姓名： 侯卫
学历： 博士
职称： 校聘副教授
所属研究所： 新药开发研究所
联系方式：**/624381
E-mail: houwei@zjut.edu.cn

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主要学习及工作简历：
2018.12-至今 浙江工业大学，药学院，新药开发研究所，助理研究员
2016.10-2018.11 浙江工业大学，药学院，师资博士后，合作导师：阮奔放教授
2011.09-2016.06 中国科学院上海药物研究所，药物化学，理学博士，导师：李援朝研究员
2007.09-2011.06郑州大学，药学，理学学士，毕业设计指导老师：刘宏民教授

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主要研究领域或方向：
1. 靶向肿瘤代谢通路关键酶的创新药物研究；
2.基于天然产物的结构多样性修饰、靶标发现和作用机制研究；
3. 类药性杂环优势骨架的合成和修饰新方法研究

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主讲（辅讲）本科及研究生课程：



本科生及研究生《英文科技写作》

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主持纵/横向科研项目：
1.国家自然科学青年基金，**，靶向谷氨酸脱氢酶NADP⁺结合口袋的小分子抑制剂及其作用机制研究，2020.1-2022.12，25万元，主持
2.浙江省自然科学青年基金，LQ19B060005，Ru(II)催化C-H活化与重氮化合物的[4+2]环化反应及其应用研究，2019.1-2021.12，10万元，主持
3.横向基金，化合物6-乙磺酰基-3-氰基吡叮（APC179-3）的技术开发，2018.09 -2019.12，50万元，主持
4.浙江工业大学药学院、中心“青年英才”项目，新型谷氨酸脱氢酶抑制剂的设计、合成和生物学评价，2018/05-2020/05，5万元，主持
5.中国博士后科学基金面上项目二等，2017M612024，噌啉类化合物的催化合成新方法及其生物活性研究，2017/05-2018/10，5万元，已结题，主持
6.浙江省自然科学面上一般项目，LY19H300002，高效低毒 KGA 别构抑制剂的作用机制及先导化合物的合成研究，2019.1-2021.12，9万元，参加
7.横向基金，抗致病性结合分枝杆菌单克隆抗体的筛选和制备，2017.11-2022.11，20万元，参加
8.国家自然科学基金青年基金项目，**，基于铑催化C-H活化构建大环内酰胺化合物的合成方法研究，2014/01-2016/12，25万元，已结题，参加

