吴强职称：教授
联系电话：
email：wuqiang@ahmu.edu.cn
研究方向：肿瘤病理1.乳腺癌临床病理；2.乳腺癌微环境对癌细胞生物学行为及肿瘤代谢的影响及其机制；3.卵巢癌诊断与治疗新手段和新方法及其机制。

个人简历科研项目论文专著专利与技术许可荣誉与奖励
吴强教授，博士生导师,安徽省学术与技术带头人。现任安徽医科大学国际教育学院院长、安徽医科大学第一附属医院病理科主任。安徽省抗癌协会肿瘤病理专业委员会主任委员、乳腺癌专业委员会副主任委员，安徽省医学会妇科肿瘤学分会常务委员，中国教育国际交流协会理事，中国高等教育学会外国留学生教育管理分会学术委员会成员。


教育经历


1981.09-1986.06 安徽医科大学临床医学系 临床医学专业 学士
1986.09-1989.06 安徽医科大学基础医学部 病理学专业 硕士
1989.07-今 安徽医科大学病理学教研室暨附属医院病理科 助教、讲师、副教授、教授
2000.09-2003.06 安徽医科大学临床药理研究所 药理学专业 博士
2005.10-2006.01 韩国高丽大学医学院病理学系暨附属安岩医院病理科 访问教授
2011.07-2001.08 韩国高丽大学附属九老医院病理科 访问****
2012.07-2012.09 澳大利亚塔斯马尼亚大学孟席斯医学研究所 访问****


从硕士研究生开始即在导师指导下开展乳腺癌的研究，先后主持国家自然科学研究基金3项，在微小RNA对乳腺癌侵袭转移的影响及机制研究以及肿瘤微环境中性粒细胞与肿瘤细胞间的相互作用对乳腺癌生物学行为的影响研究为乳腺癌预后判断及治疗提供了新思路，在Int J Cancer, Gene等杂志发表论文一百余篇，获安徽省科技进步奖3项、国家发明专利优秀奖1项。



1. 2017zhyx36安徽省转化医学研究院科研基金项目 circRNA100683在HER2阳性乳腺癌患者中的临床诊断作用 2018.01-2020.12


2. 2019H230安徽省学术和技术带头人及后备人选科研活动项目 乳腺癌侵袭转移相关circRNA的鉴定、甄选和临床应用研究 2019.1-2020.12


3. gxbjZD05安徽省高校优秀拔尖人才培育资助项目 2018.01-2019.12


4. **国家自然科学基金 miRNA在乳腺癌抗HER-2靶向治疗耐药中对HER-2蛋白表达的调控机制，2014.01-2017.12


5. **国家自然科学基金 miR-133a参与乳腺癌侵袭转移的调控及其机制，2012.01-2015.12


6. **国家自然科学基金 针对MMP-9靶基因的miRNAs筛选及外源性miRNAs干扰MMP-9表达对乳腺癌侵袭转移的影响，2009.01-2012.02



1. Zeyu Cai, Mingxun Zhang, Louis Boafo Kwantwi, Xiaomin Bi, Zhongle Cheng, Xiaojuan Ding, Tianhong Su, Hua Wang, Qiang Wu(通讯作者). Breast cancer cells promote self-migration by secreting interleukin 8 to induce NET formation. Gene, 2020Jun 13; 754: 144902.


2. Zhongle Cheng , Wei Wei, Zhengsheng Wu, Jing Wang, Xiaojuan Ding, Youjing Sheng, Yinli Han, [and] Qiang Wu（通信作者）. ARPC2 promotes breast cancer proliferation [and] metastasis. Oncol Rep，2019 41(6):3189-3200


3. Jing Wang, Yonghong Song, Mingxun Zhang, Zhengsheng Wu, Yun-Jun Xu, Jun Lin, Daishun Ling, Youjin Sheng, Yang Lu [and] Qiang Wu（通信作者）. Liposomal curcumol nanocomposite f[or] magnetic resonance imaging [and] endoplasmic reticulum stress mediated chemotherapy of human primary ovarian cancer. J. Mater. Chem. B, 2019, 7: 2938-2947


4. Xiaojuan Huang, Yu Xia, Guifang He, Lulu Zheng ,Yongping Cai, Yu Yin, [and] Qiang Wu（通信作者）. MALAT1 promotes angiogenesis of breast cancer. Oncol Rep, 2018；40: 2683-2689


5. Qing Zhang, Jiacheng Bi, Xiaodong Zheng, Yongyan Chen, Hua Wang, Wenyong Wu, Zhengguang Wang, Qiang Wu, Hui Peng, Haiming Wei, Rui Sun, Zhigang Tian. Blockade of the checkpoint recept[or] TIGIT prevents NK cell exhaustion [and] elicits potent anti-tum[or] immunity. Nature Immunology, 2018; 19(7):723-732


