丁克硕职称：副教授
联系电话：--
email：dingks@ahmu.edu.cn
研究方向：肿瘤分子病理学；非编码RNA在肿瘤中的作用机制；肿瘤靶向治疗和耐药；促癌基因；乳腺癌；胃癌。

个人简历科研项目论文专著专利与技术许可荣誉与奖励
教育经历
2004-2008 本科，中国科学技术大学，生物技术专业
2008-2014 博士，中国科学技术大学生命科学学院，肿瘤分子病理学实验室，细胞生物学专业


工作经历
2014-2017 安徽医科大学基础医学院病理学教研室/安徽医科大学第一附属医院病理科，校聘副教授/讲师
2017-至今 安徽医科大学基础医学院病理学教研室/安徽医科大学第一附属医院病理科，副教授



1. 安徽省自然科学基金青年科学基金项目，CPSF6促进胃癌细胞恶性行为并介导化疗药物抗性，2020年6月-2022年6月，基金号：**QH378


2. 国家自然科学基金青年科学基金项目，LMO4 3’端非编码区缩短调控肿瘤干细胞行为介导乳腺癌赫赛汀耐药性的研究，2016年1月-2018年12月，基金号：**


3. 安徽医科大学2014年度博士科研基金, miRNA-26靶向调控网络在乳腺癌药物抗性中的作用和机制，2015年1月-2018年1月，基金号：XJ201409


4. 安徽医科大学2015年度校科研基金, miRNA-26靶向调控HER2介导乳腺癌他莫昔芬抗药性, 2015年1月-2016年12月，基金号：2015xkj003



1. Xiang R, Han X,Ding K*, Wu Z*. CMIP promotes Herceptin resistance of HER2 positive gastric cancer cells.Pathol Res Pract. 2020; 216(2): 152776. (*Corresponding Author) (IF=1.794)


2. Cheng X, Wang X, Wu Z, Tan S, Zhu T,Ding K*. CORO1C expression is associated with po[or] survival rates in gastric cancer [and] promotes metastasis in vitro.FEBS Open Bio. 2019Jun;9(6):1097-1108. (*Corresponding Author) (IF=1.959)


3.Ding K, Wu Z, Li X, Sheng Y, Wang X, Tan S. LMO4 mediates trastuzumab resistance in HER2 positive breast cancer cells.Am J Cancer Res. 2018Apr 1;8(4):594-609.(IF=4.737)


4.Ding K, Tan S, Huang X, Wang X, Li X, Fan R, Zhu Y, Lobie PE, Wang W, Wu Z. GSE1 predicts po[or] survival outcome in gastric cancer patients by SLC7A5 enhancement of tum[or] growth [and] metastasis.J Biol Chem. 2018Jan 24. pii:jbc.RA117.001103.(IF=4.106)


5. Tan S#,Ding K#, Chong QY, Zhao J, Liu Y, Shao Y, Zhang Y, Yu Q, Xiong Z, Zhang W, Zhang M, Li G, Li X, Kong X, Ahmad A, Wu Z, Wu Q, Zhao X, Lobie PE, Zhu T. Post-tranional regulation of ERBB2 by miR26a/b [and] HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells.J Biol Chem. 2017Aug 18;292(33):13551-13564. (# Co-first Author)(IF=4.106)


6.Ding K, Yuan Y, Chong QY, Yang Y, Li R, Li X, Kong X, Qian P, Xiong Z, Pandey V, Ma L, Wu Z, Lobie PE, Zhu T. Autocrine Prolactin Stimulates Endometrial Carcinoma Growth [and] Metastasis [and] Reduces Sensitivity to Chemotherapy.Endocrinology. 2017Jun 1;158(6):1595-1611.(IF=3.8)


7.Ding K, Wu Z, Wang N, Wang X, Wang Y, Qian P, Meng G, Tan S. MiR-26a performs converse roles in proliferation [and] metastasis of different gastric cancer cells via regulating of PTEN expression.Pathol Res Pract. 2017May;213(5):467-475.(IF=1.794)


8. Lü M#,Ding K#, Zhang G, Yin M, Yao G, Tian H, Lian J, Liu L, Liang M, Zhu T, Sun F. MicroRNA-320a sensitizes tamoxifen-resistant breast cancer cells to tamoxifen by targeting ARPP-19 [and] ERRγ.Sci Rep. 2015Mar 4;5:8735.(# Co-first Author)(IF=4.011)


