张文

工作部门:药学院\化学生物学
性别:男
技术职称:高校教授
最高学位:博士
民族:汉族
籍贯:黑龙江大庆市

姓名:张文性别:男职称/学位/职位:教授/博士(工学)，博士生导师，‘十二五’浙江省高校“化学生物学”重点学科负责人从事专业：化学生物学，生物有机化学，药物化学Tel:(+86)-571-88871507；Fax:(+86)-571-88871507；13456941929；E-mail:wzhang63@zjut.edu.cn教育背景及工作经历：1992年9月—1995年4月大连理工大学化工学院应用化学专业硕士研究生研究方向:有机合成及多相催化导师：王大庆教授，李同信研究员1998年9月—2001年11月华东理工大学化学与制药工程学院应用化学专业博士研究生研究方向:生物有机荧光染料与核酸化学导师：钱旭红教授2001年12月—2003年11月日本国东北大学生命科学研究科分析生物有机化学研究室日本文部省JSPS博士后研究员研究领域:生物有机化学　(生物有机荧光染料与核酸化学)合作导师：大類洋（HiroshiOhrui）教授2003年12月—2006年3月日本国京都大学理学研究科化学系化学生物研究室日本文部省COE&JST博士后研究员研究领域:化学生物学(寡肽聚酰胺与核酸化学)合作导师：杉山弘（HiroshiSugiyama）教授2006年4月—2008年3月日本国ChemicalSoftR&DInc.首席研究员研究领域:有机合成化学与生物有机化学(有机小分子与核酸化学)2008年3月—至今日本国ChemicalSoftR&DInc.客员首席研究员2008年3月—至今浙江工业大学药学院教授研究领域:化学生物学与分子药物设计（功能有机小分子及与核酸作用的化学与生物学研究）ResearchInterest:Biology&ChemistryofSmallFunctionalMoleculesandTheirInteractionwithNucleicAcids(1)Interpretationofstructuralbiologyofinteractionofsmallmoleculeswithnucleicacids(Polyamide,Aminoglycoside,B-DNA,G-DNA,RNA)(2)Generegulationbysmallmoleculesanddesignofmoleculartargeted-drugs(3)Designandsynthesisofsmallbioactivemolecules(4)StudyonDNANanoStructureExperience:Mar.2008tonowProfessor,CollegeofPharmaceuticalSciences,ZhejiangUniversityofTechnology,China.Apr.2006toFeb.2008ChiefExecutiveResearcher,MieR&DCenter,ChemicalSoftR&DInc.,JapanJan.2006toMar.2006JSTpostdoctoralfellow,fundedbyJapanScienceandTechnologyAgency.Dec.2003toDec.2005COEpostdoctoralfellow,fundedbytheMinistryofEducation,Culture,Sports,TechnologyandScienceofJapan.Dec.2001toNov.2003JSPSpostdoctoralfellow,fundedbyJapanSocietyforthePromotionofScience,Japan.Sept.1996toAug.1998AssociateprofessorofChemistry,DepartmentofEngineering,DaqingBroadcast&TVUniversity,Daqing,China.May1995toAug.1996&Sept.1990toAug.1992Instructor,DepartmentofEngineering,DaqingBroadcast&TVUniversity,Daqing,China.Aug.1987toAug.1990Teachingassistant,DepartmentofEngineering,DaqingBroadcast&TVUniversity,Daqing,China.Jul.1983toSept.1984Chemistryteacher,TechnologyEducationDivisionofDaqingOilfieldAdministrationBureau,Daqing,Heilongjiang,China.Education:Sept.1998toDec.2001InstituteofPesticides&Pharmaceuticals,EastChinaUniversityofScienceandTechnology,Shanghai,China.DoctoralprograminAppliedChemistrywithProf.Dr.XuhongQIANwithspecializationinSynthetic&BiologicalOrganicChemistryofnaphthalene-containedheterocycliccompoundsandthethesisentitled:“ThePhotochemistryandPhotobiochemstryofNaphthalene-containedHeterocyclicDerivatives--Recognition,Labeling,CleavageandResolutionforBioorganicMolecules”.Sept.1992toApr.1995SchoolofGraduate,DalianUniversityofTechnology,Dalian,China.MasterprograminAppliedChemistrywithProfs.DaqingWANGandTongxinLIwithspecializationinFineOrganicSynthesis&HeterogeneousCatalysisandthethesisentitled:“StudyontheSynthesisofN-MethyltetrafluorophthalimideasaQuinoloneAntibacterialIntermediate”.