薛挺
Ting Xue

性别：
男
单位：
生命科学学院
专业名称：
微生物学

研究方向：
分子微生物

技术职务：
教授

行政职务：
生命科学学院副院长

办公电话：


E-mail：
xuetahau.edu.cn

实验室主页：


通讯地址：


邮政编码：

薛挺，男，1979年10月出生，教授，博士生导师，学院“微生物与动植物互作”学科方向负责人,中国微生物学会候选理事，安徽省微生物学会理事，安徽省食用菌技术协会理事。
近年来主要从事金黄色葡萄球菌、大肠杆菌调控的分子机制研究，在细菌群体感应、二元信号系统、非编码小RNA的功能机制等热点领域开展了较为深入的研究工作。
近年来在Cell research, Infection and Immunity, Journal of Dairy science,Poultry Science等期刊发表SCI论文45篇，总影响因子>150，被引>800次，H因子为18，担任Frontiers in Microbiology, Future Microbiology, Animals等SCI期刊审稿人。主持国家自然科学基金3项，主持省部级科学基金7项，参与国家自然科学基金项目等多项。
【主要研究方向】
1.大肠杆菌调控机制及其与宿主的互作机制
利用微生物学及分子生物学手段，研究群体感应系统、双组份系统、第二信使系统及宏观转录因子等调控单元，在畜禽致病大肠杆菌致病性及耐药性相关基因的表达调控中行使功能的分子机制，构建相应的分子调控网络，进而研究上述调控单元在“细菌-宿主”互作中起到的调控作用，以期为畜禽致病大肠杆菌的防治提供新的药物靶标与治疗思路。
2.奶牛及乳品源金黄色葡萄球菌、链球菌及大肠杆菌生物被膜形成及调控的分子机制
金黄色葡萄球菌、大肠杆菌及链球菌形成生物被膜是奶牛罹患隐性乳房炎的罪魁祸首，利用微生物学及分子生物学手段，探寻上述细菌生物被膜的形成及调控机制，进而探求对生物被膜细菌的新的防治手段，对奶牛隐性乳房炎的防治有重要意义。
3.动植物源益生菌的改造及功能酶的研究
利用微生物学、分子生物学、生物化学等技术手段，对动植物源益生菌进行改造，并研究其对宿主的互作效应的改变，同时可利用酶学及发酵工程学等手段，对于某些重要动植物益生菌的功能酶展开研究与应用探索。
学习经历
1997.9-2001.7 本科/学士 安徽大学 生命科学学院
2004.9-2009.6 硕博连读/博士 中国科学技术大学 生命科学学院
工作经历
2009.6-2011.5 博士后 中国科学技术大学 生命科学学院
2011.6-2013.6 特任副教授 中国科学技术大学 生命科学学院
2013.6-2016.12 副教授 安徽农业大学 生命科学学院
2016.12- 教授 安徽农业大学 生命科学学院

　主讲课程：

微生物学、微生物学实验等

　科研情况：

主持与参与的科研项目：
1.AI-2群体感应对禽致病大肠杆菌耐药性的调控机制研究，2017.1-2020.12，国家自然科学基金面上项目，批准号：**，主持。
2.金黄色葡萄球菌非编码小RNA相互作用蛋白的探寻及功能研究,2014.1-2017.12,国家自然科学基金面上项目，批准号：**，主持。
3.金黄色葡萄球菌gdpS基因调控致病靶基因的特殊分子机制研究,2013.1-2015.12,国家自然科学基金青年基金项目,批准号：**，主持。
4.金葡菌非编码小RNA相互作用蛋白的探寻及功能研究,2013.7-2014.12，第六批中国博士后科学基金特别资助。主持。
5.金黄色葡萄球菌二元信号系统的功能鉴定及其对致病性的调控研究，2012.7-2014.6，安徽省自然科学基金青年项目。批准号：**QC51，主持。
6.金黄色葡萄球菌gdpS基因及其内含小RNA对致病性的调控研究,2011.1-2012.12，中国科学技术大学青年创新基金,主持。
7.金黄色葡萄球菌RNAgdpS对proteinA等致病因子的调控机理研究,2012.1-2013.6，第50批中国博士后科学基金面上资助。批准号：2011M501054，主持。
8.金黄色葡萄球菌中新型smallRNA的发现及其与致病性相关的上下游调控通路的研究,2010.12-2011.12，第三批中国博士后科学基金特别资助。主持。
9.金黄色葡萄球菌致病性调控通路的研究，第46批中国博士后科学基金面上资助。批准号：，2010.1-2011.6，主持。
10.金黄色葡萄球菌KdpDE二元信号转导系统对致病性的调控研究，2011.1-2013.12，国家自然科学基金面上项目，批准号：**，主要参与者（排名第二）。
11.金黄色葡萄球菌非编码小RNA的功能解析，2010.1-2012.12，国家自然科学基金面上项目，批准号：**，主要参与者（排名第二）。
12.还原脱氯细菌的遗传操作系统的建立，2005.1-2007.12，国家自然科学基金面上项目，批准号：**，主要参与者。

