应激相关精神疾病研究组
summary
触觉是人类重要的感觉之一。通过触觉，我们得以感受丝绸的柔滑、麻布的粗糙，分辨纸张的厚薄、硬币的大小。母亲的爱抚可以让孩童倍感舒适和安全，握手和拥抱可以让双方感受到亲切和温暖。很多研究表明，正性触觉刺激可以促进认知发育、舒缓压抑情绪，而一些精神疾病患者往往存在触觉信息加工整合障碍。然而，触觉经历如何调节大脑发育与可塑性，进而调节认知和情绪？触觉与其它感官信息（如视觉、听觉、嗅觉）的整合如何影响大脑与行为？单模态或跨模态感觉信息加工整合异常又如何参与应激相关精神疾病的发生发展？
王晓东课题组结合行为学、活动神经元标记、化学遗传学、神经环路示踪和深度学习等技术，旨在探索跨模态感觉整合障碍在应激相关精神疾病中的作用机制。
我们欢迎感兴趣的同学加盟！
Wang C#, Liu H#, Li K#, Wu ZZ, Wu C, Yu JY, Gong Q, Fang P, Wang XX, Duan SM, Wang H, Gu Y, Hu J, Pan BX, Schmidt MV, Liu YJ,Wang XD* (2020). Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis.Nature Communications11, 6045.
Liu YJ*,#, Zhang T#, Chen S, Cheng D, Wu C, Wang X, Duan D, Zhu L, Lou H, Gong Z, Wang XD*, Ho MS*, Duan S (2021). The noncanonical role of the protease cathepsin D as a cofilin phosphatase. Cell Research, in press, doi: 10.1038\/s41422-020-00454-w.
Liu YJ*, Zhang T, Cheng D, Yang J, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS*,Wang XD*, Duan S* (2020). Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD.Science Advances6, eaba5783.
Yu JY, Fang P, Wang C, Wang XX, Li K, Gong Q, Luo BY,Wang XD* (2018). Dorsal CA1 interneurons contribute to acute stress-induced spatial memory deficits.Neuropharmacology135, 474-486.
Gong Q, Su YA, Wu C, Si TM, Deussing JM, Schmidt MV,Wang XD* (2018). Chronic stress reduces nectin-1 mRNA levels and disrupts dendritic spine plasticity in the adult mouse perirhinal cortex.Frontiers in Cellular Neuroscience12, 67.
Li K#, Shen S#, Ji YT, Li XY, Zhang LS,Wang XD* (2018). Melatonin augments the effects of fluoxetine on depression-like behavior and hippocampal BDNF-TrkB signaling.Neuroscience Bulletin34, 303-311.
Li JT#, Xie XM#, Yu JY, Sun YX, Liao XM, Wang XX, Su YA, Liu YJ, Schmidt MV,Wang XD*, Si TM* (2017). Suppressed calbindin levels in hippocampal excitatory neurons mediate stress-induced memory loss.Cell Reports21, 891-900.
Wang XX, Li JT, Xie XM, Gu Y, Si TM, Schmidt MV,Wang XD* (2017) Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory.Translational Psychiatry7, e1228.
Yang XD, Liao XM, Uribe-Marino A, Liu R, Xie XM, Jia J, Su YA, Li JT, Schmidt MV,Wang XD*, Si TM* (2015). Stress during a critical postnatal period induces region-specific structural abnormalities and dysfunction of the prefrontal cortex via CRF1.Neuropsychopharmacology40, 1203-1215.
Liao XM, Yang XD, Jia J, Li JT, Xie XM, Su YA, Schmidt MV, Si TM*,Wang XD*(2014). Blockade of corticotropin-releasing hormone receptor 1 attenuates early-life stress-induced synaptic abnormalities in the neonatal hippocampus.Hippocampus25, 528-540.
Wang XD, Su YA, Avrabos C, Wagner KV, Liebl C, Wolf M, Scharf SH, Hartmann J, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV* (2013). Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss.Nature Neuroscience16, 706-713.
Wang XD*, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart MG, Müller MB, Schmidt MV (2011). Forebrain CRF1 modulates early life stress-programmed cognitive deficits.The Journal of Neuroscience 31, 13625-13634.
Wang XD*, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, Schmidt MV (2011). Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling.Neurobiology of Disease42, 300-310.
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(1) 早年应激影响大脑发育与认知功能的分子机制；\r\r(2) 突触细胞黏附分子在学习记忆及应激相关精神疾病中的参与作用。
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2014-05-11 22:49:54
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王晓东博士，浙江大学神经科学研究所研究员、博士生导师。2011年4月博士毕业于德国马克斯•普朗克精神病学研究所\/慕尼黑大学生物学专业；2011年5月至2012年11月于德国马克斯•普朗克精神病学研究所继续从事博士后研究；2013年1月至2013年10月于北京大学第六医院开展研究工作，任助理研究员、副研究员；2013年11月加盟浙江大学医学院。
Li JT, Xie XM, Yu JY, Sun YX, Liao XM, Wang XX, Su YA, Liu YJ, Schmidt MV, Wang XD*, Si TM* (2017). Suppressed calbindin levels in hippocampal excitatory neurons mediate stress-induced memory loss. Cell Reports 21, 891-900.
