朱保建


性别：
男
单位：
生命科学学院
专业名称：
生物化学与分子生物学

研究方向：
无脊椎动物生理生化与分子免疫学

技术职务：
教授

办公电话：


办公传真：


E-mail：
zhubaojianahau.edu.cn

通讯地址：
合肥市长江西路130号

邮政编码：
230036

安徽省生物化学与分子生物学学会理事，安徽省蚕学会理事。2005年获安徽农业大学硕士学位，2008年获浙江大学博士学位。近年来主要从事无脊椎动物生理生化与分子免疫调控机制研究，先后主持农业部产业技术体系项目，教育部项目，高校自然科学研究重点项目，省自然科学基金等项目10余项，发表研究论文40余篇。参与国家自然科学基金，国际合作，科技富民强县、科技攻关等12项科研课题，获教学成果奖2项，科技进步奖1项，发明专利2项，安徽省地方标准2项，编写教材2部。

　主讲课程：

免疫学，细胞生物学

　研究方向：

无脊椎动物生理生化与分子免疫学

　科研情况：

安徽农业大学引进与稳定人才项目（yj2008-28），2008，主持。
桑植原体感染后寄主免疫相关基因的表达分析（2009zr33），2009，主持。
桑萎缩病病原的分离鉴定及其功能蛋白成分研究（2010zd10），2010，主持。
克氏原螯虾蜕皮的分子调控机理研究（**Q21），安徽省自然科学基金，2010，主持。
蜕皮激素受体调控虾蜕皮的分子作用机理研究（003），教育部博士点基金，2012，主持。
EcR调控克氏原螯虾蜕皮的分子作用机理 （KJ2014A071），高校省级自然科学研究项目，2014，主持。
安徽农业大学骨干教师培育计划（2014XKPY-38），2014，主持。
虾蜕皮激素应答基因SNIP的分子作用机理研究（**MC52），安徽省自然科学基金，2015，主持。
国家现代农业产业技术体系-黄山综合试验站（CRAS-22-SYZ10），农业部项目，2016，主持。
克氏原螯虾TGF-β/Smad信号通路调控蜕皮激素受体的分子机理 (KJ2017A145)，高校自然科学研究项目，2017，主持。
虾TUSC蛋白的免疫功能研究。省级大学生创新创业训练计划，2017。
克氏原螯虾蜕皮激素调节蛋白Esr16的分子调控机制研究（**MC77），安徽省自然科学基金，2019，主持。
科技富民强县专项计划，财政部，排名第二。
家蚕Ng基因的精确定位及粘液腺分泌相关基因的筛选与鉴定（**），国家自然科学基金，2015，排名第三。
丽蝇蛹集金小蜂毒液丝氨酸蛋白酶抑制因子抑制寄主免疫的作用机制（**），国家自然科学基金，2015，排名第三。

　获奖情况：

全省大中专学生暑期社会实践调研课题。省级三等奖，2011，指导老师.
蚕学专业创新型人才培养模式构建与实践。校级教学成果二等奖，2012.
安徽省第七届自然科学优秀学术论文。省级二等奖，2013.
生物类拔尖人才创新培养模式的探索与实践（2015cgj071-8）。省级教学成果三等奖，2015.
近江牡蛎类立克次氏体病及其防控关键技术与规模化应用。广西科学技术进步二等奖，2018.

