陈小龙教授简介：

学校及社会兼职：浙江工业大学发酵工程研究所所长，浙江省重中之重生物工程重点学科发酵工程团队负责人，浙江工业大学天台研究院院长

主要研究方向：抗生素的结构修饰、生物催化与生物转化、生物分离工程主要成果与荣誉：
浙江省高校优秀共产党员（2016）；浙江省万人好党员（2016）；
科技部中青年科技创新领军人才（2015）；台州市 500 精英人才（2015）；
浙江省“新世纪”151 第一层次人才；

2008 年获得国家科技发明二等奖 1 项(3/5)；

2007 年获得浙江省科学技术一等奖 1 项（3/11）、中国石化协会技术发明一等奖 1 项
（3/5）；

2006 年获得浙江省高校成果一等奖 1 项(1/5)、二等奖 1 项（3/5）；

2004 年被评为浙江工业大学首批青年学术骨干；



主要代表性论文论著：

1. Lu Yuele, Chen Xiaolong*. Stereoselective Behavior of the Chiral Herbicides Diclofop-Methyl
andDiclofop During the Soy Sauce Brewing Process. Chirality, 2016, 28: 78-84;

2. Lu Yuele, Chen Xiaolong*. Stereoselective Behavior of Fungicide Benalaxyl during Grape

Growth andWine-making Process. Chirality, 2016, 28: 394-398.

3. Xiao-Long Chen*, Li-Jun Zhang, Fu-Ge Li,Yong-Xian Fan, Wei-Ping Wang, Bao-Ju Li and Yin-Chu
Shen. Synthesis and antifungal evaluation of a series of maleimides. Pest Management Science,
2015，71: 433- 440.

4. Chen Xiaolong *; LuoXinrong ; Cao Feifei ;Zhu Ting
heng. Molecularcloning, expression of CPR gene from Rhizopus oryzae into Rhizopus nigericansand
its application in the 11 alpha- hydroxylation of 16 alpha,17-epoxy-progesterone Enzyme
andMicrobial Technology, 2014, 66: 28-34.

5. Zhenzhong Shen, Yongxian Fan, Fuge Li, Xiaolong Chen*, Yinchu Shen. Synthesis of a series of
N-substituted dimethylmaleimides and their antifungal activities against Sclerotiniasclerotiorum.
Journal of Pest Science, 2013,86, 363-360.

6. Yongxian Fan, Yang Yu, Xiaoqing Jia, Xiaolong Chen*, Yinchu Shen. Cloning, expression and
medium optimization of validamycin
glycosyltransferase from Streptomyces hygroscopicus var. jinggangensis for the biotransformation of
validoxylamine A to produce validamycin A using free resting cells. Bioresource Technology,
2013,131: 13-20.

7. RuiGuo, Yongxian Fan, Xiaolong Chen*, Yinchu Shen. Chiral resolution of racemic
p-methylsulfonylphenyl serine ethyl ester with lipases: The mechanism of side reaction and its
suppression. Journal of Agricultural and Food Chemistry, 2013, 61: 152-166.

8. Wei Li, Yongxian Fan, Zhenzhong Shen, Xiaolong Chen*, Yinchu Shen. Antifungal activity of simple
compounds with maleic anhydride or dimethylmaleimide structure against Botrytis cinerea. Journal
of Pesticide Science, 2012, 37: 1-5.

9. Xiaolong Chen, Xiaohui Zhu, Yicheng Ding, Yinchu Shen. Antifungal activity of tautomycin and
related compounds against Sclerotiniasclerotiorum. The Journal of Antibiotics, 2011, 64: 563- 569.

10. Xiao-Long Chen, Yu-Hua Xu, Yu-Guo Zheng, and Yin-Chu Shen. 2010. Improvement of tautomycin
production with Streptomyces spiroverticillatus by feeding glucose and maleic anhydride.
Biotechnology and Bioprocess Engineering, 15: 969-974.

11. Xiaolong Chen, Yuguo Zheng, YinchuShen.Bioassay method for the quantitative determination of
tautomycin in the fermentation broth with Sclerotiniasclerotiorum. Journal of Rapid Methods and
Automation in Microbiology, 2008, 16: 199-209.

12．Xiaolong Chen, Yuguo Zheng, YinchuShen.Natural Products with Maleic Anhydride Structure:
Nonadrides, Tautomycin, Chaetomellic Anhydride and Other Compounds. Chemical Reviews 2007, 107:
1777-1830.

13.Xiaolong Chen, Yuguo Zheng, Yinchu Shen. Voglibose (Basen (R) AO- 128), one of the most
important alpha-glucosidase inhibitors. Current Medicinal Chemistry 2006, 13: 109-116.

14．Xiaolong Chen, Yongxian Fan, Yuguo Zheng and Yinchu
Shen. Properties and production of valienamine and its related analogues. Chemical Reviews, 2003,
103: 1955-1977.

