陈远华职称：副教授
联系电话：**
email：yuanhuach@126.com
研究方向：1.孕期有害因素暴露对胎盘和胎儿发育损害的作用及其机制2.孕晚期高胆酸暴露对成年子代生殖损害的作用及其机制

个人简历科研项目论文专著专利与技术许可荣誉与奖励
陈远华副教授，医学博士、安徽省学术与技术带头人后备人选，中国毒理学会青年委员，中国预防医学会自由基专业委员会委员，安徽省解剖学会理事，“环境与职业医学杂志”青年编委。


教育工作经历


1999/09–2004/07，安徽医科大学，公共卫生学院，预防医学，学士
2004/09–2007/07，安徽医科大学，公共卫生学院，卫生毒理学，硕士
2007/07–2011/07，安徽医科大学，基础医学院，组织学与胚胎学系，助教
2010/09–2014/07，安徽医科大学，公共卫生学院，儿少卫生与妇幼保健学，博士
2011/09–2016/07，安徽医科大学，基础医学院，组织学与胚胎学系，讲师
2016/07– 至今， 安徽医科大学，基础医学院，组织学与胚胎学系，副教授



1. 安徽省高等学校自然科学研究项目重点项目，KJ2019A0224，胎盘IRE1α介导孕期胆汁淤积诱发宫内生长受限的作用，2019/07-2021/06，6万，主持。


2. 国家自然科学基金面上项目，**，胎盘内质网应激在LPS诱发胎儿宫内生长受限中的作用，2015/01－2018/12，74万，已结题，主持。


3. 国家自然科学基金青年基金，**，Wnt/β-catenin信号通路在细菌脂多糖致畸中的作用，2010/01－2012/12，20万，已结题，主持。



1. Gao XX, Ye MY, Liu Y, Li JY, Li L, Chen W, Lu X, Nie G*, Chen YH*. Prevalence [and] risk factors of intrahepatic cholestasis of pregnancy in a Chinese population. Sci Rep. 2020; doi: 10.1038/s41598-020-73378-5.


2. Chen YH, Liu ZB, Ma L, Zhang ZC, Fu L, Yu Z, Chen W, Song YP, Wang P, Wang H, Xu DX. Gestational Vitamin D Deficiency Causes Placental Insufficiency [and] Fetal Intrauterine Growth Restriction Partially through Inducing Placental Inflammation. J Steroid Biochem Mol Biol. 2020; 203:105733. doi: 10.1016/j.jsbmb.2020.105733.


3. Li L, Chen W, Ma L, Liu ZB, Lu X, Gao XX, Liu Y, Wang H, Zhao M, Li XL, Cong L, Xu DX*, Chen YH*. Continuous association of total bile acid levels with the risk of small f[or] gestational age infants. Sci Rep. 2020; 10(1):9257. doi: 10.1038/s41598-020-66138-y.


4. Lu X, Tan ZX, Wang B, Li J, Hu B, Gao L, Zhao H, Wang H, Chen YH*, Xu DX*. Maternal 1-nitropyrene exposure during pregnancy increases susceptibility of allergic asthma in adolescent offspring. Chemosphere. 2020;243:125356. doi: 10.1016/j.chemosphere.2019.125356.


5. Chen W, Gao XX, Ma L, Liu ZB, Li L, Wang H, Gao L, Xu DX*, Chen YH*. Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice. Oxid Med Cell Longev. 2019; 2019: **. doi: 10.1155/2019/**.


6. Chen YH*, Li L, Chen W, Liu ZB, Ma L, Gao XX, He JL, Wang H, Zhao M, Yang YY, Xu DX*. Pre-pregnancy underweight [and] obesity are positively associated with small-for-gestational-age infants in a Chinese population. Sci Rep. 2019;9(1):15544. doi: 10.1038/s41598-019-52018-7.


7. Fu L, Chen YH*, Xu S, Yu Z, Zhang ZH, Zhang C, Wang H, Xu DX*. Oral cholecalciferol supplementation alleviates lipopolysaccharide-induced preterm delivery partially through regulating placental steroid hormones [and] prostaglandins in mice. Int Immunopharmacol. 2019; 69:235-244. doi: 10.1016/j.intimp.2019.01.052.


8. Chen YH, Tao FB, Xu DX. The association between pre-pregnancy body mass index [and] risk of preterm delivery in Chinese population. Am J Epidemiol. 2018; 187:1123-1124. doi: 10.1093/aje/kwy016.


9. Chen YH, Fu L, Hao JH, Wang H, Zhang C, Tao FB, Xu DX. Influent factors of gestational vitamin D deficiency [and] its relation to an increased risk of preterm delivery in Chinese population. Sci Rep. 2018; 8(1):3608. doi: 10.1038/s41598-018-21944-3.


