路文杰职称：副教授
联系电话：**
email：wenjie63136@163.com
研究方向：1.代谢性疾病发生机制2.肿瘤代谢

个人简历科研项目论文专著专利与技术许可荣誉与奖励
路文杰，药理学博士，校聘副教授，硕士生导师。现任安徽医科大学基础医学院药理学党支部书记，中国药理学学会会员，中国抗癌协会整合肿瘤学专业委员会、肿瘤标志专业委员会会员。2015年毕业于四川大学生物治疗国家重点实验室/生物治疗协同创新中心，获博士学位，期间主要从事高尿酸血症及相关疾病的发病机制研究、小分子靶向抗肿瘤新药研发。2010年毕业于四川大学华西药学院，获药学学士学位。主持国家自然科学基金青年基金、安徽省自然科学基金青年基金、安徽医科大学博士科研启动基金各1项，指导省级大学生创新创业大赛项目2项。

1. **，国家自然科学基金青年基金，高尿酸血症通过上调PTP1B诱发血清胆固醇升高的作用及分子机制研究，2018.1-2020.12，20万


2. **QH209，安徽省自然科学基金青年基金，基于代谢组学技术探讨PTP1B对高尿酸血症诱发代谢综合征的介导作用及机制研究，2016.7-2018.6，8万



1. Ning, Liu; Qianqian, Sun; Hu, Xu; Xiaojuan, Yu; Wentong, Chen; Hongquan, Wei; Jie, Jiang; Youzhi, Xu; Wenjie, Lu*; Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver, The FASEB Journal, 2020, /(/): fj.R.


2. Sun, Qianqian; Yu, Xiaojuan; Peng, Chunwei; Liu, Ning; Chen, Wentong; Xu, Hu; Wei, Hongquan; Fang, Kun; Dong, Ziwei; Fu, Chuyu; Xu, Youzhi*;Lu, Wenjie*; Activation of SREBP-1c alters lipogenesis [and] promotes tum[or] growth [and] metastasis in gastric cancer, Biomedicine & Pharmacotherapy, 2020, 128: 110274.


3. Lu, Wenjie#; Sun, Qianqian#; Chen, Bo; Li, Yan; Xu, Youzhi*; Wang, Siying*; Novel agent #2714 potently inhibits lung cancer growth by suppressing cell proliferation [and] by inducing apoptosis in vitro [and] in vivo, Molecular Medicine Reports, 2019, 19(6): 4788-4796.


4. Li Man Li#; Xu You Zhi#; Lu Wen Jie#; Li Yong Huai; Tan Shi Sheng; Lin Hong Jun; Wu Tian Ming; Li Yan; Wang Si Ying; Zhao Ying Lan; Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy [and] inducing apoptosis, Oncology Letters, 2018, 15(3): 2839-2846.


5. Lu, Wen-Jie; Peng, Wen ; Sun, Qian-Qian ; Li, Yong-Huai ; Chen, Bo ; Yu, Luo-Ting ; Xu, You-Zhi *; Wang, Si-Ying *; Zhao, Ying-Lan*; #2714, a novel active inhibit[or] with potent G2/M phase arrest [and] antitum[or] efficacy in preclinical models, Cell Death Discovery, 2018, 4: 24.


6. Xiaoni Shao#; Wenjie Lu#; Fabao Gao#; Dandan Li; Jing Hu; Yan Li; Zeping Zuo; Hui Jie; Yinglan Zhao; Xiaobo Cen*; Uric Acid Induces Cognitive Dysfunction through Hippocampal Inflammation in Rodents [and] Humans, J Neurosci, 2016, 36(43): 10990-11005.


7. Xu, You-Zhi#; Li, Yong-Huai#; Lu, Wen-Jie#; Lu, Kun; Wang, Chun-Ting; Li, Yan; Lin, Hong-Jun; Kan, Li-Xin; Yang, Sheng-Yong; Wang, Si-Ying*; Zhao, Ying-Lan*; YL4073 is a potent autophagy-stimulating antitum[or] agent in an in vivo model of Lewis lung carcinoma, Oncology Reports, 2016, 35(6).