9.Ding K, Banerjee A, Tan S, Zhao J, Zhuang Q, Li R, Qian P, Liu S, Wu ZS, Lobie PE, Zhu T. Artemin, a Member of the Glial Cell Line-derived Neurotrophic Fact[or] Family of Ligands, Is HER2-regulated [and] Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-[like] Behavi[or] in Mammary Carcinoma Cells.J Biol Chem. 2014Jun 6;289(23):16057-71.(IF=4.106)


10. Tan S#,Ding K#, Li R, Zhang W, Li G, Kong X, Qian P, Lobie PE, Zhu T. Identification of miR-26 as a key mediat[or] of estrogen stimulated cell proliferation by targeting CHD1, GREB1 [and] KPNA2.Breast Cancer Res. 2014Apr 15;16(2):R40. (#Co-first Author)(IF=5.676)


11. Zhang W, Wu M, Chong QY, Zhang M, Zhang X, Hu L, Zhong Y, Qian P, Kong X, Tan S, Li G,Ding K,Lobie PE, Zhu T. Loss of Estrogen-Regulated MIR135A1 at 3p21.1 Promotes Tamoxifen Resistance in Breast Cancer.Cancer Res. 2018Sep 1;78(17):4915-4928.(IF=8.378)


12. Tan S, Li H, Zhang W, Shao Y, Liu Y, Guan H, Wu J, Kang Y, Zhao J, Yu Q, Gu Y,Ding K,Zhang M, Qian W, Zhu Y, Cai H, Chen C, Lobie PE, Zhao X, Sun J, Zhu T. NUDT21 negatively regulates PSMB2 [and] CXXC5 by alternative polyadenylation [and] contributes to hepatocellular carcinoma suppression.Oncogene. 2018Aug;37(35):4887-4900.(IF=6.634)


13. Chen C, Lei J, Zheng Q, Tan S,Ding K, Yu C. Poly(rC) binding protein 2 (PCBP2) promotes the viability of human gastric cancer cells by regulating CDK2.FEBS Open Bio. 2018Mar 22;8(5):764-773.(IF=1.959)


14. Li G, Wu X, Qian W, Cai H, Sun X, Zhang W, Tan S, Wu Z, Qian P,Ding K, Lu X, Zhang X, Yan H, Song H, Guang S, Wu Q, Lobie PE, Shan G, Zhu T. CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance.Cell Res. 2016Jun;26(6):655-73. (IF=17.848)


15. Chai P, Tian J, Zhao D, Zhang H, Cui J,Ding K, Liu B. GSE1 negative regulation by miR-489-5p promotes breast cancer cell proliferation [and] invasion.Biochem Biophys Res Commun. 2016Feb 26;471(1):123-8.(IF=2.705)


16. Zhang W, Qian P, Zhang X, Zhang M, Wang H, Wu M, Kong X, Tan S,Ding K, Perry JK, Wu Z, Cao Y, Lobie PE, Zhu T. Autocrine/Paracrine Human Growth Hormone-stimulated MicroRNA 96-182-183 Cluster Promotes Epithelial-Mesenchymal Transition [and] Invasion in Breast Cancer.J Biol Chem. 2015May 29;290(22):13812-29.(IF=4.106)


17. Jiang Y, Zhao X, Xiao Q, Liu Q,Ding K, Yu F, Zhang R, Zhu T, Ge G. Snail [and] Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition.J Mol Cell Biol. 2014Aug;6(4):352-4(IF=4.671)


18. Tan S, Li R,Ding K,Lobie PE, Zhu T. miR-198 inhibits migration [and] invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway.FEBS Lett. 2011Jul 21;585(14):2229-34.(IF=2.675)





专利与技术许可建设中...
1. 2020年，安徽医科大学优秀教师
2. 2018年，安徽医科大学科技新星
3. 2017年，乳腺癌侵袭转移和耐药性的基础研究及临床应用，安徽省科技厅，安徽省科技进步奖三等奖（排名第四）
4. 2017年, 安徽医科大学优秀研究生导师团队成员