孙冬冬


性别：
男
专业名称：
生物制药

研究方向：
纳米药物的设计与活性研究

技术职务：
副教授

行政职务：
生物制药系副主任

办公电话：


办公传真：


E-mail：
sunddwj126.com

实验室主页：


通讯地址：
安徽农业大学生命科学学院

邮政编码：
230036

孙冬冬，博士，副教授，硕士生导师。现为安徽农业大学生命科学学院生物制药系副主任，主要研究方向为天然产物的提取与开发；小分子配合物的生物活性及其调控细胞信号转导途径的功能；纳米药物的制备、缓释控制及其靶向功能的研究与应用；具有抗肿瘤、阿尔茨海默氏病、抗菌活性的化学新药研制与开发。主持国家自然科学基金青年科学基金项目、安徽省自然科学基金青年科学基金项目,安徽省教育厅项目和高校优秀青年人才支持计划项目；在天然产物的修饰，金属小分子的设计与开发，纳米修饰，分子成像以及癌症治疗领域研究有着丰富的研究经验，并取得了较好的研究成果，以第一作者或通讯作者身份发表SCI收录论文20余篇，其中包括Biomaterials，Applied Materials&Interfaces，Theranostics; Chemistry A European Journal和Dalton Trans等期刊。

　主讲课程：

药物化学、药物分析及药事管理学。

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　科研情况：

国家青年科学基金项目（2014-2017年）手性青霉胺纳米多肽抑制金属离子诱导的Aβ纤维化聚集及机制研究编号：**主持25万
安徽省青年科学基金项目（2015-2017年）编号：**QB37主持8万
安徽省教育厅项目 （2019年-2021年）编号：KJ2019A0182主持4万
高校优秀青年人才支持计划项目（2020年-2022年）主持4万