完成的重要项目及得到资助(1996-现在):1.L-(+)-Ergothioneine(ERT)的制备(2007.4-2007.11,CSE070319,DaicelChemicalIndustries,Ltd.(合作项目),200万日元,第一完成人）。2.BR-358的研发(2007.4-2007.11,CSE070314,大日本住友制药有限公司(合作项目),200万日元,第一完成人）。3.由吡咯、咪唑组成的寡肽聚酰胺基因治疗药物的研发(2006.6-2007.3,CSE060106，日本产、学、研科学技术振兴机构资助（京都大学合作)，700万日元,第二完成人）。4.集成电路(LargeScaleIntegrated(LSI))用的化学材料单聚体ArF的研发(CSE060669,2006.6-2007.3，由北海道经济产业局资助,6000万日元，第二完成人)。5.由吡咯和咪唑组成的聚酰胺特异性识别DNA序列的分子设计及生物学应用(B14-13218046，2003.12-2006.12,日本文部科学省21世纪COE项目资助,800万日元;2006.01-2006.03,由日本科学技术振兴机构（JapanScienceandTechnologyAgency,JST)资助,200万日元，第二完成人)。6.苯并[k,l]噻吨-3,4-二酰亚胺衍生物作为DNA探针的研究(No.P01281，2001.11-2003.11,日本文部科学省学术振兴会（JapanSocietyforthePromotionofScience,JSPS),1300万日元,第一完成人）。7.2,3,4,5-四氟苯甲酸作为喹诺酮抗菌药中间体的合成(1996.3-1998.8，大庆石油管理局，27万，第一完成人)。8.Moleculardesign,synthesisandapplicationofnovelfluorophoresforDNAsequencingbyhybridizationinsolution(2000.1-2001.12，由中国大庆市科委资助，6万元，第一完成人)。9.小分子化合物与G-DNA或B-DNA作用调控癌细胞中关键原癌基因c-myc的表达(上海市化学生物学（芳香杂环）重点实验室的开放基金,SKLCB-2008-04,2009.01.01-2010.12.31，第一完成人)。10.具有手性修饰的寡肽聚酰胺（polyamide）对DNA碱基的识别和PD-1基因的调控作用(教育部归国留学人员启动基金,2009.03.01-2011.02.30，第一完成人)。11.聚酰胺（polyamide）对B-DNA碱基识别的研究(浙江工业大学高层次人才引进科研启动金，2008.03-2012，第一完成人)。12.HIV感染的T细胞高表达PD-1基因的调控诱导免疫功能恢复的研究（卫生部科研基金，合作项目，WKJ2009-2-019，2009.07-2012.06，第二完成人）。13.手性修饰的聚酰胺对介导肿瘤/癌的关键原癌基因c-Kit的调控（浙江省自然科学基金，合作项目，Y2090851，2010.01-2011.12，第二完成人）。14.HIV、HBV、HCV高表达PD-1基因调控鼠模型的建立及应用研究（浙江省公益技术应用研究项目，合作项目，2011C33G1360040，2010.01-2012.12，第二完成人）。目前正在进行的重要项目及得到资助(2008-现在):1.手性非alpha-氨基酸衍生物及基因靶标调控物质聚酰胺的研发(浙江省科技厅钱江人才项目,2008R10G2020015,2009.01.01-2010.12.31)。2.重大传染性疾病分子靶向诊疗化合物手性聚酰胺的研发（浙江省“公共卫生监测与突发事件处置关键技术研究科技创新团队”项目，2011R50021，2012.06-2014.05）。3.结构新颖的手性环型聚酰胺的构建及其对PD-1基因启动子碱基序列的作用（浙江省自然科学基金，LY12B02019，2012.01-2013.12）。4.浙江省‘十二五’高校“化学生物学”重点学科建设项目（2011.01-2015.12）主要研究方向:1．分子与核酸作用结构生物学解析（Polyamide，Aminoglycosideetc.B-DNA,G-DNA,RNA）2．分子基因调控与靶向药物设计3.生物活性分子设计及合成4．DNA纳米结构的研究主要教学工作：1.药物化学（本科）2.生物化学（本科）3.化学生物学（研究生）4.生物制药技术（研究生）目前，“化学生物学与分子药物设计”研究室成员包括：研三（M3）4人，研二（M2）4人，研一（M1）2人，大四本科生（B4）4人。欢迎具有化学和生物基础的本科生、硕士生加入我们的研究团队！研究室将为你提供良好、宽松的学习和研究环境，同时这里也是你迈向科学殿堂的阶梯。