陈小龙

工作部门:生物与环境工程学院\生物工程学科
性别:男
技术职称:高校教授
最高学位:博士
民族:汉族
籍贯:浙江仙居县

学校及社会兼职：浙江省重中之重生物化工重点学科发酵工程团队负责人主要研究方向：抗生素的结构修饰、生物催化与生物转化、生物分离工程主要成果与荣誉：2008年入选浙江省“新世纪”151第一层次人才培养；2008年获得国家科技发明二等奖1项(3/5)；2007年获得浙江省科学技术一等奖1项（3/11）、中国石化协会技术发明一等奖1项（3/5）；2006年获得浙江省高校成果一等奖1项(1/5)、二等奖1项（3/5）；2004年被评为浙江工业大学首批青年学术骨干；主要代表性论文论著：1.ZhenzhongShen,YongxianFan,FugeLi,XiaolongChen*,YinchuShen.SynthesisofaseriesofN-substituteddimethylmaleimidesandtheirantifungalactivitiesagainstSclerotiniasclerotiorum.JournalofPestScience,2013,86,(inpress).2.YongxianFan,YangYu,XiaoqingJia,XiaolongChen*,YinchuShen.Cloning,expressionandmediumoptimizationofvalidamycinglycosyltransferasefromStreptomyceshygroscopicusvar.jinggangensisforthebiotransformationofvalidoxylamineAtoproducevalidamycinAusingfreerestingcells.BioresourceTechnology,2013,131:13-20.3.RuiGuo,YongxianFan,XiaolongChen*,YinchuShen.Chiralresolutionofracemicp-methylsulfonylphenylserineethylesterwithlipases:Themechanismofsidereactionanditssuppression.JournalofAgriculturalandFoodChemistry,2013,61:152-166.4.WeiLi,YongxianFan,ZhenzhongShen,XiaolongChen*,YinchuShen.AntifungalactivityofsimplecompoundswithmaleicanhydrideordimethylmaleimidestructureagainstBotrytiscinerea.JournalofPesticideScience,2012,37:1-5.5.XiaolongChen,XiaohuiZhu,YichengDing,YinchuShen.AntifungalactivityoftautomycinandrelatedcompoundsagainstSclerotiniasclerotiorum.TheJournalofAntibiotics,2011,64:563-569.6.Xiao-LongChen,Yu-HuaXu,Yu-GuoZheng,andYin-ChuShen.2010.ImprovementoftautomycinproductionwithStreptomycesspiroverticillatusbyfeedingglucoseandmaleicanhydride.BiotechnologyandBioprocessEngineering,15:969-974.7.XiaolongChen,YuguoZheng,YinchuShen.BioassaymethodforthequantitativedeterminationoftautomycininthefermentationbrothwithSclerotiniasclerotiorum.JournalofRapidMethodsandAutomationinMicrobiology,2008,16:199-209.8．XiaolongChen,YuguoZheng,YinchuShen.NaturalProductswithMaleicAnhydrideStructure:Nonadrides,Tautomycin,ChaetomellicAnhydrideandOtherCompounds.ChemicalReviews2007,107:1777-1830.9.XiaolongChen,YuguoZheng,YinchuShen.Voglibose(Basen(R)AO-128),oneofthemostimportantalpha-glucosidaseinhibitors.CurrentMedicinalChemistry2006,13:109-116.10．XiaolongChen,YongxianFan,YuguoZhengandYinchuShen.Propertiesandproductionofvalienamineanditsrelatedanalogues.ChemicalReviews,2003,103:1955-1977.11．XiaolongChen,YuguoZhengandYinchuShen.Anewmethodfortheproductionofvalienaminewithmicrobialdegradationofacarbose.BiotechnologyProgress,2005,21:1002-1003.12．XiaolongChen,YuguoZhengandYinchuShen.QuantitativeanalysisofvalienamineinthemicrobialdegradationofvalidamycinAafterderivationwithp-nitrofluorobenzenebyreversed-phasehigh-performanceliquidchromatography.JournalofChromatographyB,2005824:341-347.13．YuguoZheng,XiaolongChenandZhaoWang.Microbialbiomassproductionfromricestrawhydrolysateinairliftbioreactors.JournalofBiotechnology,2005,118:413-420.14．YuguoZheng,XiaolongChen,ZhaoWangandYinchuShen.ProductionofvalidamycinsfromcrudesubstratesbyStreptomyceshygroscopicusinanexternal-loopairliftbioreactorwithlowerheight-to-diameterratio.ChineseJournalofChemicalEngineering,2004,12:102-107.15．YuguoZheng,ZhaoWangandXiaolongChen.Productionofextracellularproteasefromcrudesubstrateswithdregsinanexternal-loopairliftbioreactorwithlowerratioofheight-to-diameter.BiotechnologyProgress,2001，17:273-27716．YuguoZheng,ZhaoWangandXiaolongChen.α-AmylaseproductionbyBacillussubtiliswithdregsinanexternal-loopairliftbioreactor.BiochemicalEngineeringJournal,2000,5:115-121.17．YuguoZheng,XiaolongChenandZhaoWang.Productionofsingle-cellproteinfromhydrolysateofricehullinexternal-loopairliftbioreactors.EnvironmentalScience,2000,21:85-88.18．YuguoZheng,ZhaoWangandXiaolongChen.CitricacidproductionfromthemashofdregsbyAspergillusnigerinanexternal-loopairliftbioreactor.ProcessBiochemistry,1999,35：237-242.19．方夏，李琳，韩君芳，吴芳，毛雪萍，陈小龙.Botrytiscinerea蛋白磷酸酶的分离纯化及酶学性质.农药，2011，50，795-798.（工大A类）20．江琴琴，陈小龙，沈寅初.产灰霉病菌物质的微生物筛选和鉴定.农药，2010，49：257-259.（工大A类）21．陈小龙，方夏，沈寅初.纹枯病菌对井冈霉素的作用机制、抗药性及安全性.农药，2010，49：481-483.（工大A类）22．黄振,陈小龙.抗真菌剂两性霉素B的结构修饰.中国抗生素杂志，2010,35:571-575.（中文核心期刊）国内外著名杂志上发表论文60多篇。授权专利有：1、陈小龙，朱小惠，芮云峰，范永仙，嘉晓勤.顺丁烯二酸酐类化合物对油菜菌核病菌的抑制作用及抑制机理.2012.9，ZL201010122276.9.2、陈小龙，芮云峰，黄振，范永仙，嘉晓勤.顺丁烯二酸酯类化合物对油菜菌核病菌的抑制.2012.9，ZL201010122683.X.3、陈小龙，刘莎莎，江琴琴，范永仙，嘉晓勤.顺丁烯二酸酐类化合物在抗灰霉病方面的应用.2012.9，ZL201010122309.X.主持的项目有：1.浙江省科学厅重大专项（2012C12003-1）“产糖基转移酶基因工程菌株的构建及其在生物催化法生产井冈霉素A中的应用”2．国家自然科学基金项目（21172198）"基于变构霉素含顺丁烯二酸酐片段的化合物衍生、优化及其抗菌核病菌活性研究"3.浙江省科学厅重大专项（2007C12088）“顺丁烯二酸酐结构先导物生物合成及农药活性化合物创制”4．浙江自然科学基金项目（编号M303049）“腺苷蛋氨酸合成酶的基因克隆及其酶学特性研究”联系办法：浙江工业大学发酵工程研究所Tel:0571-88320571