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发表论文/出版教材著作/授权专利：
(1)Hou, W.; Fang, J.;Su, L.; Ye, H.; Ruan, B. H. Design and Synthesis of Biotinylated Hexylselen as a Probe to Identigy KGA Allosteric Inhibitors by a Convenient Biomolecular Interaction Assay. Bioorg.Med.Chem.Lett.2019, 29, 2498-2502.IF: 2.442
(2)Hou, W.; Xiong, H.; Bai, R.; Xiao, Z.; Su, L.; Ruan, B. H.; Xu, H. Synthesis of Indazolo[2,1-a]Cinnolines via Rhodium (III)-Catalyzed C–H activation/annulation under mild conditions. Tetrahedron2019, 75, 4005-4009. IF: 2.379
(3)Hou, W.; Liu, B.; Xu, H. Triptolide: Medicinal chemistry, chemical biology and clinical progress. Eur. J. Med. Chem.2019, 176, 378-392. IF: 4.816
(4)Hou, W.; Zhou. Y.; Rui. J.; Bai, R.; Bhasin, A. K. K.; Ruan, B. H. Design and synthesis of novel tellurodibenzoic acid compounds as kidneytype glutaminase (KGA) inhibitors. Bioorg.Med.Chem.Lett.2019, 29, 1673-1676.
(5)Hou, W.;Fan, Q.; Su, L.; Xu, H.Synthesis of Oridonin Derivatives via Mizoroki-Heck Reaction and Click Chemistry for Cytotoxic Activity. Anticancer Agent. Med. Chem.2019, DOI:10.2174/**66**9. IF: 2.556
(6)Hou, W.; Lu, S.; Zhao, H.; Yu, Y.; Xu, H.; Yu, B.; Su, L.; Lin, C.; Ruan, B. H. Propylselen inhibits cancer cell growth by targeting glutamate dehydrogenase at the NADP⁺binding site. Biochem. Biophys. Res. Commun. 2019, 509, 262-267. IF: 2.559
(7)Hou, W.; Zhang, G.; Luo, Z.; Su, L.; Xu, H. Click chemistry-based synthesis and cytotoxic activity evaluation of 4α-triazole acetate podophyllotoxin derivatives. Chem. Biol. Drug. Des.2018, DOI: 10.1111/cbdd.13436. IF: 2.328
(8)Hou, W.; Yang, Y.; Wu, Y.; Feng, H.; Li, Y.; Zhou, B.^*Rhodium(III)-catalyzed alkylation of primary C(sp³)–H bonds with a-diazocarbonyl Compounds.Chem. Commun. 2016, 52, 9672. IF: 6.29
(9)Hou, W.; Yang, Y.; Ai, W.; Wu, Y.; Wang, X.; Zhou, B.;^*Li, Y.^*Ir^III-Catalyzed Direct C-7 Amidation of Indolines with Sulfonyl, Acyl, and Aryl Azides at Room Temperature. Eur. J. Org. Chem. 2015, 395. IF: 2.882
(10)Hou, W.; Zhou, B.;^*Yang, Y.; Feng, H.; Li, Y.^*Rh(III)-Catalyzed Addition of Alkenyl C-H Bond to Isocyanates and Intramolecular Cyclization: The Direct Synthesis: 5-Ylidene-pyrrol-2(5H)-ones. Org. Lett. 2013, 15, 1814. IF: 6.492
(11)Hou, W.; Zhang, G.; Luo, Z.; Li, D.; Ruan, H.; Ruan, B. H.; Su, L.;^*Xu, H.^* Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity. Bioorg. Med. Chem. Lett. 2017, 27, 5382. IF: 2.442
(12)Hou, W.; Luo, Z.; Zhang, G.; Cao, D.; Li, D.; Ruan, H.; Ruan, B. H.; Su, L.;^*Xu, H.^*Click chemistry-based synthesis and anticancer activity evaluation of novel C-14 1,2,3-triazole dehydroabietic acid hybrids. Eur. J. Med. Chem. 2017, 138, 1042. IF: 4.816
(13)Yang, Y.; Hou, W.(Co-first author); Qin, L.; Du, J.; Feng, H.; Zhou, B.;^*Li, Y.^*Rhodium-Catalyzed Directed Sulfenylation of Arene C-H Bonds. Chem. Eur. J. 2014, 20, 416. IF: 5.16
(14)Ruan, J. J.; Yu, Y.; Hou, W.(Co-first author); Chen, Z.; Fang, J.; Ni, M.; Zhang, W.; Li, d.; Lu, S.; Rui, J.; Wu, R.; Zhang, W.; Ruan, B. H. Kidney Type Glutaminase Inhibitor Hexylselen Selectively Kills Cancer Cells via a Three-Pronged Mechanism. ACS Pharmacol. Transl. Sci.2019, 2, 18-30.
(15)Su, L.; Zheng, Y.; Ren, P.; Luo, Z.; Hou, W.;* Xu, H.* Ruthenium(II)-catalyzed synthesis of indazolonefused cinnolines via C–H coupling with diazo compounds.Org. Biomol. Chem.2018, 16, 7236. IF: 3.423
(16)Su, L.; Hou, W.* Progress in the Synthesis of Cinnoline Derivatives. Chin. J. Org. Chem.2019, 39, 363.IF: 1.392
(17)Zhou, B.;^*Hou, W.; Yang, Y.; Feng, H.; Li, Y.^*Copper(I)-Catalyzed Aryl or Vinyl Addition to Electron-Deficient Alkenes Cascaded by Cationic Cyclization. Org. Lett. 2014, 16, 1322. IF: 6.492
(18)Zhou, B.;^*Hou, W.; Yang, Y.; Li, Y.^*Rhodium(III)-Catalyzed Amidation of Aryl Ketone O-methyl Oximes with Isocyanates via C-H Activation: Efficient Synthesis of 3-Methyleneisoindolin-1-ones. Chem. Eur. J. 2013, 15, 4701. IF: 5.16
(19)Chen, Z.; Li, d.; Xu, N.; Fang, J.; Yu, Y.; Hou, W.; Ruan, H.; Zhu, P.; Ma, R.; Lu, S.; Cao, D.; Wu, R.; Ni, M.; Zhang, W.; Su, W.; Ruan, B. H. Novel 1,3,4-Selenadiazole Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity. J. Med. Chem. 2019, 62, 589-603.IF: 6.253
(20)Su, L.; Wu, R.; Chen, X.; Hou, W.; Ruan, B.-H. FITC-labeled D-glucose analog is suitable as a probe for detecting insulindependent glucose uptake.Bioorg. Med. Chem. Lett. 2018, 28, 3560-3563. IF: 2.442
(21)Jin, Y.; Li, D.; Lu, S.; Zhao, H.; Chen, Z.; Hou, W.; Ruan, B.-H.^*Ebselen Reversibly Inhibits Human Glutamate Dehydrogenase at the Catalytic Site. Assay. Drug. Dev. Technol. 2018, 16, 115. IF: 1.593
(22)Zhu, M.; Fang, J.-Z.; Zhang, J.-J.; Zhang, Z.; Xie, J.-H.; Yu, Y.; Ruan, J.-J.; Chen, Z.; Hou, W.; Yang, G.-S.; Su, W.-K.; Ruan, B.-H.^* Biomolecular Interaction Assays Identified Dual Inhibitors of Glutaminase and Glutamate Dehydrogenase That Disrupt Mitochondrial Function and Prevent Growth of Cancer Cells. Anal.Chem.2017, 89, 1689. IF: 6.042

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个人获奖/指导学生获奖：
1.指导硕士研究生李迪获得2018年长三角药物化学会议优秀海报奖；
2.2016年上海药物研究所“新光闪药”学术年会优秀海报奖；
3.2015年度阿达玛斯学术论文优秀奖；
4.2014年上海药物研究所“新药梦”乐研讲坛学术年会口头报告优秀奖+优秀海报奖