　论文论著：

发表论文：
1. Yu, L.; Wang, H.; Han, X.; Li, W.; Xue, M.; Qi, K.; Chen, X.; Ni, J.; Deng, R.; Shang, F.; Xue, T., The two-component system, BasSR, is involved in the regulation of biofilm and virulence in avian pathogenic Escherichia coli. Avian Pathol 2020, 1-51.
2. Yu, L.; Li, W.; Xue, M.; Li, J.; Chen, X.; Ni, J.; Shang, F.; Xue, T., Regulatory Role of the Two-Component System BasSR in the Expression of the EmrD Multidrug Efflux in Escherichia coli. Microb Drug Resist 2020.
3. Yu, L.; Li, W.; Li, Q.; Chen, X.; Ni, J.; Shang, F.; Xue, T., Role of LsrR in the regulation of antibiotic sensitivity in avian pathogenic Escherichia coli. Poult Sci 2020, 99 (7), 3675-3687.
4. Xue, M.; Xiao, Y.; Fu, D.; Raheem, M. A.; Shao, Y.; Song, X.; Tu, J.; Xue, T.; Qi, K., Transcriptional Regulator YqeI, Locating at ETT2 Locus, Affects the Pathogenicity of Avian Pathogenic Escherichia coli. Animals (Basel) 2020, 10 (9).
5. Xue, M.; Raheem, M. A.; Gu, Y.; Lu, H.; Song, X.; Tu, J.; Xue, T.; Qi, K., The KdpD/KdpE two-component system contributes to the motility and virulence of avian pathogenic Escherichia coli. Res Vet Sci 2020, 131, 24-30.
6. Shang, F.; Wang, H.; Xue, T., Anti-Biofilm Effect of Tea Saponin on a Streptococcus agalactiae Strain Isolated from Bovine Mastitis. Animals (Basel) 2020, 10 (9).
7. Li, W.; Xue, M.; Yu, L.; Qi, K.; Ni, J.; Chen, X.; Deng, R.; Shang, F.; Xue, T., QseBC is involved in the biofilm formation and antibiotic resistance in Escherichia coli isolated from bovine mastitis. PeerJ 2020, 8, e8833.
8. Yu, L.; Li, W.; Qi, K.; Wang, S.; Chen, X.; Ni, J.; Deng, R.; Shang, F.; Xue, T., McbR is involved in biofilm formation and H2O2 stress response in avian pathogenic Escherichia coli X40. Poultry Science 2019, 98 (9), 4094-4103.
9. Yin, L.; Li, Q.; Xue, M.; Wang, Z.; Tu, J.; Song, X.; Shao, Y.; Han, X.; Xue, T.; Liu, H.; Qi, K., The role of the phoP transcriptional regulator on biofilm formation of avian pathogenic Escherichia coli. Avian Pathol 2019, 48 (4), 362-370.
10. Song, X.; Hou, M.; Tu, J.; Xue, M.; Shao, Y.; Jiang, H.; Liu, H.; Xue, T.; Wang, G.; Qi, K., Outer membrane proteins YbjX and PagP co-regulate motility in Escherichia coli via the bacterial chemotaxis pathway. Res Vet Sci 2019, 125, 279-284.
11. Shang, F.; Li, L.; Yu, L.; Ni, J.; Chen, X.; Xue, T., Effects of stigmata maydis on the methicillin resistant Staphylococus aureus biofilm formation. PeerJ 2019, 7, e6461.
12. Yu, L.; Shang, F.; Chen, X.; Ni, J.; Zhang, M.; Sun, D.; Xue, T., The anti-biofilm effect of silver-nanoparticle-decorated quercetin nanoparticles on a multi-drug resistant Escherichia coli strain isolated from a dairy cow with mastitis. PeerJ 2018, 6, e5711.
13. Yu, L.; Li, W.; Zhang, M.; Cui, Y.; Chen, X.; Ni, J.; Shang, F.; Xue, T., Autoinducer2 affects trimethoprim-sulfamethoxazole susceptibility in avian pathogenic Escherichia coli dependent on the folate synthesis-associate pathway. MicrobiologyOpen 2018.
14. Yu, L.; Li, W.; Zhang, M.; Cui, Y.; Chen, X.; Ni, J.; Shang, F.; Xue, T., Imidazole decreases the ampicillin resistance of an Escherichia coli strain isolated from a cow with mastitis by inhibiting the function of autoinducer 2. J Dairy Sci 2018, 101 (4), 3356-3362.
15. Shang, F.; Xue, T.; Wang, M.; Chen, X.; Yu, L.; Zhang, M., Serratia bozhouensis sp. nov., Isolated from Sewage Samples of a Dairy Farm. Current microbiology 2017, 74 (7), 827-831.