8. Lu, Wenjie#; Xu, Youzhi#; Shao, Xiaoni#; Gao, Fabao#; Li, Yan; Hu, Jing; Zuo, Zeping; Shao, Xue; Zhou, Liangxue; Zhao, Yinglan*; Cen, Xiaobo*; Uric Acid Produces an Inflammatory Response through Activation of NF-kappaB in the Hypothalamus: Implications f[or] the Pathogenesis of Metabolic Disorders, Scientific Reports, 2015, 5: 12144.


9. Xu, Youzhi#; Lu, Wenjie#; Yang, Peng#; Peng, Wen#; Wang, Chunting; Li, Manli; Li, Yan; Li, Guobo; Meng, Nana; Lin, Hongjun; Kan, Lixin; Wang, Siying; Yang, Shengyong; Yu, Luoting*; Zhao, YingLan*; A small molecular agent YL529 inhibits VEGF-D-induced lymphangiogenesis [and] metastasis in preclinical tum[or] models in addition to its known antitum[or] activities, BMC Cancer, 2015, 15: 525.


10. Lu, Wenjie; Xu, Youzhi; Zhao, Yinglan; Cen, Xiaobo*; Emerging technologies, recent developments, [and] novel applications f[or] drug metabolite identification, Current Drug Metabolism, 2014, 15(9): 865-874.


11. Xu, Youzhi#; Lin, Hongjun#; Meng, Nana#; Lu, Wenjie; Li, Guobo; Han, Yuanyuan; Dai, Xiaoyun; Xia, Yong; Song, Xiangrong; Yang, Shengyong; Wei, Yuquan; Yu, Luoting*; Zhao, Yinglan*; YL529, a novel, orally available multikinase inhibitor, potently inhibits angiogenesis [and] tumour growth in preclinical models, Br J Pharmacol, 2013, 169(8): 1766-1780.


12. Wang, Huijuan; Wang, Liang; Zhang, Hailong; Deng, Pengchi; Chen, Jie; Zhou, Bin; Hu, Jing; Zou, Jun; Lu, Wenjie; Xiang, Pu; Wu, Tianming; Shao, Xiaoni; Li, Yuan; Zhou, Zongguang*; Zhao, Ying-Lan*; (1)H NMR-based metabolic profiling of human rectal cancer tissue, Mol Cancer, 2013, 12(1): 121.


13. Wang, Liang#; Chen, Jie#; Chen, Longqi; Deng, Pengchi; Bu, Qian; Xiang, Pu; Li, Manli; Lu, Wenjie; Xu, Youzhi; Lin, Hongjun; Wu, Tianming; Wang, Huijuan; Hu, Jing; Shao, Xiaoni; Cen, Xiaobo; Zhao, Ying-Lan*; 1H-NMR based metabonomic profiling of human esophageal cancer tissue, Mol Cancer, 2013, 12: 25.


14. Li, Yan; Hu, Zhengtao; Chen, Bo; Bu, Qian; Lu, Wenjie; Deng, Yi; Zhu, Ruiming; Shao, Xue; Hou, Jing; Zhao, Jinxuan; Li, Hongyu; Zhang, Baolai; Huang, Yina; Lv, Lei; Zhao, Yinglan; Cen, Xiaobo*; Taurine attenuates methamphetamine-induced autophagy [and] apoptosis in PC12 cells through mT[or] signaling pathway, Toxicology Letters, 2012, 215(1): 1-7.



专利与技术许可建设中...
1. 2020年6月 获“优秀共产党员”称号


2. 2020年6月 获基础医学院青年教师首届微课比赛二等奖


3. 2019年3月 获基础医学院青年教师教学基本功暨课程思政竞赛基本功组一等奖


4. 2018年9月 获第一临床医学院优秀科研启蒙导师


5. 2017年10月 获安徽省药理学会2017年学术年会青年教师教学基本功竞赛一等奖