6. Xian Wang, Dongrui Jiang, Chengchen Xu, Guilu Zhu, Zhengsheng Wu, Qiang Wu（通信作者） Differential expression profile analysis of miRNAs with HER-2 overexpression [and] intervention in breast cancer cells. Int J Clin Exp Pathol 2017;10(5):5039-5062


7. Qiang Wu, Hong Yan , Siqi Tao, Xiaonan Wang , Lang Mou , Ping Chen ,Xingwang Cheng , Wenyong Wu , Zheng-sheng Wu.XIAP 3'-untranslated region as a ceRNA promotes FSCN1 function in inducing the progression of breast cancer by binding endogenous miR-29a-5p. Oncotarget, 2017, 8 (10): 16784-16800


8. Hong Yan, Min Zhao, Shan Huang, Ping Chen, Wen-yong Wu, Jin Huang, Zheng-sheng Wu, Qiang Wu（通讯作者）. Prolactin Inhibits BCL6 Expression in Breast Cancer Cells through a MicroRNA-339-5p-Dependent Pathway. J Breast Cancer 2016 ; 19(1): 26-33


9. Fei F, Zhang D, Yang Z, Wang S, Wang X, Wu Z, Qiang Wu（通讯作者） , Zhang S. The number of polyploid giant cancer cells [and] epithelial-mesenchymal transitionrelated proteins are associated with invasion [and] metastasis in human breast cancer. J Exp Clin Cancer Res. 2015; 34(1):158


10. Xiaonan Wang, Shujing Wang, Vijay Pandey, Ping Chen, Qing Li, Zhengsheng Wu, Qiang Wu（通讯作者）, [and] Peter E. Lobie. Trefoil fact[or] 3 as a novel biomarker to distinguish between adenocarcinoma [and] squamous cell carcinoma. Medicine. 2015; 94 (20): 1-10


11. Yu Yin, Tao Wang, Yongping Cai, Xiaojuan Huang, Yujie Li, Shunhua Chen, Rong Qin, Chaofu Wan, and Qiang Wu（通讯作者）. Microcystic/Reticular Schwannoma of the Mandible First Case Report [and] Review of the Literature. Medicine (Baltimore), 2015; 94(45):e1974.


12. Qiang Wu（通讯作者）, Xue Liu, Hong Yan, Yinhuan He, Shan Ye, Xingwang Cheng Guilu Zhu, Wenyong Wu, Xiaonan Wang, Xiangjun Kong, Xiaochun Xu, Peter E Lobie , Taozhu, [and] Zhengsheng Wu. B-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells. BMC Cancer. 2014; 14(1):418.


13. Haidan Jin, Minghua Cui, Jienan Kong, Xuelian Cui, ZhenhuaLin, Qiang Wu（通讯作者）, Shuangping Liu. Sineoculis homeobox homolog 1 protein is associated with breast cancer progression [and] survival outcome. Exp. Mol. Pathol, 2014; 97(1): 247–252


14. Z Wu, C Wang1, R Xiang, X Liu, S Ye, X Yang, Gg Zhang, X Xu, T Zhu [and] Q Wu（通讯作者） Loss of miR-133a expression associated with po[or] survival of breast cancer [and] restoration of miR-133a expression inhibited breast cancer cell growth [and] invasion. BMC Cancer 2012, 12:51


15. Gao Y, Wu Q（通讯作者）, Wu ZS, Zhang GH, Zhang AL, Yang F. Effects of an engineered anti-HER2 antibody chA21 on invasion of human ovarian carcinoma cell in vitro. Chin J Cancer Res, 2011; 23(2). 147-152.


16. AnLi Zhang, Hua Xue，XiaoGuang Ling, Yi Gao, Feng Yang, LianSheng Cheng, Jing Liu, Qiang Wu（通讯作者）. Anti-HER-2 engineering antibody ChA21 inhibits growth [and] induces apoptosis of SK-OV-3 cells. Journal of Experimental & Clinical Cancer Research 2010, 29:23


17. Zhang A, Shen G, Zhao T, Zhang G, Liu J, Song L, Wei W, Bing L, Wu Z, Wu Q（通讯作者）. Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 [and] trastuzumab in human ovarian carcinoma xenograft. J Ovarian Res. 2010,19;3:20


18.Zheng-sheng Wu, Qiang Wu（通讯作者）, Chao-qun Wang, Xiao-nan Wang, Yan Wang, Jing-jing Zhao, Shan-shan Mao, Gui-hong Zhang, Nong Zhang, [and] Xiao-chun Xu. MiR-339-5p inhibits breast cancer cell migration [and] invasion in vitro [and] may be a potential biomarker f[or] breast cancer prognosis. BMC Cancer 2010, 10:542



1.肿瘤蛋白p185检测试剂盒，国家发明专利，专利号：ZL 2013 1 **.7。第四发明人

1. 2016年安徽省科学技术奖（科技进步奖）三等奖，项目负责人


2. 2010安徽省科学技术奖（科技进步奖）三等奖，第二完成人


3. 2010中国专利奖优秀奖，第五完成人