文继月职称：副教授
联系电话：**
email：wenjiyue139@aliyun.com
研究方向：神经药理学:主要从事缺血性脑病的分子机制研究

个人简历科研项目论文专著专利与技术许可荣誉与奖励
教育经历


1996.09-2001.05 安徽医科大学 医学系 临床医学专业 学士
2004.09-2007.07 安徽医科大学 基础医学院 药理学专业 硕士
2011.02-2015.10 东南大学 医学院 内科学 博士



1. 杜鹃花总黄酮抗脑缺血中风的内皮源性H2S抑制神经元等细胞中RhoA-ROCK通路的硫巯基化和磷酸化调节机制，国家自然科学基金面上项目，2020/01-2023/12,参与。


2. 氯化琥珀胆碱致死大鼠法医学研究，安徽省科技计划项目，2016/12-2019/12，参与。

1. Zhang F, Chen S, Wen JY, Chen ZW. 3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection [and] inhibition of the RhoA/ROCK pathway. American Journal Physiology Cell Physiology. 2020, 319(4):C720-C733.


2. Lu WZ, Wen JY. Neuroprotective roles of total flavones of Camellia on early brain injury [and] cognitive dysfunction following subarachnoid hemorrhage in rats. Metabolic Brain Diseases. 2020, 35(5):775-783.


3.Guo Y, Yu XM, Chen S, Wen JY, Chen ZW. Total flavones of Rhododendron simsii Planch flower protect rat hippocampal neuron from hypoxia-reoxygenation injury via activation of BKCa channel. Journal of Pharmacy Pharmacology. 2020,72(1):111-120.


4. Wen JY, Lu WZ, Meng JH. Establishment of competitive binding assay to detect [and] differentiate hepatitis E virus infection. Annals of Hepatology. 2019, 18(4):590-594.


5. Wen JY, Gao SS, Chen FL, Chen S, Wang M, Chen ZW. Role of CSE-Produced H2S on cerebrovascular relaxation via RhoA-ROCK inhibition [and] cerebral ischemia-reperfusion injury in mice. ACS Chemical Neuroscience. 2019, 20;10(3):1565-1574.


6.Wen JY, Wang M, Li YN, Jiang HH, Sun XJ, Chen ZW. Vascular protection of Hydrogen Sulfide on cerebral ischemia/reperfusion injury in rats.Frontiers in neurology, 2018, Oct 19. doi: 10.3389/fneur.2018.00779. eCollection 2018.


7.Wen JY, Lu WZ, Liu ZZ [and] Meng JH. Establishment of competitive binding assay identifying the different characteristics of neutralizing epitopes of HEV. Intervirology, 2018, 60(5):190-195.


8. Lu WZ, Wen JY. The divergence of epidemiological, antigenic [and] immunogenic characteristics of hepatitis E virus of different genotypes. Future Virology, 2018, 13(1):53-60.


9. Wen JY, Behloul N, Dai X, Dong C, Liang JH, Zhang M, Shi CB, Meng JH. Immunogenicity difference between two hepatitis E vaccines derived from genotype 1 [and] 4. Antiviral Research, 2016,128 (2016) 36-42.


10. Xu MJ, Behloul N, Wen JY, Zhang JH, Meng JH. Role of asparagines at position 562 in dimerization [and] immunogenicity of the hepatitis E virus capsid protein. Infection, Genetics [and] Evolution, 2016, 37(2016):99~107.


11. Behloul N, Wen JY, Dai X, Dong C, Meng JH. Antigenic composition [and] immunoreactivity differences between HEV recombinant capsid proteins generated from different genotypes. Infection, Genetics [and] Evolution, 2015, 34 (2015) 211–220.


12.Wen JY, Chen ZW. Protective effect of pharmacological preconditioning of total Flavones of Abelmoschl Manihot on cerebral ischemic reperfusion injury in rats. American Journal of Chinese Medicine, 2007, 35(4): 653-661.



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