姓名：许岳慷
职称：****
电话：
邮箱：@qq.com

◆ 主要学习工作经历
1985年毕业于安徽医科大学临床医学系，获医学学士；1987年在毕业于安徽师范大学英语系，获文学学士；2004年毕业于澳大利亚墨尔本大学医学生物系，获哲学博士学位。先后在安徽医科大学、安徽省医学遗传中心任助教、助研等职。于1998年赴海外定居、读博并在当地WEHI医学研究所从事医学免疫学的基础与临床研究工作。现任安徽师范大学****、免疫学科带头人。
◆ 主要社会兼职
● 安徽省免疫学学会第五届理事会 常务理事
● 安徽省细胞生物学学会第六届理事会 常务理事
◆ 主要研究内容
● 免疫细胞的信号传导：当外界病原微生物侵入机体时，免疫细胞首先做出反应。本实验室主要研究免疫细胞在受到炎性刺激后，胞内信号通路中哪些分子发生了变化，这些变化最终如何改变免疫细胞功能和行为，以及根据这些变化找到并合成该分子的类似物或拮抗剂以控制炎性信号的发展，从而达到临床治疗的目的。
● 树突状细胞的发育和功能：树突状细胞在免疫反应中起着支配和主导作用。不同的生长因子和生长环境控制产生不同的树突状细胞。本实验室主要研究在不同的组织区域环境中树突状细胞的发育过程中哪些因素通过什么方式控制产生了什么类型的树突状细胞，这些树突状细胞功能上有什么区域特质，能主导着什么样的免疫反应，以及我们能否利用这些因素在体外定向生产这种树突状细胞回输体内干预免疫反应。
● 免疫生化：树突状细胞不仅调节免疫应答而且大量产生胱抑素C。胱抑素C是一种蛋白酶抑制剂，控制着组织基质内蛋白溶酶的活性。同时它也是一种纤维化蛋白，可在血管内形成纤维沉淀而破坏血管内壁。本实验室主要研究哪些因素可以调节胱抑素C的分泌，哪些因素会诱导胱抑素C纤维化的形成及分泌，以及这些因素是否可以被用于临床来治疗因蛋白溶酶活性过高、过低或胱抑素C纤维化而导致的疾病（如动脉粥样硬化和阿茲海默症等）。
◆ 主要研究课题
● 国家自然科学基金重大研究计划项目、血管组织DC的区域免疫特性及抑炎机制、**、国家基金委、主持。
● 安徽省对外科学技术合作项目、炎症条件下树突状细胞发育和功能的分子机制研究、1604b**、安徽省科技厅、主持。
● 安徽省自然基金面上项目、胱抑素C调控在血管内膜损伤机制中的研究、**MH160、安徽省自然科学基金委员会、主持。
● 澳大利亚国立卫生医学研究委员会项目基金、Regulation of Cardiovascular Disease-Associated Protease Inhibitor Cystatin C for Therapeutic Application、**、主持。
● 澳大利亚国立卫生医学研究委员会Peter Doherty基金、Improving Anti-Tumor Therapy by Genetically Modifying CD4⁺ T cells、400426、主持。
● 美国Susan Komen基金、Genetic Modification of Multiple Immune System Cells for Breast Cancer Therapy、PDF39606、主持。
◆ 主要研究成果
一、代表性论文及论著：
● Wang F, Liang S, Hu J, Xu Y*. Aryl hydrocarbon receptor connects dysregulated immune cells to atherosclerosis. Immunol Lett. 2020 Dec;228:55-63. doi: 10.1016/j.imlet.2020.10.003. Epub 2020 Oct 11. 2020.
● Sun L, Zhang W, Zhao Y, Wang F, Liu S, Liu L, Zhao L, Lu W, Li M, Xu Y*. Dendritic Cells and T Cells, Partners in Atherogenesis and the Translating Road Ahead. Front Immunol. 2020 Jul 29;11:1456. doi: 10.3389/fimmu.2020.01456. eCollection. 2020.
● Chen S, Liu L, Zhang W, Sun L, Wang F, Zhao Y, Liu S, Zhao L, Xu Y*. Suppressed Dendritic Cell Functions by Cystatin C Lead to Compromised Immunity in Vivo. Cell Immunol. 2020 Mar;349:104049. doi: 10.1016/j.cellimm.2020.104049. 2020.
● Zhang W, Zi M, Sun L, Wang F, Chen S, Zhao Y, Liang S, Hu J, Liu S, Liu L, Zhan Y, Lew AM, Xu Y*. Cystatin C regulates MHC II-peptide presentation and Erk-dependent polarizing cytokine production by bone marrow-derived dendritic cells. Immunol Cell Biol. Sep 12. doi: 10.1111/imcb.12290. 2019.