10. Fu L, Chen YH*,#, Chen X, Xu S, Yu Z, Xu DX. Vitamin D deficiency impairs neurobehavioral development in male mice. Physiol Behav. 2017; 179: 333-339. doi: 10.1016/j.physbeh.2017.07.017.


11. Shen R, Zhao LL, Yu Z, Zhang C, Chen YH*, Wang H, Zhang ZH, Xu DX*. Maternal di-(2-ethylhexyl) phthalate exposure during pregnancy causes fetal growth restriction in a stage-specific but gender-independent manner. Reprod Toxicol. 2017; 67:117-124. doi: 10.1016/j.reprotox.2016.12.003.


12. Chen YH, Hu XG, Zhou Y, Yu Z, Fu L, Zhang GB, Bo QL, Wang H, Zhang C, Xu DX. Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death [and] Intrauterine Growth Restriction through Its Anti-Inflammatory Activity. J Immunol. 2016;197(12):4762-70. doi: 10.4049/jimmunol.**.


13. Chen YH, Fu L, Hao JH, Yu Z, Zhu P, Wang H, Xu YY, Zhang C, Tao FB, Xu DX. Maternal vitamin D deficiency during pregnancy elevates the risks of small f[or] gestational age [and] low birth weight infants in Chinese population. J Clin Endocrinol Metab. 2015;100(5):1912-9. doi: 10.1210/jc.2014-4407.


14. Chen YH, Yu Z, Fu L, Wang H, Chen X, Zhang C, Lv ZM, Xu DX. Vitamin D3 inhibits lipopolysaccharide-induced placental inflammation through reinforcing interaction between vitamin D recept[or] [and] nuclear fact[or] kappa B p65 subunit. Sci Rep. 2015;5:10871. doi: 10.1038/srep10871.


15. Chen YH, Yu Z, Fu L, Xia MZ, Zhao M, Wang H, Zhang C, Hu YF, Tao FB, Xu DX. Supplementation with vitamin D3 during pregnancy protects against lipopolysaccharide-induced neural tube defects through improving placental folate transportation. Toxicol Sci. 2015;145(1):90-7. doi: 10.1093/toxsci/kfv036.


16. Chen YH, Zhao M, Chen X, Zhang Y, Wang H, Huang YY, Wang Z, Zhang ZH, Zhang C, Xu DX. Zinc supplementation during pregnancy protects against lipopolysaccharide-induced fetal growth restriction [and] demise through its anti-inflammatory effect. J Immunol. 2012;189(1):454-63. doi: 10.4049/jimmunol.**.


17. Chen YH, Xu DX, Wang JP, Wang H, Wei LZ, Sun MF, Wei W. Melatonin protects against lipopolysaccharide-induced intra-uterine fetal death [and] growth retardation in mice. J Pineal Res. 2006;40(1):40-7. doi: 10.1111/j.1600-079X.2005.00274.x.


18.Chen YH, Xu DX, Zhao L, Wang H, Wang JP, Wei W. Ascorbic acid protects against lipopolysaccharide-induced intra-uterine fetal death [and] intra-uterine growth retardation in mice. Toxicology. 2006;217(1):39-45. doi: 10.1016/j.tox.2005.08.010.


19. Chen YH, Wang JP, Wang H, Sun MF, Wei LZ, Wei W, Xu DX. Lipopolysaccharide treatment downregulates the expression of the pregnane X receptor, cyp3a11 [and] mdr1a genes in mouse placenta. Toxicology. 2005;211(3):242-52. doi: 10.1016/j.tox.2005.03.011.


20. Song YP, Chen YH (co-first author), Gao L, Wang P, Wang XL, Luo B, Li J, Xu DX. Differential effects of high-fat diets before pregnancy and/[or] during pregnancy on fetal growth development. Life Sci. 2018; 212: 241-250. doi: 10.1016/j.lfs.2018.10.008.


21. Fu L, Chen YH (co-first author), Xu S, Ji YL, Zhang C, Wang H, Yu DX, Xu DX. Vitamin D deficiency impairs testicular development [and] spermatogenesis in mice. Reprod Toxicol. 2017;73:241-249. doi: 10.1016/j.reprotox.2017.06.047.


22. Xie DD, Chen YH (co-first author), Xu S, Zhang C, Wang DM, Wang H, Chen L, Zhang ZH, Xia MZ, Xu DX, Yu DX. Low vitamin D status is associated with inflammation in patients with prostate cancer. Oncotarget. 2017; 8(13):22076-22085. doi: 10.18632/oncotarget.16195.


23. Zhou Y, Chen YH (co-first author), Fu L, Yu Z, Xia MZ, Hu XG, Wang H, Xu DX. Vitamin D3 pretreatment protects against lipopolysaccharide-induced early embryo loss through its anti-inflammatory effects. Am J Reprod Immunol. 2017; 77(3):e12620. doi: 10.1111/aji.12620.


