姓 名：傅正伟

性 别：男

工作部门：生物工程学院技术职称：教授
最高学位：博士民 族：汉
籍 贯：浙江杭州联系方式：
Email:azwfu@zjut.edu.cn

电 话：0571-88320599
主要研究方向：

1．外源物质对生物体内分泌、神经及免疫系统影响的分子机理研究
2．生物钟在衰老、抑郁症等生理功能方面的机理研究


目前主要研究项目：

1．微生物农药发现及其生态安全研究（科技部重大专项课题）
2．白兰氏鸡精对预防代谢综合症的影响（与新加坡公司的国际合作课题）
3．白兰氏鸡精对哺乳动物内部生物节律的调控作用（与新加坡公司的国际合作课题）


发表的论文、专著、教材：
以浙江工业大学为工作单位发表 SCI 论文（2007~2017 年 3 月期间；Fu, Z.：傅正伟；*通讯作者）
（SCI 论文 119 篇，其中通讯作者 JCR Q1 区 48 篇，Q2 区 34 篇，ESI 高被引论文 4）

JCR Q1 区论文（共 55 篇，其中作为通讯作者 48 篇，其他 7 篇），2015 年以来的如下：
1. Jin, Y., Wu, S., Zeng, Z., Fu, Z.* Effects of environmental pollutants on gut
microbiota. Environmental Pollution, 2017, 222:1-9
2. Wang, X., Gao, X., He, B., Jin, Y., Fu, Z.* Cis-bifenthrin causes immunotoxicity in murine
macrophages.
Chemosphere, 2017, 168:1375-1382
3. Wu, T., Jiang, J., Yang, L., Li, H., Zhang, W., Chen, Y., Zhao, B., Kong, B., Lu, P.,
Zhao, Z., Zhu, J., Fu, Z.* Timing of glucocorticoid administration determines severity of lipid
metabolism and behavioral effects in rats. Chronobiology International, 2017, 34:78-92
4. Hu, Q., Guo, F., Zhao, F., Fu, Z.* Effects of titanium dioxide nanoparticles exposure on
parkinsonism in zebrafish larvae and PC12. Chemosphere, 2017, 173:373-379
5. Asad, M., Lavoie, M., Song, H., Jin, Y., Fu, Z., Qian, H.* Interaction of chiral
herbicides with soil microorganisms, algae and vascular plants. Science of the Total Environment,
2017, 580:1287-1299
6. Liu, Z., Fu, Z., Jin, Y* Immunotoxic effects of atrazine and its main metabolites at
environmental relevant concentrations on larval zebrafish (Danio rerio). Chemosphere, 2017,
166:212-220
7. Qian, H., Zhu, K., Lu, H., Lavoie, M., Chen, S., Zhou, Z., Deng, Z., Chen, J., Fu,
Z.* Contrasting silver nanoparticle toxicity and detoxification strategies in Microcystis
aeruginosa and Chlorella vulgaris: New insights from proteomic and physiological
analyses. Science of the Total Environment, 2016, 572:1213-1221
8. Jin, Y., Wu, Y., Zeng, Z., Jin, C., Wu, S., Wang, Y., Fu, Z.* Exposure to oral
antibiotics induces gut microbiota dysbiosis associated with lipid metabolism
dysfunction and low-grade inflammation in mice. Toxicological Sciences, 2016, 154:140-152
9. Jin, C., Zeng, Z., Fu, Z., Jin, Y.* Oral imazalil exposure induces gut microbiota
dysbiosis and colonic inflammation in mice. Chemosphere, 160:349-358
10. Sun, C., Chen, S., Jin, Y., Song, H., Ruan, S., Fu, Z., Asad, M., Qian, H.* Effects
of the herbicide imazethapyr on photosynthesis in PGR5- and NDH-deficient arabidopsis
thaliana at the biochemical, transcriptomic, and proteomic levels. Journal of Agricultural and
Food Chemistry, 2016, 64:4497-4504
11. Jin, Y., Zhu, Z., Wang, Y., Yang, E., Feng, X., Fu, Z.* The fungicide imazalil
induces developmental abnormalities and alters locomotor activity during early developmental
stages in zebrafish. Chemosphere, 2016, 153:455-461
12. Bai, X., Song, H., Lavoie, M., Zhu, K., Su, Y., Ye, H., Chen, S., Fu, Z., Qian, H.* Proteomic
analyses bring new insights into the effect of a dark stress on lipid biosynthesis in Phaeodactylum
tricornutum. Scientific Reports, 2016, 6:25494
13. Liu, Z., Wang, Y., Zhu, Z., Yang, E., Feng, X., Fu, Z., Jin, Y.* Atrazine and its main
metabolites alter the locomotor activity of larval zebrafish (Danio rerio). Chemosphere, 2016,
148:163-170
14. Jin, Y., Liu, L., Zhang, S., Tao, B., Tao, R., He, X., Qu, L., Huang, J., Wang, X., Fu, Z.*
Chromium alters lipopolysaccharide-induced inflammatory responses both in vivo and in
vitro. Chemosphere, 2016, 148:436-443
15. Jin, Y., Liu, L., Zhang, S., He, R., Wu, Y., Chen, G., Fu, Z.* Cadmium exposure to murine
macrophages decreases their inflammatory responses and increases their oxidative stress.
Chemosphere, 2016, 144:168-175（ESI高被引）
16. Xie, J., Bai, X., Lavoie, M., Lu, H., Fan, X., Pan, X, Fu, Z., Qian, H.* Analysis of the
Proteome of the
Marine Diatom Phaeodactylum tricornutum Exposed to Aluminum Providing Insights into Aluminum
Toxicity Mechanisms. Environmental Science and Technology, 2015, 49:11182-11190
17. Qian, H., Lu, H., Ding, H., Lavoie, M., Li, Y., Liu, W., Fu, Z.* Analyzing Arabidopsis
thaliana root

