding Q, Zhang XJ, Yu JS, Qiang WM, Zhang ZT, Ma YY, Huang DK, Shen YJ, Fang SY, Yu YF, Wang HP, Shen YX*. Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/alpha-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy. Autophagy. 2017 Apr 3;13(4):686-702.


19. Wu F, Wang P, Shen YX, Nobuo N. Noda, Zhang H. Small differences make a big impact: Structural insights into the differential function of the 2 Atg8 homologs in C. elegans. Autophagy. 2016;12(3):606-7. doi: 10.1080/**.2015.**.


20. Zhang WP, Chen LH, Shen YX, Xu JM. Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicol In Vitro. 2016 Oct;36:186-96. doi: 10.1016/j.tiv.2016.07.017.


21. Liu J, Tao X, Zhang J, Wang P, Sha M, Ma Y, Geng X, Feng L, Shen Y , Yu Y, Wang S, Fang S, Shen Y*. Small ubiquitin-related modifier 1 is involved in hepatocellular carcinoma progression via mediating p65 nuclear translocation. Oncotarget. 2016, 7(16): 22206-22218.


22. Wang XY, Song MM, Bi SX, Shen YJ, Shen YX*, Yu YQ*. MRI Dynamically Evaluates the Therapeutic Effect of Recombinant Human MANF on Ischemia/ReperfusionInjury in Rats. Int J Mol Sci. 2016 Sep 5;17(9). pii: E1476. doi: 10.3390/ijms**.


23. FangWJ, Han C, Zhang HB, Wei WM, Liu R, Shen YX*. Preparation of amino-functionalized magnetic nanoparticles f[or] enhancement of bacterial capture efficiency. RSC Adv., 2016, 6, 67875.


24. Wu F, Watanabe Y, Guo X, Qi X, Wang P, Zhao H, Wang Z, Fujioka Y, Zhang H, Ren J, Fang T, Shen Y, Feng W, Hu J, Noda N*, [and] Zhang H*. Structural basis of the differential function of the two C. elegans Atg8 homologs,LGG-1 [and] LGG-2, in autophagy. Molecular Cell 2015 Dec 17;60(6):914-29. doi: 10.1016/j.molcel.2015.11.019


25. Chen L, Feng L, Wang X, Du J, Chen Y, Yang W, Zhou C, Cheng L, Shen Y, Fang S, Li J, Shen Y*. Mesencephalic astrocyte-derived neurotrophic fact[or] is involved in inflammation by negatively regulating the NF-kB pathway. Sci Rep 2015; 5:8133. doi: 10.1038/srep08133.


26. Liu J, Sha M, Wang Q, Ma Y, Geng X, Gao Y, Feng L, Shen Y, Shen Y*. Small ubiquitin-related modifier 2/3 interacts with p65 [and] stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma. BMC Cancer 2015, 15:675.


27. Liu J, Zhou C, Tao X, Feng L, Wang X, Chen L, Li C, Huang D, Fang S, Shen Y*. ER stress-inducible protein MANF selectively expresses in human spleen. Hum Immunol 2015, 76 (11):823-30.


28. Chen L, Wan L, Du J*, Shen Y*. Identification of MANF as a protein interacting with RTN1-C. Acta Biochim Biophys Sin. 2014; pii: gmu125. [Epub ahead of print]


29. Yang W, Shen Y, Chen Y, Chen L, Wang L, Wang H, Xu S, Fang S, Fu Y, Yu Y*, Shen Y*. Mesencephalic astrocyte-derived neurotrophic fact[or] prevents neuron loss via inhibiting ischemia-induced apoptosis. J Neurol Sci. 2014; 344 (1-2):129-38.


30. Wang L, Tang W, Jiang T, Lu P, Li Y, Sun A, Shen Y, Chen Y, Wang H, Zong Z, Wang Y, Chen L, Shen Y*. Endoplasmic Reticulum Stress is Involved in the Neuroprotective Effect of Propofol. Neurochem Res. 2014; 39(9):1741-52.


31. Wang J, Chen Q, Wang X, Zu B, Xu J, Xu Y, Zuo X, Shen Y, Wang J, Shen Y*. Deficiency of IRE1 [and] PERK Signal Pathways in Systemic Lupus Erythematosus. Am J Med Sci. 2014 Sep 15. [Epub ahead of print] PubMed PMID: **.


32. Chen Z, Zhu M, Pan X, Zhu Y, Yan H, Jiang T, Shen Y, Dong X, Zheng N, Lu J, Ying S*, Shen Y*. Inhibition of Hepatitis B virus replication by SAMHD1. Biochem Biophys Res Commun. 2014; 450(4):1462-8.


33. Wang L, Chen L, Wang Q, Wang L, Wang H, Shen Y, Li X, Fu Y, Shen Y*, Yu Y*. Circulating endothelial progenit[or] cells are involved in VEGFR-2-related endothelial differentiation in glioma. Oncol Rep. 2014 Sep 5. doi: 10.3892/or.2014.3467.