MainOriginalPapers:20.Su-LinZhang,WenZhang*,G-quadruplexstructuresandinteractiondiversitywithligands.Submitted,2013.19.Yan-LingWu,Li-WenShen,Yan-PingDing,YoshimasaTanaka,andWenZhang.PreliminarysuccessinthecharacterizationandmanagementofasuddenbreakoutofanovelH7N9influenzaAvirus.IntJBiolSci.2014.Inprint.18.Yan-LingWu*,Yan-PingDing,YoshimasaTanaka,Li-WenShen,NagahiroMinatoandWenZhang*.γδTcellsandtheirpotentialforimmunotherapy.IntJBiolSci.2014.Inprint.17.Yan-LingWu*,Yan-PingDing,YoshimasaTanakaandWenZhang*.Riskfactorsandprimarypreventiontrialsfortype1diabetes.IntJBiolSci.2013,9(6):666-678.(IF3.168).16.Yan-LingWu*,GaneshN.Pandian,Yan-PingDing,WenZhang,YoshimasaTanakaand

HiroshiSugiyama*.ClinicalgradeiPScells:needforversatilesmallmoleculesandoptimalcellsources.CHEMBIOL(IF6.157)，2013,20(11),1311-1322.15.JingLiang,Yan-LingWu,WenZhang*,YoshimasaTanaka,andHiroshiSugiyama.Thec-Kitreceptor-mediatedsignaltransductionandtumor-relateddiseases.IntJBiolSci.2013,9(5):435-443.(IF3.168)14.DongliangXie,JunyaoHe*,Yan-LingWu*,WenZhang,YoshimasaTanaka.TheestablishmentandapplicationofthreekindsoftheSCIDmouse-basedimprovedanimalmodelsintheresearchofAIDS,chronichepatitisBandC.AdvancedMaterialsResearch,2013,749,433-438.13.Yan-LingWu,JingLiang,WenZhang*,YoshimasaTanaka,andHiroshiSugiyama.Immunotherapies:TheBlockadeofInhibitorySignals.IntJBiolSci.2012,8(10):1420-1430.(IF3.168,2012)12.Hong-FeiZhang,Yan-LingWu*,Shi-KunJiang,PuWang,HiroshiSugiyama,Xing-LaiChen,WenZhang*,Yan-JuanJi,andChuan-XinGuo.RecognitionoftheNonaromaticandStereochemicalSubunit-containingPolyamidestotheFourWatson-CrickBasePairsintheDNAMinorGroove.CHEMBIOCHEM,2012,13,1366-1374.(IF3.74,2012)11.LinanLiu,YanlingWu*,ShikunJiang,TaoQiu,HongfeiZhang,andWenZhang*.TargetinghumantelomericG-quadruplexwithperfluoroalkylmetalphthalocyaninederivatives.AdvancedMaterialsResearch,2012,365,382-388.10.WenZhang*,Shi-KunJiang,Yan-LingWu*,Chuan-XinGuo,Hong-FeiZhang,HiroshiSugiyama,andXing-LaiChen.DiscriminationbetweenT/AandA/TBasePairsofPyrrole-ImidazolePolyamidesSubstitutedwithChiralβ-Hydroxy-γ-AminobutyricAcid/β-AlaninePairs.CHEMBIOCHEM,2012,13,47-50.(IF3.74,2012)9.Shi-KunJiang,PuWang,Yan-LingWu,andWenZhang*.TheRoleofAliphaticChainsofPyrrole-imidazolePolyamidesandTheirConjugatesBindingtoDNA.PROGRESSINCHEMISTRY,2011,12(11),2339-2352.(IF0.67,2012)8.YanlingWu,JingLiang,LeiChen,HuaGu,WenZhang*,FengKe,YiyuLu,NiWang,XiaohongPan.TheexpressionandclinicalsignificanceofFOXP3mRNAinperipheralbloodmonocytesfromHIV/AIDSpatients.In:2010InternationalConferenceonCellular,MolecularBiology,BiophysicsandBioengineering(CMBB2010,EditedbyXueliZhou),Qiqihar,China,InstituteofElectricalandElectronicsEngineers,Inc.