Understanding and Harnessing Microbial Chemistry
summary
杜艺岭，浙江大学医学院基础医学系\/药物生物技术研究所“****”研究员，博士生导师。课题组的主要研究方向为微生物来源的生物活性小分子的遗传与生化分子基础的解析及应用（Microbial Chemical and Synthetic Biology）。实验室通过生物化学与分子生物学、基因组学、合成生物学、有机与分析化学、结构生物学等多种技术手段，用于重要微生物活性合成代谢产物（如天然药物、毒素、化学信号分子等）的生物合成机制解析；新颖生物合成催化元件的结构与功能研究；生物合成过程基因调控机理研究；基于合成生物学与组学技术的微生物药物发现、结构创新、微生物制造等。
(Nat Communications,2020;Nat Chem Biol,2019;Nat Prod Rep, 2018;Nat Chem Biol, 2017;Nat Chem Biol, 2016;PNAS, 2015)
Microbes produce a variety of drug molecules with diversified chemical structures and biological activities. These molecules, also known as natural products, are essential to human health and have been used to combat infectious bacteria and fungi. Working at the interface of microbiology and chemistry, Dr. Yiling Du's research integrates microbial genetics, molecular biology and biochemistry, organic chemistry and structural biology approaches to study natural product biosynthetic machinery. The goal is to understand how these small molecules (natural product drugs, toxin, chemical signaling molecules etc.) are made in nature, how microbes control their biosynthetic pathways, what's the ecological role of these chemical molecules,and then engineer microbal chemistry for drug discovery and biocatalysis.
欢迎有生物学、化学、药学等专业背景的优秀学生报考实验室研究生！诚邀优秀博士毕业生到实验室进行博士后研究！
Selected publications:
Guiyun Zhao, Yuan-Yang Guo, Shunyun Yao, Xinjie Shi, Longxian Lv, Yi-Ling Du* (2020)Nitric oxide as a source for bacterial triazole biosynthesis.Nature Communications, doi: 10.1038\/s41467-020-15420-8.
Yi-Ling Du*, Melanie A Higgins, Guiyun Zhao, Katherine S Ryan* (2019) Convergent biosynthetic transformations to a bacterial specialized metabolite. Nature Chemical Biology, DOI:10.1038\/s41589-019-0331-5.
Yi-Ling Du, Hai-Yan He, Melanie A Higgins, Katherine S Ryan* (2017) A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazte. Nature Chemical Biology, 13(8):836-838.
Yi-Ling Du, Rahul Singh, Lona M Alkhalaf, Eugene Kuatsjah, Hai-Yan He, Lindsay D Eltis, Katherine S Ryan* (2016) A pyridoxal phosphate-dependent enzyme that oxidizes an unactivated carbon-carbon bond. Nature Chemical Biology, 12(3):194-199
Yi-Ling Du, Lona M Alkhalaf, Katherine S Ryan* (2015) In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazoline assembly. PNAS. 112(9):2717-2722.
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主要研究方向： 天然产物药物分子的化学生物学与合成生物学。 天然产物分子及其衍生化合物长期以来是临床药物的重要来源。作为自然界的“合成化学家”，动植物和微生物等能够在不同内外源环境信号的刺激下，启动一系列体内生物合成机器组装出具有复杂化学结构和重要生物学活性的分子，其中包括那些目前不能通过有机化学反应合成或者需要苛刻反应条件才能得到的药物分子。我们以这些天然产物药物的生物合成和调控过程为研究对象，综合基因组学、分子生物学与生物化学、合成生物学、结构生物学和有机与分析化学等多领域的技术手段，用于（1）微生物源先导药物分子的发现方法创新与药物开发；（2）新颖化学骨架与结构单元的组装途径与酶催化机制解析及重设计；（3）天然产物生物合成相关化学信号转导机制和化学生态学研究；（4）合成生物学技术在药物创新与高产优产中的应用等。
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2017-05-22 16:46:15
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Selected publications:
Yi-Ling Du, Hai-Yan He, Melanie A Higgins, Katherine S Ryan (2017) A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazte. Nature Chemical Biology, 13(8):836-838.