15．Xiaolong Chen, Yuguo Zheng and Yinchu Shen. A new method for the production of valienamine with
microbial degradation of
acarbose. Biotechnology Progress, 2005, 21: 1002-1003.

16．Xiaolong Chen, Yuguo Zheng and Yinchu Shen. Quantitative analysis of valienamine in the
microbial degradation of validamycin A after derivation with p-nitrofluorobenzene by reversed-phase
high- performance liquid chromatography. Journal of Chromatography B, 2005 824: 341-347.

17．Yuguo Zheng, Xiaolong Chen and Zhao Wang. Microbial biomass production from rice straw
hydrolysate in airlift
bioreactors. Journal of Biotechnology, 2005, 118: 413-420.

18．Yuguo Zheng, Xiaolong Chen, Zhao Wang and Yinchu Shen. Production of validamycins from crude
substrates by Streptomyces hygroscopicus in

an external-loop airlift bioreactor with lower height-to-diameter ratio. Chinese Journal of
Chemical Engineering, 2004, 12: 102-107.

19．Yuguo Zheng, Zhao Wang and Xiaolong Chen. Production of extracellular protease from crude
substrates with dregs in an external-loop airlift bioreactor with lower ratio of height-to-
diameter. Biotechnology Progress, 2001，17: 273-277.

20．Yuguo Zheng, Zhao Wang and Xiaolong Chen. α-Amylase production by Bacillus subtilis with dregs
in an external-loop airlift
bioreactor. Biochemical Engineering Journal, 2000, 5: 115-121.

21．Yuguo Zheng, Xiaolong Chen and Zhao Wang. Production of single- cell protein from hydrolysate
of rice hull in external-loop airlift bioreactors. Environmental Science, 2000, 21: 85-88.

22．Yuguo Zheng, Zhao Wang and Xiaolong Chen. Citric acid production from the mash of dregs by
Aspergillus niger in an external-loop airlift bioreactor. Process Biochemistry, 1999, 35：237-242.

23．方夏，李琳，韩君芳，吴芳，毛雪萍，陈小龙. Botrytis cinerea 蛋白磷酸酶的分离纯化及酶学性质. 农药，2011，50，795-798.（工大 A 类）

24．江琴琴，陈小龙，沈寅初. 产灰霉病菌物质的微生物筛选和鉴定. 农药，2010，49：
257-259.（工大 A 类）

25．陈小龙，方夏，沈寅初. 纹枯病菌对井冈霉素的作用机制、抗药性及安全性. 农药，
2010，49：481-483.（工大 A 类）

26．黄振,陈小龙.抗真菌剂两性霉素 B 的结构修饰. 中国抗生素杂志，2010,35:571-575.
（中文核心期刊）

国内外著名杂志上发表论文 100 多篇。出版专著有：
陈小龙，陆跃乐，范永仙，沈寅初. Validamycin and its derivatives-

Discovery, chemical synthesis, and biological activity. Elsevier, 2017.4.

授权专利有：

1. 顺丁烯二酸酯化合物在制备油菜菌核病菌抑菌剂中的应用，
ZL201010122276.9，1/5
2. 顺丁烯二酸酯类化合物对油菜菌核病菌的抑制，ZL201010122683.X，
1/5
3. 顺丁烯二酸酐类化合物在抗灰霉病方面的应用，ZL201010122309.X，
1/5
4. 一种提高变构霉素发酵产量的制备方法，ZL201010199312.1，1/5
5. 一种变构酸的制备方法，ZL201010178819.8，1/5
6. 一种顺丁烯二酰亚胺类化合物及其制备与应用，ZL201110249201.1，
1/5
7. N-(3,5-二氯苯基)-3,4-二氯-顺丁烯二酰亚胺在抗真菌感染中的应用，ZL201310462766.7，1/5
8. G6PDH 基因在提高黑根霉对甾体 C11α-羟基化能力中的应用及菌株， ZL201310505530.7，1/5
9. 一种 3,4-二氯顺丁烯二酰亚胺化合物及其制备与应用， ZL201310047509.7，2/5



主持的项目有：

1. 国家自然科学基金项目“基因组学法研究马来酰亚胺类化合物抗
Sclerotiniasclerotiorum 机制及作用靶标酶”

2. 浙江省科学厅重大专项（2012C12003-1）“产糖基转移酶基因工程菌株的构建及其在生物催化法生产井冈霉素 A 中的应用”

3．国家自然科学基金项目（21172198）"基于变构霉素含顺丁烯二酸酐片段的化合物衍生、优化及其抗菌核病菌活性研究"

4. 浙江省科学厅重大专项（2007C12088）“顺丁烯二酸酐结构先导物生物合成及农药活性化合物创制”

5．浙江自然科学基金项目（编号 M303049）“腺苷蛋氨酸合成酶的基因克隆及其酶学特性研究”

主持企业横向项目 20 余项。

联系办法： 浙江工业大学发酵工程研究所 Tel: 0571-88320571，E-mail: richard_chen@zjut.edu.cn