34. Feng LJ, Jiang TC, Zhou CY, Yu CL, Shen YJ, Li J*, Shen YX*. Activated macrophage-[like] synoviocytes are resistant to endoplasmic reticulum stress-induced apoptosis in antigen-induced arthritis. Inflamm Res. 2014; 63(5):335-46.


35. Du J, An R, Chen L, Shen Y, Chen Y, Cheng L, Jiang Z, Zhang A, Yu L, Chu D, Shen Y, Luo Q, Chen H, Wan L, Li M, Xu X, Shen J. Toxoplasma gondii virulence fact[or] ROP18 inhibits the host NF-κB pathway by promoting p65 degradation. J Biol Chem. 2014; 289(18):12578-92.


36. Tang WX, Wang LK, Wang YQ, Zong ZJ, Gao ZX, Liu XS, Shen YJ, Shen YX, Li YH. Peroxisome proliferator-activated receptor-α activation protects against endoplasmic reticulum stress-induced HepG2 cell apoptosis. Mol Cell Biochem 2014, 385(1-2):179-90.


37. Chen Z, Zhong Y, Wang Y, Xu S, Liu Z, Baskakov IV, Monteiro MJ, Karbowski M*, Shen Y*, Fang S*. Ubiquitination-Induced Fluorescence Complementation (UiFC) f[or] Detection of K48 Ubiquitin Chains In Vitro [and] in Live Cells. PLoS One. 2013; 8 (9). doi:10.1371/annotation/65881dc3-5bce-4f0b-9060-7079e16b 1877.


38. Shen Y, Sun A, Wang Y, Cha D, Wang H, Wang F, Feng L, Fang S*, Shen Y*. Upregulation of mesencephalic astrocyte-derived neurotrophic fact[or] (MANF) in glial cells is associated with ischemia-induced glial activation. J Neuroinflammation. 2012, 9(1):254. doi: 10.1186/1742-2094-9-254.


39. Shen YX*, Sun AM, Fang S, Feng LJ, Li Q, Hou HL, Liu C, Wang HP, Shen JL, Luo J, Zhou JN*. Hrd1 Facilitates Tau Degradation [and] Promotes Neuron Survival. Curr Mol Med 2012, 12 (2): 138-52


40. Cheng L, Chen Y, Chen L, Shen Y, Shen J, An R, Luo Q, Du J. Interactions between the ROP18 kinase [and] host cell proteins that aid in the parasitism of Toxoplasma gondii. Acta Trop. 2012; 122(3):255-60.


41. Xu Z, Shi H, Mei Q, Shen Y, Xu J. Effects of macrophage metalloelastase on the basic fibroblast growth fact[or] expression [and] tum[or] angiogenesis in murine colon cancer. Dig Dis Sci. 2012; 57(1):85-91.


42. Du J, Chen L, Luo X, Shen Y, Dou Z, Shen J, Cheng L, Chen Y, Li C, Wang H, Yao X. 14-3-3zeta cooperates with phosphorylated Plk1 [and] is required f[or] correct cytokinesis. Front Biosci (Schol Ed). 2012; 4:639-50.


43. Wang H, Li Q, Shen Y, Sun A, Zhu X, Fang S, Shen Y*. The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin [and] increases its solubility. Mol Cell Biochem 2011; 346: 137-145.


44. Yu YQ, Liu LC, Wang FC, Liang Y, Cha DQ, Zhang JJ, Shen YJ, Wang HP, Fang S, Shen YX*. Induction profile of MANF/ARMET by cerebral ischemia [and] its implication f[or] neuron protection. J Cereb Blood Flow Metab 2010; 30:79-91


45. Lijie Feng, Yuxian Shen*, Aimin Sun, Yujun Shen, Shengyun Fang, Jun Li* Endoplasmic reticulum stress is involved in okadaic acid-induced tau phosphorylation [and] neurotoxic effects of okadaic acid. Neural Regen Res 2010; 5: 1534-1540


46. Wang W, Shen YX, Li J, Zhang SH, Luo QL, Zhong ZR, Jiang ZJ, Shen JL. Enhanced expression of the decoy recept[or] IL-13Ralpha2 in macrophages of Schistosoma japonicum-infected mice. Chin Med J (Engl). 2009; 122:1650-4.


47. Apostolou A, Shen Y, Liang Y, Luo J, Fang S. ARMET, a UPR-upregulated protein, inhibits cell proliferation [and] ER stress-induced cell death. Exp Cell Res. 2008; 314: 2454-67.


48. Sun GP, Wang H, Xu SP, Shen YX, Wu Q, Chen ZD, Wei W. Anti-tum[or] effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tum[or] cell apoptosis [and] stimulation of IL-2 [and] TNF-alpha production. Eur J Pharmacol. 2008 28; 584(2-3):246-52.