(HongKong),2010,417-420.7.WenZhang,MasafumiMinoshimaandHiroshiSugiyama*.Basepairrecognitionofthesteeochemicallyalpha-substitutedgamma-turnofpyrrole/imidazolehairpin.JACS,2006,128,14905-14912.(IF10.677,2012).6.WenZhang,ToshikazuBandoandHiroshiSugiyama*.Discriminationofhairpinpolyamideswithanalpha-substituted-gamma-aminobutyricacidasaTG-readerinDNAminorgroove.JACS,2006,128(27),8766-8776.(IF10.677,2012).5.HiroyukiMatsuda,NoboruFukuda*,TakahiroUeno,YoshikoTahira,HirohitoAyame,WenZhang,ToshikazuBando,HiroshiSugiyama,SatoshiSaito,KoichiMatsumoto,HideoMugishima,andKazuoSerie.Developmentofgenesilencingpyrrole-imidazolepolyamidetargetingtheTGF-beta1promoterfortreatmentofprogressiverenaldiseases.JAmSocNephrol.2006,17,422-432.(IF8.987,2012).4.WenZhang,XuhongQian*,YanlingWuandHiroshiOhrui.AnewclassofDNAintercalatorandphotocleaver:bis-naphthalmideswithbromoandnitrosubstituents.HeterocyclicComm.2003,9(3),229-234.(IF0.522,2012).3.WenZhang,YanliWang,YufangXuandXuhongQian*.Newfluorescentconjugatesofuridinenucleosideandsubstituted1,8-naphthalimide:synthesis,weakinteractionsandsolventeffectsonspectra.MonatsheftefürChemie,2003,134,393-402.(IF1.629,2012).2.IvoGrabchev*,XuhongQian,VladimirBojinov,YiXiao,andWenZhang.Synthesisandphotophysicalpropertiesof1,8-naphthalimide-labelledPAMAMasPETsensorofprotonsandoftransitionmetalions.Polymer,2002,43(21),5731-5736.(IF3.379,2012).1.QianCheng*,WenZhang,YoshimichiTagami,TakayukiOritani.Microwave-induced1,3-dipolarintramolecularcycloadditionsofN-substitutedoximes,nitrones,andazomethineylidesforthechiralsynthesisoffunctionalizednitrogenheterocycles.J.Chem.Soc.PerkinTrans.I,2001,4,452-456.Otherpublications：1.WenZhang,YanlingWu.Thepreparativemethodoftetrachlorophthalicanhydride.1999,ChinaPatent,CN1222519A.2.WenZhangandHiroshiSugiyama.Designofpyrrole-imidazolepolyamidesdiscriminatingT/A.In:The4thNationalConferenceonChemicalBiologyandtheInternationalSymposiumontheInterdisciplinaryScienceofChemistrywithBiologyandMedicine,Wuhan,China,2005,p91.3.WenZhang.In:theAnnualReasearchReportofthe21thCenturyCOEProgramofKyotoUniversityAllianceforChemistryin2004,p62-63.4.WenZhang.In:theAnnualReasearchReportofthe21thCenturyCOEProgramofKyotoUniversityAllianceforChemistryin2005,p69-70.5.WenZhangandHiroshiSugiyama.Synthesisofhairpinpolyamidesandtheirbiologicalapplications.2006,Japanpatent10611342.6.WenZhang*.Amethodofpreparationofaminoandhydroxylco-protectivechiralnon-alphaaminoacidderivatives.2006,CN100509766C.7.ShikunJiang,YanlingWu,andWenZhang*.RecognitionofPy-ImPolyamideswithChiralRecognitionUnittoMethylatedCytosine.In:The6thNationalConferenceonChemicalBiologyandtheInternationalSymposiumontheInterdisciplinaryScienceofChemistrywithBiologyandMedicine,Xiamen,China,2009,p269.8.Yan-LingWu*,Yan-PingDing,JianGao,LuFang,FengKe,andWenZhang*.Suppressionofoverexpressionofc-kitgenebychirally-modifiedpolyamidesmediatingapoptosisoftwotypesofcancercells.In:The7thNationalConferenceonChemicalBiology,Nanjing,China,2011,p412.9.WenZhang*,Yan-LingWu*,Shi-KunJiang,Chuan-XinGuo,andHong-FeiZhang.Designofthenonaromaticandstereochemicalsubunit-containingpolyamides,andtheirrecognitiontoPD-1promotersequence.In:The7thNationalConferenceonChemicalBiology,Nanjing,China,2011,p389.10.WenZhang*,Yan-LingWu,andShi-KunJiang.一种含或不含β-羟基-γ-氨基酸修饰的发夹聚酰胺、制备方法及应用.2011,CN201110454689.1.11.Hong-FeiZhang,Yi-QianJiang,Jia-HuaYu,Yan-JuanJi,Yan-LingWu,WenZhang*.Design,SynthesisofNoveloxo-heterocylicnaphtalimidesandTheirInteractionwithguanine-richtelomericDNASequence.In:The28thNationalConferenceonChemistry,Chengdu,China,2012.12.Yan-LingWu*,Dong-LongXie,Yan-PingDing,JianGao,WenZhang*.Design,SynthesisofChiralSubunit-containingPolyamidesandTheirRegulationtoOverexpressionalPD-1onHIV-,HBV-andHCV-infectedCells.In:The28thNationalConferenceonChemistry,Chengdu,China,2012.13.WenZhang*,Yan-LingWu,JingLiangandBing-JiaChen.手性（S）-β-羟基-γ-氨基酸修饰的发夹聚酰胺及其应用.2013,CN201310118833.3.14.Yan-JuanJi,Yan-LingWu,andWenZhang*.Design,SynthesisofBenzothioxantheneDerivativesandTheirMediatingApoptosisofPD-1Over-expressedTumorCells.The9thAFMCInternationalMedicinalChemistrySymposium(AIMECS13),Taipei,2013.15.ZhangSu-Lin,JiYan-Juan,WuYan-Ling*,ZhangWen*.SuppressionofPD-1geneoverexpressionbythio-heterocyclicnaphthalimidesmediatingapoptosisofcancercells.The8thNationalConferenceonChemicalBiologyofChina,Shanghai,2013,p384.16.ChenBing-Jia,ChenXing-Lai,WuYan-Ling,ZhangWen*.Downregulationofc-mycgeneoverexpressionbychirally-modifiedpolyamidesmediatingapoptosisofcancercells.The8thNationalConferenceonChemicalBiologyofChina,Shanghai,2013,p385.Awards&Fellowships:1.1998年大庆科学技术进步一等奖2.JSPSpostdoctoralfellow，Japan,Nov.2001toNov.20033.COEpostdoctoralfellow,Japan,Dec.2003toDec20054.JSTpostdoctoralfellow,Japan,Jan.2006toMar.20065.2013年湖州市“南太湖精英计划”领军人才