24. Yang BB, Chen YH (co-first author), Zhang C, Shi CE, Hu KF, Zhou J, Xu DX, Chen X. Low vitamin D status is associated with advanced liver fibrosis in patients with nonalcoholic fatty liver disease. Endocrine. 2017;55(2):582-590. doi: 10.1007/s12020-016-1152-x.


25. Tan ZX, Chen YH (co-first author), Xu S, Qin HY, Wang H, Zhang C, Xu DX, Zhao H. Calcitriol inhibits tum[or] necrosis fact[or] alpha [and] macrophage inflammatory protein-2 during lipopolysaccharide-induced acute lung injury in mice. Steroids. 2016; 112: 81-87. doi: 10.1016/j.steroids.2016.05.005.


26. Bo QL, Chen YH (co-first author), Yu Z, Fu L, Zhou Y, Zhang GB, Wang H, Zhang ZH, Xu DX. Rosiglitazone pretreatment protects against lipopolysaccharide-induced fetal demise through inhibiting placental inflammation. Mol Cell Endocrinol. 2016; 423: 51-59. doi: 10.1016/j.mce.2016.01.004.


27. Tan ZX, Chen YH (co-first author), Xu S, Qin HY, Zhang C, Zhao H, Xu DX. Calcitriol inhibits bleomycin-induced early pulmonary inflammatory response [and] epithelial-mesenchymal transition in mice. Toxicol Lett. 2016;240(1):161-71. doi: 10.1016/j.toxlet.2015.10.022.


28. Xu S, Chen YH (co-first author), Tan ZX, Xie DD, Zhang C, Zhang ZH, Wang H, Zhao H, Yu DX, Xu DX. Vitamin D3 pretreatment regulates renal inflammatory responses during lipopolysaccharide-induced acute kidney injury. Sci Rep. 2015;5:18687. doi: 10.1038/srep18687.


29. Xu S, Chen YH (co-first author), Tan ZX, Xie DD, Zhang C, Xia MZ, Wang H, Zhao H, Xu DX, Yu DX. Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury. J Steroid Biochem Mol Biol. 2015;152:133-41. doi: 10.1016/j.jsbmb.2015.05.009.


30. Zhao M, Chen YH (co-first author), Chen X, Dong XT, Zhou J, Wang H, Wu SX, Zhang C, Xu DX. Folic acid supplementation during pregnancy protects against lipopolysaccharide-induced neural tube defects in mice. Toxicol Lett. 2014;224(2):201-8. doi: 10.1016/j.toxlet.2013.10.021.


31. Zhao M, Chen YH (co-first author), Dong XT, Zhou J, Chen X, Wang H, Wu SX, Xia MZ, Zhang C, Xu DX. Folic acid protects against lipopolysaccharide-induced preterm delivery [and] intrauterine growth restriction through its anti-inflammatory effect in mice. PLoS One. 2013;8(12):e82713. doi: 10.1371/journal.pone.**.


32. Zhao L, Chen YH (co-first author), Wang H, Ji YL, Ning H, Wang SF, Zhang C, Lu JW, Duan ZH, Xu DX. Reactive oxygen species contribute to lipopolysaccharide-induced teratogenesis in mice. Toxicol Sci. 2008;103(1):149-57. doi: 10.1093/toxsci/kfn027.



专利与技术许可建设中...
1. 陈远华（3/5）. 松果腺素的抗炎和抗凋亡作用机制. 安徽省自然科学一等奖. 安徽省人民政府，2017.


2. 陈远华（6/7）. 生命不同阶段暴露环境内分泌干扰物对男（雄）性生殖发育的损害效应. 中华医学科技奖. 中华医学会，2014.


3. 陈远华（4/8）. 细菌脂多糖对孕烷X受体及其靶基因CYP3A的下调作用，中华预防医学会，中华预防医学科技奖，三等奖，2009年.


4. 陈远华（3/8）.细菌脂多糖对小鼠成年肝脏、小肠、胎盘和胎肝CYP3A的下调作用，中华医学会，中华医学科技奖三等奖，2008年.


5. 陈远华（3/5）. 细菌脂多糖对小鼠成年肝脏、小肠、胎盘和胎肝CYP3A的下调作用. 安徽省自然科学二等奖. 安徽省人民政府，2008.


6. 陈远华（3/5）. 建立检测人精子细胞染色体畸变和DNA损伤的试验方法. 安徽省自然科学三等奖. 安徽省人民政府，2007.


7. 陈远华（1/3）. 安徽省第八届自然科学优秀学术论文，一等奖，2016.


8. 陈远华（1/3）. 安徽省第六届自然科学优秀学术论文，一等奖，2010.


9. 陈远华（1/3）. 安徽省第五届自然科学优秀学术论文，一等奖，2007.