● Sun L, Rautela J, Delconte RB, Souza-Fonseca-Guimaraes F, Carrington EM, Schenk RL, Herold MJ, Huntington ND, Lew AM, Xu Y*, Zhan Y. GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function. Front Immunol. 2018 Aug 28;9:1922. doi: 10.3389/fimmu.2018.01922. eCollection. 2018.
● W. Zhang, Y Ding, L. Sun, Q. Hong, Y. Sun, L. Han, M. Zi, Y. Xu*, Bone marrow-derived inflammatory and steady state DCs are different in both functions and survival. Cell Immunol, 331,100-109. 2018.
● S. Chen, X. Li, W. Zhang, M. Zi, Y. Xu*, Inflammatory compound lipopolysaccharide promotes the survival of GM-CSF cultured dendritic cell via PI3 kinase-dependent upregulation of Bcl-x. Immunol Cell Biol, doi: 10.1111/imcb.12051. [Epub ahead of print]. 2018.
● Zi M, Xu, Y*. Involvement of cystatin C in immunity and apoptosis. Immunol Lett. 196:80-90. 2018
● X Li, Y Ding, M Zi, L Sun, W Zhang, S Chen, Y Xu*. CD19, from bench to bedside. Immunol Lett, 183:86-95.2017
● Xu, Y*, Ding, Y., Li, X., and Wu, X. Cystatin C is a disease-associated protein subject to multiple regulation. Immunol Cell Biol. 93(5):442-51. 2015
● Xu Y*, Lindemann P, Vega-Ramos J, Zhang JG, Villadangos JA. Developmental Regulation of Synthesis and Dimerization of the Amyloidogenic Protease inhibitor Cystatin C in the Hematopoietic System. J Biol Chem. 289(14):9730-40. 2014.
● Xu Y*, Fairfax K, Light A, Huntington ND, Tarlinton DM. CD19 Differentially Regulates BCR Signalling through the Recruitment of PI3K. Autoimmunity. Jun 23:1-8. [Epub ahead of print]. 2014.
● Xu W, Pan H, Xu Y*, and Ye D. Interferon Regulatory Factor 5 and Autoimmune Lupus. Expert Rev Mol Med. 10.1017/erm2013.7. 2013.
● Li B, Ye Q, Xu W, Li J, Ye D and Xu Y*. GM-CSF alters dendritic cells in autoimmune diseases. Autoimmunity. 46:409. 2013.
● Zhan Y, Vega-Ramos J, Carrington EM, Villadangos JA, Lew AM and Xu Y*. The inflammatory cytokine, GM-CSF, alters the developmental outcome of murine dendritic cells. Eur J Immunol. 42:2889. 2012.
● Xu WD. Pan HF, Ye DQ, and Xu Y*. Targeting IRF4 in autoimmune diseases. Autoimmun. Rev. 11:918. 2012.
● Xu Y, Huntington ND, Harder K, Nandurkar H, Hibbs ML and Tarlinton. Phosphatidylinositol-3 kinase activity in B cells is negatively regulated by Lyn tyrosine kinase. Immunol Cell Biol. 90:903. 2012
● Xu Y*, Schnorrer P, Proietto A, Kowalski G, Febbraio MA, Acha-Orbea H, Dickins RA and Villadangos JA. Interleukin-10 Controls Cystatin C Synthesis and Blood Concentration in Response to Inflammation through Regulation of IRF-8 Expression. J. Immunol. 186:3666 . 2011.
● Xu Y*, Zhan Y, Lew AM, Naik SH and Kershaw MH. Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking. J. Immunol 179(11):7577-84. 2007.
● Huntington ND, Xu Y, Puthalakath H, Light A, Willis SN, Strasser A, Tarlinton DM. CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers. Nat. Immunol. 7(2):190-8. 2006.
● Xu Y, Harder KW, Huntington ND, Hibbs ML, and Tarlinton DM. Lyn tyrosine kinase：accentuating the positive and the negative. Immunity. 22:9-18. 2005.
● Huntington ND, Xu Y, Nutt S, Tarlinton DM. A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary NK cells. J. Exp. Med. 201:1421-33. 2005.
● Xu Y, Davies J, Ramsland P, Holmdahl R, Kumar N, Scealy M, Rowley M. Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display：implications for autoimmunity and molecular mimicry. Mol. Immunol. 41:411-9. 2004.
● Xu Y, Beavitt SJ, Harder KW, Hibbs ML, Tarlinton DM. The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent. J. Immunol. 169:6910-8. 2002.

二、主要获奖情况：
● ICB Publications of the Year Runner Up Awards, Australia
● NHMRC Project Grant (APP**, CIA), Australia.
● International Postdoctoral Travel Award from Australian Society of Immunology, Australia.
● International Travel Bursary from 4th Congress of the Federation of Immunology Societies of Asia-Oceania (FIMSA), Taipei, Taiwan.
● International Travel Award from Australian Society of Immunology.
● NHMRC Peter Doherty Fellowship, Australia.
● Susan Komen Postdoctoral Fellowship, Susan Komen Foundation, US.