16. Ma, R.; Qiu, S.; Jiang, Q.; Sun, H.; Xue, T.; Cai, G.; Sun, B., AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus. International journal of medical microbiology : IJMM 2017, 307 (4-5), 257-267.
17. Yang, Y.; Sun, H.; Liu, X.; Wang, M.; Xue, T.; Sun, B., Regulatory mechanism of the three-component system HptRSA in glucose-6-phosphate uptake in Staphylococcus aureus. Med Microbiol Immunol 2016, 205 (3), 241-53.
18. Xue, T.; Yu, L.; Shang, F.; Li, W.; Zhang, M.; Ni, J.; Chen, X., Short communication: The role of autoinducer 2 (AI-2) on antibiotic resistance regulation in an Escherichia coli strain isolated from a dairy cow with mastitis. J Dairy Sci 2016, 99 (6), 4693-4698.
19. Xue, T.; Yu, L.; Shang, F.; Li, W.; Zhang, M.; Ni, J.; Chen, X., Short communication: The role of autoinducer 2 (AI-2) on antibiotic resistance regulation in an Escherichia coli strain isolated from a dairy cow with mastitis. Journal of Dairy Science 2016, 99 (6), 4693-8.
20. Tu, J.; Xue, T.; Qi, K.; Shao, Y.; Huang, B.; Wang, X.; Zhou, X., The irp2 and fyuA genes in High Pathogenicity Islands are involved in the pathogenesis of infections caused by avian pathogenic Escherichia coli (APEC). Polish journal of veterinary sciences 2016, 19 (1), 21-9.
21. Tu, J.; Huang, B.; Zhang, Y.; Zhang, Y.; Xue, T.; Li, S.; Qi, K., Modulation of virulence genes by the two-component system PhoP-PhoQ in avian pathogenic Escherichia coli. Polish journal of veterinary sciences 2016, 19 (1), 31-40.
22. Zhang, X.; Zhu, Q.; Tian, T.; Zhao, C.; Zang, J.; Xue, T.; Sun, B., Identification of RNAIII-binding proteins in Staphylococcus aureus using tethered RNAs and streptavidin aptamers based pull-down assay. Bmc Microbiology 2015, 15.
23. Xue, T.; Ni, J.; Shang, F.; Chen, X.; Zhang, M., Autoinducer-2 increases biofilm formation via an ica- and bhp-dependent manner in Staphylococcus epidermidis RP62A. Microbes and Infection 2015, 17 (5), 345-352.
24. Tu, J.; Qi, K.; Xue, T.; Wei, H.; Zhang, Y.; Wu, Y.; Zhou, X.; Lv, X., Construction of Recombinant Pichia pastoris Carrying a Constitutive AvBD9 Gene and Analysis of Its Activity. Journal of microbiology and biotechnology 2015, 25 (12), 2082-9.
25. Chen, X.; Shang, F.; Meng, Y.; Li, L.; Cui, Y.; Zhang, M.; Qi, K.; Xue, T., Ethanol extract of Sanguisorba officinalis L. inhibits biofilm formation of methicillin-resistant Staphylococcus aureus in an ica-dependent manner. J Dairy Sci 2015, 98 (12), 8486-91.
26. Chen, C.; Zhang, X.; Shang, F.; Sun, H.; Sun, B.; Xue, T., The Staphylococcus aureus Protein-Coding Gene gdpS Modulates sarS Expression via mRNA-mRNA Interaction. Infection and Immunity 2015, 83 (8), 3302-3310.
27. Bao, Y.; Zhang, X.; Jiang, Q.; Xue, T.; Sun, B., Pfs promotes autolysis-dependent release of eDNA and biofilm formation in Staphylococcus aureus. Medical Microbiology and Immunology 2015, 204 (2), 215-226.
28. You, Y.; Xue, T.; Cao, L.; Zhao, L.; Sun, H.; Sim, B., Staphylococcus aureus glucose-induced biofilm accessory proteins, GbaAB, influence biofilm formation in a PIA-dependent manner. International Journal of Medical Microbiology 2014, 304 (5-6), 603-612.