Yang XD, Liao XM, Uribe-Mariño A, Liu R, Xie XM, Jia J, Su YA, Li JT, Schmidt MV, Wang XD*, Si TM* (2015). Stress during a critical postnatal period induces region-specific structural abnormalities and dysfunction of the prefrontal cortex via CRF1. Neuropsychopharmacology 40, 1203-1215.
url
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**
xiaodongwang@zju.edu.cn
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医学院科研楼A407
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5470
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neurostress
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2021-01-24 16:30:29
content
触觉是人类重要的感觉之一。通过触觉，我们得以感受丝绸的柔滑、麻布的粗糙，分辨纸张的厚薄、硬币的大小。母亲的爱抚可以让孩童倍感舒适和安全，握手和拥抱可以让双方感受到亲切和温暖。很多研究表明，正性触觉刺激可以促进认知发育、舒缓压抑情绪，而一些精神疾病患者往往存在触觉信息加工整合障碍。然而，触觉经历如何调节大脑发育与可塑性，进而调节认知和情绪？触觉与其它感官信息（如视觉、听觉、嗅觉）的整合如何影响大脑与行为？单模态或跨模态感觉信息加工整合异常又如何参与应激相关精神疾病的发生发展？
王晓东课题组结合行为学、活动神经元标记、化学遗传学、神经环路示踪和深度学习等技术，旨在探索跨模态感觉整合障碍在应激相关精神疾病中的作用机制。
我们欢迎感兴趣的同学加盟！
Wang C#, Liu H#, Li K#, Wu ZZ, Wu C, Yu JY, Gong Q, Fang P, Wang XX, Duan SM, Wang H, Gu Y, Hu J, Pan BX, Schmidt MV, Liu YJ,Wang XD* (2020). Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis.Nature Communications11, 6045.
Liu YJ*,#, Zhang T#, Chen S, Cheng D, Wu C, Wang X, Duan D, Zhu L, Lou H, Gong Z, Wang XD*, Ho MS*, Duan S (2021). The noncanonical role of the protease cathepsin D as a cofilin phosphatase. Cell Research, in press, doi: 10.1038\/s41422-020-00454-w.
Liu YJ*, Zhang T, Cheng D, Yang J, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS*,Wang XD*, Duan S* (2020). Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD.Science Advances6, eaba5783.
Yu JY, Fang P, Wang C, Wang XX, Li K, Gong Q, Luo BY,Wang XD* (2018). Dorsal CA1 interneurons contribute to acute stress-induced spatial memory deficits.Neuropharmacology135, 474-486.
Gong Q, Su YA, Wu C, Si TM, Deussing JM, Schmidt MV,Wang XD* (2018). Chronic stress reduces nectin-1 mRNA levels and disrupts dendritic spine plasticity in the adult mouse perirhinal cortex.Frontiers in Cellular Neuroscience12, 67.
Li K#, Shen S#, Ji YT, Li XY, Zhang LS,Wang XD* (2018). Melatonin augments the effects of fluoxetine on depression-like behavior and hippocampal BDNF-TrkB signaling.Neuroscience Bulletin34, 303-311.
Li JT#, Xie XM#, Yu JY, Sun YX, Liao XM, Wang XX, Su YA, Liu YJ, Schmidt MV,Wang XD*, Si TM* (2017). Suppressed calbindin levels in hippocampal excitatory neurons mediate stress-induced memory loss.Cell Reports21, 891-900.
Wang XX, Li JT, Xie XM, Gu Y, Si TM, Schmidt MV,Wang XD* (2017) Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory.Translational Psychiatry7, e1228.
Yang XD, Liao XM, Uribe-Marino A, Liu R, Xie XM, Jia J, Su YA, Li JT, Schmidt MV,Wang XD*, Si TM* (2015). Stress during a critical postnatal period induces region-specific structural abnormalities and dysfunction of the prefrontal cortex via CRF1.Neuropsychopharmacology40, 1203-1215.
Liao XM, Yang XD, Jia J, Li JT, Xie XM, Su YA, Schmidt MV, Si TM*,Wang XD*(2014). Blockade of corticotropin-releasing hormone receptor 1 attenuates early-life stress-induced synaptic abnormalities in the neonatal hippocampus.Hippocampus25, 528-540.
Wang XD, Su YA, Avrabos C, Wagner KV, Liebl C, Wolf M, Scharf SH, Hartmann J, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV* (2013). Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss.Nature Neuroscience16, 706-713.
Wang XD*, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart MG, Müller MB, Schmidt MV (2011). Forebrain CRF1 modulates early life stress-programmed cognitive deficits.The Journal of Neuroscience 31, 13625-13634.
Wang XD*, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, Schmidt MV (2011). Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling.Neurobiology of Disease42, 300-310.
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