　获奖情况：

安徽省道地中药材系列品种选育与应用 2016年安徽省科学技术奖三等奖 （主要项目完成人）

　论文论著：

Weiwei Zhang, Xiaoyuan Ding, Hao Cheng, Chenyang Yin, Jing Yan, Zhipeng Mou, Weiyun Wang, Danxi Cui, Cundong Fan(*),Dongdong Sun(*).Dual-Targeted Gold Nanoprism for Recognition of Early Apoptosis, Dual-Model Imaging and Precise Cancer Photothermal Therapy.Theranostics，2019; 9(19): 5610-5625.IF=8.06，SCI 1区
Weiwei Zhang, Wenwen Yu, Xiaoyuan Ding, Chenyang Yin, Jing Yan, Endong Yang, Feng Guo,Dongdong Sun(*),Weiyun Wang(*). Self-assembled thermal gold nanorod-loaded thermosensitive liposome-encapsulated ganoderic acid for antibacterial and cancer photochemotherapy.Artif Cells Nanomed Biotechnol. 2019;47:406-419.IF=4.462SCI二区
Weiwei Zhang, Zhipeng Mou, Yazhe Wang, Ying Chen, Endong Yang, Feng Guo,Dongdong Sun(*),Weiyun Wang(*). Molybdenum disulfide nanosheets loaded with chitosan and silver nanoparticles effective antifungal activities: in vitro and in vivo.Mater Sci Eng C Mater Biol Appl.2019;97:486-497.IF=4.959SCI一区
Hao Cheng, Zhipeng Mou, Weiyun Wang, Weiwei Zhang, Zhiyan Wang, Mingjun Zhang, Endong Yang,Dongdong Sun(*).Chitosan–catechin coating as an antifungal and preservable agent for postharvest satsuma oranges.Journal of Food Biochemistry.2019;e12779.IF=1.358SCI三区
Lumin Yu, Fei Shang, Xiaolin Chen, Jingtian Ni, Li Yu, Ming Zhang,Dongdong Sun(*), Ting Xue(*). The anti-biofilm effect of silver-nanoparticle-decorated quercetin nanoparticles on a multi-drug resistant Escherichia coli strain isolated from a dairy cow with mastitis.Peer J. 2018;6:e5711.IF=2.118SCI二区
Dongdong Sun,Weiwei Zhang, Qianqian Yu, Xu Chen, Meng Xu, Yanhui Zhou, Jie Liu(*), Chiral penicillamine-modified selenium nanoparticles enantioselectively inhibit metal-induced amyloid beta aggregation for treating Alzheimer's disease.J Colloid Interface Sci2017;505: 1001-10.
Dongdong Sun1, Weiwei Zhang1, Zhipeng Mou, Ying Chen, Feng Guo, Endong Yang, Weiyun Wang*Transcriptome Analysis Reveals Silver Nanoparticle-decorated Quercetin Antibacterial Molecular Mechanism.Applied Materials&Interfaces.2017，9, 11, 10047-10060.IF=8.456SCI一区
Dongdong Sun, Yanan Liu, Qianqian Yu, Qiuying Qin, Licong Yang, Yanhui Zhou, Lanmei Chen, Jie Liu*. Inhibition of tumor growth and vasculature and fluorescence imaging using functionalized ruthenium-thiol protected selenium nanoparticles.Biomaterials2014, 35, 1572-1583.IF=10.027SCI一区
Dongdong Sun, Yanan Liu, Qianqian Yu, Yanhui Zhou, Rong Zhang, Xiaojia Chen, An Hong* and Jie Liu*. The Effects of Luminescent Ruthenium(II) Polypyridyl Functionalized Selenium Nanoparticles on bFGF-induced Angiogenesis and AKT/ ERK Signaling.Biomaterials, 34 (2013) 171-180.IF=10.027SCI一区
Dongdong Sun,Yanan Liu, Du Liu, Rong Zhang, Xicheng Yang,and Jie Liu*. Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity and Live Cell Imaging Studies of Chiral Ruthenium(II) Complexes. Chem. Eur. J.2012, 18, 4285-4295.IF=5.16SCI一区
Dongdong Sun,Rong Zhang, Fang Yuan, Du Liu, Yanhui Zhou, Wenjie Mei, and Jie Liu*. Studies on characterization, telomerase inhibitory property and G-quadruplex binding of η6-arene ruthenium complexes with 1,10-phenanthroline-derived ligands.DaltonTrans2011;41:1734-41.IF=4.052SCI一区
Dongdong Sun, Nuan Li, Weiwei Zhang, Zhiwei Zhao, Zhipeng Mou, Donghui Huang, Jie Liu, Weiyun Wang*. Design of PLGA- functional quercetin nanoparticles for potential use in Alzhermer' diseaseColloid Surface B.148(2016)116-129.IF: 3.973SCI一区
Dongdong Sun, Yanan Liu, Qianqian Yu, Du Liu, Yanhui Zhou, and Jie Liu*. Selective nuclei accumulation of ruthenium(II) complex enantiomers that target G-quadruplex DNA，Journal of Inorganic Biochemistry150 (2015) 90–99.IF= 3.224，SCI一区
Dongdong Sun, Weiwei Zhang, Mengting Lv, Endong Yang, Qian Zhao, Weiyun Wang*. Antibacterial activity of ruthenium(II) polypyridyl complex manipulated by membrane permeability and cell morphology.Bioorg. Med. Chem. Lett.25 (2015) 2068–2073..IF:2.44SCI二区
Dongdong Sun, Weiwei Zhang, Nuan Li, Endong Yang, Haiping Liu, Weiyun Wang.* Silver nanoparticles-quercetin Conjugation to siRNA against multidrug-resistant Bacillus subtilis for Effective Gene Silencing: In Vitro and in Vivo.Materials Science and Engineering C63 (2016) 522–534.IF=4.959SCI一区
Dongdong Sun, Nuan Li, Weiwei Zhang, Endong Yang, Zhipeng Mou, Zhiwei Zhao, Haiping Liu , Weiyun Wang*. Quercetin-loaded PLGA nanoparticles: a highly effective antibacterial agent in vitro and anti-infection application in vivo.J Nanopart Res( 2016)1 8:3-21.2.1IF: 2.009SCI二区
Dongdong Sun, Zhipeng Mou, Nuan Li, Weiwei Zhang,Yazhe Wang, Endong Yang, Weiyun Wang*. Anti-tumor activity and mechanism of apoptosis of A549 induced by ruthenium complex[J].J Biol Inorg Chem,2016:1-12.IF: 3.63SCI二区
Dongdong Sun,Weiwei Zhang,Endong Yang,Nuan Li,Haiping Liu,Weiyun Wang*. Investigation of antibacterial activity and related mechanism of a ruthenium(II) polypyridyl complex.Inorganic Chemistry Communications56 (2015) 17–21.IF= 1.79，SCI三区
Dongdong Sun,Weizhang Wang, Jianwen Mao，Wenjie Mei，JieLiu(*)，Imidazo [4,5f][1,10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-kappa B pathway，Bioorganic & Medicinal Chemistry Letters，2012.1.1，22(1):102–105.IF=2.448SCI二区