　论文论著：

Baojian Zhu, Xinzhong Wu. Identification of outer membrane protein ompR from rickettsia-like organism and induction of immune response in Crassostrea ariakensis. Molecular Immunology, 2008, 45: 3198-3204.
Baojian Zhu, Xinzhong Wu. Characteraction and function of CREB from Crassostrea ariakensis stimulated by rickettsia like organism. Development and Comparative Immunology, 2008, 32: 1572-7581.
Baojian Zhu, ChaoliangLiu, Qiuning Liu, Lishang Dai. Characterization of a female-specific protein from the wild silkworm Actias selene. Bulletin of Insectology 2012，65 (1): 107-112.
Baojian Zhu, Qiuning Liu, Lishang Dai, Lei Wang, Yu Sun, Kunzhang Lin, Guoqing Wei, Chaoliang Liu. Characterization of the complete mitochondrial genome of Diaphania pyloalis (Lepidoptera: Pyralididae). Gene 2013，527:283-291.
Qiuning Liu, Baojian Zhu, Lishang Dai, Weiwei Fu, Kunzhang Lin, Chaoliang Liu. Overexpression of small heat shock protein 21 protects the Chinese oak silkworm Antheraea pernyi against thermal stress. Journal of Insect Physiology 2013, 59: 848-854. (co-first author)
Qiuning Liu, Kunzhang Lin, Linnan Yang, Lishang Dai, Lei Wang, Yu Sun, Cen Qian, Guoqing Wei, Dongran Liu, Baojian Zhu, Chaoliang Liu. Molecular characterization of an apolipophorinIII gene from the Chinese oak silkworm, Antheraea pernyi (Lepidoptera: Saturniidae) Archives of insect biochemistry and physiology, 2014, 88:155-167. (corresponding author)
Congfen Zhang, Lishang Dai, Lei Wang, Cen Qian, Guoqing Wei, Jun Li, Baojian Zhu, Chaoliang Liu. Eicosanoids mediate sHSP 20.8 gene response to biotic stress in larvae of the Chinese oak silkworm Antheraea pernyi. Gene, 2015, 562: 32-39. (corresponding author)
Daojun Wang, Tao Peng, Yingying Yu, Chaoliang Liu, Baojian Zhu. Smad nuclear interacting protein, snip1, mediates the ecdysteroid signal transduction in red crayfish Procambarus clarkii. J. Exp. Zool. 2015, 323A:128–136. (corresponding author)
Tao Peng, Daojun Wang, Yingying Yu, Chaoliang Liu, Baojian Zhu. Identification and expression of an ecdysteroid responsive amylase from red crayfish Procambarus clarkii. Fish Sci 2015, 81:345-352. (corresponding author)
Yu Sun, Lei Wang, Cen Qian, Lishang Dai, Jun Li, Congfen Zhang, Baojian Zhu, Chaoliang Liu. Molecular cloning and expression analysis of a hemolin-like molecule from Antheraea pernyi. International Immunopharmacology, 2015, 26: 65-71. (corresponding author)
Jun Li, Guoqing Wei, Lei Wang, Cen Qian, Kedong Li, Congfen Zhang, Lishang Dai, Qiuning Liu, Yu Sun, Dongran Liu, Baojian Zhu, Chaoliang Liu .KPNA3 Knockdown eliminate the second heat shock protein peak of heat shock response in male pupae of silkworm (Bombyx mori) by reducing heat shock factor transport into the nucleus. Gene 2016, 575: 452-457. (corresponding author)
Baojian Zhu, Hao Yu, Sen Tian, Lishang Dai, Yu Sun and Chaoliang Liu. Characterization and expression analysis of receptor for activated c kinase from silk-producing insect Antheraea pernyi. Protein & Peptide Letters, 2016, 23(10): 878-883.
Lishang Dai, Yu Sun, Yuxuan Sun, Baojian Zhu, Chaoliang Liu. Characterization and function of a cathepsin B in red crayfish (Procambarus clarkii) following lipopolysaccharide challenge. Fish and Shellfish Immunology 2016, 56: 162-168. (corresponding author)
Baojian Zhu, Lishang Dai, Yingying Yu, Daojun Wang, Tao Peng, Chaoliang Liu. A Role of Suppressor of Cytokine Signaling 2 in the Regulation of Ecdysteroid Signaling Pathway in Procambarus clarkii. Journal of experimental zoology 2016, 325(7): 441-452.
Yu Sun, Lishang Dai, Yuxuan Sun, Lei Wang, Cen Qian, Guoqing Wei, Baojian Zhu, Chaoliang Liu. Gene expression patterns in response to pathogen challenge and interaction with hemolin suggest that the Yippee protein of Antheraea pernyi is involved in the innate immune response. Journal of Invertebrate Pathology 2016,138: 10–17.(corresponding author)
Yuxuan Sun, Lei Wang, Guoqing Wei, Qian Cen, Lishang Dai, Yu Sun, Muhammad Nadeem Abbas, Baojian Zhu, Chaoliang Liu. Characterization of the Complete Mitochondrial Genome of Leucoma salicis (Lepidoptera: Lymantriidae) and Comparison with Other Lepidopteran Insects. Scientific Reports, 2016, 6:39153. (corresponding author)
