郑红职称：教授
联系电话：**
email：hzhen30@126.com
研究方向：1.血液免疫2.干细胞代谢调控

个人简历科研项目论文专著专利与技术许可荣誉与奖励
郑红，教授，博士生导师，安徽医科大学海外高层次“三类人才”引进，安徽省人才计划入选者，现任病理生理学教研室主任，主要进行激活突变SHP2与肿瘤发生的分子机制及其与造血干细胞发育和功能调控的机制研究，并取得了一些创新性的研究成果，以第一作者发表高水平论文多篇，其中包括Nature, PNAS, 两篇Science子刊(Science Advances, Science Signaling), Blood, JBC等，2018年获安徽省高层次人才平台奖补资助（个人），获2019年安徽省高校学科（专业）拔尖人才，担任Current Molecular Pharmacology等国际期刊的论文评审，现主持两项在研国家自然科学基金。承担本科生、硕士研究生和留学生课程，并作为副主编参编教材1部。


教育经历
2003.9-2006.6 安徽医科大学 药理学，博士学位
1997.9-2000.6 安徽医科大学 外科学（烧伤），硕士学位
1986.9-1991.6 安徽医科大学 临床医学，学士学位


工作经历
2014.1-2017.5 美国埃默里大学，Research Associate
2008.6-2013.12 美国凯斯西储大学，Research Associate
2000.7-2010.2 安徽医科大学病理生理学教研室，讲师/副教授，教研室副主任，机能中心副主任
1991.7-1997.8 安徽丝绸厂职工医院，医生



1. 国家自然科学基金委面上项目，(Shp2)调控小鼠造血干细胞骨髓微环境促进骨髓增殖性肿瘤发生及其机制，201701-202012，60万元，


2. 国家自然科学基金委面上项目，谷氨酰胺载体ASCT2在激活突变Ptpn11(Shp2)致骨髓增殖性肿瘤和白血病中的作用及机制，201901-202212，57万元。

1. Wu M, Ma M, Tan Z, Zheng H (通讯作者), Liu X. Neutrophil: A New Player in Metastatic Cancers. Front. Immunol., 24 September 2020 | https://doi.org/10.3389/fimmu.2020.565165


2. Liu J, Fang Q, Lin H, Yu X, Zheng H(通讯作者), Wan Y. Alginate-poloxamer/silk fibroin hydrogels with covalently [and] physically cross-linked networks f[or] cartilage tissue engineering. Carbohydr Polym. 2020 Nov 1;247:116593.


3. Zheng H, Yu WM, Shen J, Kang S, Hambardzumyan D, Li JY, Shen Y, Kenney AM, Chen J, Qu CK. (2018) Mitochondrial oxidation of the carbohydrate fuel is required f[or] neural precursor/stem cell function [and] postnatal cerebellum development. Sci Adv. 2018 Oct 10;4(10):eaat2681.


4. Zheng H, Yu WM, Waclaw RR, Kontaridis MI, Neel BG, Qu CK. Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner. Sci Signal. 2018 Mar 20;11(522).


5. Dong L*, Yu WM*, Zheng H* (co-first author), Loh ML, Bunting ST, Pauly M, Huang G, Zhou M, Broxmeyer HE, Scadden DT, Qu CK. Leukemogenic effects of Ptpn11 (Shp2) activating mutations in the stem cell microenvironment. Nature. 2016 Nov 10;539(7628):304-308.


6. Dong L, Zheng H, Qu CK. CCL3 is a key mediat[or] f[or] the leukemogenic effect of Ptpn11-activating mutations in the stem-cell microenvironment. Blood. 2017 Sep 21;130(12):1471-1474.


7. Liu X, Zheng H (co-first author), Li XB, Wang SY, Meyerson HJ, Yang WT, Neel BG, Qu CK. Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis [and] increase susceptibility to DNA damage-induced malignancies. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):984-9.


8. Liu X, Zheng H (co-first author), Yu WM, Cooper TM, Bunting KD, Qu CK. Maintenance of hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood. 2015 125(10):1562-5.


9. Zheng H (corresponding author), Wang SY, Zhou PK, Liu W, Ni F. Effects of Ligustrazine on DNA damage [and] apoptosis induced by irradiation. Environmental Toxicology [and] Pharmacology. 2013, 36: 1197–1206.


10. Zheng H, Li SH, Hsu P, Qu CK. Acute induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) leads to cellular senescence [and] apoptosis. J Biol Chem. 2013, 288(36): 25727-38.


11. Xu D, Zheng H (co-first author), Yu WM, Qu CK. Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder. PLoS ONE. 2013, 8(5): e63152.


12. Liu X, Zheng H, Qu CK. An essential role of protein tyrosine phosphatase Shp2 (Ptpn11) in the maintenance of chromosome stability. Cancer Res. 2012, 72 (20):5296-306.


13. Zheng H, Alter S, Qu CK. SHP-2 tyrosine phosphatase in human diseases. Int J Clin Exp Med. 2009, 2(1): 17-25.


14. Zheng H, Zhou PK, Chen ZW, et al. Protective effect of Vanillin derivative dimethoxyvanillin on radiation-induced DNA damage. Eur J Pharm Sci. 2008 Jan, 33(1):52-9.


15. Zheng H, Chen XL, Chen ZW, et al. Effect of Ligustrazine on liver injury after burn trauma. Burns. 2006, 32：328-34.


16. Gao S, Chen ZW, Zheng H, et al. Ligustrazine attenuates acute myocardium injury after thermal trauma. Burns. 2007, 33(3):321-7.


17. Zheng H, Chen XL, Han ZX, et al, Ligustrazine attenuates acute lung injury after burn trauma. Burns. 2005, 31(4):453-458.



专利与技术许可建设中...
1. 2008年安徽省教学成果三等奖（第二完成人）


2. 2008年安徽医科大学教学成果奖二等奖（第二完成人）