29. Yang, Y.-H.; Jiang, Y.-L.; Zhang, J.; Wang, L.; Bai, X.-H.; Zhang, S.-J.; Ren, Y.-M.; Li, N.; Zhang, Y.-H.; Zhang, Z.; Gong, Q.; Mei, Y.; Xue, T.; Zhang, J.-R.; Chen, Y.; Zhou, C.-Z., Structural Insights into SraP-Mediated Staphylococcus aureus Adhesion to Host Cells. Plos Pathogens 2014, 10 (6).
30. Xue, T.; Zhang, X.; Sun, H.; Sun, B., ArtR, a novel sRNA of Staphylococcus aureus, regulates alpha-toxin expression by targeting the 5 ' UTR of sarT mRNA. Medical Microbiology and Immunology 2014, 203 (1), 1-12.
31. Xue, T.; Chen, X.; Shang, F., Short communication: Effects of lactose and milk on the expression of biofilm-associated genes in Staphylococcus aureus strains isolated from a dairy cow with mastitis. Journal of Dairy Science 2014, 97 (10), 6129-6134.
32. Xue, T.; Zhao, L.; Sun, B., LuxS/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC 8325. International Journal of Antimicrobial Agents 2013, 41 (1), 85-89.
33. Sun, H.; Yang, Y.; Xue, T.; Sun, B., Modulation of cell wall synthesis and susceptibility to vancomycin by the two-component system AirSR in Staphylococcus aureus NCTC8325. Bmc Microbiology 2013, 13.
34. Bao, Y.; Li, Y.; Jiang, Q.; Zhao, L.; Xue, T.; Hu, B.; Sun, B., Methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) of Staphylococcus aureus is essential for the virulence independent of LuxS/AI-2 system. International Journal of Medical Microbiology 2013, 303 (4), 190-200.
35. Yu, D.; Zhao, L.; Xue, T.; Sun, B., Staphylococcus aureus autoinducer-2 quorum sensing decreases biofilm formation in an icaR-dependent manner. Bmc Microbiology 2012, 12.
36. Xue, T.; You, Y.; Shang, F.; Sun, B., Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325. Medical Microbiology and Immunology 2012, 201 (1), 81-92.
37. Xue, T.; You, Y.; Hong, D.; Sun, H.; Sun, B., The Staphylococcus aureus KdpDE Two-Component System Couples Extracellular K+ Sensing and Agr Signaling to Infection Programming. Infection and Immunity 2011, 79 (6), 2154-2167.
38. Zhao, L.; Xue, T.; Shang, F.; Sun, H.; Sun, B., Staphylococcus aureus AI-2 Quorum Sensing Associates with the KdpDE Two-Component System To Regulate Capsular Polysaccharide Synthesis and Virulence. Infection and Immunity 2010, 78 (8), 3506-3515.
39. Fei, E.; Ma, X.; Zhu, C.; Xue, T.; Yan, J.; Xu, Y.; Zhou, J.; Wang, G., Nucleocytoplasmic Shuttling of Dysbindin-1, a Schizophrenia-related Protein, Regulates Synapsin I Expression. Journal of Biological Chemistry 2010, 285 (49), 38630-38640.
40. Xue, T.; Zhao, L.; Sun, H.; Zhou, X.; Sun, B., LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing. Cell Research 2009, 19 (11), 1258-1268.
41. Shang, F.; Xue, T.; Sun, H.; Xing, L.; Zhang, S.; Yang, Z.; Zhang, L.; Sun, B., The Staphylococcus aureus GGDEF Domain-Containing Protein, GdpS, Influences Protein A Gene Expression in a Cyclic Diguanylic Acid-Independent Manner. Infection and Immunity 2009, 77 (7), 2849-2856.
42. Ma, J.; Ren, Z.; Ma, Y.; Xu, L.; Zhao, Y.; Zheng, C.; Fang, Y.; Xue, T.; Sun, B.; Xiao, W., Targeted Knockdown of EGR-1 Inhibits IL-8 Production and IL-8-mediated Invasion of Prostate Cancer Cells through Suppressing EGR-1/NF-kappa B Synergy. Journal of Biological Chemistry 2009, 284 (50), 34600-34606.
43. Wang, X.; Sahr, F.; Xue, T.; Sun, B., Methylobacterium salsuginis sp nov., isolated from seawater. International Journal of Systematic and Evolutionary Microbiology 2007, 57, 1699-1703.