Yi-Ling Du, Rahul Singh, Lona M Alkhalaf, Eugene Kuatsjah, Hai-Yan He, Lindsay D Eltis, Katherine S Ryan (2016) A pyridoxal phosphate-dependent enzyme that oxidizes an unactivated carbon-carbon bond. Nature Chemical Biology, 12(3):194-199
Yi-Ling Du, Katherine S Ryan (2016) Catalytic reportoire of bacterial bisindole formation. Current Opinion in Chemical Biology, 31:74-81
Yi-Ling Du, Lona M Alkhalaf, Katherine S Ryan (2015) In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazoline assembly. PNAS. 112(9):2717-2722.
Yi-Ling Du, Katherine S Ryan (2015) Expansion of bisindole biosynthetic pathways by combinatorial construction. ACS Synthetic Biology, 4(6):682-688
欢迎有生物学、化学、药学等专业背景的优秀学生报考实验室研究生！诚邀优秀博士毕业生到实验室进行博士后研究！
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+86-
yldu@zju.edu.cn
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浙江大学紫金港校区生物实验中心118
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2021-01-24 15:30:43
content
杜艺岭，浙江大学医学院基础医学系\/药物生物技术研究所“****”研究员，博士生导师。课题组的主要研究方向为微生物来源的生物活性小分子的遗传与生化分子基础的解析及应用（Microbial Chemical and Synthetic Biology）。实验室通过生物化学与分子生物学、基因组学、合成生物学、有机与分析化学、结构生物学等多种技术手段，用于重要微生物活性合成代谢产物（如天然药物、毒素、化学信号分子等）的生物合成机制解析；新颖生物合成催化元件的结构与功能研究；生物合成过程基因调控机理研究；基于合成生物学与组学技术的微生物药物发现、结构创新、微生物制造等。
(Nat Communications,2020;Nat Chem Biol,2019;Nat Prod Rep, 2018;Nat Chem Biol, 2017;Nat Chem Biol, 2016;PNAS, 2015)
Microbes produce a variety of drug molecules with diversified chemical structures and biological activities. These molecules, also known as natural products, are essential to human health and have been used to combat infectious bacteria and fungi. Working at the interface of microbiology and chemistry, Dr. Yiling Du's research integrates microbial genetics, molecular biology and biochemistry, organic chemistry and structural biology approaches to study natural product biosynthetic machinery. The goal is to understand how these small molecules (natural product drugs, toxin, chemical signaling molecules etc.) are made in nature, how microbes control their biosynthetic pathways, what's the ecological role of these chemical molecules,and then engineer microbal chemistry for drug discovery and biocatalysis.
欢迎有生物学、化学、药学等专业背景的优秀学生报考实验室研究生！诚邀优秀博士毕业生到实验室进行博士后研究！
Selected publications:
Guiyun Zhao, Yuan-Yang Guo, Shunyun Yao, Xinjie Shi, Longxian Lv, Yi-Ling Du* (2020)Nitric oxide as a source for bacterial triazole biosynthesis.Nature Communications, doi: 10.1038\/s41467-020-15420-8.
Yi-Ling Du*, Melanie A Higgins, Guiyun Zhao, Katherine S Ryan* (2019) Convergent biosynthetic transformations to a bacterial specialized metabolite. Nature Chemical Biology, DOI:10.1038\/s41589-019-0331-5.
Yi-Ling Du, Hai-Yan He, Melanie A Higgins, Katherine S Ryan* (2017) A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazte. Nature Chemical Biology, 13(8):836-838.
Yi-Ling Du, Rahul Singh, Lona M Alkhalaf, Eugene Kuatsjah, Hai-Yan He, Lindsay D Eltis, Katherine S Ryan* (2016) A pyridoxal phosphate-dependent enzyme that oxidizes an unactivated carbon-carbon bond. Nature Chemical Biology, 12(3):194-199
Yi-Ling Du, Lona M Alkhalaf, Katherine S Ryan* (2015) In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazoline assembly. PNAS. 112(9):2717-2722.
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