49. Xu Z, Shi H, Li Q, Mei Q, Bao J, Shen Y, Xu J. Mouse macrophage metalloelastase generates angiostatin from plasminogen [and] suppresses tum[or] angiogenesis in murine colon cancer. Oncol Rep. 2008; 20(1):81-8.


50. Li Y, Shen YX*, Feng LJ, Liu LH, Chen FH, Wu Q, Wang Hua. Blockage of the formation of new blood vessels by recombinant human endostatin contributes to the regression of rat adjuvant arthritis. Eur J Pharmacol 2007; 567: 166-70.


51. Shen Y, Ballar P, Apostolou A, Doong H, Fang SY. ER stress differentially regulates the stabilities of ERAD ubiquitin ligases [and] their substrates. Biochem Biophys Res Commun 2007; 352: 919-924.


52. Shen YX*, Zhang GG, Liu LH, Wang H, Xu SY. Suppressive of effects of melatonin on amyloid peptide-induced glial activation in rat hippocampus. Arch Med Res 2007; 38: 284-290.


53. Ballar P, Zhong Y, Nagahama M, Tagaya M, Shen Y, Fang S*. Identification of SVIP as an endogenous inhibit[or] of ER-associated degradation. J Biol Chem 2007; 282:33908-14.


54. Yang H, Zhong XY, Ballar P, Luo SQ, Shen YX, Rubinsztein DC, Monteiro MJ, Fang SY*. Ubiquitin ligase Hrd1 enhances the degradation [and] suppresses the toxicity of polyglutamine-expanded huntingtin. Exp Cell Res 2007; 313: 538-50.


55. Liu YJ, Zhuang J, Zhu HY, Shen YX, Tan ZL, Zhou JN*. Cultured rat cortical astrocytes synthesize melatonin: absence of a diurnal rhythm. J Pineal Res 2007; 43: 232-8.


56. Shen Y, Ballar P, Fang SY*. Ubiquitin ligase gp78 increases solubility [and] facilitates degradation of the Z variant of alpha-1-antitrypsin. Biochem Biophys Res Commun 2006; 349:1285-93.


57. Ballar P, Shen Y, Yang H, Fang SY*. The Role of a Novel p97/Valosin-containing Protein-interacting Motif of gp78 in Endoplasmic Reticulum-associated Degradation. J Biol Chem 2006; 281:35359-68


58. Hou HL, Shen YX, Zhu HY, Sun H, Yan XB, Fang H, Zhou JN*. Alterations of hHrd1 expression are related to hyperphosphorylated tau in the hippocampus in Alzheimer's disease. J Neurosci Res 2006; 84:1862-70.


59. Zhong XY, Shen YX, Ballar P, Apostolou A, Agami R, Fang SY*. Ubiquitin ligase gp78 enhances p97/VCP-polyubiquitin binding [and] promotes degradation of polyubiquitinated protein. J Biol Chem 2004; 279: 45676-45684


60. Yue L, Wang H, Liu LH, Shen YX*, Wei W*. Anti-adjuvant arthritis of recombinant human endostatin in rats via inhibition of angiogenesis [and] proinflammatory factors. Acta Pharmacol Sin 2004; 25: 1182-5


61. Shen YX*, Xu SY, Wei W, et al. The protective effects of melatonin from oxidative damage induced by amyloid beta-peptide 25-35 in middle-aged rats. J Pineal Res 2002; 32: 85-9.


62. Shen YX*, Xu SY, Wei W, et al. Melatonin blocks rat hippocampal neuronal apoptosis induced by amyloid beta-peptide 25-35. J Pineal Res 2002; 32: 163-7.


63. Shen YX*, Xu SY, Wei W, et al. Melatonin reduces memory changes [and] neural oxidation damage in mice treated with D-galactose. J Pineal Res 2002; 32: 173-8.


64. Shen YX*, Wei W, Xu SY. Protective effects of melatonin on the cortical -hippocampal neurotoxicity induced by amyloid beta-peptide 25-35. Acta Pharmacol Sin 2002; 23: 71-6.


65. Shen YX*, Wei W, Yang J, et al. Improvement of melatonin to learning [and] memory impairment induced by amyloid -peptide 25~35 in elder Rats. Acta Pharmacol Sin 2001; 22: 797-803.



1. 沈玉先; 吴正升; 李红; 李庆; 沈玉君; 基于MANF作为标记物的肝细胞癌和肝内胆管细胞癌鉴别产品及方法, 2018-7-24, 中国, ZL2.2. (专利)。

1. 2019年安徽省科学技术奖（自然科学类）一等奖（第一完成人）；


2. 2019 年第五届互联网+大学生创新创业大赛全国铜奖、安徽省金奖 (指导教师)；


3. 2015年安徽省科学技术奖（科技进步类）二等奖（第二完成人）；


4. 2014年安徽省科学技术奖（科技进步类）二等奖（第三完成人）。