Baojian Zhu, Lin Tang, Yingying Yu, Daojun Wang, Chaoliang Liu. Identification and expression patterns of 20-hydroxyecdysoneresponsive genes from Procambarus clarkii. Genes Genom 2017, 39: 601-609.
Muhammad Nadeem Abbas, Saima Kausar,Yuxuan Sun ,Yu Sun, Lei Wang, Cen Qian,Guoqing Wei, Baojian Zhu, Chaoliang Liu. Molecular cloning, expression, and characterisation of E2F transcription factor 4 from Antheraea pernyi, Bulletin of Entomological Research, 2017, 107(6):839-846. (corresponding author)
Baojian Zhu, Lin Tang, Yingying Yu, Huimin Yu, Lei Wang, Cen Qian, Guoqing Wei, Chaoliang Liu. Identification of ecdysteroid receptor-mediated signaling pathways in the hepatopancreas of the red swamp crayfish, Procambarus clarkii. General and Comparative Endocrinology 2017, 246: 372–381.
Baojian Zhu, Yingying Yu, Jin Gao, Yuanyuan Feng, Lin Tang, Yuxuan Sun, Liangli Yang. Characterization and function of a novel calmodulin-like protein from crayfish Procambarus clarkii. Fish & Shellfish Immunology 2017, 67: 518-522.
Yuxuan Sun, Lin Tang, Jin Gao, Yuanyuan Feng, Tao Peng, Yingying Yu, Liangli Yang, Yu Sun, Baojian Zhu. A role of tumor susceptibility gene 101 (TSG101) in innate immune response of crayfish Procambarus clarkii. Developmental and Comparative Immunology, 2017, 76: 268-273. (corresponding author)
Muhammad Nadeem Abbas, Baojian Zhu, Saima Kausar, Lishang Dai, Yuxuan Sun, Ji Wu Tian, Chaoliang Liu. Suppressor of cytokine signaling 2-12 regulates antimicrobial peptides and ecdysteroid signaling pathways in Bombyx mori (Dazao). Journal of Insect Physiology 2017,103: 47–56. (corresponding author)
Yu Sun, Chen Chen, Jin Gao, Muhammad Nadeem Abbas, Saima Kausar, Cen Qian, Lei Wang, Guoqing Wei, Baojian Zhu, Chaoliang Liu. Comparative mitochondrial genome analysis of Daphnis nerii and other lepidopteran insects reveals conserved mitochondrial genome organization and phylogenetic relationships. PLoS ONE 2017, 12(6): e**. (corresponding author)
Yuxuan Sun, Lin Tang, Pei Wang, Muhammad Nadeem Abbas, Jiwu Tian, Baojian Zhu, Chaoliang Liu. Cathepsin L like protease can regulate the process of metamorphosis and fat body dissociation in Antheraea pernyi. Developmental and Comparative Immunology, 2018, 78:114-123. (corresponding author)
Muhammad Nadeem Abbas, Saima Kausar, Yuxuan Sun, Ji Wu Tian, Baojian Zhu, Chaoliang Liu. Suppressor of cytokine signaling 6 can enhance epidermal growth factor receptor signaling pathway in Bombyx mori (Dazao). Developmental and Comparative Immunology 2018, 81:187-192. (corresponding author)
Jiawei Zhang, Qingqing Li, Guoqing Wei, LeiWang, CenQian, YuSun, Jiwu Tian, Baojian Zhu, Chaoliang Liu. Identification and function of lebocin-like gene from the Chinese oak silkworm, Antheraea pernyi. Archives of insect biochemistry and physiology, 2018, e1516. (corresponding author)
Jin Gao, Yu Sun, Yuxuan Sun, Chen Chen, Saima Kausar, Jiwu Tian, Baojian Zhu, Chaoliang Liu. Identification and function of cAMP response element binding protein in Oak silkworm Antheraea pernyi. Journal of Invertebrate Pathology 2018,151:14-20.(corresponding author)
Yuanyuan Feng, Maolin Ma, Xiaojiao Zhang, Die Liu, Lei Wang, Cen Qian, Guoqing Wei, Baojian Zhu. Characterization of small GTPase Rac1 and its interaction with PAK1 in crayfish Procambarus clarkii. Fish and Shellfish Immunology, 2019, 87:178–183. (corresponding author)
Jiawei Zhang, Qingqing Li, Guoqing Wei, Lei Wang, Cen Qian, Yu Sun, Jiwu Tian, Baojian Zhu, Chaoliang Liu. Identification and function of a lebocin-like gene from the Chinese oak silkworm, Antheraea pernyi. Journal of Invertebrate Pathology 2019,166: 107-207. (corresponding author)
Qingqing Li, Jiawei Zhang, Yu Sun, Lei Wang, Cen Qian, Guoqing Wei, Baojian Zhu, Chaoliang Liu.Immunological function of the antibacterial peptide attacin-like in the Chinese oak silkworm, Antheraea pernyi. Protein & Peptide Letters, 2020, 27(10): 953-961.(corresponding author)
Die Liu, XiaojiaoZhang, Xiaoxiao Liu, Awei Zhang, Baojian Zhu. Roles of a small GTPase Sar1 in ecdysteroid signaling and immune response of red swamp crayfishProcambarus clarkii. International Journal of Biological Macromolecules 2021,166: 550-556. (corresponding author)