proteome provides insights into the molecular bases of enantioselective imazethapyr toxicity.
Scientific Reports, 2015, 5:11975
18. Jin, Y., Liu, Z., Peng, T., Fu, Z.* The toxicity of chlorpyrifos on the early life stage of
zebrafish: Asurvey on the endpoints at development, locomotor behavior, oxidative stress and
immunotoxicity. Fish and Shellfish Immunology, 2015, 43:405-414（ESI高被引）
19. Jin, Y., Zeng, Z., Wu, Y., Zhang, S., Fu, Z.* Oral exposure of mice to carbendazim induces
hepatic lipid
metabolism disorder and gut microbiota dysbiosis. Toxicological Sciences, 2015, 147:116-126
20. Wu, T., Yao, C., Tsang, F.*, Huang, L., Zhang, W., Jiang, J., Mao, Y., Shao, Y., Kong, B.,
Singh, P., Fu, Z.* Facilitated physiological adaptation to prolonged circadian disruption through
dietary supplementation with essence of chicken. Chronobiology International, 2015,
32(10):1458-1468

科研成果及专利：
1. 过氧化氢在制备微囊藻毒素抑制剂中的应用（ZL 2011 1 0032486.3），发明，授权 2013.6
2. 无外界动力推动的离子交换树脂层析装置（ZL 2013 2 0542803.0），实用新型，授权 2014.3
3. 无外界动力推动的离子交换树脂层析方法及装置（ZL 2013 1 0394008.6），发明，授权 2015.3
4. 一种提高三角褐指藻脂质积累的培养方法（ZL 2014 1 0092191.9），发明，授权 2016.3
研究生培养等教学情况：
已培养研究生数十人，学生多次入选“学校研究生十佳学术之星”，两人获浙江省研究生优秀毕业论文。


奖励和荣誉：
浙江省优秀教师暨浙江省高校优秀教师、省三育人先进个人、省高校中青年学科带头人、省钱江高级人才“特聘教授”、省新世纪 151 人才工程第一层次、日本金泽大学客座教授、日本星药科大学特任教授。


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